“Pancef”: instructions for use of the suspension for children and antibiotic analogues

Is your baby sick again and the doctor has prescribed antibiotics? Any parent wants the medications their child takes to be not only effective, but also as safe as possible. Pancef for the treatment of infections in children from 6 months of age is one such remedy. Read more about the pros and cons of this antibiotic, step-by-step preparation of the suspension and dose calculation in our review.

Pancef is a third generation antibiotic.

Pancef's analogues

Pancef has many similar drugs, which, along with identical properties, have different prices.
Cheap analogues include injection drugs:

• Ceftriaxone – produced in Russia, price of 1 bottle – from 28 rubles;
• Ceftidine - made in India, price of 1 bottle - 75 rubles;
• Claforan - made in Great Britain, price of 1 bottle - 175 rubles.

All other analogues are in the same price range, differing only slightly in cost from Pancef.

Ixim Lupine

Ixim Lupine is a drug for the treatment of children, similar to Pancef, produced in India, in the form of a dry powder (for preparing a suspended solution with water).

The price ranges from 450 to 570 rubles. The bottle contains 25 grams of the drug for the preparation of 50 milliliters of suspension, containing 100 milligrams of cefixime.

Sumamed

Sumamed is a semi-synthetic antibiotic of the azalide group. Has a broad spectrum antibacterial effect. Produced in Israel in tablet form (for adults) and powder form for preparing a suspended solution (for children). It is used similarly to Pancef, the price range is from 360 to 500 rubles, depending on the dosage and the number of tablets or bulk substance in the package.

Cost and analogues

Antibiotic drugs from the cephalosporin group are quite popular medications that are often prescribed by doctors to treat various infectious diseases. Some medicines contain the same active ingredient as Pancef - Cefixime. Among the drug analogues:

• Suprax (Jordan);
• Ixim Lupine (India);
• Ceforal Solutab (Italy).
• Cemidexor (China).

The price of medicines directly depends on the country that produces them, so Pancef is cheaper than its analogues. Its average cost in Russian pharmacies is from 450 to 700 rubles, while the price of antibiotics containing the same active ingredient ranges from 500 to 900 rubles.

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Contraindications

Before starting to take the drug, a person must undergo tests. Based on them, the doctor will be able to identify the causative agent of the infection, as well as determine its sensitivity to the antibiotic. In addition, the specialist will take into account the list of existing contraindications.

The use of the product is strictly prohibited in the following situations:

• children up to 6 months - for a suspension prepared from granules, up to 12 years - for tablets;
• there is damage to the kidneys and liver;
• liver and kidney failure is observed;
• the girl is expecting a child or is breastfeeding him;
• there is individual hypersensitivity to the components of the drug;
• severe allergic reactions to penicillins have been observed in the past;
• The pathogens that cause the disease have individual resistance to the effects of cefixime.

Prescribed with caution to elderly people

Chemical component

Antibiotics and alcohol react chemically. As a result, the healing properties of medications are inhibited. Ethanol can change the activity of enzymes, disrupting the usual metabolism of drugs. People who regularly drink alcohol develop tolerance (immunity) to antibiotics.

Such medications are able to cross the blood-brain barrier. Such drugs penetrate into the brain tissue. Under the influence of ethyl alcohol, biochemical processes change in it, and the activity of certain areas is inhibited. It is impossible to predict what effect an antibacterial agent will have on altered tissues.

Drinking alcohol leads to a decrease in the activity of biocatalysts, which accelerate the breakdown of antibiotics, which slows down the effect of the drugs and increases their toxicity.

Alcohol is incompatible not only with antibiotics, but also with sedatives, hypnotics and antiviral drugs.

pharmachologic effect

The active substance of Pancef is cefixime, which has bactericidal properties. It disrupts the synthesis of bacterial cell walls, which causes their death. It affects various types of microorganisms. Cefixime is resistant to β-lactamases, which are produced by most bacteria, both gram-positive and gram-negative.

• Panzef is very active against such gram-positive bacteria as Streptococcus agalactiae; as well as many gram-negative bacteria, such as Proteus vulgaris, Haemophilus parainfluenzae, Shigella spp., Klebsiella oxytoca, Klebsiella pneumoniae, Pasteurella multocida, Salmonella spp., Providencia spp., Citrobacter diversus, Citrobacter amalonaticus, Serratia marcescens.
• Research and clinical practice also prove the effectiveness of the drug against such gram-positive bacteria as Streptococcus pyogenes and Streptococcus pneumoniae, as well as such gram-negative bacteria as Moraxella (Branhamella) catarrhalis, Haemophilus influenzae, Proteus mirabilis, Escherichia coli, Neisseria gonorrhoeae.
• Some microorganisms are resistant to the effects of cefixime, so the use of this drug in the treatment of infections caused by such pathogens is prohibited. These include Enterococcus (Streptococcus) serogroup D, Pseudomonas spp., Listeria monocytogenes, most Staphylococcus spp. Bacteroides fragilis, Enterobacter spp., Clostridium spp.

Operating principle

"Pancef" is an antibiotic of the cephalosporin group and belongs to the third generation. It has a fairly wide range of effects on various infectious agents, and the effect on microbes itself is bactericidal. It is associated with the ability of cefixime to block the process of membrane synthesis in bacterial cells, resulting in the death of microorganisms.

Pancef has high activity against the following bacteria:

• Pneumococcus.
• Streptococcus pyogenes.
• Haemophilus influenzae.
• Moraxella catharalis.
• Escherichia coli.
• Gonococcus.
• Proteus.
• Different types of Klebsiella.
• Pasteurella.
• Salmonella.
• Citrobacter.
• Serration.
• Providence.
• Shigella.

However, most staphylococci, clostridia, bacteroides, and enterobacters do not die under the influence of such a medicine. Resistance to the effects of cefixime is also noted in some listeria, enterococci, streptococci, acinetobacter and pseudomonads.

After taking the medicine orally, cefixime enters the blood in an amount of 40-50% of the total dose.

The drug is excreted primarily in the urine. Due to the long period of maximum plasma concentration and half-life, Pancef can be taken only once a day.

Granules for preparing suspensions

In this dosage form, Pancef should also be taken orally, having previously prepared a suspension from granules. To do this, immediately before the first use, using a measuring cap, add 40 ml (to obtain 60 ml of suspension) or 66 ml (to obtain 100 ml of suspension) of boiled water cooled to room temperature in 2 stages into the bottle and after each addition, shake vigorously until homogeneous suspension.

Adults and adolescents over 12 years of age (with a body weight of more than 50 mg) are usually prescribed 400 mg once a day or 200 mg 2 times a day.

For uncomplicated gonorrhea, as a rule, a single dose of 400 mg is sufficient.

For children under 12 years of age (with body weight less than 50 mg), Pancef is prescribed at a dose of 8 mg/kg 1 time per day or 4 mg/kg 2 times per day at 12-hour intervals.

Doses used depending on the child’s weight:

• 37.5-50 kg: 15-20 ml of suspension (300-400 mg of cefixime);
• 25-37.5 kg: 15 ml (300 mg cefixime);
• 12.5-25 kg: 10 ml (200 mg cefixime);
• 6-12.5 kg: 5 ml (100 mg cefixime);
• Up to 6 kg: 2.5 ml (50 mg cefixime).

The duration of therapy is on average 7-10 days, for infectious diseases caused by Streptococcus pyogenes - at least 10 days.

The suspension should be shaken well before use.

To dose the finished suspension, you must use the included measuring cap, which should be rinsed well with water after each use.

Due to differences in bioavailability, it is not recommended to replace the suspension with tablets.

Regardless of the dosage form of Pancef used, in patients with impaired renal function, the dose is reduced depending on creatinine clearance (CC):

• CC 21-60 ml/minute and patients on hemodialysis - by 25%;
• CC less than 21 ml/minute and patients on peritoneal dialysis - by 50%.

Methods of administration

According to the instructions and reviews, Pancef in tablet form is prescribed to adults and children over 12 years of age.
The norm is calculated at 8 mg per kg of weight; you need to take the medicine once a day or divide it into 2 times. The highest norm is 400 mg per day. Treatment takes from 1 week to 10 days. The syrup is prescribed to adults and children of any age. You cannot prepare the solution in advance. Shake the bottle of powder and add 40 ml of cool boiled water. Shake until smooth, then let the medicine stand for 3-5 minutes. A measuring cap is used for the required dosage.

