Among the low-dose oral contraceptives, Logest can be distinguished, the instructions for use of which explain in detail the indications and dosage regimen in different cases. This German drug has several analogues, but many Russian women prefer the original. Positioned as a hormonal contraceptive with minimal side effects.
This monophasic combined oral contraceptive has been developed. It is this German pharmaceutical giant that owns the registration number of the drug. Today, Logest tablets are produced in Germany and France. Accordingly, this is Delpharm Lille. The composition of the drugs fully corresponds to that specified in the registration certificate. The price is also approximately the same. On the Russian market you can purchase Logest of both French and German production. All information useful for the patient and doctor is contained in the instructions for use.
Medicines used in the treatment of pathology
The gynecologist selects a medicine for endometriosis based on the severity of the disease. The drugs used are:
- to reduce the production of sex hormones;
- from uterine bleeding;
- to eliminate pain symptoms and other negative manifestations;
- before surgery;
- during the rehabilitation period, after surgery.
Medicines for endometriosis should be taken only according to the regimen prescribed by a doctor. You should strictly adhere to the recommended course duration, since many medications, with longer use, can cause many side effects.
What medications are used to treat endometriosis? This question is often asked by women who have discovered this pathology. As a rule, several groups of drugs are used in the treatment of this disease, these are:
- Gonadotropin-releasing hormone agonists. The medications are hormonal. Reduce the amount of estrogen production. Can be used both in tablet form and as injections. The body is put into artificial menopause. Menstruation stops coming due to lack of estrogen. Against this background, the endometrium also stops growing. The lesions regress. Such drugs should be treated for about six months. Longer therapy can lead the body to early menopause. The best drugs for endometriosis in this group are the drugs Zoladex, Diferelin, Buserelin.
- Antigestagens, inhibitors of gonadotropic hormone production. Drugs in this category inhibit the production of luteinizing and follicle-stimulating hormones. Suppress progesterone production. The drugs are available in the form of tablets and capsules. Medicines have significant side effects. The most popular medications are Mifepristone and Danazol.
- Gestagens. Another group of medications used in the treatment of endometriosis. Progesterone tablets stabilize the menstrual cycle, lengthening the second phase. The most effective drugs in this category include Norkolut, Duphaston, and Utrozhestan. Medicines can be prescribed not only in the form of tablets, but also in the form of injections.
- Combined oral contraceptives. They contain estrogens and gestagens. Stimulates the production of female sex hormones. Stabilize development and prevent endometrial growth. Drugs in this category are taken for about six months. Popular: “Janine”, “Klaira”, “Diane-35”, “Jess” and “Yarina”.
Intrauterine devices can be used to treat the disease. The most popular is Mirena. Sometimes medications containing male hormones and androgens are used. One of these drugs is Methyltestosterone. In addition to these medications, non-hormonal medications can also be used in the treatment of endometriosis.
Treatment of endometriosis is complex and long-term, at least six months. To achieve a good result, you must follow all doctor's instructions. Do not violate the treatment regimen. The disease is very serious and can progress, so self-medication in this situation should be excluded.
Composition "Logest"
The drug belongs to hormonal contraceptives that protect women from unplanned pregnancy. The photo “Logest” is presented at the beginning of the article. The manufacturer positions Logest as the safest in the group of monophasic COCs due to its ultra-low content of the hormonal component.
Composition of Logest hormones and additional components of the tablet:
- ethinylestradiol,
- gestodene,
- polyvidone,
- corn starch,
- sucrose,
- talc, etc.
The first two components of the composition, which are indicated in the instructions for use, are the main active ingredients. These are synthetically created hormones, analogues of those produced by a woman’s endocrine glands. Their content in one tablet is 20 mcg and 75 mcg, respectively.
Important! It is due to the small dose of ethinyl estradiol that the tablets are considered safe and in some countries are sold without a doctor's prescription.
One package contains 21 tablets - this number of tablets is designed for 1 course of use, if you use the tablets as indicated in the instructions for use.
Janine
Janine belongs to the low-dose monophasic oral combined estrogen-progestogen contraceptives . The drug suppresses ovulation, changes the viscosity of the cervical secretion and through it sperm cannot penetrate into the uterine cavity.
The contraceptive exhibits antiandrogenic activity and increases the level of high-density lipoproteins in the blood. When taking Zhanine, the likelihood of developing endometrial and ovarian cancer decreases.
Indications for use
The main indication indicated in the instructions for use is oral contraception. It is this drug, as the safest, that is prescribed to patients who are protecting themselves from pregnancy for the first time using COCs. The mechanism of action of the tablets is similar to other standard drugs. Due to regular microdoses of hormones, the process of maturation and release of the egg into the uterine cavity is inhibited. Additionally, the abundant secretion of thick cervical fluid is stimulated, which is an additional barrier to sperm. According to the instructions, it blocks their penetration into the uterus.
In addition to contraception, Logest is prescribed according to the instructions for:
- irregular periods,
- endometriosis,
- heavy bleeding during menstruation,
- pronounced PMS with a deterioration in general well-being.
The drug can be prescribed to women who have a systematic sex life. To prevent cancer during menopause, Logest is prescribed after 50 years. These are the recommendations that are mentioned in the instructions for use.
"Logest" for endometriosis
The drug is indeed prescribed for the growth of the inner layer of the uterus in women, although the instructions for use do not indicate information about the treatment of the problem. Everything has to do with a good balance of hormones in the composition. Doctors have information that endometriosis is a hormone-dependent condition, which often provokes an imbalance of a woman’s own sex hormones.
To normalize hormonal status and reduce the risk of developing a tumor in the uterus, the drug Logest is prescribed.
Important! According to the instructions, fibroids, which often grow with endometriosis, are not a contraindication for its use.
You need to take tablets to treat the disease according to the usual regimen, which is explained in detail in the instructions for use.
