"Tranexam": instructions for use for bleeding, indications and contraindications + reviews

How to replace the medication

You can replace the original product with drugs containing the same active substance.
These drugs are called structural analogues. If the body does not accept tranexamic acid, the doctor will recommend medications that have a similar effect. Structural analogues are:

• Tranexamic acid;
• Stagemin;
• Troxaminate;
• Transamcha;
• Exacyl.

The following drugs can be excellent substitutes for the original drug and have a similar effect on the body:

• Aminocaproic acid;
• Ambien;
• Aprotex;
• Aprotinin;
• Vero Narcap;
• Vikasol;
• Goombix;
• Dicynone;
• Ingitril;
• Contrikal;
• Polycapran;
• Trascolan.

There are many analogues of Tranexam, but only a doctor can replace the original drug

Effective analogues - table

Contraindications

There are certain contraindications for the use of the drug, in which its use is strictly prohibited:

• subarachnoid hemorrhage (between the meninges, occurs spontaneously);
• increased sensitivity to drugs;
• thrombosis;
• renal failure;
• hematuria of the urinary system;
• problems with color perception.

Instructions for use and dosage

The dosage of the drug and the duration of therapy for each pregnant woman are selected individually by the attending physician. This depends on the general condition of the patient, as well as the degree of threat to the fetus. Tranexam should not be taken on its own without a doctor's prescription - this can cause unwanted pathological reactions.

Tranexam dosage regimen:

If there is a threat of miscarriage

During a spontaneous abortion in early pregnancy, bleeding occurs or spotting from the vagina is noted. To maintain pregnancy, Tranexam is prescribed 1-2 capsules per day according to the instructions until symptoms are completely relieved. The duration of the course is approximately 1 week.

1st trimester

The first trimester is an important period of pregnancy, during which the fertilized egg attaches to the wall of the uterus, as well as the formation of all the main structures of the new organism.

During this period, it is important to exclude the influence of any toxic or medicinal drugs or stressful situations on the expectant mother’s body, since ignoring or improperly following the doctor’s recommendations can lead to spontaneous termination of pregnancy.

If there is a threat of miscarriage, it is important to start treatment in a timely manner to save the embryo. Tranexam has established itself as an effective remedy for eliminating uterine bleeding, which in most cases allows you to get rid of such pathology

The recommended daily dose is 250–500 mg tranexamic acid. Treatment continues until bleeding stops completely.

2nd trimester

The second trimester is marked by the fact that the embryo ceases to be considered an embryo and moves to a new status - it becomes a fetus. In the second trimester, the fetus is less exposed to external factors, so the number of medications that can be used during this period increases significantly. However, there are critical periods when exposure to certain external factors can lead to a negative pregnancy outcome.

Can be taken in the second trimester for nagging pain in the lower abdomen and lower back, bleeding

It is important that the doctor prescribes treatment based on the symptoms, as well as the general condition of the expectant mother.

If a slight nagging pain appears in the back or lower abdomen, a pregnant woman is strictly prohibited from taking any medications on her own, including Tranexam. Therapy is the same as in the first trimester.

3rd trimester

The third trimester plays a significant role in the development of a small organism. During this period, all organs and systems complete their development. For example, lung tissue will be fully formed only in the last month, that is, between 37–39 weeks

It is important to prevent the onset of premature labor and maintain pregnancy until the beginning of the 38th week, when the fetus is ready to be born

In the third trimester, a pregnant woman may face a diagnosis such as premature aging of the placenta. This pathology is characterized by the deposition of calcium salts in the placenta, as well as the formation of lobules in its structure. As a result, blood flow may be disrupted, so the fetus will not be able to receive the required amount of oxygen and nutrients. It is for the treatment of such a disease that Tranexam can be prescribed.

Premature ripening of the placenta may not always be dangerous for the condition of the unborn child. Only by Doppler monitoring of the fetus is the seriousness of the diagnosis established. The risk of placental abruption remains the same as in the previous trimester. If this happens, tranexamic acid is used.

With IVF

Not all women can get pregnant naturally, so the only option for having a baby is through in vitro fertilization, or IVF. Before such a procedure, the woman is prescribed Tranexam, which must be taken so that the fertilized egg attaches to the wall of the uterus and does not come out along with menstrual blood.

If bleeding subsequently occurs, then Tranexam is injected into the body of the expectant mother using a dropper. After stopping, pills are prescribed.

Dosage and rules of administration

Elena Arieva

Isabel Nurieva

Zhanna Novikova

Tranexam is available in solution and tablets. One pill contains 250 or 500 mg of the active substance, and 1 ml of solution contains 50 mg. The tablets are usually packaged in ten pieces in a circuit with cells. They are located in a cardboard box in plates with instructions for use.

Instructions for the use of Tranexam tablets for periods that last too long or with large blood loss indicate that the standard dose for taking the drug is one tablet 3 times a day. They need to be taken every 7-8 hours. The course of treatment should not exceed eight days. However, the instructions allow for different dosage options in special cases: sometimes 2 or even 4 tablets three times a day may be required. Therefore, only a doctor should prescribe the drug and its dosage.

You should know how to take Tranexam for heavy menstruation and pathological uterine bleeding.

After the doctor makes a diagnosis, he will determine the dose and method of administration of the drug

There are several treatment regimens for this remedy:

• Over the course of several days, you can take only the same number of tablets.
• For some diseases, the dosage should be lower than standard.
• Initially, a high dose of the drug is started, then it is reduced.

For different conditions, the drug can be used in different ways, so it is forbidden to take it independently, without the recommendation of a doctor.

I had to take the drug Tranexam several times after abdominal operations. The doctor prescribed the drug first intravenously, and then in tablet form. I consider Tranexam a good and highly effective remedy. After starting to take this medication, the bleeding stopped.

Elena, 42 years old

My period was late for about a week, and then suddenly I started bleeding heavily. At the same time, one pad only lasted about twenty minutes. The gynecologist prescribed me Tranexam tablets. I took them for about five days, two tablets a day. After starting treatment, the bleeding began to subside and on the third day it returned to normal. The drug begins to act quickly, I did not notice any side effects on myself. I recommend the tablets!

Yulia, 29 years old

After I started bleeding in the very middle of my cycle, the gynecologist prescribed me the drug Tranexam. You had to take it twice a day, two tablets after meals. The doctor said that if the bleeding does not stop after three days, then she will need to continue taking the drug for another two days. However, this was not necessary because the bleeding stopped on the third day! Of course, this product is not the cheapest, but it is really very effective!

Inna, 35 years old

What are the contraindications

Tranexam is an effective hemostatic drug in tablet or ampoule form, which has various contraindications. Pregnant women are allowed to use the medication only on the recommendation of a doctor, when the benefits of using the drug outweigh the harm to the fetus

Please note that Tranexam can be excreted in breast milk and cross the placenta.

During pregnancy, this drug is prescribed with caution.

The drug is contraindicated in the case of subarachnoid hemorrhage and an increased possibility of an allergic reaction to the components.

Tranexam is used with caution in the following situations:

1. Thrombosis or an increased likelihood of its development. But the drug can be replaced with another one with a similar effect.
2. Thrombohemorrhagic complications.
3. Visual impairment, eye diseases.
4. Hematuria of the upper urinary tract.
5. Kidney failure.
6. Myocardial infarction.

It is prohibited to use the drug together with other medications that stop bleeding. It is also not recommended to combine the use of Tranexam and antibacterial agents of the penicillin or tetracycline series.

Analogs

The following drugs are complete analogues of the drug:

• "Trenax";
• "Tugina".

The following drugs act on different mechanisms compared to Tranexam, but also provide a hemostatic effect:

• "Vikasol";
• "Etamzilat";
• "Dicynon";
• "Ascorutin".

Tranexam is one of the most effective hemostatic drugs. It helps literally within five minutes after intravenous administration. This action is especially important during surgical interventions. Reviews of Tranexam for uterine bleeding also prove its high effectiveness and safety if the rules of administration and doctor’s recommendations are followed.

Instructions for use of Tranexam: method and dosage

Pills

Tranexam tablets are intended for oral administration.

• For local fibrinolysis, 1000–1500 mg is prescribed 2–3 times a day.
• For bleeding due to von Willebrand disease - 1000–1500 mg 3–4 times a day. The duration of treatment is 3–10 days.
• For profuse uterine bleeding - 1000–1500 mg 3–4 times a day for 3–4 days.
• For nosebleeds - 1000 mg 3 times a day for 7 days.
• After cervical conization surgery - 1500 mg 3 times a day for 12–14 days.
• For patients with coagulopathies after tooth extraction - 1000–1500 mg 3–4 times a day for 6–8 days.
• For bleeding during pregnancy - 250-500 mg 3-4 times a day until bleeding stops completely. The duration of treatment is 7 days.
• For symptoms of inflammation and allergies - 1000–1500 mg 2–3 times a day for 3–9 days.
• For hereditary angioedema - 1000–1500 mg 2–3 times a day intermittently or continuously (depending on the presence of prodromal symptoms).
• If the excretory function of the kidneys is impaired, the dosage regimen is adjusted. If the level of creatinine in the blood is 120–250 µmol/l - 1000 mg 2 times a day. With a creatinine level of 250–500 µmol/l - 1000 mg 1 time per day. If the creatinine level is more than 500 µmol/l - 500 mg 1 time per day.
• For generalized fibrinolysis, treatment begins with parenteral (iv) administration of the drug, followed by a transition to oral administration of 1000–1500 mg 2–3 times a day.

Solution for intravenous administration

Tranexam solution is administered intravenously (drip, stream).

• For local fibrinolysis - 250-500 mg 2-3 times a day.
• For generalized fibrinolysis - 15 mg/kg every 6-8 hours. In this case, the solution injection rate is 1 ml/min.
• For bladder surgery or prostatectomy, the solution is administered during surgery (at a dose of 1 g). Then 1 g every 8 hours for 3 days. After this, they switch to oral administration of the tablet form until gross hematuria disappears.
• In case of a systemic inflammatory reaction, with a high risk of bleeding - 10-11 mg/kg 20-30 minutes before the intervention.
• For patients with coagulopathies before tooth extraction - 10 mg/kg. After tooth extraction, they switch to oral administration of the tablet form of the drug.
• In case of impaired renal excretory function, the dosage regimen is adjusted. If the level of creatinine in the blood is 120–250 µmol/l - 10 mg/kg 2 times a day. At 250–500 µmol/l - 10 mg/kg 1 time per day. At >500 µmol/kg - 5 mg/kg 1 time per day.