The dose is calculated as follows:

• adults and children over 12 years of age – 400 mg. 1 time or 2 times 200 mg;
• 5 - 11 years - 6 - 10 ml of the drug per day, can be drunk or divided into 2 doses;
• 2 – 4 years – 5 ml once or in 2 doses;
• from six months to 1 year – from 2 to 4 ml.

The doctor prescribes the dosage for babies under 6 months individually.

What is Pancef

The drug is used to treat diseases caused by pathogens. Pancef is especially effective in the fight against streptococcus, staphylococcus, salmonella, hemophilus, moraxella, E. coli, Proteus, gonococcus and Klebsiella.

Release form and main composition of the drug

The drug is available in the form of tablets, ready-made suspension and granules for its own preparation. The tablets are white in color, while the capsules are pale yellow. The finished suspension is characterized by a white or yellow color with a pronounced citrus odor. The tablet has an oblong shape and is coated with a light coating for easier swallowing. There is also a red stripe on the side of the tablet.

The main active ingredient of the drug is cefixime trihydrate. The auxiliary components of the tablets include: magnesium, food gelatin, corn starch, macrogol and calcium.

In granular form, the additional ingredients are sodium benzoate, sucrose, citrus flavor and xanthan gum.

Mechanism and time of exposure

How long does it take for the antibiotic Pancef to act after use: after taking the drug, absorption occurs from 50 minutes to 2 hours.

The maximum concentration of the active substance in the blood occurs six hours after administration. There is no specific data on the mandatory use of Pancef with food, but after clinical studies it was found that the drug is absorbed into the blood more quickly with food.

A high concentration of the drug in the body remains for a long period. The drug is excreted mostly through urine and about 10% through bile.

Indications and contraindications

Pancef has a number of significant indications and contraindications, like any medicine.

Although the medicine is successful in treating diseases of the upper and lower respiratory tract, the antibiotic Pancef is not prescribed for sinusitis, since there is no positive result in this case.

Contraindications are:

• allergy;
• age when using tablets - up to 12 years, when using a suspension - no younger than 6 months;
• pregnancy and lactation;
• colitis;
• renal failure.

Among the side effects you can observe:

1. Manifestation of allergies (rashes, itching, redness, itching in the genital area).
2. My head begins to feel very dizzy.
3. Impaired blood formation.
4. Gastrointestinal tract disorders.
5. Vaginitis.
6. Candidiasis.
7. Jaundice.

Dosage for adults and children

When taking the medicine in tablet form for adults weighing more than 50 kg, the daily dose is prescribed no more than 0.4 g per day. This norm can be divided into two steps. The average course of treatment for gonorrhea and streptococcal infection is 7 days. If the patient has kidney problems, the doctor constantly monitors the level of creatinine in the blood. For those who need hemodialysis, the daily norm is reduced by 20-25%, in dialysis - by 50%.

How to dilute the antibiotic Pancef

In order to prepare a suspension from the drug granules, you need to mix them with cooled boiled water. A 0.006 liter bottle will require approximately 0.04 liters of water, and a 0.1 liter bottle will require 0.065 liters of water. It must be added to the container in stages; after each addition, you need to thoroughly shake the powder to dissolve the drug.

Instructions for use of the antibiotic Pancef for children: from 6 months to 12 years with a body weight of less than 50 kg, the daily dose of the drug is prescribed daily at 0.008 g per day. This rate can be divided into two doses of 0.004 g every twelve hours.

For children over 12 years of age with a body weight of more than 0.05 g, the daily norm is, as for adults, 0.4 g per day, 1 time. The approximate duration of treatment for children is about 7-12 days.

Side effects

Possible side effects may include the following:

• The drug may cause hives, fever, skin itching, redness and other types of allergic reactions.
• Treatment with a suspension may be accompanied by abdominal pain, nausea, constipation, dysbacteriosis, vomiting, diarrhea, cholestasis, stomatitis or the appearance of jaundice.
• Due to the use of Pancef, hematopoiesis may be inhibited, which leads to a decrease in the number of blood cells and bleeding.
• In a biochemical blood test, an increase in indicators such as urea, bilirubin, transaminases and creatinine is possible.
• In some patients, the medicine provokes tinnitus, dizziness, and headaches.
• In rare cases, the suspension causes nephritis, shortness of breath, candidiasis or hypovitaminosis B.

Side effects

Like many medications, Pancef has side effects:

• Allergic reactions: urticaria, itching, shortness of breath, rash;
• From the gastrointestinal tract: stool disorder, disturbance of intestinal microflora, signs of jaundice, stomatitis, vomiting, candidiasis, flatulence;
• Nervous system: tinnitus, pain in the head;
• Change in blood formula: decrease in the number of red blood cells, leukocytes, platelets, increase in the level of creatinine, bilirubin, urea.

Thrush in the mouth and vitamin B deficiency may occur.

Contraindications

It is a very effective and safe drug, however, there are a number of contraindications to its use. It is not recommended to use the drug in patients with hypersensitivity to its active substance, as well as to any other components of the drug. The use of this drug is also contraindicated in patients with hypersensitivity to penicillamine and penicillins.

It is prohibited for patients to use the medicine during pregnancy and breastfeeding. Pancef for children is approved for use only after the patient reaches six months of age

Particular caution is required when prescribing the drug to elderly patients and against the background of renal failure. A history of colitis may also be a contraindication.

Compatibility

The myth that you should not drink alcohol after taking antibiotics is only partially true. At the beginning of the 21st century. A number of studies have shown that ethanol does not react with all groups of antibiotic agents.

Some drugs in the cephalosporin group include a side group called methyl-tetrazole-thiol, similar to part of the Disulfiram molecule. After contact with ethyl alcohol, side effects typical of the specified composition can be expected from such drugs.

Some drugs - Levomycetin, Biseptol and a number of others - in combination with ethyl alcohol cause practically asymptomatic intoxication.

Instructions for use

It is necessary to dilute the granules with water before the first use, since the shelf life of the prepared medicine is short.

To add water, use a measuring cap, and pour the liquid in two stages, shaking the closed bottle vigorously after each dilution.

The finished drug is also dosed using a cap, which is sold along with the bottle. After the child drinks the suspension, this cap must be rinsed and dried. Before each subsequent use, the liquid inside the bottle must be shaken.

The average duration of treatment with Pancef is from 7 to 10 days. The drug can be taken once or divided into two doses. For a child aged 6 months to 12 years weighing less than 50 kg, the dosage of the suspension is calculated based on his body weight. Such a patient is given 8 mg/kg per day - this amount can be taken once or divided into 2 doses of 4 mg/kg.

The annotation for the granules also contains a table of approximate doses based on the baby’s weight. If a child is over 12 years old, then he is given 400 mg of cefixime per day, which corresponds to 20 ml of suspension. The drug can be taken twice - 10 ml per dose (200 mg of active substance).

Instructions and dosage

The amount of medicine taken depends on age and weight.

Due to the fact that the drug leaves the body through the liver and kidneys, for children with pathologies of these organs the daily dose is reduced to 75% of the norm, sometimes to 50%. It should be remembered that only a doctor can determine the dosage of the medicine, the frequency and duration of its use.

In case of overdose, side effects may occur. The child needs to rinse the stomach and undergo symptomatic therapy. The prepared solution is stored for no more than 2 weeks in a place where children cannot reach it. Storage is carried out at room temperature. Pancef can only be bred once.

Suspension

To prepare the solution, you need to pour cool boiled water inside the bottle with granules. The volume of liquid is measured by the cap supplied and depends on the dosage of the medicine in the bottle: to dissolve 32 g of granules, add 40 ml of water, 53 g - 66 ml. Dilute the entire preparation before first use, shake for better dissolution.

Treatment lasts from 7 to 10 days. The daily dose for children from six months to 12 years depends on body weight and is calculated based on 8 mg per kilogram of the child’s weight. The daily dose can be given at once or in two doses. To make it easier to calculate the drug, you can use the dosage calculation table:

Children over 12 years of age weighing more than 50 kg are recommended to take 400 mg of medication per day (20 ml of solution). Frequency – once or twice. In the latter case, the single dose is 10 ml. The solution must be shaken before each use.

Pills

Pancef in tablet form is prescribed only to children over twelve years of age weighing more than 50 kg. They give 400 mg per day, which corresponds to one tablet. If necessary, it can be divided in half and drunk in 2 doses.

Indications for use

However, there is an amendment in the instructions that babies under six months should be given the drug with caution, so you should consult a doctor about the possibility of using it for infants. Tablets are recommended for children over twelve years of age.