Positive effect from taking
At the first signs of endometriosis, women do not try to undergo surgical intervention. The first step in treatment is drug therapy. The first-line drugs in the initial stages of endometriosis development are combined oral contraceptives.
Preference is given to monophasic agents that are able to maintain the level of hormones in the blood at the same level. It is better if this drug contains a gestagen. Since endometrioid tissue directly depends on the content of estrogen in the body, to eliminate endometriosis it is necessary to reduce the estrogenic influence to a minimum.
So Diane-35 has all the necessary properties. It not only inhibits the production of large amounts of estrogen in the body, but also has a good gestagenic effect. After starting treatment, women note a decrease in pain intensity, or no pain at all. There is a decrease in menstrual blood loss due to the slow growth of the endometrium. The most important thing is that the foci of endometriosis decrease or disappear altogether.
Contraindications
Any hormonal drug, even the safest one from a medical point of view, has a lot of contraindications. Especially if its use is intended for a long time. Instructions for use indicate the following contraindications for Logest:
- varicose veins, thrombosis, thromboembolism, any suspicion of these diseases,
- history of cardiovascular diseases or existing ones (coronary heart disease, angina pectoris, etc.),
- migraine, frequent intense headaches,
- diabetes,
- liver diseases, benign or malignant tumors of the organ,
- diseases of the pancreas, including pancreatitis,
- malignant tumors of internal organs,
- pregnancy and lactation,
- individual intolerance to the components of the composition.
Contraceptive pills "Logest" should not be taken in case of unexplained bleeding from the genital organs, as well as in case of kidney disease. The instructions for use recommend that before starting to take COCs, you should be examined by a gynecologist, endocrinologist and therapist, and take the necessary tests to minimize the risk of side effects.
Treatment regimens
For endometriosis
In the practice of treating endometriosis, a common scheme is to continuously take COCs, that is, take them daily without pauses and take “empty” pills. Monthly menstruation, for the health of a modern woman who is not planning a child in the near future, poses a health threat. Repeated successive cyclical changes in hormones during natural ovulation increase the likelihood of developing ovarian cancer, anemia, arthritis, bronchial asthma, endometriosis, uterine fibroids, PMS (premenstrual syndrome) and dysmenorrhea.
It has been proven that long-term continuous use of tablet contraceptives has a pronounced effect in reducing the risk of gynecological pathologies and improves the quality of life of women¹.
The decision to prescribe hormonal or surgical therapy is made only by the attending physician, taking into account the phenotype and age of the patient, the condition of her bone tissue, mammary glands, localization, course and extent of the disease. Endometriosis is a chronic, persistent disease in which no medicine can eliminate the foci of cell proliferation, having only a temporary suppressive effect on their activity. This is achieved by maintaining the body's condition with low concentrations of estrogen in the blood.
For contraception
From the first day of menstruation, take 1 tablet per day, 21 days in a row at the same time. The next 7 days there is a break in treatment and bleeding occurs, reminiscent of menstruation. On the 8th day from the last pill, start drinking 1 tablet from a new blister.
If one dose has been missed, the woman should take the pill as soon as she discovers this fact. Even if it’s the next day and it’s your turn to take the medicine as scheduled, that is, 2 pills at once. If more than 12 hours have passed since the missed dose, then over the next 10 days the contraceptive effect of the medicine decreases and the woman must use barrier methods of contraception.
To ensure correct use of the medication if you miss a dose, it is recommended to consult with your doctor.
Side effects of Logest
Not all women take hormonal medications painlessly. Here is a list of side effects of Logest, which are indicated in the instructions for use:
- headache,
- nausea, epigastric pain,
- tension in the mammary glands,
- swelling,
- decreased libido,
- allergy,
- mood swings,
- weight gain,
- bleeding in the middle of the cycle.
A woman may also notice more intense vaginal discharge in the first months of using the pill.
Consequences of refusing Logest for long-term use
Doctors say that long-term use of COCs does not have a negative impact on women's health. On the contrary, if a woman starts taking COCs after 40, she additionally protects herself from the likelihood of developing malignant tumors of the pelvic organs.
If a young girl has been taking COCs for a long time, the consequences of such use can be expressed in an unstable menstrual cycle in the first 2-3 months after discontinuation. This is due to the fact that the ovaries have forgotten how to work at full capacity and are increasing the rate of production of sex hormones. If a woman has gynecological diseases, ultrasound monitoring should be done every 3-6 months.
Directions for use and doses
The method of prescribing Diana 35 for endometriosis does not differ from the use of other combined oral contraceptives. The package of this drug contains 21 tablets. Each tablet contains the above dose of the drug. They must be taken regularly, at the same time of day, without breaks. If you miss tablets, if the interval is no more than 24 hours, then the missed time must be compensated by taking the remaining tablet.
If more time has passed since the omission, then you need to consult an obstetrician-gynecologist.
The packaging is quite ordinary, it is a cardboard box with information in Russian. There is a blister inside. On the back of the blister there is information about taking the drug. Step-by-step instructions help a woman navigate taking pills, and also not forget about the time of use. The days of the week and sequential arrows are indicated. It is more convenient to start from the present day of the week. This will help you avoid getting confused about your days and forgetting about your appointment.
After taking the missed pills, you should take a 7-day break. There are no special features in taking Diane-35 for endometriosis. The dosage for each pill is the same, so if a woman accidentally drinks the wrong pill that is in the sequence, nothing bad will happen. The drug is monophasic.
The course of treatment for endometriosis is selected strictly individually, but usually it lasts 6 months with subsequent monitoring of symptoms. During the appointment, the woman must keep a calendar describing the main symptoms that bother her. This way the doctor will be able to assess the dynamics of treatment and the development of the process in the body; if necessary, he can stop treatment or increase its duration.
