What Nise tablets help with: indications and instructions for use, reviews, price of the drug

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Disorders of the musculoskeletal system are often accompanied by pain and significantly complicate the lives of patients. Currently, almost every pharmaceutical company offers a wide selection of drugs with analgesic effects. Various pharmacological forms help to quickly eliminate pain and improve the course of the pathological process. One of these products is Nise gel.

Storage conditions

The drug is sold to the public through a network of pharmacies for free sale; a prescription from a doctor is not required. The product should be stored in its original packaging for two years from the date of issue. The room temperature should not exceed 25 degrees. Children's access to the place where medicines are stored should be limited.

NSAIDs for external use.

The drug "Nise Gel" contains nimesulide. Preparations based on it (“Nimesulide”, “Nise”, “Nimegesic”, “Aktasulide”, “Sulaidin”, “Prolide” and others) are drugs that effectively fight fever and inflammation, and also have a strong analgesic effect.

Medicines that contain nimesulide have extensive indications for use. “Nise”, “Nimesil”, “Novolid” and other drugs are indicated for osteoarthritis and osteoarthrosis, bursitis, tendonitis, for postoperative and post-traumatic pain, as well as for various inflammatory processes and gynecological diseases. The maximum effect after taking them orally is achieved after one and a half to two hours. External agents based on nimesulide - in particular, Nise gel, the use of which in parallel with ingestion of the agents enhances their effect, in addition, have a distracting and locally irritating effect. Thus, the composition of the drug “Nise Gel”, in addition to its active component, includes menthol, methyl salicylate and capsaicin. The last of them, an alkaloid, contained in abundance in red hot pepper, promotes a rush of blood to the painful area and warms it up. The menthol contained in Nise Gel (the instructions say so) has an additional external analgesic effect by stimulating cold receptors. Finally, methyl salicylate, a derivative of salicylic acid, a volatile substance with a characteristic strong odor, reduces inflammation and infiltration in tissues, improves microcirculation in them.

The instructions attached to the drug "Nise Gel" describe the indications for its use. These are various diseases of the musculoskeletal system, accompanied by inflammation or degenerative changes: arthritis, rheumatic and gouty joint pain, radiculitis, osteoarthritis, bursitis, sciatica, lumbago, as well as osteochondrosis with radicular syndrome. It should be applied to clean, dry, undamaged skin in an even, thin layer. To do this, squeeze out a column of gel about three centimeters long from the tube, apply it to the skin in the most painful place and rub it gently, without pressure. The instructions recommend using Nise Gel 3-4 times a day. It should be understood: since the absorption of nimesulide through the skin is insignificant, a serious effect can only be obtained by combining this drug with other drugs.

Like most medicines, “Nise Gel” has contraindications for use - this is, first of all, individual intolerance to nimesulide or other non-steroidal anti-inflammatory drugs, for example, “Nise Gel” (the instructions say this) cannot be used for severe liver dysfunction and kidneys, with peptic ulcer in the acute stage, pregnancy. If this medicine must be used by a nursing mother, the child should be weaned from the breast for the duration of treatment. In addition, Nise Gel is contraindicated for skin diseases - both infectious and dermatitis of various natures. It is not recommended for use on children under 12 years of age.

Side effects from the use of this drug include a variety of external allergic manifestations: itching and flaking, rash and redness of the skin, and in some cases even burns.

When using it, you should be careful and avoid contact with mucous membranes, open wounds or damaged skin. Hands must be washed thoroughly after applying Nise Gel.

“Nise Gel” is available in tubes of 20 g. It should be stored in a cool place, avoiding freezing. The product must be used within a week after opening the tube.

The drug "Nise" is a gel for topical use. You will find what this remedy is, what its indications are, side effects, pharmacological action and other information in the materials of this article.

How to take Nise tablets?

The presented drug acts quickly and effectively, but it is important to follow the recommendations for its use. It is advisable to first consult with a doctor before taking Nise - using the medicine in the wrong dosage can cause negative side effects. Additionally, it is necessary to clarify the duration of the therapeutic course.

At what age can you take Nise?

The described medication is prescribed mainly to adults. Adolescents over 12 years of age with a body weight of 40 kg or more can take Nise tablets in the standard dosage of 100 mg. If the weight is less, the amount of nimesulide is calculated at 3-5 mg per 1 kg. The drug in question is not prescribed to children under 3 years of age. If the child has reached the specified age, it is allowed to use dispersible Nise - tablets for children that dissolve in water. They are available in a dosage of 50 mg of the active ingredient in each pill.

How to take Nise for toothache?

An anti-inflammatory agent based on nimesulide is used to relieve discomfort before and after dental procedures. In these situations, Nise is prescribed according to the classical scheme - tablets for toothache are taken 2 times a day, 1 piece (100 mg). The maximum daily dosage is 200 mg. Experts advise taking pills before meals, but if you experience discomfort in the stomach or intestines, it is better to use Nise tablets after a meal. The duration of the course is calculated individually, but should not exceed 15 days.

How to take Nise for osteochondrosis?

