A synthetic combination medicine with a broad spectrum of action is Klion-D 100. The instructions for use indicate that vaginal suppositories, 250 mg and D 100 tablets, injections in ampoules are used as an antifungal, antibacterial and antiprotozoal agent. Gynecologists indicate that the medicine helps in the treatment of thrush and other vaginitis.
Release form and composition
The following dosage forms of Klion are produced:
- solution for infusion: colorless or slightly greenish or greenish-yellow, transparent, has no mechanical inclusions (100 ml in glass bottles, 1 bottle in a cardboard box);
- tablets: flat-cylindrical, white or white with a tint from yellowish-greenish to light yellow with greenish, scored on one side, chamfered on both sides (10 pcs. in strip packs, 2 packs in a cardboard box).
Composition of 1 tablet: active ingredient: metronidazole – 250 mg.
Composition of 1 ml solution:
- water for injection – up to 1 ml;
- sodium hydrogen phosphate dodecahydrate – 0.6 mg;
- additional components: sodium chloride – 8 mg;
- active ingredient: metronidazole – 5 mg;
- sodium dihydrogen phosphate dihydrate – 0.45 mg.
Composition of the drug
Klion D 100 - tablets for vaginal use, oval, white, pointed at one end. The length of the tablet is 24 mm, on one side there is an engraving “100”. The manufacturer of the drug is the Hungarian corporation Gedeon Richter. Because of the method of application, patients and doctors often call Klion D suppositories, but unlike suppositories, Klion D tablets do not have a fat base; this drug is not produced in the form of suppositories.
Composition of the drug:
- The first active ingredient is metronidazole, 100 mg.
- The second active ingredient is miconazole nitrate, 100 mg.
- Excipients that form the tablet provide it with hardness, disintegration, and shelf life - magnesium stearate, hypromellose, sodium bicarbonate, povidone, silicon dioxide.
The tablets are sealed in 10 pieces in soft aluminum strips, which are packed in cardboard boxes. Each box contains instructions for Klion D suppositories, but since this is a prescription drug, information about it is primarily intended for doctors. Patients can read the instructions about the rules for using vaginal tablets and learn about the symptoms of overdose.
Indications for use
What does Klion-D 100 help with? Suppositories, tablets and injections are prescribed if the patient has:
- pseudomembranous colitis;
- all types of diseases caused by Bacteroides, Peptostreptococcus, Clostridium, Peptococcus spp.;
- condition after operations as part of prevention;
- radiation therapy for patients with tumors;
- trichomoniasis, giardiasis, cutaneous leishmaniasis, balantidiasis, amoebic liver abscess, amoebiasis and other protozoal infections;
- stomach ulcer or erosion caused by the bacterium Helicobacter pylori.
Instructions for use
Klion D 100 vaginal suppositories and tablets
Intravaginally. 1 vaginal tablet (pre-moistened with water) is inserted deep into the vagina in the evening before bed for 10 days in combination with taking the drug Klion orally.
Tablets 250 mg
The drug is taken orally during or after meals (with milk), without chewing.
Giardiasis: adults are prescribed 500 mg 2 times a day for 5-7 days.
Children over 8 years old - 500 mg per day (in 2 doses), aged 5 to 8 years - 375 mg per day, aged 3 years and older - 250 mg per day; the daily dose should be divided into 2 doses; course of treatment - 5 days. The dose of the drug can be 15 mg/kg per day in 3 divided doses for 5 days.
Treatment of chronic alcoholism: prescribed at a dose of 500 mg per day for a period of up to 6 (not more than) months.
For the prevention of infectious complications: 750-1500 mg per day in 3 divided doses 3-4 days before surgery, or a single dose of 1 g on the first day after surgery. 1-2 days after surgery (when oral administration is already allowed) - 750 mg per day for 7 days.
Trichomoniasis: adults are prescribed 250 mg 2 times a day for 16 days or 400 mg 2 times a day for 5-8 days. Women must additionally be prescribed Klion in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g per day. Between courses you should take a break of 3-4 weeks with repeated control laboratory tests.
An alternative treatment regimen is to prescribe 2 g once to the patient and his sexual partner.
For children aged 2-5 years, the drug is prescribed at a dose of 250 mg per day, for children aged 5-10 years - 250-375 mg per day; over 10 years - 500 mg per day. The daily dose should be divided into 2 doses. The course of treatment is 10 days.
Liver abscess: the maximum daily dose is 2.5 g in 1 or 2-3 doses over 3-5 days, in combination with antibiotics (tetracyclines) and as part of complex therapy.
Children from 3 years old - 1/4 adult dose, at the age of 3-7 years - 1/3 adult dose, at the age of 7-10 years - 1/2 adult dose.
- Asymptomatic amebiasis (if a cyst is detected): adults are prescribed a daily dose of 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.
- Ulcerative stomatitis: adults are prescribed 500 mg 2 times a day for 3-5 days. In this case, the drug is not indicated for children.
- Chronic amebiasis: 1.5 g per day in 3 divided doses for 5-10 days.
- For eradication of Helicobacter pylori: 500 mg 3 times a day for 7 days (as part of combination therapy, for example, in combination with amoxicillin 2.25 g per day).
- Acute amoebic dysentery: 2.25 g per day in 3 divided doses until symptoms stop.
- Treatment of anaerobic infection: maximum daily dose - 1.5-2 g.
- Balantidiasis: 750 mg 3 times a day for 5-6 days.
- Pseudomebranous colitis: 500 mg 3-4 times a day.
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Price of suppositories and tablets
Klion tablets for oral administration in a dosage of 250 mg in an amount of 20 pieces cost from 85 rubles, the price of vaginal tablets is much higher - 10 pieces from 340 rubles.