The drug Tranexam

According to the clinical and pharmacological classification, Tranexam is classified as a drug with hemostatic and antitumor effects. This is an inhibitor of fibrinolysis - the process of transition of the substance plasminogen into plasmin, which are involved in hematopoiesis. The active substance of the drug is tranexamic acid. It helps stop blood production and prevent uterine bleeding. According to indications, doctors prescribe Tranexam - the instructions for use of the drug say this.

Composition and release form

There are two forms of release of Tranexam - oral tablets and solution for parenteral administration. Detailed composition of each type:

Pharmacodynamics and pharmacokinetics

The mechanism of action of the active substance Tranexam is that the acid specifically affects the activation of plasminogen, inactivates it, preventing it from being converted into plasmin. Locally, systemically, it has a hemostatic effect on bleeding associated with an increase in the concentration of fibrinolysis (platelet pathology, menorrhagia). Due to the suppression of the production of kinins and active proteins involved in allergic reactions, it has an antiallergic and anti-inflammatory effect.

When taken orally, up to 50% of the drug is absorbed, the maximum concentration is reached after three hours. Binds to plasma proteins, penetrates the placental barrier, and is excreted in breast milk in a concentration of 1%. It acts for 17 hours in tissues, 7-8 hours in plasma. If kidney function is impaired, there is a risk of accumulation of the active substance. When administered intravenously, the analgesic activity of the drug was confirmed.

Indications for use

According to the instructions for use, indications for use differ depending on the form of release. The drug is used under medical supervision for the following conditions:

• thrombosis of cerebral vessels;
• deep vein thrombophlebitis;
• thromboembolic syndrome;
• myocardial infarction;
• threat of thrombosis development;
• thrombohemorrhagic complications;
• color vision impairment;
• hematuria of the urinary tract;
• renal failure.

Tranexam tablets

According to the instructions for use, Tranexam hemostatic tablets have the following indications for use:

• uterine, postpartum, nosebleeds, stomach bleeding, after removal of the prostate, tooth extraction with hemorrhagic diathesis;
• the risk of bleeding due to increased local fibrinolysis, von Willebrand disease or other coagulopathies;
• hematuria;
• malignant tumors;
• angioedema of hereditary type;
• allergic reactions (eczema, urticaria, drug rash, dermatitis);
• tonsillitis, pharyngitis, stomatitis, laryngitis.

Tranexam in ampoules

According to the instructions for use, Tranexam solution can be used for the following indications:

• bleeding during or after surgery;
• bleeding during pregnancy;
• pancreatic or prostate cancer;
• hemophilia;
• hemorrhagic complication;
• leukemia;
• streptokinase therapy;
• bladder surgery;
• surgical intervention for sepsis, peritonitis, gestosis, shock, pancreatic necrosis.

Will it help?

The manufacturer assures that the medication is safe and effective if you follow the instructions accompanying the Tranexam tablet. Reviews about the drug contain information about unwanted side effects that worried many patients, at the same time, the drug really reliably fights the main manifestations of the pathological condition, so its use is considered completely justified.

Under no circumstances should you prescribe Tranexam yourself. As can be seen from the responses of lovers of self-medication, such an experience always left negative impressions without any benefit to the body.

Adverse reactions

Therapy with Tranexam does not always take place without consequences; in some cases, complications make themselves felt from various angles.

Non-structural analogues

In cases where the use of this medicine is unacceptable due to contraindications and/or adverse reactions, non-structural hemostatic analogues are used to stop uterine bleeding and heavy menstruation.

Name of analogue Active ingredient Forms of release of the drug Contraindications for use Use during pregnancy Average price Manufacturers Gordox aprotinin intravenous injections

drug intolerance; lactation; thrombohemorrhagic syndrome.

prohibited for use in the early stages 4500–5000 rub. for 25 ampoules Gedeon Richter (Hungary) Aminocaproic acid aminocaproic acid

solution for infusion; substance-powder for preparing a solution.

hypersensitivity; hypercoagulable states with a tendency to thrombus formation and embolism; chronic renal failure; cerebrovascular accident; DIC syndrome.

prohibited up to 40 rubles. for 100 ml

Moskhimfarmpreparaty im. N.A. Semashko; Dalkhimpharm; Biochemist; East Farm and others (Russia).

Vikasol menadione sodium bisulfite

solution for intramuscular administration; pills; powder-substance.

hypersensitivity; hypercoagulability; thromboembolism; hemolytic disease of the newborn.

allowed under the supervision of a doctor from 16 rubles. up to 100 rub.

Sishui Xierkang Pharmaceutical Co. (China); Moskhimfarmpreparaty im.

N.A. Semashko; Binnopharm CJSC; Novosibkhimpharm; Dalkhimpharm; Ellara LLC; Ozon LLC (Russia); Darnitsa (Ukraine).

Etamsylate etamsylate

injection; powder substance; pills.

hemorrhages; thrombosis; thromboembolism.

carefully

injection solution - 300 rub. per packaging; tablets - up to 100 rub.

for 10 pcs.

Biochemist; Veropharm; Biosynthesis OJSC; Novosibkhimpharm (Russia); Lugansk HFZ Public Joint Stock Company (Ukraine); Olainfarm (Latvia); Shandong Fanming Pharmaceutical Group Co., Ltd (China); MedPro Inc. (Latvia).

Crinon progesterone vaginal gel

hypersensitivity; acute porphyria; malignant tumors; acute thrombosis; lactation; renal failure; hypertension; diabetes; migraine; asthma; epilepsy; cardiovascular failure.

under control in the early stages; at a later date - prohibited.

up to 2500 rub. per package

Ares Trading S.A. Company, Switzerland; Serono Limited, UK.

Pepper water extract liquid Polygonum pepper (water pepper) herb extract liquid for oral administration

hypersensitivity to the components of the drug; increased blood clotting; thromboembolism; children under 18 years of age; alcoholism; traumatic brain injury; liver diseases.

prohibited up to 40 rubles. per bottle

Camellia NPP; BEGRIF; Rostov Pharmaceutical Factory CJSC; Tyumen Chemical and Pharmaceutical Plant; Tula Pharmaceutical Factory (Russia).

Ambien aminomethylbenzoic acid

solution for intravenous administration; substance-powder.

tendency to thrombosis; kidney dysfunction.

prohibited up to 2500 rub. for 10 ampoules Pharmzaschita NPC (Russia)

Analogues: photo gallery

Gordox is a highly effective drug at an affordable price Aminocaproic acid is a quick and cheap remedy for stopping uterine bleeding Etamsylate is a popular analogue of Tranexam Vikasol is a common remedy for reducing blood loss Ambien is an effective domestic remedy in the fight against bleeding Pepper water extract liquid is a frequently used herbal medicine for treatment of uterine bleeding Crinon - a highly effective vaginal remedy for stopping uterine bleeding

Composition and release forms

The drug is produced in 2 dosage forms:

• tablets designed for internal use;
• solution intended for intravenous administration.

For minor blood loss, a woman is recommended to take Tranexam in tablet form. The pills have a biconvex shape. On top they are covered with a white film shell.

Tranexam tablets are white, film-coated pills.

In the tablet product, tranexamic acid is combined with the following auxiliary components:

• hydroxypropylcellulose,
• microcrystalline cellulose,
• sodium carboxymethyl starch,
• calcium stearate,
• talc,
• colloidal silicon dioxide.

They produce tablets containing 250 mg and 500 mg of the active substance.

In case of extensive blood loss, Tranexam comes to the rescue in the form of a solution for intravenous injection . The medicine is packaged in ampoules of 5 ml. It is a clear liquid with a light brown tint.

The only excipient of Tranexam in ampoules is distilled water

The composition of the medicine includes:

• transescamic acid (in 1 ampoule - 250 mg);
• distilled water.

Possible alternatives to Tugin

If it is not possible to purchase Tranexam, you should consult a doctor to select an alternative option. Sometimes the doctor advises you to stop on the medicine “Tugina”. This remedy has a good effect on bleeding and an increased likelihood of bleeding. You can use the remedy if angioedema has been diagnosed since birth. The substance allows you to control the activity of plasmin, thereby minimizing the risk of complications and relapses.

The medicine "Tugina" is intended for intravenous administration. The dosage is chosen based on body weight - 10 mg/kg. The highest concentration in the blood serum is achieved just one hour after the procedure. After another hour, a third of the resulting product is eliminated in urine. A day after the drug enters the body, more than 90% of the active compound is eliminated. A cumulative effect is observed in organic tissues. The ability to penetrate the blood-brain and placental barriers has been revealed. In the milk secreted by the mother's glands, the substance is observed in a concentration of about 1% of that characteristic of blood plasma. No teratogenic effect was detected. The volume of distribution is estimated at 9-12 liters, the ability to form strong bonds with whey proteins is no more than 3%.

Pharmacological properties

Tranexam is included in the drug group of fibrinolysis inhibitors and has the ability to have an antifibrinolytic effect.

The active substance is capable of slowing down the activation of profibrinolysin in a special way and converting it into the protein plasmin.

Other effects of the drug should also be noted:

• local and general hemostatic effects during bleeding;
• anti-inflammatory;
• antiallergic;
• anti-infective;
• antitumor.

Clinical studies prove the analgesic effect of Tranexam, as well as the enhancement of the effect of opiates.

The distribution of acid throughout the tissues is, in general, quite smooth. Only in the cerebrospinal fluid is the substance concentrated by one tenth compared to the content in plasma. The initial volume for distribution is from 9 liters, the compound is also distinguished by its ability to penetrate into the seminal fluid, where it reduces activity but does not affect sperm migration. The combination with plasma proteins is about 3 percent.

Preservation in tissues lasts approximately 17 hours, in plasma - about eight.

Only a small part of the substance is metabolized. The kidneys are responsible for excretion.

Features of application

It was revealed that the drug “Tugina” persists in organic tissues in concentrations sufficient for a pronounced effect for at least 17 hours. For blood serum this figure is eight hours. A small percentage of the active component is transformed; renal clearance is 7 l/h, which is similar to plasma clearance.

In gynecological practice, the drug "Tugina" is used for abruption, placenta previa, in case of fetus localization outside the uterus and for bleeding after childbirth. Indications for administration will be cesarean section, uterine rupture. The composition is a drug recommended for miscarriage, helps prolong pregnancy, and prevent reproductive losses.