Back pain, inflammation and swelling are also effectively relieved by nimesulide. If osteochondrosis relapses, the standard method of taking Nise is prescribed - 100 mg 2 times a day. Similarly, tablets are used for symptomatic treatment of other musculoskeletal pathologies with pain syndrome. The duration of treatment is determined depending on the severity of clinical signs, mainly 7-12 days.

Can I take Nise for a headache?

The presented pharmacological remedy helps with the problem in question, but not always. Nise painkillers are recommended only if an attack occurs against the background of:

• increased body temperature;
• inflammatory processes, for example, meningitis;
• tension;
• overwork;
• stress;
• lack of sleep;
• changes in weather conditions;
• toothache;
• blows and bruises;
• surgical interventions;
• medical procedures;
• noise;
• blood pressure surges;
• osteochondrosis;
• pinched nerve roots and other factors.

Nise tablets are ineffective if the cause of the pain is migraine. In this case, no anti-inflammatory non-steroidal medications will help. For migraine attacks, it is better to take medications that have a direct effect directly on the dilated blood vessels in the brain and block the sensitivity of the trigeminal nerve receptors. These medications include triptans.

How long does the Nise tablet last?

The duration of the analgesic and anti-inflammatory effect depends on the nature of the discomfort, its intensity and cause. Nise 100 mg tablets block discomfort for 0.5 days. The degree of pain relief gradually decreases, because nimesulide begins to be eliminated from the body after 2-5 hours. The maximum analgesic effect is observed 20-25 minutes after taking the tablet.

How many times a day can I take Nise?

The recommended frequency of use of the medication in question is limited to two times. In extremely rare situations, the doctor may allow you to take Nise tablets more often - the use of an anti-inflammatory drug is allowed in a maximum daily dosage of 400 mg. Exceptional cases when nimesulide is prescribed 4 times a day occur in surgical practice. After some operations, the severity of the pain syndrome is too intense, and in order to avoid a state of shock, the analgesic will be used in an increased dose.

How long can you take Nise tablets?

The duration of symptomatic therapy should correspond to the specific situation. Only a specialist decides how many days Nise can be taken. The maximum recommended duration of treatment is 15 days. More often, nimesulide is used until swelling and signs of inflammation disappear - 7-10 days or less. For headaches, menstrual pain, and toothache, the medication is used for 2-3 days or once.

Can Nise be taken with alcohol?

There are no direct instructions regarding the simultaneous use of nimesulide and the consumption of alcoholic beverages. Nise tablets help with headaches and fever associated with a hangover, quickly and effectively relieving the condition. Doctors just do not recommend using the described drug in parallel with strong drinks and on the eve of parties. Nise and alcohol are poorly compatible, because ethanol can retain fluid in the body. Along with it, nimesulide accumulates in the digestive system, which can provoke dangerous consequences.

Beneficial features

The drug "Nise Gel" has anti-inflammatory, antipyretic, antiplatelet and analgesic effects. It suppresses the formation of prostaglandins in areas of inflammation and selectively inhibits type 2 cyclooxygenase.

The drug rarely has side effects due to inhibition of prostaglandin synthesis in healthy tissues. It slows down the processes of lipid peroxidation and their metabolites and does not affect hemostasis and phagocytosis.

When taken orally, the drug can be well absorbed directly from the stomach and intestines. The maximum concentration of the drug is reached 1.5-2.5 hours after administration. Its half-life reaches three hours.

The main metabolite in the drug is the active hydroxynimesulide. This drug undergoes biotransformation processes in the liver. It is excreted primarily by the kidneys. With prolonged use it is not able to accumulate.

In the form of a gel, the drug has a local analgesic and anti-inflammatory effect. With its help, pain in the joints disappears or is weakened at rest and in a state of movement. Morning joint stiffness and swelling are neutralized as a result.

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Pharmacological properties

The drug belongs to the group of non-steroidal anti-inflammatory drugs and has a pronounced effect. When the product is applied to the affected area, the active component penetrates into the blood and directly to the source of inflammation. Further, the active substance suppresses the synthesis of enzymes that provoke the development of the pathological process, which helps to significantly slow it down.

Another property of the drug will be the elimination of pain of varying intensity. This is also possible by slowing the progression of the disease. The drug also relieves local hyperthermia, which has a beneficial effect on the general condition of the patient.

Since the inflammatory process is stopped, the body has the opportunity to launch processes to combat the source of the disease. As a result, recovery progresses much faster and other medications can work more effectively. The menthol content has an irritating effect at the site of application and allows the patient to be distracted from acute pain until it is eliminated.

After applying the product to the affected area, the therapeutic effect is observed within 15 minutes, which indicates the high penetrating ability of the active components in the composition. The maximum concentration in the blood is observed 1-2 hours after application. The advantage of this form of the drug is that it does not pass through the organs of the digestive and urinary systems and any pathologies do not interfere with achieving the result.

It is noted that after application the substances quickly penetrate under the skin, into the joint cavity and muscle tissue. Despite the fact that nimesulide penetrates into the systemic bloodstream, its concentration there is insignificant, this allows minimizing negative reactions from organs and systems.