Pancef is prescribed when infectious-inflammatory diseases are detected that were caused by the following pathogenic microorganisms:

• pneumococci;
• streptococci;
• Haemophilus influenzae;
• diplococcus;
• Klebsiella;
• coli;
• proteas;
• salmonella;
• Citrobacter.

Used to treat diseases:

Indications

Granules are used in the treatment of infections caused by bacteria susceptible to cefixime. The drug is prescribed for the following symptoms :

• For pharyngitis, sinusitis, inflammation of the adenoids, sore throat, inflammation of the middle ear and other infections that are localized in the upper respiratory tract and ENT organs.
• For tracheobronchitis, pneumonia or bronchitis.
• For bacterial infection of the urinary tract.
• With an uncomplicated form of gonorrhea.

Pharmacological effect

Pancef is an antibacterial drug from a series of cephalosporins, which belongs to the third generation of broad-spectrum antibiotics. Shows high efficiency in relation to:

1. Gram-positive and gram-negative aerobic bacteria;
2. Gram-negative and gram-positive anaerobic bacteria.

Shows resistance to beta-lactamases. Bioavailability after administration is about 50-60%. When taken with food, adsorption increases by 0.8 hours. The half-life is about 2-6 hours, depending on the dosage and form of the drug, as well as the characteristics of the particular organism.

Pancef or Suprax – which is better?

Pancef is an antibiotic produced in Macedonia and is a generic or reproduction of Suprax (Italy) based on cefixime. It is available in tablets for adults and suspensions for children. Price – 400-850 depending on the shape.

Suprax is better suited for children, since clinical trials were conducted on it; there may be differences in excipients, purification, and manufacturer of raw materials.

Disadvantage: the cost is 1.5-2 times higher. Available in capsules, suspensions for children, dispersible or water-soluble or oral tablets for children and people with swallowing difficulties.

The indications and restrictions for prescribing the two medications are the same.

Instructions for use

The antibiotic Pancef in tablet form can be taken by adults and children (over 12 years of age). For a child, the dosage is calculated depending on body weight: 8 mg per kilogram of weight during the day, or 4 mg per kilogram twice a day. The limit dose is 0.4 g of medication per day. For adults with an uncomplicated form of gonorrhea, it is enough to take tablets once at a dose of 400 mg. The duration of antibacterial therapy ranges from 7 to 10 days.

Instructions for use of Pancef suspension for children and adults:

1. Adult patients and children over 12 years of age weighing over 50 kilograms are prescribed to take 0.4 g per day or 4 mg per kg of weight - twice a day.
2. Children 5-11 years old - 8 mg per kilogram once a day or 4 mg per kg - 2 times. In other words, 6-10 ml of suspension per day.
3. Children aged 2-4 are prescribed 5 ml of medicinal suspension.
4. From 6 months to a year – 2-4 ml of suspension.
5. Duration of therapy is 7-10 days.

The suspension is prepared before use. The bottle with granules is shaken. Add 40 ml of clean water (room temperature) to it. Water is added in two stages, after each addition the bottle is shaken vigorously. Then you need to let the medicine brew for five minutes. A special cap is used for dosing (it is sold along with the medicine).

Reception during pregnancy and lactation

The instructions for use of the drug Pancef indicate that treatment of pregnant women is not recommended. However, under medical supervision, the medication is prescribed to pregnant patients, but only in cases where the benefit to the mother outweighs the harm to the child. If the drug is prescribed during lactation, then breastfeeding is stopped and the baby is transferred to artificial feeding.

Interaction with other medications

The combination of Pancef and diuretics, calcium antagonists is undesirable, since the latter drugs inhibit the removal of the active ingredient from the body, which leads to a toxic effect. Antacids reduce the absorption of cefixime. When combined with the drug Carbamazepine, the concentration of the latter increases. Pancef significantly reduces the prothrombin index and enhances the therapeutic effect of drugs aimed at thinning the blood.

Special Recommendations

If there is hypersensitivity to cephalosporin antibiotics, an allergic reaction develops. In this case, treatment is stopped immediately, symptomatic therapy is prescribed (in accordance with the available clinic).

When treated with Pancef, dysbacteriosis and pseudomembranous colitis may develop. A false positive reaction to glucose in the urine cannot be ruled out either. A false-positive Coombs test is rarely observed.

Analogs

If necessary, replace “Pancef” with a similar drug, “” is most often chosen, since such an antibiotic also contains cefixime, and one of its forms is, which is prepared from granules. This “Suprax” is available in glass bottles, supplemented with a measuring syringe or spoon. After adding water inside such a bottle, a sweet strawberry cream or white suspension is formed with a concentration of the active ingredient of 100 mg/5 ml.

Suprax is prescribed for the same diseases for which Pancef is effective. Contraindications, possible negative effects and methods of use for such drugs are also the same. The solid form of this drug is capsules and strawberry dispersible tablets (they are called “Suprax Solutab”). They are used in the treatment of children over 12 years of age, replacing the tableted "Pancef".

Instead of such antibiotics, the doctor may prescribe other medications with antimicrobial action:

• "". This medicine also belongs to cephalosporin antibiotics, but to the second generation (its effect is ensured by cefuroxime). "Zinnat" form is allowed from 3 months of age, and tablets are given to children over three years of age.
• "". The main component of such tablets is josamycin. The drug is used when a child weighs more than 10 kilograms, but in pediatrics it is often replaced with Vilprafen Solutab, since these are soluble tablets from which a suspension is prepared.
• "". This drug contains midecamycin and is available in two forms. The suspension can be given to children of any age, and tablets - from 3 years of age (weighing more than 30 kg).
• "". This azithromycin-based antibiotic is prescribed to babies older than six months, and dispersible tablets are prescribed from 3 years of age.
• "Augmentin". This one, based on a combination of amoxicillin and clavulanic acid, can be prescribed even to infants. The drug is also available in tablets, approved from the age of 12 (with a weight of more than 40 kg).

Such drugs are very effective in treating bacterial infections, but should not be used without a doctor’s prescription, because each of them has its own characteristics of use, contraindications and acceptable dosages.

Dosage and regimen of Pancef

For adults, Pancef is prescribed at a dose of 400 milligrams per day. Taking the medicine does not depend on the timing of meals.

During pregnancy and lactation

During pregnancy and breastfeeding, before prescribing, the likelihood of recovery and the possibility of side effects on the development of the fetus or infant are assessed, after which the doctor prescribes treatment.

When a nursing mother takes the medicine, it is necessary to switch to artificial feeding of the child.

Use in children

To treat children, Pancef syrup is used, which is obtained by mixing the dry substance with cooled, boiled water. The suspension is prepared before use according to the attached instructions; the dose of the drug is calculated according to the child’s weight, at the rate of 9 milligrams per 1 kilogram of weight. For acute enteritis, the drug is taken at a dose of 4.5 milligrams per 1 kilogram of weight, 2 times a day.

Clinical trials on the safe use and effectiveness of treatment in infants under 6 months have not been conducted.

Reviews

You can see mostly good reviews about the use of Pancef granules in children, in which the medicine is called effective and easy to use.

Thanks to its pleasant taste, most children do not protest against this antibiotic. In addition, mothers like that this drug can only be given once a day.

Among the disadvantages of the suspension are its short shelf life and the frequent occurrence of adverse reactions, for example, allergies in the form of a rash or loose stools.

Also, some mothers consider Pancef to be a little expensive. In addition, if a child weighs more than 25 kg, then parents complain that even the largest bottle is not enough for one course of treatment.

Release form and composition

There are two main forms of release of the antibiotic Pancef:

• Elongated, biconvex, cream-colored tablets coated with a special coating. They contain 400 mg of Cefixime. The drug is packaged in an aluminum blister for 5 or 6 tablets. A standard cardboard pack contains 6 or 10 tablets.
• Yellow granules for making a suspension. When the suspension is completely ready for use, it acquires a white or slightly yellowish tint. 10 ml of the finished substance contains 200 mg of Cefixime.

Pancef contains a small amount of auxiliary components. These include: gelatin, Macrogol 4000, titanium dioxide, hypromellose, magnesium stearate, etc.

Hangover syndrome

Combining alcohol and any antibiotics means going through a severe hangover. Such drugs slow down the formation of acetic acid. This increases the time it takes for alcohol to leave the blood. It lingers there, prolonging the state of intoxication, intensifying the hangover.