The drug in question can be used for menorrhagia, uterine conization, prostate surgery, bleeding caused by a device inside the uterus.

Is it possible to take tranex while breastfeeding?

The therapeutic effect of the drug is due to the content of tranexamic acid. The main effect of acid is associated with the effect on the blood clotting process.

Effect of taking

To maintain the fluid state of the blood and protect against the formation of clots, the body requires the consistent completion of a chain of biochemical reactions. One of the stages is the conversion of plasminogen to plasmin. Tranexamic acid inhibits this reaction, exerting an antifibrinolytic effect.

Tranexamic acid has a systemic and local hemostatic effect. In addition, it can influence the formation of kinins - substances responsible for the severity of inflammation and allergies. Tranexamic acid has antiallergic and anti-inflammatory effects. Its antitumor properties are also known and are currently being studied.

Thus, tranexamic acid stops bleeding by making the blood thicker and multiple blood clots forming. It does not affect either the vascular wall or the platelets themselves.

Instructions for use of "Tranexam"

Miscarriages often occur when women begin to bleed. In a normal state, when carrying a child, a woman experiences only white discharge, in which there should be no itching, burning, or other subjective signs. But spotting indicates that there is a possible risk of miscarriage.

Tranexam increases blood clotting and makes it thicker. With this drug you can quickly stop bleeding and thereby save the child. It (the drug) consists of:

• tranexamic acid (this is the main active ingredient);
• sodium glycolate;
• microcrystalline cellulose;
• silicon dioxide.

During pregnancy, Tranexam helps even in the most severe cases - for example, with detachment of the ovum or premature aging of the placenta. But this kind of pathology can only be detected after an ultrasound examination. In most cases, the drug is prescribed comprehensively, that is, in tandem with other medications. It is important that throughout the course of treatment the doctor monitors the coagulogram of the pregnant woman.

According to the manufacturer's instructions, the drug can be prescribed during pregnancy, including in the early stages. Especially if a woman has been diagnosed with a “primary miscarriage.” In addition, Tranexam successfully eliminates the manifestations of an allergic reaction and relieves inflammation.

In recent studies conducted by doctors at the Moscow Scientific Center for Obstetrics, 60 pregnant women who were diagnosed with a threat of miscarriage took part.

Studies have shown that women taking Tranexam felt better on the second day of treatment. The bloody discharge stopped. In addition, the reasons that threaten the loss of the child were identified. These include:

• infectious diseases;
• endocrinopathy;
• problems with immunity;
• myoma;
• malformations in the development of the uterus;
• other factors that are not so common.

"Tranexam" is available in the form of a solution in 1 ml ampoules containing 50 mg of tranexamic acid. At home, the drug is most often used in tablets, each containing 250 mg. How to drink Tranexam during heavy periods and use it in case of other bleeding can be seen in the table.

Table - use of "Tranexam"

Tablets for oral administration Solution for intravenous injections

We suggest you read: Doctors for a child in the first year of life
Tranexamic acid is excreted by the kidneys after metabolic transformations. Therefore, if their functioning is disrupted, doses must be adjusted taking into account creatinine clearance and other important tests reflecting the condition of the organ.

When is it prescribed?

"Tranexam" is prescribed for the following purposes:

• as a hemostatic agent - when performing any operations, as well as in case of acute bleeding in obstetric-gynecological, surgical, oncological, dental practice;
• for anti-inflammatory purposes - for tonsillitis, pharyngitis, laryngitis, stomatitis;
• as an antiallergic medicine - for eczema, urticaria, contact dermatitis, angioedema.

Indications for the use of the drug are liver diseases, leukemia for the prevention of possible bleeding in cases of suspected increased bleeding.

In gynecology

In 90% of cases, Tranexam is used to stop bleeding associated with increased fibrinolysis. In gynecological practice it is used for the following conditions:

• with heavy menstruation - with uterine fibroids, endometriosis, endometrial hyperplasia and polyps, with dysfunction;
• after curettage - to reduce discharge after abortions, miscarriages, hysteroscopies;
• with acyclic bleeding - they can appear due to dysfunction, while taking oral contraceptives.

Some women are interested in whether it is possible to stop their periods this way or even avoid them in some month. With the help of Tranexam, it is only possible to reduce the abundance and duration of bleeding. Reviews from practicing doctors confirm this.

The drug is often used during pregnancy to stop bleeding. Its safety has not been proven in extensive studies, but long-term observation of women to whom it is prescribed according to indications proves the absence of a significant negative effect on the developing baby.

"Tranexam" is prescribed at any stage of pregnancy and after childbirth in the form of injections or tablets. It is indicated in the following situations:

• if there is a threat of miscarriage with bleeding;
• with retrochorial hematoma (placental abruption);
• with postpartum hemorrhage;
• with manual separation of the placenta.

Tranexam is also prescribed for bleeding as a result of central or marginal placenta previa. The duration of treatment should not exceed three days in women with hereditary thrombophilias and antiphospholipid syndrome, since further therapy will cause the opposite effect - termination of pregnancy.

Tranexamic acid passes into breast milk, so its use during lactation is not recommended. If you have heavy periods, which often happens when your cycle is restored after childbirth, it is better to replace Tranexam with a similar drug.

Other Features

If bleeding begins while carrying a child, then you need to take 1-2 tablets of Tranexam 3-4 times a day (unless a different dosage has been prescribed by your doctor). Often the course of treatment lasts about 7 days, but on the recommendation of a doctor it can be extended. Sometimes intravenous injections are prescribed.

It is worth remembering that before taking it, you must consult your doctor, who will prescribe the required dose in accordance with the specific problem and physiological characteristics of the body.

If you are prescribed to take Tranexam to stop menstruation or another type of bleeding, you should not combine this with taking other hemostatic agents. Such combinations can lead to activation of thrombus formation and serious complications. Also, you should not combine Tranexam with the following drugs:

• blood components;
• penicillins;
• tetracyclines;
• "Dipyridamole";
• "Diazepam";
• hypertensive drugs.

Possible side effects

Tranexam, like all other medications, has its side effects. So, a woman may experience:

• nausea;
• vomit;
• disturbances in the functioning of the central nervous system (such as weakness, blurred vision, dizziness, etc.);
• heartburn;
• disruption of the cardiovascular system and, as a result, pain in the chest area.

Who should not use it

The use of Tranexam tablets, and especially intravenous injections, should be prescribed by a doctor. The drug has contraindications and side effects. You should not use the medicine if:

• recorded allergic reactions to it;
• acute thrombosis;
• high risk of thrombosis (thrombophlebitis, heart attack);
• color vision impairment;
• renal failure.

While taking Tranexam, the following adverse reactions are possible:

• dyspepsia – nausea, vomiting, heartburn, loss of appetite;
• disruption of the central nervous system - dizziness, weakness, drowsiness;
• cardiovascular disorders – thrombosis, thromboembolism, decreased blood pressure;
• allergic manifestations - urticaria, itching, Quincke's edema, anaphylactic shock.

If you experience any complaints while taking the medication, you should immediately seek medical help. There are no data on overdose of the drug.

Contraindications

Speaking about Tranexam during pregnancy, doctors emphasize that taking this drug is unacceptable in cases of impaired blood supply to the brain, thrombosis and varicose veins. In addition, the drug is not prescribed intravenously to women who have previously received a blood transfusion or some of its components.

It is not recommended to combine Tranexam with Diazepam or drugs of the tetracycline group, otherwise thrombosis may develop. It is prohibited to take it with hemostatic drugs. Finally, taking the drug is contraindicated for those who are allergic to it (or some of its components); This also includes cases of subarachnoid bleeding.

When breastfeeding, you should also be careful, because active substances can enter the baby’s body through breast milk.

Analogs

The following drugs act on different mechanisms compared to Tranexam, but also provide a hemostatic effect:

• "Vikasol";
• "Etamzilat";
• "Dicynon";
• "Ascorutin".

Tranexam is one of the most effective hemostatic drugs. It helps literally within five minutes after intravenous administration. This action is especially important during surgical interventions. Reviews of Tranexam for uterine bleeding also prove its high effectiveness and safety if the rules of administration and doctor’s recommendations are followed.

Let's sum it up

If a pregnant woman feels dizzy, weak, or simply has unknown health problems (especially in the early stages), she should immediately consult a doctor. Only he will be able to determine which of the modern pharmacological drugs is best to use.

Tranexam is certainly one of the most popular medications. It is characterized by a powerful effect on the body, quickly and effectively eliminating the problem. But special caution must be exercised, since the drug has many contraindications. And only a doctor can decide whether Tranexam is needed during pregnancy.

The cost of 10 tablets averages from 200 to 250 rubles.

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Pharmadynamics

Tranexamic acid is an antifibrinolytic agent that specifically inhibits the activation of profibrinolysin (plasminogen) and its conversion to fibrinolysin (plasmin). It has local and systemic hemostatic effects in bleeding associated with increased fibrinolysis (platelet pathology, menorrhagia), as well as anti-inflammatory, anti-allergic, anti-infective and anti-tumor effects due to the suppression of the formation of kinins and other active peptides involved in allergic and inflammatory reactions. The experiment confirmed the intrinsic analgesic activity of tranexamic acid, as well as the potentiating effect on the analgesic activity of opiates.

Composition and principle of action

The therapeutic effect of the drug is due to the content of tranexamic acid. The main effect of acid is associated with the effect on the blood clotting process.

Effect of taking

How long to take Traxecam, what was the effect? To maintain the fluid state of the blood and protect against the formation of clots, the body requires the consistent completion of a chain of biochemical reactions. One of the stages is the conversion of plasminogen to plasmin. Tranexamic acid inhibits this reaction, exerting an antifibrinolytic effect. As a result, the rate of formation of blood clots increases and bleeding stops.

Tranexamic acid has a systemic and local hemostatic effect. In addition, it can influence the formation of kinins - substances responsible for the severity of inflammation and allergies. Tranexamic acid has antiallergic and anti-inflammatory effects. Its antitumor properties are also known and are currently being studied.

Thus, tranexamic acid stops bleeding by making the blood thicker and multiple blood clots forming. It does not affect either the vascular wall or the platelets themselves.

Method of administration and dosage of Tranexam

Tranexam tablets are intended for oral administration.