Side effects

Adverse reactions with the use of the gel are extremely rare. If the patient has hypersensitivity to the components of the product, an allergy may develop:

• peeling of the skin;
• itching of the skin;
• change in skin color;
• burning sensation.

Reactions of this nature do not require discontinuation of the drug and disappear on their own.

Adverse reactions from the following list occur extremely rarely, in particular with prolonged and improper use:

• a feeling of tightness behind the sternum;
• burning sensation in the larynx;
• digestive disorders;
• headache and migraine;
• dizziness;
• nausea and;
• delayed diuresis;
• anemia.

If these symptoms occur, you should seek emergency medical help. In some cases, emergency refusal to use the product and its subsequent replacement is indicated. In rare cases, with prolonged use of the gel, renal failure develops, the symptom of which is disruption of the processes of removing fluid from the body.

Where to buy and how much the drug costs

Eugene. I consider it a good pain reliever, especially for toothache. Doctors do not recommend taking it on an empty stomach.

Alyona. Nise took the pills several times when her leg hurt to the point of lameness. Before that, I used the gel of the same name for leg pain. It helped.

Anya. But I didn’t like it because of the deterioration of my eyesight. I took it for neck pain. I felt better 1 hour after taking it. It turned out to be a strong drug, but the long list of side effects is frightening. Although it must be admitted that almost every painkiller has the same list.

Vladimir. My mother takes these pills in the morning for joint pain. I drank them a couple of times for headaches. They help both me and my mother. Just don’t take them more than the permitted limit.

Nise side effects

When using the gel, there are few side effects, but they do exist. In rare cases, local reactions occur, such as a burning sensation, itching, urticaria, change in skin color at the site of application of Nise, peeling of the skin. Such symptoms disappear on their own within 24 hours and after discontinuation of the drug. Long-term use of the gel and application over a large area of ​​skin cause a number of systemic reactions, if they occur, you should consult a doctor:

• leukopenia;
• burning sensation behind the sternum and in the larynx;
• anemia;
• nausea with bouts of vomiting;
• thrombocytopenia (a condition of low platelet count);
• digestive disorders;
• allergic reactions (anaphylactic shock);
• formation of small erosions and ulcers on the mucous membrane of the digestive tract;
• fluid retention in the body;
• increased activity of liver transaminases (enzymes);
• dizziness;
• headache;
• migraine.

Clotrimazole ointment for men

A large percentage of fungal diseases occur in lesions of the genital organs. Among men's problems, thrush (candidal balanitis) is distinguished. The disease is caused by fungi of the genus Candida. Thrush is transmitted sexually; the disease is transmitted by one of the partners - a man or a woman. Often candidiasis is not accompanied by pronounced symptoms: sometimes dryness, burning and itching of the genital organ, pain when urinating, and discomfort during sexual intercourse are disturbing.

If you have the listed symptoms or if your partner is ill, you should consult a doctor for a consultation, because an advanced fungal disease can cause the development of prostatitis or chronic diseases of the genitourinary system. To treat candidiasis, doctors often prescribe Clotrimazole for men.

The formulation of the drug in the form of a cream received positive feedback during treatment - a positive effect is achieved so quickly and it is convenient to use. Nuances:

Small doses of the drug quickly stop the development of the disease; further use of the drug leads to the death of the pathogen within a week.

1. For complete recovery, the course of treatment can last up to three weeks.
2. To achieve a therapeutic effect, it is necessary to apply a thin layer of cream to the washed affected area two to three times a day.
3. The ointment is poorly absorbed, so it is recommended not to get dressed immediately after applying the drug.
4. During treatment, you should wear comfortable, breathable clothing made from natural fibers.

Candida fungi are always present in the body, but begin to multiply quickly and cause inflammation when the immune system is weakened or antibiotics are taken, so a greater treatment effect is achieved with fortifying medications and diet. The patient is prescribed fermented milk foods, dietary supplements, and a diet excluding sweet, hot, spicy and fried foods is recommended.

Contraindications

The drug is not recommended for use in patients with intolerance to the components of the drug. Other contraindications:

• skin damage at the application site - infectious, allergic, wounds;
• gastrointestinal pathologies - ulcerative, bleeding;
• liver and kidney failure;
• severe reactions to other NSAID drugs (bronchospasm);
• during pregnancy and breastfeeding;
• children under 7 years old.

The ointment requires monitoring when used in cardiovascular pathologies, severe forms of hypertension, diabetes mellitus without insulin dependence, as well as in elderly patients.

If there are known reactions to Aspirin, Paracetamol and other NSAID medications, you should inform your doctor when prescribing.

special instructions

The doctor individually sets the dosage rate for Nise for patients with impaired liver and kidney function.

Also, consultation with a doctor is necessary for patients with an allergic reaction to aspirin.

During therapy, dizziness may occur, so during this period it is better to refrain from operating equipment and activities that require increased concentration.