Drug interactions
The following drugs affect the effectiveness of COCs:
- "Ampicillin"
- "Tetracycline"
- "Phenobarbital"
- "Rifampicin"
- NSAIDs.
Logest does not affect the absorption and effectiveness of drugs. This is indicated in the instructions for use.
Logest and alcohol
The instructions for using the pills do not indicate the connection between alcohol intake and COCs. However, in medical practice there is an opinion that any medications should not be taken 3 hours before and 3 hours after drinking alcoholic beverages.
How to cure endometriosis
Endometriosis occurs as a result of hormonal imbalance and is often diagnosed in women of reproductive age. The pathology is accompanied by numerous discomforts, sudden bleeding and a sharp decrease in immunity. But the main danger of the disease lies in the high probability of developing complications, one of which is infertility.
Before treating any type of endometriosis, a complete examination of the patient is carried out to determine the stage of the inflammatory process and the presence of concomitant pathologies. Carrying out therapy at the initial stage of the disease will help avoid unwanted surgical intervention.
The right approach to treatment
Treatment of the disease can be either conservative or surgical. Endometriosis can be cured quickly and effectively only through an integrated approach. To do this, you must follow all medical recommendations:
- diet. Foods that retain fluid in the body and slow down the effect of pharmacological drugs should be completely excluded from the daily menu. Eating fatty, fried, spice-rich foods is not allowed;
- physical activity. Long walks in the fresh air increase metabolism and normalize blood circulation in the pelvic organs. It is necessary to limit serious physical activity during treatment, including heavy lifting;
- drinking plenty of fluids. If the patient has not been diagnosed with any pathologies of the urinary system, then doctors recommend that she drink 2.0–2.5 liters of liquid daily: pure still water, sour berry fruit drinks, chamomile or green tea with a slice of lemon, rosehip decoction.
If necessary, patients are prescribed physiotherapeutic procedures: massage, hirudotherapy, therapeutic exercises. In the process of treating endometriosis, there is often a need to use sedatives, immunomodulators, and antispasmodics. To prevent liver and pancreas dysfunction, doctors recommend taking hepatoprotectors.
What will happen if there is no treatment?
Endometriosis is characterized by pathological benign proliferation of tissues that are morphologically and functionally similar to the endometrium. It can be diagnosed in one of the parts of the reproductive system. But there are exceptions - the pathology affects the abdominal wall, the mucous membrane of the bladder, and the intestines. If a patient has genital endometriosis, in addition to hormonal imbalance, endometrioid cysts are detected.
When determining treatment tactics, the doctor takes into account the following factors:
- general health;
- duration of the disease;
- the state of the body's resistance to infectious pathologies;
- location of inflammatory foci;
- severity of symptoms;
- speed of spread of the inflammatory process.
Depending on the clinical picture of the disease, patients may be prescribed drugs for internal and external use (capsules, tablets, vaginal and rectal suppositories). Douching with infusions of medicinal plants and solutions of drugs with anti-inflammatory and disinfectant effects helps treat endometriosis at home. Therapy for this disease is lengthy, often requiring the use of expensive drugs for parenteral administration.
But if it is not treated for a long time, then after a short time serious complications will arise. The most dangerous manifestations of pathology include the formation of malignant tumors that are difficult to treat. Therefore, having discovered an endometrioid cyst, doctors immediately begin treatment. This will help prevent tissue degeneration into cancerous tumors.
Frequent bleeding provokes a decrease in hemoglobin levels and the development of iron deficiency anemia. This condition causes:
- fatigue;
- dryness and pallor of the skin;
- brittle hair, delamination of nail plates;
- frequent relapses of viral and bacterial infections;
- exacerbation of chronic diseases.
What else is dangerous about endometriosis - the insignificant severity of symptoms at the initial stage of the inflammatory process. The woman attributes the deterioration in her health to overwork or colds. Gynecologists recommend that patients undergo a complete medical examination at least twice a year. This significantly reduces the number of women who are concerned about whether endometriosis can be cured. And if a pathology is detected, it will allow you to immediately begin treatment and avoid the development of complications.
Treatment with pharmacological drugs
Drugs for the treatment of endometriosis are selected by the doctor individually for each patient, depending on the type and stage of the pathology. A woman’s childbearing age is of great importance, so preference is given only to conservative treatment. Surgeries are resorted to in the absence of a positive result from the use of external and internal drugs. The prerequisites for surgical operations are heavy blood loss, adhesions, and severe pain.
Birth control pills Diane-35 will help cure endometriosis
Combined oral contraceptives
In most cases, drug treatment for endometriosis begins with single-phase birth control pills. The duration of the course of treatment is several months, during which the active ingredients of the drugs (gestagens or estrogens) suppress ovulation.
Such drugs have a pronounced therapeutic effect:
- eliminate pain in the lower abdomen;
- prevent bleeding;
- normalize hormonal levels;
- slow down the spread of inflammatory processes.
The therapeutic effect of oral contraceptives is to artificially increase hormonal levels in the systemic bloodstream. This makes it possible to stop the production of excess amounts of these biologically active substances by the endocrine glands using medication. The most commonly prescribed medications by doctors include:
- Diana-35;
- Regulon;
- Janine;
- Logest.
After a course of using birth control pills, endometrioid tissue stops growing, and the severity of postovulation changes in the endometrium noticeably decreases. Hormonal drugs have a significant number of contraindications, which include diabetes mellitus and certain pathologies of the cardiovascular and urinary systems.
Progestins
The drug contains ingredients similar in action to progesterone produced in a woman’s body. A course of medications prevents the high likelihood of developing endometrial hyperplasia due to the increased content of estrogen in the bloodstream. This group includes drugs with contraceptive properties or those that do not have the properties of oral contraceptives:
- Duphaston;
- Utrozhestan 100 and 200;
- Byzanne.