Dosage of Tranexam tablets:

• for local fibrinolysis - 2-3 times a day 1-1.5 g;
• for nosebleeds - 3 times a day, 1 g for 7 days;
• for uterine bleeding - 3-4 times a day, 1-1.5 g for 3-4 days;
• for bleeding during pregnancy - 3-4 times a day, 250-500 mg until bleeding stops for 7 days;
• for bleeding due to coagulopathies - 3-4 times a day, 1-1.5 g for 3-10 days;
• in the presence of symptoms of inflammation and allergies - 2-3 times a day, 1-1.5 g for 3-9 days;
• for angioedema of a hereditary nature - 2-3 times a day, 1-1.5 g;
• after tooth extraction if the patient has coagulopathy - 6-8 days 3-4 times a day, 1-1.5 g;
• after conization of the cervix - 12-14 days, 3 times a day, 1.5 g;
• for generalized fibrinolysis after intravenous administration, tablets of 1-1.5 g are prescribed 2-3 times.

Tranexam injection solution is administered intravenously.

Dosage of Tranexam solution:

• for generalized fibrinolysis - 15 mg per kg at a rate of 1 ml per minute every 6-8 hours;
• for local fibrinolysis - 2-3 times a day, 250-500 mg;
• for bladder surgery or prostatectomy - 1 g during surgery, then 1 g every 8 hours for three days. Then Tranexam tablets are prescribed.
• before tooth extraction if the patient has coagulopathy - 10 mg per kg of weight, after extraction Tranexam tablets are prescribed.
• if there is a high risk of bleeding - 10-11 mg per kg half an hour before surgery.

For patients with renal impairment, the dosage should be adjusted.

Reviews: “Powerful stuff”

Tranexam is a powerful thing. They prescribed it to me, but I didn’t take it for long, 2-3 days. I think you will also take it for a short time, as soon as it stops bleeding, it will be canceled. I understand that it’s unpleasant to swallow handfuls of pills, but there’s nowhere to go. But it doesn’t harm the doll. Get well!

Forget-me-not, https://deti.mail.ru/id1004369158/

I have placenta previa, and this Monday I also started having a little discharge. I took an ambulance to the hospital, they looked at me and allowed me to go home, but they prescribed complete rest and Tranex for 5 days, 4 tablets a day. The discharge went away in the evening after taking the drug, and now I feel good. Health to you!

Natalya, https://deti.mail.ru/id1013684767/

Hello! I’m 15 years old, I had very heavy periods, it was pouring like buckets, I went to the gynecologist, she prescribed tranex, said if it doesn’t stop flowing, then I need to go to the hospital, my periods passed, but after that I haven’t had my periods for 2 months .

Liana, https://www.baby.ru/u/usr1777667/

I drank 2 Tranixam. The tablet 3 times a day for 3 days helped, it continued to rain for 20 days (out of stupidity, to get rid of painful periods, I experimented with duphaston; the result was periods without stopping)

Polkinamamka, https://www.baby.ru/u/soleveig/

After the birth, bleeding began, which could not be stopped. The hospital prescribed a drip (Tranexam). They made several IVs and everything stopped. Thank you, it helped!

Marina, https://www.rlsnet.ru/comment/traneksam

What is tranexamic acid

The international name of the drug is Tranexamic acid, the drug affects the composition of the blood and the processes of hematopoiesis. The product belongs to the group of amino acids, acts as a hemostatic, and tranexamic acid is used as the main active ingredient. The main ingredient of the medicine has an antiallergic, antifibrinolytic effect on the body. The acid has the properties of a systemic or local hemostatic drug for bleeding caused by increased fibrinolysis.

Compound

The medicine is available in two forms, which are based on the same active substance, but differ slightly in additional components. The following components of tranexamic acid are distinguished:

1. Tablets for oral administration of the drug. Active ingredients: 250/500 tranexamic acid. Auxiliary ingredients: hyprolose, core - MCC, colloidal silicon dioxide, talc, carboxymethyl starch, calcium stearate. The shell consists of macrogol, titanium dioxide, hypromellose, talc.
2. Solution for injection intravenously. Active substance – 50 g of tranexamic acid, excipients – 1 liter of water for injection.

Pharmacological properties

The main directions of the medicinal effect of acid are antiallergic, antifibrinolytic, anti-inflammatory effects. The drug competitively inhibits plasminogen activator; at higher concentrations it binds plasmin. The medication has the property of extending thrombin time, inhibiting the development of peptides and kinins, which are involved in the formation of allergic and inflammatory diseases.

Compound

The dosage form of the drug is an injection solution. This is a liquid that has no color or has a slight brown tint, located in 5 ml ampoules.

The active ingredient is tranexamic acid, which is contained in an amount of 50 mg in 1 ml of solution.

The medication is supplemented with a component such as liquid for injection.

There is another dosage form - tablets.

Indications for use of Tranexam

According to the instructions, Tranexam in tablet form is used for:

• bleeding during pregnancy;
• danger of bleeding or bleeding against the background of increased local fibrinolysis (gastrointestinal, nasal, uterine bleeding, prostatectomy, bleeding after conization of the cervix, tooth extraction if the patient has a hemorrhagic diathesis, hematuria);
• danger of bleeding or bleeding against the background of increased generalized fibrinolysis (manual separation of the placenta, postpartum hemorrhage, leukemia, operations on the chest organs, oncological diseases of the pancreas and prostate glands, liver diseases);
• inflammatory diseases (pharyngitis, tonsillitis, laryngitis, stomatitis);
• allergic diseases (urticaria, eczema, toxic and drug rashes, allergic dermatitis);
• angioedema of a hereditary nature.

Tranexam solution is used for:

• surgical interventions on the bladder;
• danger of bleeding or bleeding against the background of increased generalized fibrinolysis (bleeding during and after operations, postpartum hemorrhage, chorionic detachment, bleeding during pregnancy, hemophilia, manual separation of the placenta, thrombocytopenic purpura, cancer of the prostate and pancreas, hemorrhagic complications of fibrin therapy, diseases liver, leukemia, after treatment with streptokinase) and local fibrinolysis (hematuria, bleeding after tooth extraction if the patient has hemorrhagic diathesis, prostatectomy, uterine, nasal, gastrointestinal, pulmonary bleeding, conization of the cervix);
• surgical interventions for peritonitis, sepsis, severe and moderate gestosis, pancreatic necrosis, shock and other critical conditions.

When is it prescribed?

"Tranexam" is prescribed for the following purposes:

• as a hemostatic agent - when performing any operations, as well as in case of acute bleeding in obstetric-gynecological, surgical, oncological, dental practice;
• for anti-inflammatory purposes - for tonsillitis, pharyngitis, laryngitis, stomatitis;
• as an antiallergic medicine - for eczema, urticaria, contact dermatitis, angioedema.

Indications for the use of the drug are liver diseases, leukemia for the prevention of possible bleeding in cases of suspected increased bleeding.

In gynecology

In 90% of cases, Tranexam is used to stop bleeding associated with increased fibrinolysis. In gynecological practice it is used for the following conditions:

• with heavy menstruation - with uterine fibroids, endometriosis, endometrial hyperplasia and polyps, with dysfunction;
• after curettage - to reduce discharge after abortions, miscarriages, hysteroscopies;
• with acyclic bleeding - they can appear due to dysfunction, while taking oral contraceptives.

Some women are interested in whether it is possible to stop their periods this way or even avoid them in some month. With the help of Tranexam, it is only possible to reduce the abundance and duration of bleeding. Reviews from practicing doctors confirm this.

During pregnancy and lactation

The drug is often used during pregnancy to stop bleeding. Its safety has not been proven in extensive studies, but long-term observation of women to whom it is prescribed according to indications proves the absence of a significant negative effect on the developing baby.

Trinixan is prescribed at any stage of pregnancy and after childbirth in the form of injections or tablets. It is indicated in the following situations:

• if there is a threat of miscarriage with bleeding;
• with retrochorial hematoma (placental abruption);
• with postpartum hemorrhage;
• with manual separation of the placenta.

Tranexam is also prescribed for bleeding as a result of central or marginal placenta previa. The duration of treatment should not exceed three days in women with hereditary thrombophilias and antiphospholipid syndrome, since further therapy will cause the opposite effect - termination of pregnancy.

Tranexamic acid passes into breast milk, so its use during lactation is not recommended. If you have heavy periods, which often happens when your cycle is restored after childbirth, it is better to replace Tranexam with a similar drug.

Tranexam tablets instructions

The instructions contain both information about the drug Tranexam itself and a set of instructions for its effective use in treatment.

Form, composition, packaging

The drug Tranexam is produced in tablets with a film-like coating, which are white in color and biconvex. The tablets themselves have two types and differ only in the concentration of the active component - tranexamic acid 250 milligrams or 500 milligrams.

The required proportions of hyprolose, microcrystalline cellulose, calcium stearate, colloidal silicon dioxide, sodium carboxymethyl starch and talc are auxiliary.

The tablet shell consists of several substances: macrogol, titanium dioxide, hypromelose and talc.

The drug is delivered to pharmacies in cardboard packs containing one, two, three or five blister packs with a dozen tablets in each.

Storage period and conditions

The medicine Tranexam is stored for no more than three years at the appropriate temperature, which should not exceed thirty degrees. Do not use tablets when they have expired and do not allow children into the storage area or disposal area.

Pharmacology

Being a hemostatic agent, Tranexam suppresses the process of destruction of blood clots. The effect of the drug is not only local, but also systemic. It manifests itself in the presence of bleeding of various etiologies.

Due to the ability to inhibit peptide formations that are involved in the occurrence of inflammation or allergies, the drug can be classified as an anti-allergenic and anti-inflammatory type of drug.

Pharmacokinetics

Taking the drug in a dose not exceeding 2 grams, its absorption occurs by only 50 percent. The maximum concentration can be achieved no earlier than three hours later.

The active substance of the drug binds only three percent to blood plasma protein. In addition to the spinal cord fluid, distribution in other tissues occurs evenly. It has been noted that tranexamic acid penetrates the barriers of the placenta and BBB and into breast milk. Can be found in male semen fluid.

The metabolism of the drug is insignificant. Excretion occurs via the kidneys almost unchanged for twelve hours after administration.

If the patient has functional renal impairment, taking the medication may provoke the accumulation of its active component.

