In clinical practice, close attention is paid to the postoperative period after hysteroscopy with removal of a polyp in the uterus or a diagnostic study. The health of the uterus in the future will depend on how accurately and conscientiously a woman follows the doctor’s recommendations.
Despite the fact that the operation is considered minimally invasive, during recovery after hysteroscopy you will have to follow the same rules as after abdominal surgery. However, despite this, the duration of the rehabilitation period will still be shorter than after laparoscopy or laparotomy of the uterus.
Composition and form of the medicine
Longidaza is prescribed in the form of rectal and vaginal suppositories. 1 suppository contains longidase and hyaluronic acid with an activity of 3000 MO. The excipient is cocoa butter, which helps the candle dissolve gradually, releasing the active ingredient. The package contains ten candles.
Due to the cocoa butter content, the candles are light yellow with a characteristic odor. The color structure may be marbled - this does not indicate low quality of the drug.
Features of treatment with Longidase:
When taking antihistamines and hormonal drugs simultaneously, the effectiveness of Longidase may be reduced. Conversely, drugs from the antibiotic, anesthetic and diuretic groups increase the potency of Longidase. In addition, it is prohibited to combine this medicine with benzodiazepines, furosemide, and phenytoin. Clinical trials and reviews of patients treated with Longidaz injections and suppositories indicate the effectiveness of this drug in the complex of restoring fertility and getting rid of infertility. After using the drug, the patency of the fallopian tubes improves, nagging pain in the pelvis is eliminated, and pathological discharge disappears. Ultrasound results indicate a beneficial effect of Longidase on the structure of the endometrium. In general, the drug makes a significant contribution to the elimination of certain forms of infertility.
Source www.kroha.net
Very often, abortions, chronic inflammation or infections of the genital organs become the cause of the development of infertility due to the formation of adhesions or gluing of tissues that can appear during neglected or untreated processes in the pelvis or fallopian tubes. In such cases, Longidaza suppositories for adhesions help change the current situation.
Medicinal properties
Longidaza suppositories after laparoscopy are prescribed to facilitate rehabilitation and prevent complications. The active substance has a number of effects:
- enzymatic;
- antioxidant;
- immunomodulatory;
- anti-inflammatory;
- chelating.
The drug destroys the basis of connective tissue, inhibits reverse reactions aimed at the production of connective tissue components. It is based on chondroitin derivatives and hyaluronic acid. Under the influence of Longidase, their properties change: viscosity becomes less, the ability to bind metal ions and water becomes less, and the movement of fluid between cells becomes easier. This manifests itself in the following effects:
- reduction of tissue swelling;
- increasing the range of motion of joints;
- thinning of scars;
- reducing the risk of adhesions;
- reduction of contractures and prevention of their occurrence.
Longidaza does not damage healthy connective tissues, but destroys tissues with altered structure and composition in the area of fibrosis. The composition of the drug allows the enzyme to remain stable for twenty days at temperatures up to 37 oC. The enzyme produced by the body loses activity during the day under these conditions.
The composition contains not only an enzyme, but also a carrier. It binds iron, copper, and heparin ions. They are released when the connective tissue matrix in the affected area is destroyed.
It does not accumulate in the body, but penetrates into all tissues and organs. When administered rectally, it is quickly distributed and absorbed into the systemic circulation. The maximum concentration is reached after an hour. Excreted by the urinary system.
Contraindications for use
Gynecologists prescribe Longidaza suppositories for the complex treatment of connective tissue hyperplasia, the formation of adhesions that accompany pathologies such as chronic endomyometritis, ovarian cysts, endometriosis, intrauterine synechiae, and tubo-peritoneal infertility. Also, these suppositories are used for preventive purposes to prevent the formation of adhesions after artificial termination of pregnancy (abortion) and operations (for example, laparoscopy) on the pelvic organs.
It should be noted that Longidaza suppositories are well tolerated by patients, but contraindications to their use must be taken into account. It is not recommended to use this remedy in case of pulmonary bleeding, the presence of malignant oncological tumors, acute renal failure, or increased individual sensitivity to proteolytic enzyme preparations.
It has been proven in practice that the use of Longidase does not pose any dangers, toxic poisoning or global side effects.
Longidaza is a rectangular red and white box. The medicine itself is a white-yellow powder that is dissolved in water to prepare injections.
It is worth noting that Longidaza is available in two forms.
The second form is suppositories that are inserted into the body rectally or vaginally.
In addition to its focus on a specific type of disease, the destruction of scars and bruises, the drug is able to have an antioxidant effect, destroy toxins and waste in the body.
As a rule, rectal suppositories for endometriosis are prescribed when it is necessary to achieve a good pain relief effect without using large doses of analgesics. Typically, suppositories containing NSAIDs (non-steroidal anti-inflammatory drugs) are used for such purposes. For example, indomethacin and diclofenac are considered quite effective. They help relieve severe pain.
If the pain is spastic in nature, which most often occurs with intestinal endometriosis, suppositories containing papaverine or belladonna will help.