Elderly patients are rarely prescribed this drug. This is due to the fact that nimesulide is excreted from the body through the kidneys and urinary system, which often suffer from dysfunction at this age. Visual impairment, fluid retention in the body and impaired cardiovascular activity may also occur.

It is not recommended to combine alcohol and drug intake.

Indications for use

Nise gel is included in the therapeutic regimens of patients diagnosed with various diseases of the musculoskeletal system. A topical medication is used to prevent further destruction of bones, cartilage and joints. The drug is used to relieve the inflammatory process and reduce the severity of pain during exacerbation of chronic diseases of the spinal column. In the treatment of injuries and severe bruises, the use of Nise gel is also practiced to eliminate swelling of soft tissues located near the injuries.

Nise gel is used as a pathogenetic and symptomatic treatment for the following pathologies:

• radiculitis;
• gout at the relapse stage;
• rheumatoid arthritis;
• osteochondrosis of any localization (cervical, thoracic, lumbar);
• Bekhterev's disease;
• psoriatic arthritis;
• osteoarthritis;
• osteoarthritis;
• periarthritis;
• tendinitis;
• lumbago;
• sciatica;
• bursitis.

Neurologists recommend that patients rub the drug into the area of ​​inflammation in cases of pinched nerves in the spinal column, intervertebral hernias and neuralgia. Nise gel quickly relieves pain and swelling from sprained ligaments, including the ankle.

Clotrimazole ointment for thrush detailed instructions

Clotrimazole is an ointment that helps with thrush. It has a thick consistency. The ointment is applied directly to the labia. The drug is white. It received this shade due to the presence of paraffin, alcohol, purified water and other components. The ointment was developed specifically to combat fungal spores of various origins.

It is usually used for candidiasis. Can be used not only by women, but also by men. It can also be used if fungal diseases begin to develop on the feet, skin and mucous cavities.

Women

• The ointment is used primarily to combat fungal plaques that provoke microsporia and lichen. The drug has been demonstrating its increased level of effectiveness for a long time.
• However, in order to overcome the disease, it is necessary to undergo a full course of therapy. It can be a minimum of 5 days and a maximum of 10 days.
• The duration of treatment will depend on the form of the disease and the degree of its complexity. The effectiveness of the drug is determined by how correctly the patient uses the ointment.

The drug Clotrimazole is manufactured in small tubes with a capacity of 20 ml.

From the very beginning, the first signs of the disease appear in the form of redness, severe burning, and itching in the genital area. If these symptoms occur, you should immediately consult a doctor. Based on the examinations performed, he will be able to make an accurate diagnosis and prescribe the necessary treatment.

During thrush, the drug is used according to the following scheme:

• The ointment should be applied in a thin layer to the vaginal walls.
• The drug must be applied no more than once per day.
• The duration of therapy is 3 days or more.

Before you decide to use the ointment, you must perform important procedures - take a bath or shower. This is necessary so that the infection cannot enter the vagina.

Use the ointment with extreme caution, without violating the rules from the instructions. Simply apply the product in circular motions into the skin

The dosage is approximately 5 g.

Analogs

Nimesulide, the active component of the ointment, is included in the following topical medications:

1. Nimulid. Available in the form of a light texture gel. Has a volume of 10, 20, 30 g. The active substance content is 1%. Made in India. It has the same scope and features of application. Price – from 130 rubles.
2. Sulaydin – gel 1%. From 410 rubles for 30 Turkey.
3. Nimesulide – gel 1%. Belarus. From 180 rubles.
4. Nimid – gel 1%. Price from 175 rubles. India.

Exact analogues of Nise gel are not cheap drugs. All of them are produced abroad. However, thanks to the same active substance, they can be full-fledged substitutes for Nise.

Medicines for external use and with a similar effect, having other active ingredients:

• Diclofenac – from 60 rubles;
• Ibuprofen – from 20 rubles;
• Ketonal - from 250 rubles;
• Fastum Gel – from 230 rubles;
• Voltaren - from 450 rubles.

Cheap analogues of Nise gel can only be found in Russia and with a different active ingredient. The price of drugs with nimesulide varies little.

It must be remembered that all analogues differ from the original in the accompanying components, so you need to consult a doctor about replacement. Each remedy has its own contraindications and negative effects.

Analogues of the drug

The cost of the drug is quite high, so many are looking for a substitute that will cost less but have the same therapeutic effect. There are several analogues of Nise gel that have a similar composition and effect on the body:

1. Voltaren emulgel. It also belongs to the group of non-steroidal anti-inflammatory drugs, but has an effect due to the content of diclofenac. The manufacturer claims that the product effectively combats pain and other signs of inflammation in various pathologies of the joints and spinal column. The medicine is not prescribed to children under 12 years of age, to patients with an allergic reaction, to patients with stomach or duodenal ulcers. The standard course of therapy lasts from 10 to 14 days, depending on the severity of the condition.
2. Fastum gel. It contains ketoprofen and is also classified as an NSAID. It has a pronounced anti-inflammatory, antipyretic and analgesic effect, allowing to relieve acute symptoms of diseases of the musculoskeletal system. Prescribed in courses of 10 to 14 days. The product is strictly contraindicated during lactation and pregnancy, children under 12 years of age, as well as patients with chronic psoriasis, dermatitis or eczema.
3. Gel Dicloran. Manufactured by an Indian pharmaceutical company. It is based on the active ingredient diclofenac, which has a rapid therapeutic effect and retains it for a long time. The medicine is used in the treatment of neuralgia, neuritis, radiculitis, osteochondrosis and other disorders. Contraindicated in children and adolescents under 18 years of age, pregnant and lactating women, patients with aspirin asthma or an allergic reaction to this group of drugs.
4. Polish product Ultrafastin. It contains ketoprofen, which has properties similar to the original drug. Prescribed in short courses of 7-10 days. Usually this is enough to get results. The product is contraindicated for patients with severe forms of psoriasis, eczema, dermatitis, purulent wounds and cracks at the site of application. It should not be used during pregnancy and breastfeeding, since the effect of ketoprofen on the fetus is unknown.
5. Cream Dolgit. Produced in Germany. The therapeutic effect is carried out due to the content of ibuprofen. The active component is also included in the group of NSAIDs and has a pronounced analgesic and anti-inflammatory effect. The drug is used only for the treatment of adults and has a number of contraindications and side effects.

It is not recommended to replace the original product with one of its analogues. Each patient requires an individual approach.

Nise is an effective medicine that allows you to quickly cope with acute pain, reduce signs of inflammation, relieve fever and slow down the progression of the pathological process. It is recommended to use only after consulting a specialist in order to prevent complications.

Contraindications and side effects

Despite the effectiveness and speed of the product, its use in some cases can be harmful to health. There are several contraindications that will prevent its use for therapeutic purposes:

• Individual hypersensitivity to the drug or a tendency to allergic manifestations.
• A severe form of gastric ulcer with the threat of perforation of its wall.
• Acute stage of gastritis with increased acidity of gastric juice.
• Children under 3 years of age.
• During pregnancy and breastfeeding.
• Violation of the integrity of the skin at the site of intended application.
• The presence of a focus of purulent inflammation with the threat of spontaneous opening at the site of application.
• Liver cirrhosis at an advanced stage.
• Chronic kidney failure.

The medicine should be used with extreme caution in patients with type 1 diabetes mellitus, acute vascular insufficiency, and chronic heart failure. It is better not to mix the product with other drugs of similar effect.

If recommendations are not followed or instructions are violated, patients experience adverse reactions:

• Constant sleepiness and inability to concentrate.
• Memory loss and anxiety.
• Burning at the site of application, hyperemia and swelling.
• The appearance of unbearable itching and peeling of the skin.
• Change in color of the epidermis at the site of application.

If the patient has used the gel for a long period, its active ingredients are absorbed into the blood in excessive quantities and provoke general negative reactions in the form of pain in the stomach, frequent loose stools, spasm of intestinal smooth muscles, nausea and vomiting. In rare cases, patients experience an exacerbation of chronic pathologies of the digestive system.

Compatibility with other drugs

Considering the composition of the drug, you should not take it with medications such as Phenytoin, Digoxin, and drugs with lithium. When Nise interacts with these drugs, there will be no expected therapeutic effect.

Patients with diabetes mellitus and those using hypoglycemic drugs, if Nise therapy is necessary, need to keep their blood sugar levels under control.

Concomitant use of Nise and antihypertensive drugs can lower blood pressure.

It is prohibited to carry out simultaneous therapy with tablets with anticoagulants due to the high risk of internal bleeding. Also, you should not combine Nise with non-steroidal anti-inflammatory drugs.

What is it used for?

• arthritis (including rheumatoid and psoriatic);
• radiculitis;
• lumbago;
• sciatica;
• osteochondrosis;
• presence of radicular syndrome;
• bursitis;
• osteoarthritis;
• arthralgia;
• ankylosing spondylitis;
• inflammatory diseases of ligaments and tendons;
• myalgia (both rheumatic and non-rheumatic in nature);
• inflammatory processes in soft tissues caused by bruises, sprains, ligament ruptures and other injuries;
• pain resulting from injuries and after surgery;
• headache, dental, periodic female pain;
• febrile conditions, including against the background of infectious and inflammatory diseases.

The use of this remedy is effective in acute phases of inflammation, accompanied by pain, swelling and fever.

Clotrimazole ointment for women

Thrush or candidal vulvitis in women is accompanied by symptoms:

• itching, burning and swelling of the genitals;
• mucous discharge is yellowish or white, sometimes there is copious liquid discharge or curdled flakes;
• unpleasant smell.

Clotrimazole for women is used in the treatment of thrush. The use of ointment for the treatment of candidiasis has received positive reviews - it immediately eliminates unpleasant itching and burning. The ointment comes on sale with a nozzle convenient for douching. The cream is administered once a day for three days. For chronic disease, it is recommended to use the cream three times a day for two weeks.