Tranexam against uterine bleeding

The drug Tranexam is widely used in gynecological practice to stop uterine bleeding, restore and reduce the volume of menstruation. The medication can be prescribed to pregnant women who have experienced bleeding and are diagnosed with a threat of miscarriage.

Tranexam is an effective remedy for stopping uterine bleeding.

The drug is recognized as first aid because it can effectively and quickly stop bleeding.

The active substance of Transecam is tranexamic acid. It is she who gives the drug the following positive properties:

• antifibrinolytic (the ability to stop bleeding by activating the fibrinolytic system, which promotes the dissolution of fibrin (clots), thereby thinning the blood);
• hemostatic (hemostatic effect is dictated by improved blood clotting);
• anti-infective;
• antiallergic;
• anti-inflammatory;
• antitumor;
• analgesic.

Mechanism of action

Prolonged, excessively intense bleeding is dictated by the high content of fibrinolysin in the blood. This picture is observed when platelets are unable to produce the required amount of plasmin (a component that ensures blood clotting). After penetration into the body, Tranexam triggers a complex mechanism of reactions that stop bleeding.

The drug ensures the conversion of fibrinolysin to plasmin. Thanks to this transformation, bleeding is stopped.

What is uterine bleeding

Women need to understand what is hidden under this term and be able to distinguish menstruation from pathology.

Uterine bleeding is a serious pathology that can occur in women at any age.

Uterine bleeding is heavy discharge of blood from the uterus, which differs from the physiological process in the following features:

• bleeding lasts more than 7 days;
• large blood clots are present;
• blood loss exceeds 80 ml.

special instructions

Quite often, Tranexam is prescribed during early pregnancy. The drug helps eliminate the threat of miscarriage. But such a prescription should be monitored by a doctor to eliminate risks to the health of the mother and baby. Before taking Tranexam in the early stages, you should undergo a series of examinations to exclude the presence of conditions for which the use of tranexamic acid is prohibited, for example, thrombosis.

During breastfeeding, it is better to avoid taking the medicine, since its content in milk is quite high. Doctors prescribe the drug only if there is a real risk to the mother's health. During the treatment period, you will have to stop feeding the baby.

During pregnancy, if there is a threat of miscarriage, the gynecologist may prescribe Tranexam to stop bleeding and spotting.

Before you start taking Tranexam for heavy menstrual or uterine blood loss, you need to undergo an examination by an ophthalmologist to understand the condition of the fundus of the eye, how sharp your vision is and whether there are any disturbances in color perception. It should be remembered that simultaneous use of the drug with hemocoagulase and hemostatic agents can lead to increased thrombosis. Do not combine with urokinase, tetracyclines, diazepam, hypertensive drugs, or penicillin-containing solutions.

Side effects and overdose of Tranexam

Tranexam has a systemic effect, so side effects that occur during treatment can affect all important systems of the body.

From the gastrointestinal tract: dyspepsia, loss of appetite and heartburn.

From the side of the central nervous system: general weakness, dizziness, drowsiness, blurred vision and inability to perceive color pictures.

From the vascular system: thrombosis, tachycardia, hypotension.

Allergic reactions: itching, swelling, urticaria and skin rash.

No evidence of overdose was found.

Contraindications for use

This drug is contraindicated for use in cases of high sensitivity to its components and subarachnoid hemorrhage.

In addition, Tranexam should be used with caution in case of renal failure, thrombosis, color vision disorders, myocardial infarction

Some side effects may occur while using this medication. When taking hemostatic tablets, heartburn, loss of appetite, rashes, diarrhea, dizziness, nausea, thrombosis, impaired color vision and other similar manifestations may occur.

Tranexam is widely used in gynecology as a drug that prevents the threat of miscarriage. It can be prescribed by a doctor after a special examination of the woman.

If you need to take this particular drug, you must stop breastfeeding.

This is a potent drug and may have adverse effects on the body. If it is not suitable, it can be replaced with drugs that contain a similar active substance, so-called structural analogues. If the body does not accept tranexamic acid, the doctor may prescribe medications that have a similar effect. The main analogues of Tranexam include Traxara, Exacil, Cyclocapron and Troxaminate, Traxekam for bleeding. They are similar to it in their action, indications and contraindications.

https://youtube.com/watch?v=uzUQ_oEMlG8

Who should not use it

The use of Transekam tablets, and especially intravenous injections, should be prescribed by a doctor. The drug has contraindications and side effects. You should not use the medicine if:

• recorded allergic reactions to it;
• acute thrombosis;
• high risk of thrombosis (thrombophlebitis, heart attack);
• color vision impairment;
• renal failure.

While taking Tranexam, the following adverse reactions are possible:

• dyspepsia – nausea, vomiting, heartburn, loss of appetite;
• disruption of the central nervous system - dizziness, weakness, drowsiness;
• cardiovascular disorders – thrombosis, thromboembolism, decreased blood pressure;
• allergic manifestations - urticaria, itching, Quincke's edema, anaphylactic shock.

If you experience any complaints while taking the medication, you should immediately seek medical help. There are no data on overdose of the drug.

Features of application

Tranexam is a universal remedy that can help a woman at different periods of life. But it is not recommended to use it yourself. Like any medication, Tranexam has a number of contraindications and can cause side effects.

Indications for use

The medicine is recommended by gynecologists for:

• dysfunctional bleeding (pathologies caused by a lack of sex hormones);
• bleeding in adolescence;
• menstruation, which is characterized by large blood loss;
• bleeding in pregnant women, including those caused by fibroids, as well as postpartum bleeding;
• placental abruption prematurely.

Tranexam can be used not only to stop bleeding, but also to prevent its occurrence (for prophylactic purposes).

Use during pregnancy and lactation

The medicine can be used by pregnant and nursing mothers. But for this category of women, Tranexam should only be prescribed by the attending physician!

During lactation, only a doctor can prescribe Tranexam, and the baby must not be fed.

The components of the drug are able to penetrate into breast milk and through the placental barrier. Therefore, the medication is used only for vital indications. If a woman is prescribed Tranexam during the lactation period, then it is recommended to stop breastfeeding for a while.

Side effects

Although undesirable manifestations are rare, they cannot be ignored. The most commonly reported side effects after using Tranexam:

• Lack of appetite.
• Vomiting and nausea.
• Heartburn.
• Stool disorder.
• Dizziness.
• General weakness and drowsiness during the day.
• Visual impairment.
• Thrombosis.
• Tachycardia.
• Pain in the chest.
• A sharp decrease in blood pressure if the drug is administered intravenously too quickly.
• Skin rashes.
• Itching and hives.

Tranexam and its effect on the female body

Most spontaneous miscarriages can be prevented if medical correction of the resulting pathology is carried out in a timely manner. A characteristic symptom of trouble is scarlet or brown discharge from a woman’s birth canal. The drug Tranexam is able to stop bleeding and stabilize the woman’s condition. It promotes blood thickening by accelerating its clotting, therefore effectively stopping the process of miscarriage.

On a note! Many women diagnosed with primary miscarriage are prescribed Tranexam for the purpose of prevention, even if everything is fine with the pregnancy.

Tranexam is a synthetic antifibrinolytic that helps preserve fibrin clots and increase the fibrinolytic activity of the blood. As a result of this effect on the female body, the medication stops bleeding of any nature.

The drug Tranexam is produced in two pharmacological forms - tablets and solution. The active substance of the drug is tranexamic acid. In addition to it, Tranexam contains additional components, the list of which depends on the form of the drug.

Tranexam tablets contain talc, cellulose, and silicon dioxide. The injection solution contains only water as an excipient.

Since Tranexam is a fast-acting hemostatic agent, it is used to increase blood clotting when there is a threat of miscarriage. The therapeutic effect is observed within three hours from the moment the drug is administered to a woman. In the case of intravenous administration of Tranexam, the hemostatic effect appears much faster.

Tranexamic acid also has antiallergic and anti-inflammatory properties. This makes it possible to use Tranexam during pregnancy to relieve acute allergic reactions, as well as foci of inflammation in the ENT organs.

Indications for use for expectant mothers

Tranexam is the drug of choice for uterine bleeding during pregnancy, which occurs for various reasons: from placental abruption to premature birth. Less common is the use of this drug for the following pathologies in expectant mothers:

• allergic reactions: urticaria, dermatitis, skin rashes, itching;
• inflammatory diseases of the respiratory system and oral cavity: tonsillitis, pharyngitis, laryngitis, tonsillitis, stomatitis;
• gastrointestinal bleeding.

Antifibrinolytic therapy with Tranexam has proven to reduce blood loss and reduce the need for donor blood products - red blood cells and FFP.

THEIR. Khapiy, A.F. Lopatin

“Efficacy and safety of using the drug Tranexam in surgical practice”

In which cases should you choose tablets, and in which cases should you choose a solution?

Tranexam tablets are convenient for use on an outpatient basis and are more often prescribed in case of minor blood loss and for their prevention. The solution is used when it is necessary to stop bleeding that directly threatens the health and life of the pregnant woman and fetus. There are research results showing that immediate administration of tranexamic acid increased the survival rate of patients with acute traumatic and postpartum hemorrhage by 70%. In addition, injections, unlike tablets, practically do not cause side effects associated with gastrointestinal disorders.

When purchasing Tranexam, you need to keep in mind that tablets are available in pharmacies without a prescription, and ampoules are available only with a prescription.

When will it help?

When prescribing the drug, the doctor will definitely tell you why Tranexam tablets help and how to use them so as not to harm yourself. The main indication for prescribing the composition is bleeding or an increased likelihood of its formation if fibrinolysis is activated, and the systemic effect covers the entire body. Often this type of bleeding occurs during and shortly after surgery, as well as shortly after childbirth. There are risks associated with manual removal of the placenta and bleeding that appears during gestation.

"Tranexam" is prescribed for hemophilia and chorionic detachment. The drug is indicated for oncological diseases localized in the pancreas and prostate gland. The basis for the prescription is a complication of the course affecting fibrinolysis. The medicine is used for purpura, leukemia, a number of liver diseases and against the background of the use of streptokinase.

From the instructions describing what Tranexam tablets help most effectively, it follows that the drug can be used for angioedema caused by hereditary factors. Sometimes the drug is prescribed as part of a comprehensive course of treatment for eczema, dermatitis, rashes caused by medications or toxic compounds. The drug is indicated in the treatment of urticaria and a number of other allergic reactions.