Viferon suppositories are almost always included in complex therapy for endometriosis, so let’s look at the pharmacodynamics of this drug.
The main active component of the drug has antiviral, immunomodulatory, and antiproliferative effects. Typically, drugs have a complex composition that helps achieve some additional effects. For example, if antioxidants are present in the suppositories, then the antiviral activity of the main active substance is enhanced (especially on B- and T-lymphocytes).
Longidaza suppositories are an effective and good remedy that has recently been actively prescribed in the gynecological field. The drug is an active substance identical to the trade name, combined with carrier substances and the enzyme hyaluronidase. This mixture ensures high stability of the active components, which makes treatment more effective, and the product itself is in great demand in gynecological practice.
The medicine is produced in the form of suppositories and lyophilisate for dilution and subcutaneous administration by injection. The product has the following positive properties: it is a strong antioxidant, destroys free radicals, strengthens local immunity, has anti-inflammatory properties of average effectiveness, removes toxins and breakdown products from tissues, helps reduce adhesions process in the genitals, improves microcirculation of fluid in the intercellular space.
https://youtu.be/NYvJnyVs2DA
Drug interactions
Often, suppositories with hyaluronidase after laparoscopy are prescribed in combination with antibiotics. The effectiveness of treatment may be reduced by the following medications:
- salicylates;
- cortisone;
- estrogens;
- antihistamines;
- corticotropin.
When combining with other drugs, it is important to take into account the enhancement of their effect during the use of Longidase. The doctor should be informed of any medications that are being taken at the time the suppository is prescribed.
Patient reviews
“Health problems began about 5 years ago, the inflammatory processes were relieved with various painkillers and anti-inflammatory tablets. The symptoms disappeared, and it seemed that the treatment was over. As a result, it turned out that during this time many adhesions had formed in the pelvis and they could not be treated with medications. They suggested laparoscopy. After the operation, Longidaza suppositories were prescribed vaginally to prevent new adhesions from appearing. Now everything is fine, they didn’t appear again, and I recovered quickly after the operation.”
“Six months ago there was a frozen pregnancy, then severe inflammation after cleansing. In the hospital - antibiotics, IVs and Longidaza suppositories. The doctor prescribed them on time, according to him, suppositories for both adhesions and inflammation. I’ve recovered, and soon we’ll try to become parents again.”
“I was prescribed Longidaza for the treatment of fallopian tube obstruction. We decided to try this method before surgery, but the treatment took a long time; it turned out to be more profitable to take a large package than two small ones. I feel better, and according to the examination results, the dynamics are also good, so we hope.”
Does the endometrium grow quickly after hysteroscopy surgery?
Complete recovery after surgery on the uterus is recorded when the endometrium becomes intact, uniform and capable of performing its functions. In this regard, after hysteroscopy there are some features of the postoperative period. For example, healing of the endometrial layer of an organ always occurs through natural regeneration. The tissue recovers on its own within several days or weeks, depending on the scale of the surgical intervention and the area of the wound surface.
It is very difficult to forcibly restore the original state of the endometrium, since the ability of this type of uterine cavity tissue to divide and regenerate is influenced by several factors:
- hormonal background;
- immunity;
- intake of basic nutrients and biologically active substances into the body.
In most women with standard health indicators, restoration of the endometrial layer occurs after 1-2 menstrual cycles.
How to restore the endometrium
Experts say that restoration of the endometrium after hysteroscopy is a purely intimate and unique matter for each patient. They prefer to intervene in the process if, a month after the intervention, ultrasound reveals insufficiently rapid tissue regeneration. This most often occurs during treatment after hysteroscopy of an endometrial polyp that is large in size and has a wide base. In this case, the wound surface is extensive and requires the use of additional measures:
- taking medications to balance hormonal levels;
- taking medications to stimulate the immune system and regenerative abilities of the body;
- taking antibiotics or anti-inflammatory drugs to prevent infection of postoperative wounds;
- carrying out physiotherapy, massage and so on.
A good stimulating effect is achieved by following proper nutrition and moderate physical activity. As a rule, the efforts pay off quite quickly - after 2-3 weeks the endometrium begins to recover more intensively.
Note! It is impossible to use stimulating drugs without consulting a doctor, since there is a possibility that instead of normal endometrial tissue, connective or scar tissue will grow at the site of the postoperative wound.
I used it after laparoscopy. Is it worth the expense?
Hello, readers of my review! Unfortunately, I had good reasons to take Longidaza
– I had to undergo laparoscopy due to a ruptured cyst, read about the operation: https://irecommend.ru/content/uvezli-po-skoroi-s-ra. . After this operation, there is a high probability of an adhesive process; in the future, in order to remove the formed adhesions, you again need to do a laparoscopy. It might turn out to be some kind of vicious circle, and I was very afraid of falling into this circle. Adhesions can cause many problems, including tubal obstruction, ectopic pregnancy, infertility, etc. In general, to avoid this, do not spare anything.