After ethyl alcohol enters the stomach, the body begins to produce a special enzyme that promotes the removal of metabolic products. Medicines of the described group block the synthesis of this compound, which provokes the accumulation of acetaldehyde (a poison, the composition of which can be compared with the composition of formaldehyde used in embalming), i.e. a disulfiram-like reaction occurs. The consequences of toxic shock in this case:

• chills turning into fever;
• a sharp drop in blood pressure;
• vomit;
• suffocation;
• convulsions.

Such manifestations are possible after contact of medications with the mucous membranes of a person who is intoxicated. After drinking alcohol, antibacterial drugs of any form become potentially dangerous: injections, drops, suppositories, tablets.

Possible side effects

The use of any drug carries a risk of side effects. Pancef is no exception. While taking it, undesirable consequences may occur that disrupt the functions of the digestive system, hematopoiesis, genitourinary organs and nervous system. From the gastrointestinal tract the following may appear:

• dry mouth;
• anorexia;
• diarrhea;
• nausea and manifestations of the gag reflex;
• dysbacteriosis;
• flatulence;
• other problems that occur extremely rarely.

To prevent the development of dysbiosis, doctors often recommend the simultaneous use of probiotic medications (Linex, Normobact, etc.). From the circulatory system, the following consequences may appear:

• decrease in the number of platelets in the blood;
• hemolytic anemia;
• decrease in the number of leukocytes;
• decrease in neutrophil levels.

Possible nervous system disorders when taking the drug:

• noise in ears;
• headaches of varying intensity;
• dizziness.

• interstitial nephritis (impairment of normal kidney function);
• increased nitrogen content in urine;
• feeling of discomfort when urinating.

Side effects

• candidiasis;
• glossitis;
• jaundice;
• neutropenia;
• dizziness;
• epigastric pain;
• hyperbilirubinemia;
• nephritis (interstitial form);
• dysbacteriosis;
• discomfort when urinating;
• eosinophilia;
• dry mouth;
• skin hyperemia;
• skin itching;
• fever;
• stomatitis;
• flatulence;
• thrombocytopenia;
• diarrhea syndrome;
• migraine headaches;
• leukopenia;
• vomit;
• anorexia;
• hemolytic anemia;
• pseudomembranous enterocolitis;
• hives;
• nausea.

Indications for use

According to the instructions, Pancef should be prescribed for the treatment of:

1. Otitis media.
2. Uncomplicated urinary tract infections;
3. Uncomplicated gonorrhea of ​​the cervix and urethra;
4. Bacterial infections of the upper and lower respiratory tract, namely: pharyngitis, sinusitis, tonsillitis, acute bronchitis and exacerbations of chronic bronchitis.

Film-coated tablets. In this dosage form, Pancef should be taken orally.

• For adults and children over 12 years of age weighing more than 50 kg, the daily dose is 400 mg (1 time/day or 200 mg 2 times/day). The duration of the course of treatment is 7-10 days. For uncomplicated gonorrhea - 400 mg once.
• Children under 12 years of age – 8 mg/kg body weight 1 time/day or 4 mg/kg every 12 hours.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

Granules for the preparation of suspension for oral administration:

• Adults and adolescents over 12 years of age with a body weight of more than 50 kg take the drug once a day, 400 mg or 2 times a day, 200 mg. For uncomplicated gonorrhea, use 400 mg once.
• For children under 12 years of age (with body weight less than 50 mg), Pancef is prescribed at a dose of 8 mg/kg 1 time per day or 4 mg/kg 2 times per day at 12-hour intervals.

Doses used depending on the child’s weight:

• 37.5-50 kg: 15-20 ml of suspension (300-400 mg of cefixime);
• 25-37.5 kg: 15 ml (300 mg cefixime);
• 12.5-25 kg: 10 ml (200 mg cefixime);
• 6-12.5 kg: 5 ml (100 mg cefixime);
• Up to 6 kg: 2.5 ml (50 mg cefixime).

Infectious and inflammatory diseases caused by microorganisms sensitive to cefixime:

• upper respiratory tract infections (tonsillitis, pharyngitis, sinusitis);
• otitis media;
• lower respiratory tract infections (bronchitis, tracheo-bronchitis);
• urinary tract infections;
• uncomplicated gonorrhea (urethra and cervix).

It is necessary to dilute the granules with water before the first use, since the shelf life of the prepared medicine is short.

According to the instructions, Pancef should be prescribed for the treatment of:

• Uncomplicated urinary tract infections;
• Bacterial infections of the upper and lower respiratory tract, namely: pharyngitis, sinusitis, tonsillitis, acute bronchitis and exacerbations of chronic bronchitis;
• Uncomplicated gonorrhea of ​​the cervix and urethra;
• Otitis media.

Pancef for children up to 50 kg is prescribed in the form of a suspension based on their body weight - from three to nine mg per 1 kg of weight (but not more than 12 mg/kg).

The average duration of therapy with Pancef is 7-10 days. For diseases caused by Streptococcus pyogenes, therapy is usually longer (at least 10 days); for the treatment of uncomplicated gonorrhea of ​​the cervix and urethra, 400 mg of the drug is taken once.

If renal function is impaired, the dose is reduced by 25-50%.

The medication is used in the case of inflammatory processes in various organs and systems of the body caused by infections.

Pancef is recommended in urology and gynecology for:

• Cervicitis
• Urethritis
• Gonorrhea without complications.

The medication is effective for pathologies of the respiratory system and hearing organs:

• Pharyngitis
• Mononucleosis
• Sinusitis
• Otitis
• Sore throat
• Pneumonia
• Bronchitis
• Tracheitis.

Description of the drug

Pancef (PANCEF) is an antibiotic from the group of cephalosporins (semi-synthetic compounds based on 7-aminocephalosporic acid) of the third generation. The product is available in the form of tablets and granules for the preparation of a suspension (children's form). The active substance of the drug is cefixime. Country of origin: Macedonia (pharmaceutical company Alkaloid AD).

The mechanism of action of Pancef is described in more detail in the instructions for use () and is associated with the bactericidal (germ-destroying) activity of cefixime:

• blocks the construction of the cell wall of microorganisms;
• destroys bacteria lacking a protective membrane.

The product has a wide range of medicinal properties and acts against the main pathogens of infections of the respiratory and urinary system in children. Pancef's great advantage is its resistance to protective bacterial enzymes, which means fast and reliable results.

Pediatricians prescribe Pancef for:

• bacterial infections of the respiratory system - sinusitis, tonsillitis;
• otitis (inflammation of the middle ear);
• bronchitis, tracheobronchitis;
• uncomplicated pneumonia;
• urinary tract infections, cystitis, exacerbation of pyelonephritis.

An antibiotic is prescribed for inflammation of the middle ear, acute and chronic otitis media.

After administration, the medicine is absorbed in the intestines.

A high concentration of the drug remains in the blood serum for a long time, which allows it to be taken once a day.

Contraindications to Pancef

Pancef is contraindicated for use in patients with hypersensitivity to the components of this drug. The drug should not be used during pregnancy and breastfeeding. Pancef does not apply to children if they have not reached the age of six months

The drug is prescribed with caution to elderly patients and persons with renal failure. The use of Pancef by such patients should be under the supervision of a physician.

Hypersensitivity to cephalosporins and penicillins. Children under 12 years of age.

Carefully

Old age, renal failure, colitis (history).

The use of cefixime during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to prescribe during lactation, breastfeeding should be stopped.

"Pancef" should not be given to children who have been shown to be hypersensitive to antibiotics of the cephalosporin or penicillin group.

If you have had colitis or renal failure, the suspension should be used with caution.

Pancef is not prescribed in the following cases:

• Against the background of hypersensitivity to the active (cefixime) or auxiliary components of the drug, as well as to penicillamine and penicillins;
• During pregnancy;
• While breastfeeding.

Pancef is not used for children until they reach six months of age.

The antibiotic is not prescribed to patients with allergies to penicillins and cephalosporins.

Pancef is not recommended for children under six months of age

Prescribed with caution to elderly people and those diagnosed with kidney disease and inflammatory processes in the large intestine

“Cefixime inhibits normal intestinal microflora. Therefore, in parallel with the use of medication, it is necessary to take probiotics to maintain its balance.”

Use during pregnancy and lactation

In case of urgent need to take medication during lactation, breastfeeding must be abandoned.

special instructions

The drug is prescribed with particular caution to patients with chronic kidney and liver diseases, as well as to the elderly.

While using the drug, women may develop persistent thrush or intestinal dysbiosis. To prevent the negative effect of the antibiotic on the intestinal microflora, drugs from the group of probiotics can be prescribed at the same time.