Tranexam is a hemostatic drug for pregnant women

In a general sense, by obstetrics doctors understand bleeding associated with pathologies of the organs of the reproductive system, including the uterus, and occurring during pregnancy, during childbirth and the postpartum period. The causes of blood loss are quite varied. Bleeding does not always indicate any existing disorders. But in any case, they are a reason for urgent consultation with a doctor.

Among the most common causes, doctors identify the following:

• threat of spontaneous abortion;
• ectopic pregnancy;
• placenta previa;
• premature placental abruption;
• inflammation of the uterus;
• premature birth.

All of the above pathologies pose a danger to the normal development of the fetus. In addition, heavy blood loss itself disrupts the fetoplacental metabolism between the body of the woman and the fetus. Also, in recent years, the World Health Organization has focused on the timely prevention of bleeding in the early stages. There is research indicating that this causes hematomas in the placenta, which increases the risk of premature pregnancy and fetal growth restriction.

Placental stratum is one of the main causes of bleeding during pregnancy

A special biological system called hemostasis is responsible for the timely stopping of bleeding and maintaining the necessary blood viscosity in the human body. If dangerous bleeding occurs, appropriate hemostatic drugs are used that affect the mechanisms of blood coagulation and restoration of damaged vessels. These drugs are divided into two main groups: coagulants and fibrinolysis inhibitors. The former directly affect blood clotting, the latter - on the process of splitting and dissolving blood clots and clots, which is the final stage of hemostasis.

Principle of action, active substance and release forms

Most fibrinolysis inhibitors are obtained synthetically by pharmacists based on the following acids:

• aminocaproic;
• para-aminobenzoic;
• tranexamic.

The hemostatic drug Tranexam is a fibrinolysis inhibitor made on the basis of tranexamic acid. This acid suppresses the formation of a specific protein in the blood - plasmin, which affects the process of building a protective network for damaged blood vessels. According to some data, this substance is the most promising for the production of hemostatic drugs, since it is an order of magnitude more effective than aminocaproic acid. Tranexam meets all the necessary requirements for local and systemic hemostatic drugs used during pregnancy:

• does not affect the growth and development of the fetus;
• has a rapid effect, which is important in case of threatened abortion;
• does not accumulate in the body after repeated use and, accordingly, does not have a toxic effect;
• does not cause microthrombosis and does not disrupt the function of the placenta.

Also, when studying the properties of tranexamic acid, it was found that it suppresses active substances involved in allergic reactions and inflammatory processes. Therefore, Tranexam is increasingly prescribed in cases of allergies and respiratory diseases.

Due to its combination of effectiveness, safety and availability, tranexamic acid is included in the World Health Organization's list of essential medicines. Tranexam, in turn, is on the list of vital medications, which is approved annually by the Russian Government. The effects of tranexamic acid have been well studied in large studies around the world. This is especially true for problems with perioperative blood loss and postpartum hemorrhage.

Tranexam is available in the form of film-coated tablets and a solution for intravenous administration in ampoules. The tablets are produced at the state enterprise “Moscow Endocrine Plant”, and the injection product is produced at the JSC “Obninsk Chemical and Pharmaceutical Company”.

Tranxam is available in the form of tablets and solution for injection.

Safety during pregnancy

According to the official instructions, Tranexam can be used at any stage of pregnancy, as it does not cause a teratogenic effect. In Russia, several research institutes conducted studies of the drug on pregnant women, the results of which confirmed the effectiveness and safety of the drug. But the number of women who took part in the studies was small and did not meet modern Western medical standards.

The active substance of the drug in question, tranexamic acid, has been assigned a high safety category B by the US Department of Health Drug Administration. This means that animal studies have not found a teratogenic effect on the fetus of this substance, and there has been no proper standardized study in pregnant women.

Characteristics of Tranexam

Manufacturers: Moscow Endocrine Plant and Obninsk Chemical Physics Complex (Russia). Product release form: film-coated tablets, injection solution (administered intravenously). The active substance is tranexamic acid. Dosage of this component in 1 tablet: 250, 500 mg. The amount of tranexamic acid in 1 ml of solution is 50 mg. You can purchase the drug in packages containing 10 and 30 tablets or 10 ampoules of 5 ml.

The drug has anti-inflammatory, antiallergic, antitumor properties.

The main properties of Tranexam:

• hemostatic;
• anti-inflammatory;
• antitumor;
• antiallergic.

The main component in the composition of the drug contributes to the inhibition of the function of plasminogen activator. If the dosage of the substance is increased, plasmin binds. In addition, there is an increase in prothrombin time. As a result, a hemostatic effect is manifested, due to which bleeding caused by increased fibrinolysis slows down.

The drug helps reduce the rate of production of kinin, as well as other peptides. As a result, anti-inflammatory, antiallergic, and antitumor properties are manifested. Tranexamic acid is a group of analgesics, but has a moderate effect.

When administered orally, no more than 50% of the substance is absorbed. The maximum efficiency limit is reached after 3 hours. The active component binds to plasma proteins slightly (3%). It is excreted by urination. Moreover, most of the active component (95%) is removed from the body unchanged. Indications for the use of hemostatic tablets and solution for injections:

• bleeding that developed against the background of increased fibrinolysis (the drug is prescribed both for the treatment and for the prevention of such pathological conditions);
• threat of miscarriage;
• Werlhof's disease;
• liver diseases;
• history of allergic reactions: angioedema, eczema, dermatitis, urticaria;
• inflammatory processes in the upper respiratory tract;
• stopping and preventing uterine bleeding after medical procedures;
• surgical intervention.

Tranexam should not be used in case of individual intolerance to the components in the composition, subarachnoid hemorrhage. The drug can be used with caution in the following pathological conditions:

• thrombosis of various etiologies;
• hemorrhage;
• renal failure;
• hematuria from the upper urinary tract.

Side effects of the drug are manifested by disruption of the digestive tract:

• nausea;
• heartburn;
• loose stools;
• loss of appetite;
• gagging.

Additionally, blurred vision, drowsiness, thrombosis, itching and rash on the outer integument are noted. Compatibility of Tranexam: the drug cannot be prescribed simultaneously with other hemostatics due to an increased risk of blood clots.

Drug therapy may be accompanied by drowsiness.

Tranexam: instructions during pregnancy

Tranexam is not capable of causing severe harm to a pregnant woman, so it is available without a prescription. However, it has an active effect on the process of blood clotting, so there is no place for any self-prescription here.

Indications for use of the drug Tranexam during pregnancy

Breakthrough uterine bleeding during pregnancy is not the only indication for the use of Tranexam. Obstetricians-gynecologists try not to wait for dangerous complications of pregnancy and prescribe the hemostatic agent Tranexam during pregnancy as soon as the first signs of trouble appear.

Direct indications for the use of Tranexam are:

• Bleeding and risk of bleeding in the near future.
• Pain localized in the lower abdomen that is not associated with gastrointestinal disorders.
• Any abnormal vaginal discharge from scarlet to light brown.
• Partial detachment of the chorion according to ECHO signs of ultrasound.
• Transthecal hematoma in the 1st trimester.
• Acute processes in the pelvis of an inflammatory nature.
• Pathologically low placement of the placenta in the 1st-2nd trimesters.
• The course of gestation against the background of uterine defects.
• Prevention of miscarriage in patients with established miscarriage.

Important! Tranexam is prescribed not only to maintain pregnancy, but also to prevent bleeding during a cesarean section or a difficult birth process.

Tranexam: how much to drink during pregnancy

Tranexam tablets are taken orally regardless of diet. The dosage of the drug depends on the existing pathology, so only the attending doctor can say exactly what dosage regimen is necessary.

During pregnancy, the intensity of bleeding, the condition of the fetus and the weight of women can be taken into account. On average, for bleeding, it is recommended to take 6-8 tablets of tranexamic acid. The daily dose should be divided into 3-4 doses.

Tranex injections during pregnancy are administered intravenously. The dosage regimen is selected individually depending on the condition of the expectant mother. As a rule, a single dose is 15 ml/kg of a woman’s body weight every 8 hours.

On a note! The injection form of the drug is used if oral administration is not possible. After the woman’s condition has stabilized, the administration of Tranexam by dropper during pregnancy is stopped and a tablet form of the medication is prescribed.

When is Tranexam prohibited for use during pregnancy?

Tranexam cannot always be used for bleeding during pregnancy, since it has several strict contraindications for use. It is prohibited to administer Tranexam to a woman in the following cases:

• intolerance to tranexamic acid;
• severe renal dysfunction;
• increased risk of blood clots;
• the patient has a history of seizures;
• myocardial infarction;
• thrombosis;
• ophthalmological diseases associated with retinal pathologies;
• subarachnoid hemorrhage;
• hematuria.

Important! Before using Tranexam, a woman should be examined by an ophthalmologist. Taking this drug can cause blockage of the retinal artery and impair visual acuity if a woman has problems with her vision.

Tranexam: side effects and overdose

Prescribing Tranexam for discharge during pregnancy can lead to the development of a number of complications from various organs. Until the end of treatment, the woman should be under the supervision of a gynecologist and therapist in order to notice the development of side effects in time and adjust the dose of Tranexam.

While taking Tranexam tablets, a woman may develop the following pathologies:

• decreased appetite;
• vomit;
• dizziness;
• heartburn;
• hypotension;
• stool disorder;
• drowsiness;
• necrosis of kidney tissue;
• color vision impairment;
• convulsions;
• allergic reactions (skin rash, itching, urticaria);
• thrombosis;
• anaphylaxis.

Intravenous administration of Tranexam acts more aggressively on the female body, so the list of side effects is much wider:

• allergic reactions;
• anorexia;
• severe nausea;
• diarrhea;
• anaphylactic shock;
• tachycardia;
• migraine;
• heart pain;
• blurred vision;
• general weakness;
• convulsions;
• stomach pain;
• thromboembolism.

Exceeding the recommended dose leads to an overdose of Tranexam.

Signs of overdose are:

• uncontrollable vomiting;
• fainting;
• convulsions;
• hypotensive crisis;
• Strong headache.

Important! Treatment of overdose with Tranexam consists of restoring water-salt balance and diuresis.

"Troxaminate"

The product is produced in Pakistan in the form of capsules with a dose of 0.5 grams of tranexamic acid. The composition contains a number of additional components, the main ones of which are: starch and magnesium stearate. The application is justified:

• for bleeding caused by an increase in general fibrinolysis after or during surgical interventions, with leukemia, malignant tumors, during and after childbirth;
• with local excessive destruction of blood clots accompanying other bleeding.