Doctors note the selective effect of these pharmacological drugs on progestin receptors of the mucous membranes of the organs of the reproductive system. If a woman is prescribed Duphaston for ovarian endometriosis, then while taking the pills, the reproductive function of the body is not only preserved, but also restored.
Duphaston is used in the treatment of endometriosis to prevent the development of endometrial hyperplasia
GnRH agonists
Another group of drugs used in the treatment of endometriosis are gonadoliberin agonists. These drugs suppress the production of hormones in the pituitary gland, causing a decrease in the production of estrogen in the ovaries. A woman experiences artificial menopause. How long it will last is decided by the doctor after assessing the degree of tissue damage. The most effective treatments for endometriosis are:
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- Zoladex;
- Buserelin;
- Nafarelin.
When used over a long period of time, these drugs promote the leaching of calcium from bone tissue and provoke its demineralization, the dangerous consequences of which are fractures of various organs of the musculoskeletal system. Therefore, the duration of use of the drugs should not exceed six months. GnRH agonists are expensive drugs and are used only when combined oral contraceptives are unsuccessful.
The drugs have a significant number of side effects (dryness of the vaginal mucous membranes, increased heart rate), the possible manifestation of which doctors immediately warn patients about.
Treatment with vaginal and rectal suppositories
Suppositories with anti-inflammatory, antibacterial and antimycotic effects will help cure any type of endometriosis. As the pathology develops, damage to healthy tissue increases, the infectious process accelerates, and severe pain occurs. Often pathogenic microorganisms - bacteria and fungi - join the inflammation. They form new foci of infection and cause general intoxication of the body.
Rectal suppositories
Rectal suppositories with non-steroidal anti-inflammatory drugs can slow down the progression of endometriosis. These include:
- Indomethacin;
- Movalis (active ingredient meloxicam);
- Voltaren or Diclofenac;
- Flamax or Ketoprofen.
For severe pain, it is possible to use suppositories with belladonna, which have a powerful antispasmodic effect. These suppositories are used only as prescribed by a doctor, since the natural ingredients of the drug exhibit many side effects, including the development of allergic reactions.
Rectal and vaginal suppositories are widely used in the treatment of endometriosis
Vaginal suppositories
Before treating endometriosis, laboratory tests are carried out on biological samples from patients to detect infectious pathogens and determine their sensitivity to antibacterial drugs. If viruses, bacteria or yeast have been identified, then women are recommended to use suppositories with antimycotic and antimicrobial activity.
At the initial stage of endometriosis, vaginal suppositories will help cure the disease and eliminate internal discomfort:
- Terzhinan. This combination drug has antifungal, antiseptic and antimicrobial effects. The composition of the drug includes Neomycin, Nystatin, Ternidazole and Prednisolone, which defines a wide therapeutic range of vaginal suppositories. Terzhinan is used both for the treatment of endometriosis and concomitant infections of the genitourinary system. Prednisolone is a hormonal drug, so suppositories can only be prescribed by the attending physician;
- Fluomizin. The active ingredient of vaginal suppositories is dequalinium chloride, which exhibits extensive antimicrobial properties against most gram-negative and gram-positive microorganisms, including E. coli. This hormone-free drug is used in the treatment of endometriosis in case of associated bacterial infection.
The duration of the therapeutic course is up to 10 days. The time interval is directly dependent on the severity of the inflammatory process and the patient’s health status.
Suppositories for restoring vaginal microflora
In the treatment of endometriosis, especially at the moderate and severe stages of the pathology, many pharmacological drugs are used. Such a number of diverse chemical compounds negatively affects not only the intestinal microflora, but also the vagina. Women complain of dry mucous membranes, pain and burning after urination, pain during sexual intercourse. Suppositories with beneficial lacto- and bifidobacteria will help correct the negative situation:
- Vaginorm S;
- Lactozhinal;
- Lactonorm;
- Acylact;
- Bifidumbacterin.
These suppositories are characterized by a rapid onset of therapeutic action and ease of use; a pronounced local effect is possible. It is necessary to use vaginal suppositories with beneficial bacteria for 10-14 days simultaneously with eubiotics for internal use - Lactobacterin, Bifiform, Acipol.
Doctors almost always recommend that patients use Longidaza suppositories, which are administered both vaginally and rectally. The drug has the following therapeutic properties:
- helps reduce the severity of the inflammatory process;
- influences the synthesis of inflammatory mediators;
- increases the body's resistance to bacterial and viral infections;
- increases local immunity.
Longidaza prevents the formation of adhesions in endometriosis, promotes their rapid and effective resorption, which allows you to do without surgery. The drug exhibits antioxidant, proteolytic, anti-inflammatory effects.
In addition to pharmacological drugs, medicinal herbs are used in the treatment of endometriosis
Traditional medicine recipes
Doctors often prescribe pharmacological drugs to their patients, the active ingredients of which are hormones. Many women are wary of such medications and begin to look for replacements in traditional medicine recipes. This is not only impractical, but also extremely dangerous - the disease tends to progress rapidly. Folk remedies are used in the treatment of the disease, but only after conservative therapy to improve the well-being of patients.
Healers recommend using medicinal herbs, flowers and roots:
- yarrow;
- bear ears;
- St. John's wort;
- marshmallow;
- sage;
- chamomile;
- successions.
Dry crushed plants are mixed in equal proportions, poured with boiling water and drunk instead of regular tea. Doctors recommend that women douche with herbs to enhance the therapeutic effect of taking medications. Plant raw materials have pronounced antimicrobial, anti-inflammatory and antiseptic properties. After treatment with folk remedies, discomfort and loss of strength disappear, and the active functioning of all vital systems is gradually restored.
Women who have experienced negative symptoms of the pathology are wondering whether endometriosis can be cured quickly and permanently. Of course, treatment for the disease is long-term, requiring the use of serious pharmacological drugs. But if all medical recommendations are followed, the patients recover completely. Numerous reviews indicate complete healing from endometriosis.