The drug does not have a direct effect on the functioning of the central nervous system and does not inhibit the speed of psychomotor reactions.

Pharmacological effects and contraindications

Antibiotic Pantsev is a third generation medicine. Compared to other drugs, it is characterized by greater effectiveness against pathogenic microflora. The product affects the synthesis of microbial cells, which leads to their death. The suspension (syrup) is widely used in pediatric practice, which allows the medicine to be positioned as an antibiotic for children.

The Pantsef suspension contains cefixime, a substance that has biological activity against most gram-positive and gram-negative microbes. This component is resistant to beta-lactamases, and resistance to the antibacterial substance develops very slowly.

After use of the drug, bioavailability varies from 50 to 60%. If taken with food, absorption increases by 40 minutes. Half-life – up to 6 hours inclusive. The half-life is determined by the dosage used, the age of the patient, the form of the medication, and the physiological characteristics of the patient.

Contraindications:

1. Organic intolerance to the active component or the drug as a whole.
2. Age up to six months.
3. Breastfeeding.
4. Time of pregnancy.

Suspension and tablets are carefully prescribed to patients of the elderly age group, persons with a history of colitis, renal failure

Pancef tablets

If for some reason the drug is not suitable for the patient, an allergic reaction occurs, or treatment is not successful, then it may be necessary to replace it with an analogue. An analogue of the antibiotic Pancef is a drug with the same active ingredient, but possibly with a different dosage and other excipients.

The most popular analogues:

1. "Suprax".
2. "Cefspan".
3. "Tsemidexor".
4. "Ixim Lupin."

Suprax has the same basic substance as Pancef with a value of 400 Mg. The drug is the most accurate analogue, as it has the same indications, contraindications and treatment regimen.

Cefspan contains the active ingredient cefixime, but in addition to the list of indications for use, like Pancef, it is actively used in the treatment of scarlet fever and cholecystitis. The treatment regimen is similar.

Cemidexor contains the main active substance ceftibuten. Therefore, this drug is actively used in cases where medications containing cefixime have caused allergies or are ineffective.

Although Ixim Lupine contains cefixime, its dosage reaches 0.1 g. In cases of treatment regimen, indications and contraindications, the use is similar to Pancef.

Active substance: cefixime (in the form of cefixime trihydrate) 400,000 mg - 447,630 mg.

Excipients: microcrystalline cellulose, pregelatinized starch, calcium dihydrogen phosphate, gelatin, corn starch, sodium lauryl sulfate, magnesium stearate, hypromellose, macrogol 4000, titanium dioxide E 171.

Description

Oblong, biconvex, film-coated, creamy-white tablets with a score line on one side.

Pharmacotherapeutic group: antibiotic - cephalosporin

ATX code: [J01DD08]

Pharmacological properties

Pharmacodynamics

Cefixime is a third-generation cephalosporin antibiotic for oral administration with pronounced antibacterial activity against most gram-positive and gram-negative microorganisms.

The mechanism of action is due to inhibition of the synthesis of the pathogen's cell membrane. Resistant to beta-lactamases of both gram-positive and gram-negative microorganisms. Highly active against Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Haemophilus influenzae, Haemophilus parainfluenzas, Moraxella catarrhalis (including

strains producing beta-lactamases), Escherichia coli, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter spp. (including Citrobacter diversus), Serratia marcescens.

Pseudomonas spp., Acinetobacter spp., some strains of Streptococcus, Enterococcus spp. (methicillin-resistant strains), Listeria monocytogenes, Bacteroides fragilis, most strains of Staphylococcus, Enterobacter and Clostridium are resistant to cefixime.

Pharmacokinetics

Absorption: After oral administration, the absorption of cefixime is 40-50%, regardless of food intake; however, it was noted that maximum concentrations (Cmax) in plasma are achieved faster by 0.8 hours when taking the drug with food. When taking the drug in tablet form at a dose of 400 mg, the concentration in plasma is 3.5 mcg/ml. Maximum plasma concentrations are achieved after 2-6 hours.

Distribution: Plasma protein binding is 50-60%. The volume of distribution is 0.6-1.1 l/kg. High concentrations of the drug remain for a long time in blood plasma, bile, and urine.

Excretion Cefixime is excreted mainly by the kidneys by glomerular filtration. The half-life in healthy people is 3-4 hours. If renal function is impaired with a creatinine clearance (CC) of 20-40 ml/min, the half-life increases and averages 6.4 hours, with a creatinine clearance of 5-20 ml/min -11. 5 hours

Inside. For adults and children over 12 years of age weighing more than 50 kg, the recommended daily dose is 400 mg (1 time per day once or 200 mg twice a day). For uncomplicated gonorrhea - 400 mg once. The average duration of treatment is 7-10 days. For infections caused by Streptococcus Pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function, the dose is set depending on the creatinine clearance in the blood serum: with a creatinine clearance of 21-60 ml/min or in patients on hemodialysis, the daily dose should be reduced by 25%; with creatinine clearance of 20 ml/min or less or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Photo of instructions for use of panzef tablets, part 1

Photo of instructions for use of panzef tablets, part 2

According to the instructions, the simultaneous use of the drug with blockers of tubular secretion, including allopurinol and diuretics, increases the toxicity of Pancef.

Also during therapy, it should be taken into account that Pancef enhances the effect of indirect anticoagulants, and antacids, which contain magnesium or aluminum hydroxide, help slow down the absorption of the drug and reduce its therapeutic effect.

Pancef (tablets) 400 mg are available in cardboard packs (5 pieces in two blisters or 6 pieces in one).

The tablets are elongated, biconvex, cream-colored, film-coated on top.

One tablet of the drug includes:

• Active ingredient – ​​cefixime 400 mg
• Excipients: starch, gelatin, MCC, titanium dioxide, sodium dodecyl sulfate, calcium dihydrogen phosphate, stabilizer E571, ethylene glycol polymer (macrogol).

Directions for use and doses

Pancef is taken orally.

The instructions for use of the medication contain the following recommendations for taking tablets:

• The dose for adults and children over 12 years of age weighing at least 50 kg is 400 mg per 24 hours (half a tablet morning and evening). Course – from a week to 10 days
• Gonorrhea is treated by taking 400 mg once
• For children weighing less than 50 kg, the dose is calculated based on the norm of 9 mg per kilogram of weight. The attending physician, based on the symptoms and individual characteristics of the patient, may increase the dose to 12 mg. The course of therapy is 7-10 days
• Treatment of disorders caused by Streptococcus pyogenes lasts at least 10 days
• For patients with kidney problems, the dose of the medication is reduced by at least a quarter.

According to the instructions for use from the manufacturer, Pancef interacts with other medications and chemical compounds as follows:

• Increases the toxicity of ectacrynic acid (increases the manifestation of negative effects on the kidneys and ENT organs)
• Increases the chance of bleeding when taken with Warfarin and anticoagulants
• Antacids reduce the bioavailability of the drug, thereby reducing the therapeutic effect.

Properties

As reviews indicate, Pancef is very popular in pediatrics. The big advantage is that bacterial resistance to the drug develops very slowly. The product is a 3rd generation cephalosporin antibiotic. Due to its composition, it has pronounced bactericidal and antimicrobial properties. Particular effectiveness is observed for gram-positive and gram-negative, aerobic and anaerobic bacteria.

The active component has a destructive effect on the synthesis of bacterial pathogen cells, as a result of which the microorganism dies.

Other

The issue of simultaneous use of alcohol-containing drinks and antibiotics is not only the consequences of their interaction. But also in the fact that initially such drugs are prescribed during a person’s illness, when his body is weakened and susceptible to the negative effects of bacteria.

Alcohol will always be a stress and a blow to your health. And even a healthy person needs some time to recover from it. During illness, a weakened body has to simultaneously fight an enemy whose appearance is objective (bacteria), and the danger to which it has exposed itself - ethyl alcohol. Accordingly, the load on a person’s defenses increases, the effectiveness of treatment decreases, the course of the disease is prolonged, and complications can be expected.

If the duration of the course is not several days, but longer, then it is better to ignore the desire to drink. The duration of treatment means the seriousness of the situation, the severity of the disease and the high likelihood of the negative effects of alcohol on health and the effect of medications.

Nowadays, many people “live on antibiotics”, believing that with their help they can quickly improve their health and avoid complications after illness.

It is only recommended to take these medications strictly as prescribed by a doctor.