The initial single dose of the medicine is 2 tablets 3 times a day. Usually the doctor recommends a course of treatment, which can last up to 2 weeks. The difference between “Troxaminate” and the original is the imported production of tablets and a smaller amount of excipients, which may play a role in the patient’s sensitivity to certain components of the drug.

Interaction with other drugs

No practical studies have been conducted on this issue. Theoretical tests are carried out before the drug is released for sale, and they talk about the following:

• Tranexamic acid interferes with the achievement of the therapeutic effect of thrombolytic drugs.
• Its simultaneous use with prothrombin complex drugs (including antibiotics) increases the risk of thrombosis.
• The risk of heart attack exists with the simultaneous use of tranexamic acid and Ampicillin, Ranitidine and Nitroglycerin.
• In combination with hemostatic agents there is a risk of increased thrombus formation.
• It is not recommended to use Tranexam together with anticoagulants, or (if there is an urgent need) this should take place in a hospital under the constant supervision of a specialist.

But in principle, you should always read the instructions carefully and tell your doctor about all your problems, because even nasal drops may be unsafe. And if you think that this list does not include vitamin complexes, then you are mistaken. All advertised Elevit pronatal, all headache remedies recommended by your mother, for example, Nurofen, all seemingly natural suppositories for pregnant women, should be carefully studied by you to see if one drug matches another.

Tranexam for uterine bleeding: instructions for use + reviews

There are many reasons that can cause uterine bleeding in women. The modern drug Tranexam is often used in treatment - an effective remedy that allows you to cope with new bleeding or heavy periods in the shortest possible time.

Description of the drug Tranexam

The drug Tranexam is often used to treat uterine bleeding. It is used in therapy to reduce and restore the volume of menstruation, to stop bleeding and reduce the risk of miscarriage against the background of bleeding.

Tranexam has a systemic and local hemostatic effect on the body.

The main active ingredient of this medicine is tranexamic acid. It can influence fibrinolysin, a substance found in the blood that prevents it from clotting.

An increased content of fibrinolysin provokes intense and prolonged bleeding. This occurs when platelets are unable to sufficiently produce plasmin, a component that ensures normal blood clotting. Tranexam is able to convert fibrinolysin into plasmin, thereby helping to stop the increased secretion of bloody biological fluid.

Pharmacological effect of the drug on the human body:

• local and systemic hemostatic (hemostatic);
• anti-inflammatory;
• antihistamine (anti-allergic);
• anti-infective;
• antitumor;
• analgesic (pain reliever).

Release forms and composition of the drug

The drug has two forms of release: tablets and solution for intravenous administration.

The tableted product consists of convex white tablets covered with a water-soluble film. The solution is a clear liquid, colorless or with a slight light brown tint.

Tablets contain:

• active substance: tranexamic acid in the amount of 250 or 500 mg;
• auxiliary components: core: cellulose, hyprolose, talc, silicon dioxide, sodium carboxymethyl starch and calcium stearate;
• shell: titanium dioxide, talc, macrogol, hypromellose.

The composition of the solution for injection in an amount of 1 liter:

• tranexamic acid in a volume of 50 g;
• excipient - distilled water up to 1 liter.

The drug in injections is always more effective than tablets, but you should not use it at your own discretion

Uterine bleeding can be caused by various conditions or pathologies. They are conventionally divided into 2 categories:

1. The result of systematic disorders in different organs or systems.
2. Dysfunctions associated with changes in the functioning of the reproductive organs.

There are many reasons for such uterine bleeding. Among them:

1. Extragenital (not related to diseases of the genitourinary system): Liver diseases, for example, cirrhosis and liver failure.
2. Diseases of the cardiovascular system, such as atherosclerosis, hypertension.
3. Infections:
   flu;
4. measles;
5. sepsis;
6. typhoid fever.
7. Functional decrease in thyroid function.
8. Blood diseases:
   hemophilia;
9. hemorrhagic vasculitis;
10. low levels of vitamins C and K in the body.

Such bleeding can be caused by an additional number of factors:

• chronic illnesses;
• emotional and mental overexcitation;
• prolonged stress;
• physical overload;
• heredity;
• hypovitaminosis;
• mental trauma;
• endocrine diseases;
• complications after childbirth or abortion.

In addition to the above indications, the basis for prescribing Tranexam, at the discretion of the attending physician, may be allergic reactions, blood diseases and surgical interventions.

The risk of developing uterine bleeding is assessed by determining PCT in a blood test: https://krasnayakrov.ru/analizy-krovi/chto-takoe-rst-v-analize-krovi-opredelenie.html

Uterine bleeding - video

Contraindications

There are a number of contraindications to the use of Tranexam:

• hypersensitivity to the components of the drug;
• subarachnoid hemorrhages (spontaneous effusions of blood into the cavity between the meninges, the result of a ruptured aneurysm or traumatic brain injury);
• thrombosis of various origins: cerebral vessels;
• myocardial infarction;
• thrombophlebitis;

It is not recommended to take Tranexam together with:

• penicillins;
• tetracyclines;
• drugs for the treatment of hypertension;
• other hemostatic agents (hemostatic drugs).

Use of Tranexam during pregnancy and lactation

Tranexam is widely used in gynecology as a remedy that can prevent the threat of miscarriage. It is prescribed by a doctor after a thorough examination of the pregnant woman, since in the presence of certain health problems, for example, in the case of thrombosis, the use of this drug is prohibited.

During lactation, the medication is taken exclusively for health reasons, since Tranexam carries a potential risk for the child. At the same time, it is recommended to stop breastfeeding for the duration of treatment and switch the baby to formula.

Possible side effects

When using Tranexam in tablets, especially if the prescribed dosage is violated, the following side effects may occur:

• nausea and vomiting;
• heartburn;
• unstable stool, possible diarrhea;
• skin itching;
• rashes on the body;
• weakness of the whole body (lethargy);
• dizziness;
• drowsiness;
• decreased appetite;
• color vision impairment;
• thrombus formation.

A solution for infusion (intravenous and intramuscular administration) can cause the following undesirable effects:

• allergies in the form of: rashes;
• hives;
• skin itching;

Instructions for use of tablets and solution

Tranexam tablets are taken orally (by mouth) 3-4 times a day. Dosages and duration of treatment are determined by the doctor in accordance with the diagnosed disease. Usually the course duration is no more than two weeks. Therapy is carried out under the supervision of medical staff; independent use is prohibited.

Important! Doctors do not recommend using Tranexam for more than three menstrual cycles in a row.

The solution for infusion is administered dropwise or in a stream. The dose is calculated by a specialist. Sometimes a one-time use is enough. The maximum duration of treatment is three days.

Tranexam's analogs

There are structural and pharmacological analogues of this drug. Those medications that are based on the same active ingredient have similar effects and contraindications to Tranexam:

• Exacyl;
• Troxaminate;
• Traxara;
• Cyclocapron.

What can replace the medicine - table

Drugs used for uterine bleeding - gallery

In the past, Vikasol was often used to stop bleeding, but now it has been replaced by more modern drugs Dicynon - an effective drug used to prevent heavy bleeding Vilate - one of the most expensive and effective hemostatic agents Ambien will help stop uterine bleeding A popular substitute for Tranexam - Methylergobrevin

Reviews from patients who took Tranexam

Tranexam is a potent drug, not a miracle cure. Treatment of uterine bleeding with its help should be under the supervision of a physician.

• Author: Evgenia Yablokova
• Print

krasnayakrov.ru

Pharmakinetics

Absorption after oral administration of doses in the range of 0.5–2 g is 30–50%. Tmax when taken orally 0.5; 1 and 2 g - 3 hours, Cmax - 5; 8 and 15 μg/ml, respectively. Plasma protein binding (profibrinolysine) - less than 3%.

Distributed relatively evenly in tissues (with the exception of cerebrospinal fluid, where the concentration is 1/10 of the plasma concentration); penetrates the placental barrier into breast milk (about 1% of the concentration in maternal plasma). It is found in seminal fluid, where it reduces fibrinolytic activity, but does not affect sperm migration. The initial volume of distribution is 9–12 l. Antifibrinolytic concentration in various tissues lasts 17 hours, in plasma - up to 7-8 hours.

A small part is metabolized. The AUC curve has a three-phase shape with T1/2 in the final phase - 3 hours (for solution for intravenous administration - 2 hours). Total renal clearance is equal to plasma (7 l/h). Excreted by the kidneys (the main route is glomerular filtration) - more than 95% unchanged during the first 12 hours.

Two metabolites of tranexamic acid have been identified - N-acetylated and deaminated derivatives. In case of impaired renal function, there is a risk of accumulation of tranexamic acid.

Tranexam's analogs

Utrozhestan is a drug available in tablet form that contains the hormone Progesterone.
The drug helps maintain the pregnancy process. That is why it is prescribed when there is a threat of spontaneous abortion, accompanied by uterine bleeding and cramping pain. The drug can be used at any stage of pregnancy as prescribed by a specialist. Dicynone is a medicine available in the form of tablets and solution for infusion. The drug is used to stop bleeding of various etiologies. In obstetric practice, the medication is prescribed when there is a threat of spontaneous abortion. The drug can be used from the 1st trimester of pregnancy.

Duphaston is a medicine that contains a synthetic analogue of the female hormone progesterone. The medicine is used to support pregnancy when there is a threat of premature termination of pregnancy. The drug is approved for use at any time.

Actovegin is a drug that promotes tissue regeneration. It contains components of the blood of calves. The drug is used as part of complex therapy for uterine bleeding and impaired blood supply to the fetus. The drug can be used from the first trimester of pregnancy.

Curantil is a medicine that contains Dipyridamole. The drug is available in tablet form. Curantil is indicated for stabilizing the condition after thrombosis and embolism. The drug is also used in cases of impaired blood supply to the fetus and its retardation in growth and development. The medication can be used from the early stages of pregnancy.

Etamzilate is a medicine with the same active ingredient, produced in the form of tablets and solution for injection. The drug is used to treat bleeding of various etiologies, blood disorders, and inflammatory diseases. The drug is approved for use from the first weeks of pregnancy.