Veronica, Nizhny Novgorod:
“I was diagnosed with endometriosis in a rather advanced form. The doctor was inclined to perform surgery, but before that he decided to try hormonal therapy. I drank Diane-35 for several months and was very afraid of the side effects. And nothing - my hair didn’t fall out, I didn’t gain weight, my veins didn’t swell. But I got rid of endometriosis.”
Svetlana, Krasnoyarsk:
“I made an appointment with a doctor after unsuccessfully trying to get pregnant. Endometriosis was discovered in a rather serious form. After a course of treatment with Zolades, the disease went away and the long-awaited pregnancy occurred. In addition to injections, the doctor prescribed Indomethacin suppositories and an infusion of boron uterus.”
Marina, Rostov-on-Don: “I treated endometriosis with Utrozhestan 200. There were no unpleasant sensations, the drug was well tolerated. Additionally, I inserted Terzhinan suppositories, took multivitamins and Linex. Improvement came within two weeks - pain and spotting disappeared.”
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Analogues of "Logest" in composition
Below is a list of direct analogues of Logest based on its constituent components:
- "Milvane"
- "Ginelea",
- "Femoden"
- "Lindynet."
“Logest” or “Jess”: which is better?
These drugs differ in one component. In Logest it is gestodene, and in Jess it is drospirenone. In each individual case, only the doctor decides which drug is best for the patient. Self-prescription of COCs is fraught with consequences. Before use, be sure to read the instructions for use.
“Janine” or “Logest”: which is better
These drugs also differ in their constituent components. Therefore, there is no point in talking about the priority of one over the other. Only a thorough examination of the hormonal status and condition of the genital organs can answer the question of which COC is better. If a doctor gives a woman a choice between these two drugs, she can give preference to Logest as the most microdosed one. In any case, it is important to study the instructions for use with an emphasis on special instructions.
Mirena spiral and NuvaRing ring
For the treatment of endometriosis, in addition to tablets and injections, contraceptives in the form of spirals and special contraceptive rings are used:
- the Mirena hormonal intrauterine device is valid for 5 years, contains the slowly released progesterone hormone, inhibits the spread and growth of endometrial lesions;
- The NuvaRing ring contains a small amount of hormones, therefore it is considered practically safe; it is inserted vaginally and protects the body from pathological growth of the endometrium.
Prescribed for the treatment of endometriosis in women before menopause. Not for pregnant and lactating women. Taking Jessa tablets can lead to the development of migraines, nausea, and pain in the genitals.
Reviews from women about "Logest"
Each drug, even with microdoses of active ingredients, affects a person’s well-being and health. The female body is very sensitive to hormonal imbalances, which is why doctors often prescribe them to stabilize the condition and protect against pregnancy. Reviews from doctors about the pros and cons of Logest contain a lot of useful information. Feedback from women who are taking or have abandoned this COC will be no less useful.
Reviews of women over 30 years old about Logest
Ilyina Daria Vasilievna, 32 years old, Voronezh I have 2 children, a son and a daughter, one marriage and, I hope, there will be no others. My husband and I are planning on having more children, so we decided to use COCs. Since the treatment will be long-term, I selected the medicine very carefully and studied the instructions for use. To do this, I consulted with many doctors and took the same type of tests several times so as not to miss anything. As a result, the choice fell on Logest - it contains a minimal dose of hormones, which I have always been suspicious of. I take the pills as indicated in the instructions for use and taking into account the doctor’s recommendations. There are no adverse reactions, only in the first two months I felt a little nauseous and had a tugging in my lower abdomen. I hope that my good health will continue. Sviridova Kristina Mikhailovna, 37 years old, Moscow Could not adapt to Logest, after two cycles she switched to Janine. I felt unwell: headaches, dizziness, nausea, pressure surges. Perhaps the drug is good, but it did not suit me. The doctor said it’s all about individual intolerance to gestodene.
Reviews of women over 40 years old about Logest
Smirnova Maria Petrovna, 46 years old, Ryazan I have been taking Logest for almost 4 years. My gynecologist recommended this method of contraception not only as protection against pregnancy. She said that if you take hormones in premenopause, the risk of cancer is significantly reduced. Moreover, the longer you take it, the better. At first I didn’t feel well, but then I got used to it, everything is fine. I plan to take the drug, as stated in the instructions for use, until menopause. I feel calmer this way. Grishko Tatyana Ivanovna, 45 years old, Chisinau I am in my second marriage, I live an active sex life, but, of course, I don’t plan to have children. Of all the contraceptives that suited my indications, I settled on Logest. I saw the most positive reviews about it, it suited me too, everything is fine.
Hormonal drugs
To relieve pain, loss of strength and heavy discharge, medications such as:
The following will help support your immune system and improve your overall well-being:
- Cycloferon
- Retinol
- Ascorbic acid
- Tocopherol
- Thiamine
- Pyridoxine
The advantage of this group of drugs is the preservation, and in some cases, the complete restoration of a woman’s reproductive functions.
A prerequisite before use in drug treatment of endometriosis is a detailed examination to identify missing hormones.
A characteristic feature of hormonal therapy is the duration of use. This may be why contraceptives with reduced dosages are usually prescribed for endometriosis.
When the lining grows
A popular drug that is prescribed when signs of lining growth appear. According to statistics, in 90% of cases, the growth of lesions is inhibited, pain and inflammatory processes are blocked.
In the drug treatment of endometriosis, Janine promotes anovulation, inhibits the production of certain hormones, reducing their concentration and the contractility of the tubes.
As a result, the patient experiences regression of pathology and improvement in well-being.
One of the most common medications for endometriosis. The product includes 2 types of tablets - a placebo (taken at intervals) and a combination of gestagen and estrogen (active form for 24 days).