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pharmachologic effect
Klion-D 100 is a broad-spectrum drug. The main active ingredient is metronidazole, which is a derivative of nitro-5-imidazole. The mechanism of action of this substance is to restore the 5-nitro group in anaerobic microorganisms and protozoa. This leads to the death of microorganisms due to the interaction of the reduced 5-nitro group of metronidazole with the DNA of the microorganism cell.
Klion-D 100 is active against a large number of microorganisms, such as Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Gardnerella vaginalis, and it is also active against anaerobic bacteria - Bacteroides spp. Veillonella spp., Fusobacterium spp., Prevotella spp.
The use of this drug is also effective for the treatment of diseases caused by certain gram-positive microorganisms, such as Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. Facultative anaerobes and aerobic microorganisms are insensitive to Klion-d 100, but its use is recommended for the treatment of mixed aerobic-anaerobic infections.
Klion-D 100 is very effective against fungi, including dermatophytes and yeast fungi. Suppositories for intravaginal use effectively fight Candida albicans. Miconazole is able to suppress the biosynthesis of ergosterol in fungal cells, which leads to their death. At the same time, the normal microflora and pH of the vagina do not change during treatment with this drug.
Which is better - Metromicon neo or Klion-d
The Russian analogue of Klion-D is the drug Metromicon-Neo. Available in the form of suppositories for the treatment of urogenital infections. Contains metronidazole and miconazole, provides antifungal, antiprotozoal and antimicrobial effects.
The same composition and content of active components as in Metromicon-Neo suppositories is characteristic of Neo-Penotran. It is distinguished by its high cost and imported manufacturer.
Differences between analogues:
- country of origin (the second drug is a joint production of Germany and Russia, the first is domestic);
- cost – Metromicon-neo is cheaper;
- dosage of active substances - Metromicon-neo contains 5 times more miconazole.
Otherwise, the substitutes are similar. Perhaps they differ in the quality of raw materials and the frequency of adverse reactions. Which is better depends on the individual.
Contraindications
Absolute:
- liver failure (when prescribing Klion in high doses);
- I trimester of pregnancy and breastfeeding period;
- organic lesions of the central nervous system, including epilepsy;
- leukopenia, including a complicated medical history;
- age up to 3 years (tablets);
- individual intolerance to the components of the drug and other nitroimidazoles.
Relative (diseases/conditions in the presence of which the use of Klion requires caution):
- liver/renal failure;
- II–III trimesters of pregnancy.
Side effects
The drug is well tolerated by patients, but in some cases the following adverse reactions develop:
- Change in urine color;
- Increased vaginal discharge;
- Changes in the clinical blood picture;
- From the digestive tract - in rare cases, stool disturbances, changes in taste, dry mouth, nausea, abdominal pain, increased gas formation;
- Allergic reactions - skin rash, urticaria, in rare cases, the development of angioedema;
- From the central nervous system – dizziness and headaches;
- Local manifestations - discomfort, itching, burning, swelling, redness of the mucous membranes, sensation of a foreign body in the vagina.
Pharmacokinetics and pharmacodynamics of the drug
This product exhibits local activity, killing pathogenic microorganisms in the vaginal mucosa. Metronidazole contained in suppositories is able to penetrate into the blood. The highest concentration of the substance is determined between 6 and 12 hours after the usual method of use.
Metronidazole enters the mother's milk, the embryo, overcoming the placental barrier, and into the spinal cord and brain. Part of the substance that penetrates the blood is excreted mainly through the kidneys (the urine turns a specific brownish or red tint due to the presence of metabolites in it). A small amount of metronidazole and its derivatives is excreted in the feces.
Candles Klion D
Miconazole does not have the ability to be absorbed into the bloodstream. It is not detectable in urine and feces. A significant portion of miconazole is present in the vagina for quite a long time. This fact explains the destructive effect of such a medicine on Candida fungi.
Drug analogues also have the same pharmacokinetics and pharmacodynamics.
special instructions
During the period of use of the drug, you should not drink alcohol (risk of developing disulfiram-like reactions). During the period of use of the drug, it is recommended to abstain from sexual intercourse. Simultaneous treatment of sexual partners is recommended.
Metronidazole can immobilize treponemes, resulting in a false-positive TPI test (Nelson test). When using Klion-D 100, slight leukopenia may be observed, so it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.
If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.
Reviews about the medicine
Maria “The gynecologist prescribed Klion-D for the treatment of thrush, the unpleasant symptoms completely disappeared after the second use. During use, I felt a slight burning sensation for the first 10 minutes after administration.”
Galina “After detecting an infection in a vaginal smear, the doctor prescribed Klion-D. I used it for 10 days, a second smear showed that the infection still remained, the doctor added 5 more suppositories, the next test was already normal.”
Ekaterina “I used Klion-D twice - against thrush and a few years later against trichomonas, both times there was a wonderful effect - 10 days and no problems.”
Anna “As soon as unpleasant vaginal discharge began, I immediately went to the doctor - Klion-D was prescribed. I was disappointed - the burning sensation was very strong, and after the 5th suppository, spotting mixed with blood began. The doctor stopped the drug."
Video: Klion-D - application in gynecology.
https://youtu.be/3Nk7KEtprmA
Analogues of the drug Klion
Analogues are determined by structure:
- Rosex.
- Rosamet.
- Tricho-PIN.
- Metron.
- Metroseptol.
- Flagyl.
- Trichopolum.
- Metronidal.
- Deflamon.
- Metronidazole.
- Metrogil.
- Trichobrol.
- Orvagil.
- Batsimex.
- Cyptrogyl.
- Metrolacare.
- Efloran.
- Metrovagin.
- Metroxan.
- Trichosept.