Features of the action

With some diseases and pathologies, women may experience uterine bleeding, which is sometimes confused with menstruation.
A sign of bleeding is the release of a large volume of blood from the uterus (more than 85 mg per day). In this case, the woman has to change the pad every hour or two. The main signs of bleeding are cramping pain in the abdomen, the presence of a large number of clots in the blood, as well as fatigue and weakness that occurs against the background of the development of anemia. The drug Tranexam affects blood clotting, slowing down and completely stopping the activity of the fibrinolysis enzyme (its high content provokes heavy bleeding). In addition, the transformation of plasminogen, a component of plasma, stops. In this case, a hemostatic effect is manifested, which is necessary to stop bleeding.

Tranexam has the following pharmacological effects on the body:

• Hemostatic;
• Anti-infective;
• Antitumor;
• Anti-inflammatory;
• Antiallergic;
• Painkiller.

If you take Tranexam tablets orally, up to 50% of the substance is absorbed. In this case, the maximum concentration of the main component is observed after approximately three hours. Tranexamic acid binds to proteins and can cross the placenta. It is also excreted into breast milk (concentration 1%). The effect of the drug lasts for 17 hours (in tissues), but in plasma no more than 8 hours. When using the drug intravenously, an analgesic effect is achieved.

pharmachologic effect

Drug group: Medicine to stop bleeding. Therapeutic effects of Tranexam:

• Blocking fibrin dissolution;
• Blocking plasminogen activation;
• Preventing the conversion of plasminogen to plasmin;
• Stopping bleeding caused by menorrhagia;
• Stopping bleeding caused by platelet pathologies;
• Suppression of the formation of biologically active substances that cause inflammatory reactions;
• Blocking the formation of biologically active substances that cause hypersensitivity reactions;
• Anti-inflammatory effect;
• Anti-infective effect;
• Antiallergic effect;
• Antitumor effect.

Pharmacokinetics:

• able to penetrate the placental barrier;
• able to penetrate the blood-brain barrier;
• distributed evenly throughout all tissues of the body;
• reaches its maximum concentration three hours after taking it;
• The therapeutic concentration of Tranexam in tissues is maintained for 17 hours.

Home first aid kit

In addition to Tranexam analogues in tablets and injections, there are a number of folk methods that stop bleeding:

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Undoubtedly, treatment with traditional methods is only an addition to the main therapy. If bleeding is detected, you must consult a doctor and follow his recommendations and prescriptions. The medicinal herbs available in the home medicine cabinet - analogues of "Tranexam" with a hemostatic effect, can only serve as an addition to the main treatment or be used to prevent the disease. Only a complex of herbs and medications prescribed by a specialist will effectively cope with any kind of bleeding.

Source

Composition of the drug

The active component of the drug is Tranexamic acid.
The medicine belongs to the group of fibrinolysis inhibitors because it has a hemostatic effect. The most important effect of Tranexamic acid is antifibrinolytic. The drug helps disable the enzyme that causes the breakdown of blood clots. Due to the described action, the medicine increases the viscosity of the intravascular fluid and promotes the activation of the coagulation system.

Tranexamic acid also has an anti-inflammatory effect. It reduces the severity of swelling, reduces pain, relieves redness of the skin and mucous membranes.

The medication has an antiallergic effect. The medicine reduces the production of substances that cause an atypical reaction in the human body. Tranexamic acid reduces local and systemic manifestations of allergies.

The drug has high bioavailability and is well absorbed from the gastrointestinal tract. The drug then enters the bloodstream. The maximum concentration of Tranexamic acid in plasma is observed 3 hours after administration.

The activity of the drug remains for 18 hours. Complete cleansing of the blood from traces of Tranexamic acid is observed 4-5 days after the last dose. Most of the medication is excreted from the body through the kidneys along with urine.

When is it prohibited to use?

The instructions for use provide a list of contraindications for the use of Tranexam, these are:

• individual intolerance;
• vein diseases (varicose veins);
• tendency to thrombosis;
• kidney dysfunction;
• disturbances in the blood supply to the brain.

It is prohibited to administer the drug intravenously if the patient has previously received a blood transfusion. But such patients can take pills. The drug should not be taken in combination with tetracycline antibiotics, as the combination of these drugs can cause the formation of blood clots.

Treatment with Tranexam during breastfeeding is not allowed, since the active substance passes into milk.

Side effects

Taking Tranexam rarely causes negative side reactions, however, they are not excluded. Possible appearance:

• nausea and heartburn;
• dizziness, weakness;
• tachycardia;
• skin allergic reactions.

So, Tranexam during pregnancy is most often prescribed to relieve the threat of miscarriage. The drug is safe for the fetus, so it can be used for treatment at any time, including in the first trimester. The doctor determines how long the treatment will last and what the dose of the drug should be depending on the patient’s health condition.

Contraindications and side effects

Tranexam is considered a fairly safe medication. The main contraindication for use by expectant mothers is individual intolerance to the components of the drug. But the instructions note that the medicine should be used with caution in the following pathologies:

• thrombosis, thrombophlebitis;
• hemorrhagic complications;
• the appearance of blood in the urinary tract;
• renal failure;
• color vision disorders.

Tranexam should be used with great caution in case of thrombophlebitis.
When treated with tranexamic acid, the expectant mother may experience undesirable reactions:

• allergies in the form of skin rashes and itching;
• gastrointestinal disorders: nausea, vomiting, diarrhea;
• dizziness, loss of strength, decreased appetite;
• increased heart rate;
• disturbance of color perception and clarity of vision;
• thrombosis.

If such phenomena occur, a pregnant woman should immediately consult a doctor who will change the treatment regimen or select another drug.

Interaction with other drugs

Doctors do not recommend combining Tranexam with other hemostatic drugs, as the risk of blood clots increases. Also, in the form of a solution, the medicine is incompatible with a number of medications:

• blood products;
• solutions with penicillin, urokinase;
• solutions with hypertensive drugs, tetracyclines, dipyridamole and diazepam.

Effect of the drug on the fetus

According to the instructions for use, the drug is classified as “B” class of drugs: Tranexam can be used during pregnancy if there are serious indications.
In studies on laboratory animals, it was established that the medication does not have a teratogenic effect on the fetus - Tranexam does not contribute to the occurrence of congenital anomalies. Also, the drug does not have a toxic effect - it does not cause delays in the growth and development of the unborn child.

Some gynecologists exclude the possibility of using any medications in the early stages of pregnancy. Before the 13th week of the gestation period, all the organs of the unborn child are formed. Taking medications can contribute to disruption of fetal tissue division. However, if there are serious indications, taking Tranexam is not prohibited even in the 1st trimester of pregnancy.

Starting from the second trimester of gestation, Tranexam has a wider list of indications for use. By this period, the main organs and systems of the fetus have been formed.

The drug can be used in late pregnancy until the birth period. The drug does not affect uterine activity, so it does not reduce the intensity of contractions. Also, Tranexam does not help slow down the dilatation of the cervix during childbirth.

"Cyclocapron"

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The Swiss medicine became widespread in Russia in the early 2000s, when everything imported was considered more prestigious and of higher quality. However, a foreign-made medicine with tranexamic acid turned out to be too expensive for domestic buyers. Gradually they stopped prescribing and taking it, as was the case with Transamcha tablets. In addition, Cyclocapron tablets are incompatible with penicillin solutions, tetracycline and blood products.

Analogs allowed during pregnancy

Dozens of hemostatic drugs are produced based on tranexamic acid. The following complete analogues of Tranexam are available on the Russian pharmaceutical market:

• Stagemin;
• Gemtraniks;
• Troxaminate;
• Exacyl;
• Cyclohemal.

If tranexamic acid is intolerant, pregnant women may be prescribed drugs such as Vikasol or Dicinone.

Vikasol is a synthetic analogue of vitamin K, increases blood clotting and is a coagulant. According to most experts, during pregnancy this drug can be prescribed only for serious indications and with great caution. Although some sources indicate that when studying the effect of Vikasol on animals, they discovered an adverse effect of the drug on fetal development. The risk of hemolytic anemia and jaundice in the fetus and newborn is reported to be increased.

The active ingredient of Dicynon is ethamsylate - a substance with a hemostatic effect, which, when administered intravenously, begins to be felt within 5-15 minutes and lasts for four hours. During pregnancy, doctors prescribe this medicine, taking into account the benefit/risk ratio.

Table: Tranexam and other hemostatic agents

Photo gallery: Tranexam analogues

Troxaminate is a structural and functional analogue of Tranexam

Vikasol is a synthetic analogue of vitamin K

Dicinone, along with Tranexam, is one of the most prescribed hemostatic drugs during pregnancy

From regular communication with a gynecologist I knew, I drew some conclusions regarding the prescription of hemostatic drugs. Doctors' recommendations change over time. It should be understood that Tranexam is a symptomatic drug that prevents large blood loss. If bleeding occurs during pregnancy, the reasons for it can be very diverse. To clarify them, numerous special examinations are often necessary, for which sometimes there is not enough energy and time. Therefore, doctors usually prescribe complex treatment with standard safe drugs based on their experience and clinical picture. Among the most prescribed medications are Duphaston and Utrozhestan, which increase progesterone levels, which prevents miscarriages and premature birth. Also, Dicinon or Tranexam are usually prescribed together with them to stop bleeding. Moreover, recently there has been an increase in the prescriptions of Utrozhestan and Tranexam. According to the doctor, the relative safety of these drugs allows them to be used even at the slightest suspicion of a threat of miscarriage, without worrying that they will harm the development of the fetus. I can confirm that such drugs have helped some of our friends and relatives bear more than one child.

Which is better: Tranexam or Dicynon?

When bleeding

The choice of a more effective remedy is made taking into account the initial data: the presence of pathologies accompanied by intensive formation of blood clots; composition and properties of the blood at the time of treatment (for example, increased or decreased viscosity), etc. For this reason, it is difficult to give an unambiguous answer as to which drug will be more effective in treating bleeding. The speed of action must be taken into account. For example, with uterine bleeding, Tranexam helps faster, because it has a direct effect on plasminogen, which is involved in the blood clotting process.

For heavy periods

It is acceptable to use both means. However, with heavy periods, the risk of uterine bleeding increases, which means it is recommended to start treatment with Tranexam.

During pregnancy

If in the early stages of pregnancy there are signs of a threat of miscarriage (the stomach has become hard, slight bleeding has appeared), both remedies can be used. Both Dicynon and Tranexam penetrate the placenta in small quantities. The gynecologist should choose the drug and prescribe the treatment regimen.