If the pathology continues to develop, Jess is replaced with the drug Lactinet, which does not contain estrogen, in the drug treatment of endometriosis.
Acts as a placebo
This is a group of contraceptives that contains a minimal concentration of hormones. These include Regulon, Marvelon, Novinet, Lindinet and others.
All medications for the drug treatment of endometriosis are taken according to a similar regimen. However, effectiveness is observed only during the period of therapy. After withdrawal, relapse is possible.
Hormonal pills for endometriosis help block the production of estrogen. These are progestogens and drugs from the group of gonadoliberin agonists:
- Gestrinone. Slows down the process of hormone production by the ovaries.
- Danazol. Helps stop menstruation, suppresses ovulation.
- Mifepristone. Reduces pain, prevents the appearance of bleeding in endometriotic lesions.
By taking oral contraceptives, for example Zhanine, Regulon, you can normalize hormonal levels and stop the development of the disease.
To reduce pain in the lower abdomen, stop uterine bleeding, and also to combat other symptoms, non-hormonal drugs are used for endometriosis.
Cyclodinone and Endoferin are often prescribed. They help normalize hormonal levels. The active substances in their composition negatively affect endometrial tissue, stopping their growth.
Appointments are also given:
- Immunomodulators (Roncoferon).
- Antispasmodics (No-Shpa, Spazmalgon).
- Iron preparations (Ferroplex, Fenyuls) to prevent anemia.
- Vitamins to strengthen the body.
The role of hormonal treatment for endometriosis is enormous; it is quite effective and is used after surgery to prevent the appearance of new lesions.
Reviews from gynecologists about Logest
Koreyvo Svetlana Petrovna, gynecologist, Moscow This drug has proven itself well on the Russian market. Most patients easily tolerate it after a short adaptation period. What can you say about pregnancy after Logest? Patient reviews are not particularly negative. As after any other COC, you need to allow the ovaries and endometrium of the uterus to restore their previous function. This will take 1-3 months. Then you can safely try. Gureeva Ekaterina Ivanovna, gynecologist, Krasnodar As a rule, low-dose COCs are well tolerated and give the least side effects. In addition, all products of their metabolism are eliminated from the body within 36 hours. In general, the German company Bayer has an excellent reputation throughout Europe. You can trust their drugs. From my practice, I can say that there are both positive and negative reviews of the drug. Everything is very individual and sometimes it takes 3-4 times to find the perfect product.
Symptoms of endometriosis
The main factors in the development of pathology are identified:
- Hormonal imbalance in the body, when one hormone exceeds another, progesterone levels decrease, which leads to disruption of the adrenal glands.
- During menstruation, blood flows from the endometrium into the abdominal cavity, where the cells begin to grow. This leads to pathology.
- Genetic inheritance is one of the causes of the disease.
- Decreased immunity means that the body does not fight endometrial cells outside the uterus. Therefore, the cells take root and begin to grow.
Endometriosis occurs from various factors: frequent abortions, inflammation of the female genital organs, the use of coils, mechanical interventions.
This disease is considered one of the most mysterious in the field of gynecology. Sometimes this disease occurs without symptoms, but there are cases when they are pronounced. It depends on the form and severity of endometriosis, on the presence of other gynecological diseases, and even on the psychological state of the woman.
Pain during menstruation, also during sexual intercourse with a partner. The pain is especially felt in the lower abdomen and lower back; it can vary in intensity.
Menstrual irregularities occur, periods become heavy, brown discharge appears before and after menstruation.
A woman may not know about the disease until she decides to become pregnant. Endometriosis is the main cause of infertility, as reproductive function is impaired. Nausea and vomiting may occur, and body temperature rises.
There are four stages of disease development. It is important not to aggravate the situation and start treatment at an early stage, then the result will come sooner.
What to choose?
The gynecologist should select a contraceptive depending on the woman’s hormonal background. Janine and Diane 35 are used for contraception. But the second drug is recommended for the treatment of androgen-dependent forms of acne of moderate and severe severity, which is accompanied by seborrhea and not, as well as for hirsutism in women of childbearing age.
For acne, the hormonal remedy Diane 35 can be used only when antibiotic therapy or local remedies have failed.