A prerequisite for recovery is adherence to the rules of personal intimate hygiene, wearing cotton underwear, exclusion of sexual activity during treatment and simultaneous treatment of the sexual partner. The drug can be prescribed without the presence of characteristic signs of the disease for the sanitation of the birth canal for women in the last trimester of pregnancy.

Side effects

The negative effects of the ointment can manifest themselves in the form of skin reactions - itching, slight swelling of the skin, changes in pigmentation, peeling. If possible, the dose should be reduced; discontinuation is not required.

Possible systemic reactions:

1. headache;
2. dyspeptic symptoms – diarrhea, nausea, vomiting;
3. allergic manifestations (up to anaphylactic shock);
4. the appearance of gastrointestinal ulcers, bleeding;
5. anemia;
6. increased blood content in urine;
7. thrombocytopenia;
8. increased duration of bleeding;
9. leukopenia.

You should inform your doctor about any changes in your condition due to the use of Nise ointment.

With the recommended regimen of use, overdose does not occur.

Adverse reactions

When administered vaginally, there may be adverse reactions. In some cases there are:

• swelling of the labia,
• increased burning sensation,
• discharge,
• painful sensations during sexual intercourse.

Side effects provoke discomfort in the vagina, irritation and redness of the mucous membranes. Signs of cystitis and urticaria rarely develop. The appearance of the above symptoms requires interrupting therapy and making an appointment with a doctor.

The drug is prescribed with caution to patients over 60 years of age and people suffering from liver failure. Vaginal tablets are not prescribed for men

For this category of patients, topical creams, ointments and systemic antifungal drugs are used.

Pharmacokinetics

The active and auxiliary ingredients of Nise gel penetrate into the systemic bloodstream in small quantities. For example, traces of the metabolic product of nimesulide are not detected at all, provided that the patient complies with the recommended single dosages and the duration of the course of treatment. The analgesic effect occurs in approximately 15-30 minutes. With a single use of an external agent in the bloodstream, a maximum therapeutic concentration is created after 24 hours. It is approximately 300 times lower than that determined when taking Nyz orally in tablet form or Nimesulide in granules.

During clinical trials, the duration of the analgesic effect in patients was established - from 30 minutes to six hours. A decrease in the severity of pain had a positive effect on a person’s ability to perform everyday routine tasks (movement, dressing, toileting, performing light and heavy work) - in 60% of patients after applying 1 g of the product and in 66% after distributing 2 g on the skin drug.

Pharmacological effect

Clotrimazole is a drug with pronounced antifungal properties, which belongs to the imidazole derivative. The use of the drug makes it possible to inhibit the synthesis of ergosterol, thereby disrupting the permeability of fungal cells, causing their death. Clotrimazole - the active component of the ointment is effective against dermatophytes, yeast, mold fungi, and has an antibacterial effect against staphylococcal and streptococcal infections. This drug can be used for various fungal diseases.

After application to the skin, the active component is quickly absorbed into the upper and deep layers of the epidermis and practically does not penetrate into the bloodstream. A special feature of the drug is the fact that after use the therapeutic effect will not be noticeable immediately, but after a while. However, with long-term use, the effect of the drug will be 100%

It is very important to maintain skin hygiene when using the ointment, and also not to skip its application.

This ointment not only allows you to get rid of a fungal infection, but also significantly reduces infection of the skin with other bacteria, which often complicate the treatment process and the course of the disease.

Instructions for use and dosage

The ointment is used externally.

Instructions for using Nise ointment:

1. Before applying Nise, the area of ​​skin is washed with clean water, washing away dirt and remnants of medications used previously.
2. Take 1-3 cm of ointment. The drug should lie on the skin in a thin layer. The volume of medication is selected depending on the size of the painful area.
3. Lubricate the projection of the spine or joint without rubbing, with light movements and patting until the product dries.
4. You need to wash your hands well when finished, removing any remaining Nise ointment. Protect eyes and mucous membranes from contact with the product.
5. Use 3-4 times a day is allowed.
6. Duration of use – up to 10 days.

A longer course must be agreed with your doctor. If there is no improvement, the drug will have to be changed after consultation with a specialist.

Nise ointment is not recommended for use by children. Patients over 7 years of age can be used as prescribed by a doctor in dosages specified by a specialist. Strict adherence to the course and frequency of application is required.

Nise tablets can be prescribed in combination with ointment.

Baths before applying the solution

Before using Clotrimazole, various foot baths are very useful, which will not only relieve fatigue, but will help get rid of the annoying fungus. These can be mixtures prepared according to folk recipes, or pharmacy versions of herbal infusions, which are recommended to combat the disease in question. Let's highlight the most popular foot baths, which are recommended to be used before Clotrimazole solution:

1. Dilute tar soap with warm water, add a few tablespoons of sea salt. Take the bath for 10-15 minutes, simply lowering your feet into it.
2. Mix a few grams of manganese and boric acid in a separate container. Dilute this liquid with 2-3 liters of warm water and dip your feet in it. Massage your feet and nails in water for 5 minutes, then pat dry with a towel.
3. Combine vinegar essence and pine needle extract in a 1:1 ratio and mix with 5 portions of water. It is allowed to take such a bath for up to 15 minutes, and after it apply Clotrimazole to the affected areas.
4. Prepare a paste from several heads of garlic (1-2) and dilute it with 2 liters of cold water, put your feet in the bath, take the treatment procedure for 5-7 minutes, after which you are allowed to rinse.