Uncontrolled use of antibiotics can cause severe harm to the body.

Let's look at all this from the alcohol side. Namely, the compatibility of alcohol and antibiotics.

Conditions for dispensing from pharmacies

You can buy the drug only with a doctor's prescription.

Price

The cost may vary depending on the region, pharmacy, and dosage form. You will have to pay 450-500 rubles for the suspension; you can buy tablets for 750-850 rubles. The children's version of the suspension costs about 570 rubles.

You can buy the drug only with a doctor's prescription.

Overdose

If the dose is exceeded, side effects increase in the form of nausea, repeated vomiting, and watery stools. This threatens to dehydrate the body. Then you should rinse your stomach, drink plenty of fluids and take sorbents.

If the dose of Pancef is exceeded, nausea occurs.

Also, an overdose of the drug causes vomiting.

To get rid of the effects of an overdose of Pancef, you need to drink a lot of liquid.

If a child accidentally receives a suspension in too high a dose, this will lead to side effects or an increase in them. To treat an overdose, gastric lavage should be performed and symptomatic treatment should be prescribed.

Drug interactions

Drugs that block tubular secretion (diuretics, allopurinol and others) inhibit the excretion of the active substance of the antibiotic by the kidneys and increase the risk of toxicity.

Cefixime reduces the prothrombin period and increases the activity of indirect anticoagulants.

Antacid medications that contain aluminum or magnesium hydroxide inhibit the absorption of the active substance in question. When cefixime is combined with carbamazepine, the plasma level of the latter increases.

Drug analogues

Antibiotics of the cephalosporin group are quite popular in pediatrics and are often prescribed for the treatment of children. The cost of Pancef is about 450-700 rubles per 100 ml bottle and 600 rubles per pack of 10 tablets, so sometimes patients ask to replace the medicine with a more affordable analogue. In addition, the choice of another remedy may be required if you are individually intolerant to the components of Pancef. Antibiotic analogues are presented in the table below.

Analogues are determined by structure:

1. Cefspan.
2. Ceforal Solutab.
3. Suprax Solutab.
4. Ixim Lupin.
5. Suprax.
6. Cemidexor.

Analogs of cephalosporin antibiotics include:

1. Cephalexin.
2. Cefoxitin.
3. Longacef.
4. Forcef.
5. Alphacet.
6. Suprax.
7. Zeftera.
8. Cefuroxime.
9. Cephabol.
10. Vicef.
11. Ceftazidime.
12. Clafotaxime.
13. Liforan.
14. Proxim.
15. Spectraceph.
16. Maxipim.
17. Ifitsef.
18. Azaran.
19. Cefotaxime.
20. Cefaxon.
21. Cefurabol.
22. Natsef.
23. Solexin.
24. Duracef.
25. Ospexin.
26. Biotraxon.
27. Boncephin.
28. Tsedex.
29. Zinforo.
30. Kefotex.
31. Ephipim.
32. Terzef.
33. Maxiceph.
34. Megion.
35. Cefoperazone.
36. Sulperazon.
37. Hizon.
38. Rocephin.
39. Medakson.
40. Ceforal Solutab.
41. Zinatsef.
42. Zinnat.
43. Totatsef.
44. Cefezol.
45. Cefazolin.
46. Sulceph.
47. Cefepime.
48. Ketoceph.
49. Anceph.
50. Claforan.
51. Ceftriaxone.

How to take Pancef

The dosage regimen depends on the disease, the form of the drug, and the individual characteristics of the patient. It is recommended to consult a doctor to select a suitable regimen.

Take an antibiotic orally.

How to breed

To prepare the suspension, pour 40 ml of water into the bottle with the powder, then shake until the mixture becomes homogeneous, then leave the product for 5 minutes. The container must be shaken before use. For convenience, use a special measuring cap. The cap should be rinsed with warm water after each use of the medicine.

It is recommended to consult a doctor to select a suitable regimen.

Before or after meals

If taken with food, the rate of absorption will increase. Some doctors recommend taking it after meals.

How many days to drink

The course of treatment usually lasts from 7 to 10 days. If necessary, the doctor can extend it.

To combine or not

Of course, the answer to this question will depend on what antibiotics we are dealing with. If the required drug is definitely not compatible with alcohol, the doctor will inform you about this first. Most of the popular medicines do not produce negative consequences from such a mixture. To be on the safe side, it is best to check with your doctor about how long before you can drink alcohol.

The doctor, most likely, for the same safety of the patient, will prohibit drinking alcohol throughout the course. If the treatment falls before a holiday (that is, the patient knows for sure that he will want to drink), you can ask why it is impossible to combine the prescribed drug and alcohol. Drinking alcoholic beverages will most likely simply weaken the body without affecting the treatment itself. Therefore, for greater effectiveness of therapy, doctors can prohibit such mixing.

According to doctors, it is more dangerous if a patient misses a prescribed dose of medication because he has already drunk alcohol.

Another important point is what doses of alcohol we are talking about. All studies and laboratory observations were based on the permissible level of ethyl alcohol. We are not talking about uncontrolled and excessive drinking of vodka and cognac. For example, European scientists have calculated how much alcoholic beverages can be drunk during antibiotic treatment without complications.

Women can consume no more than 3 servings of strong alcohol based on the assumption that one serving contains 10 ml of pure ethanol. For men, the number of such servings increases to 4, with the same calculation (1 serving – 10 ml of ethanol). That is, even with antibiotics, you can afford a glass of wine or champagne and not worry about the consequences.

Of course, it is better to avoid systematic drinking during the entire period of treatment. Constant use of such a “cocktail” will simply lead to the disease prolonging and the immune system to be greatly weakened. To definitely avoid unpleasant consequences, you can drink it 24 hours after taking the medicine and 20 hours before the first dose. On the last day of course therapy, you can drink 12 hours after the last dose of the medicine was taken.

People with kidney failure or liver problems will need to take longer breaks because the elimination process takes longer for them.

Myths about the combination of alcohol and antibiotics

Alcohol weakens the effect of antibacterial drugs

NO . In most cases, alcoholic drinks do not affect the therapeutic effect of drugs in this group. The only exception is therapy against the background of chronic alcohol consumption, which can occur in alcoholism. In this case, a more efficient breakdown of the active substance is sometimes possible, caused by an increase in the number of enzymes responsible for this. Although more often the opposite happens - the elimination of the antibiotic slows down, it accumulates and causes side effects.

But drinking alcohol can interfere with your recovery in other ways. After all, factors such as rest and nutrition are very important in treatment. Alcohol interferes with healthy sleep, interferes with the absorption of vital nutrients from food, increases blood sugar levels, and depletes the body. With chronic or sudden and heavy consumption of alcoholic beverages, the immune system can suffer so much that any medications will be of little use.

Antibiotics that can be combined with alcohol

Not all antibiotics have interaction effects with alcohol, but avoiding alcohol while sick is important.

Other common antibiotics that are often prescribed to treat infections include:

• amoxicillin + clavulanate (Augmentin);
• amoxicillin (Amoxil);
• ciprofloxacin (Cipro);
• cephalexin (Keflex);
• levofloxacin (Levaquin);
• azithromycin (Zithromax);
• moxifloxacin (Avelox);
• clindamycin (Cleocin).

While taking these medications, no side effects directly caused by alcohol consumption were observed.

Source: zdorovko.info

Other names and classification

It is a third generation antibiotic. Belongs to the group of cephalosporins.

Pancef is a third generation antibiotic that is administered orally.

International nonproprietary name

The international nonproprietary name of the drug is Cefixime.

In Latin

In Latin the drug is called Pancef.

Registration number

The product number is LSR-009444/09-241109.

ATX

The product code is J01DD08.

Antibiotics in which alcohol is prohibited

The best known among them is metronidazole . It is used in the treatment of various intestinal, dental, skin, and pulmonary infections. Many sources say that when therapy with this drug is combined with alcohol intake, a disulfiram-like reaction may occur. But this claim is quite controversial, since studies conducted in 2003 found no evidence of this.

Later, another small study was conducted in which Finnish men took metronidazole for five days, and they did not experience any side effects after drinking alcohol. However, the authors of these trials acknowledge that this does not exclude the possibility that some people may be harmed, and the rule that alcohol is incompatible with the antibiotic metronidazole remains in force.

There is also a list of antibiotics, the use of which is more dangerous when drinking alcohol. This primarily includes the group of cephalosporins ( cefotetan , ceftriaxone ), as well as tinidazole , linezolid and erythromycin . Their interaction with alcohol is well known, and doctors usually warn about it.