Before starting to use Diane-35, it is necessary to conduct a general medical examination (including mammary glands and cytological examination of cervical mucus), exclude pregnancy and disorders of the blood coagulation system. With long-term use of the drug, preventive control examinations must be carried out every 6 months. If there are risk factors, the potential risks and expected benefits of therapy should be carefully assessed and discussed with the woman before she decides to start taking the drug. If any of these conditions or risk factors worsen, worsen, or appear for the first time, discontinuation of the drug may be necessary. The estimated incidence of venous thromboembolism (VTE) when taking low-dose estrogen oral contraceptives (less than 50 mcg ethinyl estradiol) is up to 4 per 10,000 women per year, compared with 0.5-3 per 10,000 women not taking oral contraceptives. However, the incidence of VTE when taking combined oral contraceptives is lower than the incidence of VTE associated with pregnancy (6 per 10,000 pregnant women per year). The patient should be warned that if symptoms of venous or arterial thrombosis develop, she should immediately consult a doctor. These symptoms include unilateral leg pain and/or swelling; sudden severe chest pain radiating to the left arm or without radiating; sudden shortness of breath; sudden attack of coughing; any unusual, severe, prolonged headache; increased frequency and severity of migraines; sudden partial or complete loss of vision; diplopia; slurred speech or aphasia; dizziness; collapse with/without partial seizure; weakness or very significant loss of sensation that suddenly appears on one side or in one part of the body; movement disorders; symptom complex “acute” abdomen. The relationship between taking combined oral contraceptives and arterial hypertension has not been established. If persistent arterial hypertension occurs, Diana-35 should be discontinued and appropriate antihypertensive therapy prescribed. Taking the contraceptive can be continued if blood pressure normalizes. If liver dysfunction occurs, temporary discontinuation of Diane-35 may be required until laboratory parameters normalize. Recurrent cholestatic jaundice, which develops for the first time during pregnancy or previous use of sex hormones, requires discontinuation of combined oral contraceptives. Although combined oral contraceptives have an effect on tissue resistance to insulin and glucose tolerance, there is usually no need to adjust the dose of glucose-lowering drugs in patients with diabetes. Nevertheless, this category of patients should be under close medical supervision. Women prone to chloasma should avoid prolonged exposure to the sun and ultraviolet radiation while taking combined oral contraceptives. If symptoms have recently developed or become significantly worse in women with hirsutism, other causes, such as androgen-producing tumor, congenital adrenal dysfunction, should be considered in the differential diagnosis. While taking Diane-35, irregular bleeding (spotting or breakthrough bleeding) may sometimes occur, especially during the first months of therapy. Therefore, any irregular bleeding should be assessed only after an adaptation period of approximately 3 cycles. If irregular bleeding recurs or develops after previous regular cycles, non-hormonal causes should be considered and adequate diagnostic measures taken to exclude malignancy or pregnancy. These may include diagnostic curettage. In some cases, withdrawal bleeding may not develop during a break in taking the pill. If you do not take the pill regularly or if there are no two menstrual-like bleedings in a row, pregnancy should be excluded before continuing to take the drug. If any of the conditions, diseases and risk factors listed below currently exist, the potential risks and expected benefits of combined oral contraceptives should be carefully weighed on an individual basis and discussed with the woman before she decides to start taking the drug. In the event of worsening, intensification or the first manifestation of any of these conditions, diseases or an increase in risk factors, the woman should consult with her doctor, who may decide whether to discontinue the drug. Diseases of the cardiovascular system The results of epidemiological studies indicate a relationship between the use of COCs and an increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders) when taking combined oral contraceptives. These diseases are rare. The risk of developing venous thromboembolism (VTE) is greatest in the first year of taking such drugs. An increased risk is present after initial use of combined oral contraceptives or resumption of use of the same or different combined oral contraceptives (after a dosing interval of 4 weeks or more). Data from a large prospective study involving 3 groups of patients indicate that this increased risk is predominantly present during the first 3 months. General risk of VTE in patients taking low-dose combined oral contraceptives (containing ethinyl estradiol - VTE manifested as deep vein thrombosis or pulmonary embolism can occur with all combined oral contraceptives. Thrombosis of other blood vessels (eg hepatic, mesenteric, renal, cerebral veins and arteries or retinal vessels).There is no consensus regarding the relationship between the occurrence of these events and the use of combined oral contraceptives.Symptoms of deep vein thrombosis (DVT) include the following: unilateral swelling of the lower extremity or along a vein in the leg, pain or discomfort in the leg only in an upright position or when walking, a local increase in temperature in the affected leg, redness or discoloration of the skin on the leg.Symptoms of pulmonary embolism (PE) include the following: difficulty or rapid breathing; sudden cough, incl. with hemoptysis; sharp pain in the chest, which may intensify with deep inspiration; sense of anxiety; severe dizziness; fast or irregular heartbeat. Some of these symptoms (eg shortness of breath, cough) are non-specific and may be misinterpreted as signs of other more or less severe events (eg respiratory tract infection). Arterial thromboembolism can lead to stroke, vascular occlusion, or myocardial infarction. Symptoms of a stroke include: sudden weakness or loss of feeling in the face, arm or leg, especially on one side of the body, sudden confusion, problems with speech and comprehension; sudden unilateral or bilateral vision loss; sudden disturbance in gait, dizziness, loss of balance or coordination; sudden, severe or prolonged headache for no apparent reason; loss of consciousness or fainting with or without an epileptic seizure. Other signs of vascular occlusion: sudden pain, swelling and slight blue discoloration of the extremities, acute abdomen. Symptoms of myocardial infarction include: pain, discomfort, pressure, heaviness, a feeling of squeezing or fullness in the chest, arm, or behind the breastbone; discomfort radiating to the back, cheekbone, larynx, arm, stomach; cold sweat, nausea, vomiting or dizziness, severe weakness, anxiety or shortness of breath; fast or irregular heartbeat. Arterial thromboembolism can be fatal. The risk of developing thrombosis (venous and/or arterial) and thromboembolism increases: - with age; - in smokers (with an increase in the number of cigarettes or an increase in age, the risk increases, especially in women over 35 years of age). If you have: - obesity (body mass index more than 30 kg/m2); - family history (for example, venous or arterial thromboembolism ever in close relatives or parents at a relatively young age). In the case of a hereditary or acquired predisposition, the woman should be examined by an appropriate specialist to decide on the possibility of taking combined oral contraceptives; - prolonged immobilization, major surgery, any leg surgery or major trauma. In these situations, it is advisable to stop using combined oral contraceptives (in the case of planned surgery, at least 4 weeks before it) and not resume use for two weeks after the end of immobilization; - dislipoproteinemia; - arterial hypertension; - migraine; — diseases of the heart valves; - atrial fibrillation. The possible role of varicose veins and superficial thrombophlebitis in the development of venous thromboembolism remains