Release form, composition and packaging

Nise comes in tablet and gel form. Its active component is the substance nimesulide.

The tablets have a flat-cylindrical biconvex shape. They are smooth to the touch, the color is almost white with a subtle yellowish tint. One tablet contains 100 mg of the active ingredient.

They contain the following excipients:

• calcium hydrogen phosphate;
• cellulose with microcrystalline structure;
• starch obtained from corn grains;
• talc;
• magnesium stearate;
• sodium carboxymethyl starch;
• colloidal silicon dioxide.

Each blister contains 10 tablets. A cardboard pack may contain 1, 2 or 10 blisters. Nise Kid dissolvable tablets are also produced, designed primarily for children. The amount of active ingredient in them is 50 mg.

• macrogol;
• N-methyl-2-pyrrolidone;
• propylene glycol;
• isopropanol;
• carbomer;
• thiomersal;
• butylated hydroxyanisole;
• potassium dihydrogen phosphate;
• aromatic component "narcissus-938";
• water.

The gel is produced in laminated tubes made of aluminum. Their capacity can be 20 or 50 g. The tube with the gel is placed in a cardboard pack.

There is another form of the drug - granules intended for preparing a medicinal suspension. This form of medication is optimal for treating children.

Features of the drug

This drug has the greatest effect in the development of diseases caused by molds, yeasts, as well as dermatophytes and other pathogens that are sensitive to the effects of clotrimazole, the active substance of the drug.

To see what the drug Clotrimazole is, watch the video below:

Composition of Clotrimazole

The main active ingredient is clotrimazole, of which 1 g of the product contains 10 mg (meaning 100% dry matter). Auxiliary components include the following:

• polyethylene glycol cetostearyl ether;
• propylene glycol;
• cetostearyl alcohol;
• polyethylene glycol 400;
• proxanol 268.

Externally, the drug is an ointment that is white in color, has a uniform consistency, and has a slight specific medicinal odor.

Dosage forms

The drug is offered for sale in the form of aluminum tubes with bouchons, which have an internal varnish coating that is approved for use.
The tube with a leaflet describing the composition and method of use is contained in a cardboard package. Clotrimazole is also sold in the following forms:

• vaginal tablets that have the appearance of a parallelepiped with slightly rounded corners. They contain 100 mg of active substance. There are 6 pieces in the blister;
• ointment (cream), white in color and uniform consistency, for external use. The active substance in the ointment is 10 mg per 1 g of ointment. The ointment is packaged in tubes of 30 g, 20 g. Vaginal cream 2% is offered in tubes of 50 g;
• a solution also used for external use. The solution (1%) is packaged in orange bottles and their volume can be 15 or 30 ml.

Indications for use of the drug

As indicated in the instructions for use, “Nise gel” is recommended in the following cases:

1. Pain in the spine.
2. Radiculitis.
3. Damage to tissues and joints that develops against the background of metabolic processes.
4. Rheumatism.
5. Ankylosing spondylitis.
6. Lesions of the inner lining of the vagina.
7. Myalgia.
8. Various neuralgia, nerve damage.
9. Tendinitis.
10. Osteoarthritis.
11. Osteoarthritis.
12. Arthritis.
13. Lumbodynia.
14. Synovitis.
15. Bursitis.

The drug can be used to eliminate the pain that accompanies these pathologies in adult patients, but only if they have no contraindications to this.

The use of Nise Gel in pediatrics is prohibited. If there are acute indications, the doctor may recommend the drug to patients over 7 years of age. In such cases, the general well-being of the little patient should be constantly monitored. If negative reactions occur, use of the drug should be discontinued.

According to the instructions for Nise Gel, the use of the drug by pregnant women and during the lactation period is not recommended, since the active substance in the drug has the ability to penetrate the systemic bloodstream. The use of the gel can provoke various developmental defects in the baby.

Clotrimazole in the treatment of fungus

The main active substance clotrimazole is an element with a wide range of actions. Thanks to him the drug:

• slows down and then stops the biosynthesis of fungal sterol (the latter is a key component in the production of the parasite's intercellular membrane);
• destroys the structure of already developed fungal cells, increasing the degree of permeability of their membranes (not only the mycelium dies, but also the spores located on the skin surface);
• disinfects the surface;
• partially relieves symptomatic manifestations (swelling, itching, redness).

However, the medicine does not give immediate results, but acts gradually. For this reason, it is necessary to be patient and steadily follow the course of treatment. Clotrimazole anti-fungal solution fights the parasite faster.

Along with this drug, it is possible to use additional funds. For example, taking multivitamin complexes to strengthen the immune system.