Table of antibiotics incompatible with alcohol

What drugs are not friendly with alcohol?

What drugs cannot be combined with alcohol (click to enlarge)

First, let's look at antibiotics that interact with ethyl alcohol and cause intoxication (nausea, convulsions, severe headache). This:

• ketoconazole (for example, Livarol suppositories);
• co-trimoxazole (for example, the well-known “Biseptol”);
• chloramphenicol;
• metronidazole;
• moxalactam;
• tinidazole;
• furazolidone;
• cefamandole;
• cefoperazone;
• cefotetan.

It is worth paying attention to groups of antibiotics and popular names of drugs, the use of which together with alcohol can lead to serious consequences, even death:

1. A group of antibiotics - fluoroquinols . They, in turn, can be divided according to the active substances found in them:

• gatifloxacin (drug options: Zarquin, Gatispan and others);
• grepafloxacin (drug options: Raxar);
• levofloxacin (drug options: Zolev, Glevo, Lebel, Levoxa, Levolet, Levostad, Levoflox, Loxof, Tigeron, Flexid, Remedia, Signicef, Tavanik and others);
• lomefloxacin (drug options: Lomflox);
• moxifloxacin (drug options: Avelox, Aquamox, Vigamox, Megaflox, Moxin, Moflaxia, Rotomox, Ultramox and others);
• norfloxacin (drug options: Bactinor, Girablok, Norilet, Norflox, Norbactin, Chibroxin and others);
• ofloxacin (drug options: Glaufos, Dancil, Zanotsin, Oflo, Oflox, Tarivid, Taritsin and others);
• pefloxacin (drug options: Pefloxacin-AKOS, Abaktal);
• pipemidic acid (drug options: Palin);
• sparfloxacin (drug options: Sparflo);
• ciprofloxacin (drug options: Alcipro, Ificipro, Quintor, Tseprova, Ciloxan, Ciprodox, Ciprosan, Cipromed and others).

Compound

Dosage forms of Pancef:

• Film-coated tablets: pale cream, biconvex, oblong, with a score on one side (5 or 6 pieces in a perforated blister, made of PVC/TE/PVDC film and aluminum foil; 1 blister of 6 pieces or 2 blisters of 5 pieces in a cardboard box);
• Granules for oral suspension: pale yellow to yellow; prepared suspension: homogeneous, white or pale yellow liquid with the smell of orange (60 ml of suspension - 32 g of granulate each in a dark glass bottle with a screw-on aluminum cap, with a PE gasket and tamper evident, in a cardboard box 1 bottle with measuring cap; 100 ml of suspension - 53 g of granulate in a dark glass bottle with a screw-on aluminum cap, with a PE gasket and tamper evident, in a cardboard box 1 bottle with a measuring cap).

The active substance is cefixime (in the form of cefixime trihydrate), the content depends on the form of release:

• Film-coated tablets: 0.4 g/piece;
• Granules for preparing a suspension for oral administration: 60 ml of suspension – 1.207 g (0.1 g/5 ml); 100 ml of suspension – 2 g (0.1 g/5 ml).

Additional components:

• Tablets: microcrystalline cellulose, titanium dioxide (E171), macrogol 4000, hypromellose, magnesium stearate, sodium lauryl sulfate, corn starch, gelatin, calcium dihydrogen phosphate, pregelatinized starch;
• Granules: orange flavor, sodium benzoate, xanthan gum, sucrose.

The main active component of the drug is cefixime, presented in the form of a trihydrate.

Among the excipients are sodium benzoate and xanthan gum, orange flavor and sucrose, which gives the antibiotic a pleasant sweetish taste.

Drinking alcohol for diarrhea

Drinking alcohol cannot be beneficial for any body system. And in some cases, exceeding a certain limit or regular abuse of alcohol can lead to serious consequences. Many traditional treatments use alcohol, claiming that it is beneficial and helps with certain conditions. However, the effect of alcohol on a person with diarrhea cannot be called positive.

Can you drink alcohol if you have diarrhea?

Diarrhea, also popularly called diarrhea, and alcohol are closely related. There are certain restrictions on drinking alcohol if a person has an intestinal disorder.

From a medical point of view, alcohol and acute diarrhea are incompatible. With diarrhea, the disorder is caused by a violation of the microflora and irritation of the mucous membrane. Alcohol can only worsen this condition. In adults, even after a single dose of alcohol-containing drinks, diarrhea may occur, as the water-salt balance is disturbed. Alcohol abuse causes the development of alcoholic hepatitis and colitis, which are also often accompanied by diarrhea.

There are many ways to avoid diarrhea when drinking alcohol. The most common of them include:

• diluted drinks;
• drinking without gases;
• following a certain diet the day before drinking.

All of them are aimed at normalizing intestinal function. However, if his mucous membrane is already damaged, then no matter what alcoholic drink a person drinks, serious consequences await him. For example, a violation of the water-salt balance, which leads to damage to the membrane and, as a result, even greater intestinal upset.

Alcohol is perceived by the body as poison, and all its resources are aimed at eliminating toxins. The advice of traditional medicine - a glass of vodka with salt, can only aggravate a person’s condition and increase the imbalance in the digestive system. But alcohol does not contribute to its restoration in any way, because it destroys most of the beneficial bacteria that live in the intestines.

Consequences of drinking alcohol for diarrhea

Diarrhea is a way for the body to remove accumulated toxins and alcohol breakdown products. Drinking alcohol during diarrhea can cause the following symptoms:

• Painful stool.

  Due to dehydration of the body, the process of defecation causes discomfort and pain, since stool due to diarrhea and alcohol is often hard.

• Black feces Appears after drinking red wine, which contains iron, or as a result of bleeding in the intestines.
• Bloody discharge. Appear after severe damage to the intestinal mucosa as a result of prolonged alcohol consumption.
• Severe bloating. It is provoked by stagnation of food in the intestines, since it is not able to be digested due to the lack of enzymes and necessary microorganisms, which were destroyed by ethanol.

All these are the consequences of drinking alcohol and treating diarrhea with it. It is very important to seek qualified help in time and not rely on the advice of traditional medicine, especially if a person notices bleeding. The described symptoms are caused by the lack of beneficial bacteria that were destroyed by ethanol.

A person who drinks more often faces health problems. Research has proven that a certain dose of alcohol, which is 30 grams. ethyl alcohol may be harmless. Exceeding the norm has quite serious consequences for the whole organism and for the intestinal environment in particular.

Diarrhea and vomiting are often caused by intoxication, as a way to cleanse the body of unwanted substances. The digestive organs are under stress and require treatment. The first action in this case should be to lavage the stomach and restore the water balance in the body with still water or weak tea.

If the disorder occurs after each intake of alcohol-containing drinks, then it is necessary to contact a gastroenterologist and identify what exactly and what causes the disturbances in the gastrointestinal tract and the balance of microflora. Treatment for diarrhea should not be started without certain tests, because diarrhea can appear for various reasons and without the assistance of alcohol. Only after finding them out can you start taking special medications.

Advice! To treat diarrhea, you can take probiotics - drugs that restore intestinal microflora. It is important to maintain proper nutrition, excluding fatty and fried foods, and plenty of fluids help eliminate the negative consequences of water-salt imbalance.

Today, almost every person knows that drinking alcohol in large quantities leads not only to social problems, but also to loss of health. There are people who are not afraid to combine various medications with alcohol. Unfortunately, they do not know what the consequences of such use are and what consequences there may be.

The drug Mydocalm is a drug that is widely used in pharmacology. Let's try to figure it out: is it possible to combine Mydocalm with alcoholic drinks?

Application of Mydocalm

This medicine is produced and sold in two forms: ampoules and tablets. Used as a pain reliever and to relieve muscle spasms. There is a group of people who are prescribed this medicine:

1. It is prescribed to people suffering from disorders of the central nervous system.
2. If a person has very high muscle tone, then this drug must be prescribed.
3. Any disease of the musculoskeletal system can be treated with this drug.
4. It is also prescribed for various vascular diseases.

As you can see, it has a wide spectrum of action. But mainly it is designed for the body’s nervous system and musculoskeletal system. The use of this medicine with alcohol-containing tinctures was observed, but did not cause any side effects.

Combining Mydocalm with alcoholic drinks

There are especially cases where, when taking the drug, people experienced serious reactions and allergies associated with the gastrointestinal tract. In the case when Mydocalm is taken with alcohol, there are also a number of problems that arise against this background. It appears this way:

1. A person experiences headaches.
2. Unpleasant sensations and weakness in the muscles.
3. Nausea, vomiting.
4. Stomach upset, diarrhea.
5. Decreased appetite.
6. Skin itching.
7. Hives.