controversial. The increased risk of thromboembolism in the postpartum period should be taken into account. Poor peripheral circulation may also occur in diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) and sickle cell anemia. An increase in the frequency and severity of migraine during use of combined oral contraceptives (which may precede cerebrovascular events) may be grounds for immediate discontinuation of these drugs. Biochemical indicators indicating a hereditary or acquired predisposition to venous or arterial thrombosis include the following: resistance to activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C deficiency, protein S deficiency, antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant). When assessing the risk-benefit ratio, it should be taken into account that adequate treatment of the relevant condition may reduce the associated risk of thrombosis. It should also be taken into account that the risk of thrombosis and thromboembolism during pregnancy is higher than when taking low-dose oral contraceptives (ethinyl estradiol content - Tumors The most significant risk factor for the development of cervical cancer is persistent human papillomavirus infection. There are reports of a slight increase in the risk of developing cervical cancer with long-term use combined oral contraceptives. However, an association with combined oral contraceptives has not been proven. Controversy remains as to the extent to which these findings are related to screening for cervical pathology or to sexual behavior (lower use of barrier methods of contraception). Meta-analysis 54 Epidemiological studies have shown that there is a slightly increased relative risk of developing breast cancer diagnosed in women who used combined oral contraceptives (relative risk - 1.24). The increased risk gradually disappears within 10 years of stopping these drugs. Because breast cancer is rare in women under 40 years of age, the increase in breast cancer diagnoses in women currently or recently taking combined oral contraceptives is small relative to the overall risk of breast cancer. Its connection with the use of combined oral contraceptives has not been proven. The observed increased risk may also be a consequence of earlier diagnosis of breast cancer in women using combined oral contraceptives. Women who have ever used combined oral contraceptives are diagnosed with earlier stages of breast cancer than women who have never used them. In rare cases, during the use of combined oral contraceptives, the development of liver tumors has been observed, which in some cases led to life-threatening intra-abdominal bleeding. In case of severe abdominal pain, liver enlargement or signs of intra-abdominal bleeding, this should be taken into account when making a differential diagnosis. Other Conditions Women with hypertriglyceridemia (or a family history of this condition) may have an increased risk of developing pancreatitis while taking combined oral contraceptives. Although slight increases in blood pressure have been described in many women taking combined oral contraceptives, clinically significant increases have rarely been reported. However, if a persistent, clinically significant increase in blood pressure develops while taking combined oral contraceptives, these drugs should be discontinued and treatment of arterial hypertension should be initiated. Taking combined oral contraceptives can be continued if normal blood pressure values are achieved with antihypertensive therapy. The following conditions have been reported to develop or worsen both during pregnancy and while taking combined oral contraceptives, but their association with combined oral contraceptives has not been proven: jaundice and/or pruritus associated with cholestasis; formation of gallstones; porphyria; systemic lupus erythematosus; hemolytic uremic syndrome; chorea; herpes during pregnancy; hearing loss associated with otosclerosis. Cases of Crohn's disease and ulcerative colitis have also been described during the use of combined oral contraceptives. In women with hereditary forms of angioedema, exogenous estrogens may cause or worsen symptoms of angioedema. Acute or chronic liver dysfunction may require discontinuation of combined oral contraceptives until liver function tests return to normal. Recurrent cholestatic jaundice, which develops for the first time during pregnancy or previous use of sex hormones, requires discontinuation of combined oral contraceptives. Although combined oral contraceptives may have an effect on insulin resistance and glucose tolerance, there is no need to change the therapeutic regimen in diabetic patients using low-dose combined oral contraceptives (ethinyl estradiol content - Chloasma may sometimes develop, especially in women with a history of chloasma of pregnancy. Women prone to chloasma should avoid prolonged sun exposure and UV exposure while taking combined oral contraceptives.Preclinical safety dataPreclinical data obtained from routine repeated-dose toxicity and genotoxicity studies, carcinogenicity potential and reproductive toxicity do not indicate a particular risk to humans.However, it should be remembered that sex steroids may promote the growth of certain hormone-dependent tissues and tumors. Laboratory tests Taking combined oral contraceptives may affect the results of some laboratory tests, including liver, kidney, thyroid, adrenal function, plasma transport protein levels, carbohydrate metabolism, coagulation and fibrinolysis parameters. Changes usually do not go beyond normal values. Reduced effectiveness The effectiveness of combined oral contraceptives may be reduced in the following cases: missed pills, vomiting and diarrhea, or as a result of drug interactions. Effect on the menstrual cycle While taking combined oral contraceptives, irregular bleeding (spotting or breakthrough bleeding) may occur, especially during the first months of use. Therefore, any irregular bleeding should be assessed only after an adaptation period of approximately three cycles. If irregular bleeding recurs or develops after previous regular cycles, careful evaluation should be performed to rule out malignancy or pregnancy. Some women may not develop withdrawal bleeding during a pill-free break. If combined oral contraceptives are taken as directed, the woman is unlikely to be pregnant. However, if combined oral contraceptives have previously been taken irregularly or there are no two withdrawal bleedings in a row, pregnancy should be excluded before continuing to take the drug. Medical examinations Before starting or resuming taking the drug Zhanin®, it is necessary to familiarize yourself with the woman’s life history, family history, conduct a thorough general medical examination (including measuring blood pressure, heart rate, determining body mass index) and gynecological examination, including examination of the mammary glands and cytological examination of scrapings from the cervix (Pap test), exclude pregnancy. The scope of additional studies and the frequency of follow-up examinations are determined individually. Typically, follow-up examinations should be carried out at least once a year. The woman should be warned that drugs such as Janine® do not protect against HIV infection (AIDS) and other sexually transmitted diseases.
Should I take Diane-35?
Cyproterone acetate is contained in a dosage of 2 mg per 1 tablet, and ethinyl estradiol is 0.035 mg. The composition also includes auxiliary substances that have no effect on the body.
If you have a severe allergic reaction, you should pay attention to the composition.
Ethinyl estradiol in combination with cyproterone acetate has a positive effect on excessive androgen production, reducing it. Therefore, it copes well with the task of reducing the manifestations of hyperandrogenism. This product has a slight estrogenic effect and more progesterone properties. The above hormones act on the body and prevent the production of its own hormones.
Thanks to this mechanism, the drug allows you to maintain the level of hormones in the body at the same level. The production of your own estrogens and the ovulation process are suppressed. In the initial stages of development of endometriosis, of any localization, the drug is indicated. It can slow down the development of the process.