All this can also happen due to the simultaneous use of alcohol and medication. We should not exclude situations that end more disastrously. Shortness of breath or pulmonary edema can be fatal.

In cases where studies of the drug were carried out, scientists identified its relationship with drugs that are used as anesthesia for patients. Mydocalm behaved unpredictably, it enhanced the effect of these drugs and caused deep sleep. The patients felt very bad, there was general malaise and weakness. Afterwards, severe irritability set in, and then apathy towards everything that was happening.

The effect of alcohol on the body

Many years ago, doctors proved that drinking alcohol in reasonable quantities has a positive effect on the human body. But its excessive consumption leads to severe disorders and diseases.

A simple example can be given: by treating any wound or abrasion with alcohol, it will heal quickly. That is, some cells are killed, this is what happens to the human brain when alcohol enters the brain. In this case, you should not hope that if you drink alcohol in moderation, it will not cause any deviations.

Metabolism in the body is disrupted with frequent consumption of alcoholic beverages. Very often, children born into families of alcoholics have disabilities and are developmentally behind their peers.

Mixing a drug such as Mydocalm with alcoholic drinks is possible, but not recommended. If a situation arises in which you need to take part in a large banquet and drink some alcohol, it is best to simply consult with a specialist in advance.

Use of drugs with alcohol

In order to understand the compatibility of Mydocalm with alcohol, it will be enough to contact a specialist who will be able to explain in detail to each patient why this should not be done. In each individual case, different side effects may occur.

There are many brave souls who allow themselves to take medications with alcoholic beverages. All this can easily lead to unpredictable consequences and end very sadly. Health must be protected and not wasted on such experiments.

Patients' opinions

Larisa, 26 years old, Krasnodar

They sent me to another city for work. The day after my arrival I fell ill. The doctor said I had a respiratory tract infection and prescribed an antibiotic. After the first dose, I had side effects: headache, nausea, dizziness, diarrhea. I had to cancel and replace it with another one.

Ekaterina, 29 years old, Nizhny Novgorod

Pancef was prescribed for cystitis. The treatment lasted only 7 days. The symptoms disappeared quickly. No side effects were identified.

Why is Pancef prescribed?

It is used for diseases of the urinary tract: urethritis, cystitis, cervicitis. Used to treat pneumonia, bronchitis, and sinusitis. Prescribed for infectious and inflammatory diseases in the respiratory tract. Can be used to treat both acute and chronic infections. Used for diseases of the ENT organs: otitis media, sinusitis, pharyngitis.

Can be prescribed to patients with acute intestinal infection, mononucleosis, tonsillitis, and tonsillitis.

Myths and facts

Let's start with the fact that there are a lot of groups of antibiotics, and their areas of influence on the body are also completely different. How do antibiotics work in our body? According to the mechanism of action, all antibiotics can be divided into two groups:

• Bacteriostatic . They leave alive the bacteria that make a person sick, but at the same time suppress their further growth and reproduction.
• Bactericidal . They destroy bacteria, which are then eliminated from the body.

We will not go into the full list of antibiotic groups; it will take many pages. Let's move on to the description of the “myths” about their compatibility with alcohol:

Myth 1 . Alcohol affects the therapeutic effect of antibiotics. Of course, it all depends on which group, and what active substances are in the antibiotic that you will take, and how often you consume alcoholic beverages. Below we will talk about those active substances in antibiotics with which it is strictly forbidden to drink alcohol-containing drinks.

At the same time, we can say that this is not entirely a myth, because alcoholic drinks really interfere with recovery. Many antibacterial substances react with ethanol. The action of the antibiotic will slow down a little, but it will still work.

Myth 2. This myth dates back to ancient times and dates back to the Second World War. The theory behind this myth is that back then, the antibiotic penicillin was used to treat wounded soldiers.

There was not enough medicine for everyone, so urine was taken from patients and the drug was isolated from it again. At the same time, even drinking beer interfered with doctors and complicated the extraction of medicine. The consumption of alcoholic beverages was strictly prohibited.

In our opinion, this is an interesting theory, but most likely just a rumor that influenced the spread of the myth that alcohol is incompatible with antibiotics.

Another version of the “horror story” that one should not drink alcohol during antibiotic treatment was put forward by military doctors in order to protect tipsy WWII soldiers from contracting sexually transmitted diseases.

Myth 3 . This myth is talked about a lot and often. This is an increased effect on the liver. Experts say that alcohol affects the metabolism of antibiotics, reducing the activity of liver enzymes.

In addition, antibiotics themselves enhance the effect of alcohol, which means the treatment will be ineffective. As a result, the liver receives a double load and really “suffers” from the combination of antibiotic and alcohol.

Applications and dosages

for adults

The daily dosage of the drug and the duration of the course of treatment should be determined individually for each specific patient. This action can only be performed by a doctor. The permissible amount of the drug directly depends on:

• body weight of the sick person;
• diagnosis;
• age;
• characteristics of the body;
• other factors influencing the patient's condition.

Typically the standard dose is 400 mg per day. The patient should take one tablet once a day. Pancef should be consumed at the same time. It is advisable to perform the actions after eating. The products must not be chewed. If necessary, the drug can be taken with water.

The duration of the course of taking the medicine is 5-10 days. The exact duration of the period depends on the diagnosis. If the first improvements appear, you should not stop taking the drug yourself. As a result of such actions, a relapse may occur, and the disease will return again with renewed vigor. In this case, the infectious agent will acquire resistance to the active substance Pancef.

for children

Children can take the drug after reaching the age of 12 years. The dosage and duration of use are determined by the doctor. Self-prescription of the drug is strictly prohibited.

During pregnancy and lactation, the use of the product is highly undesirable. In the first trimester, doctors do not prescribe the drug. Its use can cause serious problems with the development of the fetus. Subsequently, the medicine can be used, but only if there are vital indications. In some situations, the doctor may prescribe an analogue of the medication.

When is it possible

The next question, which will certainly interest our readers, is how many days after taking antibiotics can you drink cognac, wine or other alcoholic beverages. There is only one answer: the more time passes, the better.

Some antibiotics have worked and are starting to leave the body, while others continue to work for several days. Particular caution should be exercised by people with liver or kidney disease.

Their body simply cannot cope with the “cocktail” of antibiotics and alcohol, so it is worth refraining from drinking alcohol during the entire antibiotic treatment and for 3-4 days after its completion.

About the compatibility of antibiotics and alcohol, watch the following video:

The course of antibiotic treatment is quite long (at least 1-2 weeks), so many people have questions about their compatibility with alcohol. Many have heard that this combination is very dangerous, but it turns out that this is not always the case. There are several myths that even some doctors can get confused about.

In what cases is it prescribed?

Does taking Suprax help with sore throat and in what situations is it justified? The drug is a third-generation antibiotic belonging to the class of cephalosporins (the active substance is cefixime). It is highly effective against streptococci, pneumococci, Klebsiella, Shigella, and other bacteria.

If the disease was caused by microorganisms sensitive to the drug, it will speed up recovery. It is in these cases that Suprax should be prescribed. Among diseases of the ENT organs, indications for antibiotic therapy include purulent tonsillitis, acute tonsillitis, sinusitis, sinusitis, pharyngitis, tracheitis, and otitis media.

Storage conditions

The shelf life of a sealed bottle of Pancef is 3 years, but if you prepare a suspension from granules, it can be stored for no longer than 14 days from the moment of dilution with water. You can keep the drug at home at room temperature, choosing a place where the medicine cannot be reached by a small child.

If the patient has a predisposition to an allergy to penicillins, then it is better to refuse the medication.

When taking an antibiotic, the microflora is disrupted. Against this background, pseudomembranous colitis may develop.

The first trimester of pregnancy is an absolute contraindication. In the 2nd and 3rd trimester, antibiotic treatment can be carried out, but only after consultation with a doctor.

If the drug is prescribed to a nursing mother, lactation will have to be abandoned during antibacterial therapy. The child is transferred to artificial feeding.

Pancef in the form of a suspension is approved for children from 6 months. The tablets can be given to adolescents over 11 years of age.

It is not recommended to drive a car during treatment with Pancef.

May affect the functioning of the nervous system. Therefore, increased concentration is required. It is not recommended to drive a car or operate complex machinery during treatment.