As well as other antimycotic drugs (it is better to consult a doctor about this). In any case, an integrated approach will speed up the death of the fungus and recovery will come earlier.

Action of active substances

As mentioned above, the drug "Nise" includes such active substances as nimesulide, methyl salicylate, menthol and capsaicin. What role do they play in the presented medicine? You will get the answer to this question below.

• Nimesulide is a selective cyclooxygenase-2 inhibitor. It exhibits anti-inflammatory and analgesic effects.
• Methyl salicylate is a derivative of salicylic acid. It has a distracting and local irritating effect.
• Menthol promotes an analgesic effect, which is accompanied by a feeling of slight chill.
• Capsaicin has locally irritating properties, causes tissue hyperemia and increased blood flow at the site of application, and also promotes the removal of biological endogenous substances.

Features of Clotrimazole solution

The anti-fungal solution contains 1% clotrimazole - 10 mg of active substance per 1 ml. The base of the drug is 96% ethyl alcohol and isopropyl myristate (helps to evenly distribute the composition over the surface).

The liquid preparation is packaged in bottles with a dropper or spray with a capacity of 15, 20, 30 ml, and then in cardboard boxes with attached instructions for use. The solution is clear or slightly yellowish, with a specific alcoholic odor.

Indications for use of the drug

Use 1% clotrimazole solution in the following cases:

• fungal infections of the mucous membranes and epidermis caused by various pathogens (fungal stomatitis, various candidiasis, dermatophytosis, microsporia, etc.),
• pityriasis versicolor and versicolor versicolor, erythrasma,
• mycotic lesions complicated by bacterial infection and suppuration (pyoderma),
• periungual felons,
• complex treatment of onychomycosis,
• preventive treatment of the birth canal.

Contraindications and warnings

The drug is prohibited if you are allergic to clotrimazole or other substances from the imidazole group. Another possible obstacle is related to the presence of ethyl alcohol in the solution. It, unlike the active substance, is easily absorbed through the mucous membranes and skin. This is not advisable for pregnant women and children under 12 years of age. In addition, alcohol often causes burning and dry skin.

No studies have been conducted on the safety of Clotrimazole in the first trimester of pregnancy, so it is not indicated for use during this period. It is unknown whether clotrimazole passes into breast milk, so use during lactation should also be avoided. In the second and third trimester of pregnancy, use is permitted only as prescribed by a doctor.

The drug in the form of an alcohol solution is intended exclusively for topical use and cannot be taken orally.

It is important to avoid getting the composition into the eyes - this will cause a chemical burn to the mucous membrane. For the same reason, the solution is not applied to damaged skin (wounds, scratches, severe scratching)

In this case, alcohol will cause a strong burning sensation.

Side effects

Possible negative reactions of the body to the drug include:

• tingling and burning at the site of application of the solution,
• skin redness,
• rash like urticaria,

• blisters with clear fluid,
• edema,
• irritation, peeling and dryness of the dermis (associated with the presence of alcohol).

In case of allergic manifestations, the clotrimazole solution is replaced with agents from other pharmacological groups. In case of minor short-term irritation, discontinuation of the drug is not required.

Trade names

Clotrimazole 1% drops can be purchased at any pharmacy. There are other trade names for this drug:

• Clotrimazole Akrikhin. Manufacturer: Medana Pharma (Poland) commissioned by the Russian company Akrikhin. 15 ml bottle with dropper. Approximate price 200 rubles,
• Candide. Manufacturer: Glenmark (India). Bottle with dropper 20 and 30 ml. Average cost 350-450 rubles,
• Candida for the oral cavity. Bottle 15 ml. A solution with the addition of glycerol and propylene glycol. Approximate price 300 rubles,
• Kanizon. Manufacturer: Agio Pharmaceuticals (India). Bottle with a capacity of 20 ml. Costs about 120 rubles.

Important! Clotrimazole solution in the form of a spray is produced by the German companies Bayer and Ratiopharm (Kanesten and Kandibene), but they are currently not sold in Russia

pharmachologic effect

The unique combination of active and auxiliary ingredients of Nise gel allows it to be used as a means for complex treatment. Doctors include the drug in therapeutic pathogenetic regimens to prevent further destructive and degenerative destruction of articular and cartilage tissues. And the anti-inflammatory effect of the external agent provides a rapid reduction in symptoms: pain, stiffness of movement, severe swelling.

The synthesis of Nise gel, the main effect of which is aimed at suppressing the activity of cyclooxygenase, made it possible to avoid the occurrence of pronounced side effects from oral administration of PVNP. This drug is completely safe for patients with high blood pressure and those prone to ulceration of the mucous membranes of the gastrointestinal tract.

Pain is the body’s protective reaction to the influence of internal and external negative factors. Two mechanisms are involved in its launch:

• local. After the development of the inflammatory process, the nerve impulse is transmitted to the central nervous system;
• central. The brain recognizes pain and produces a response to the occurrence of the received signal.

Pain, as a companion to almost all diseases of the musculoskeletal system, is initiated by various substances that excite nociceptors (tissue, plasma, tachykinins). A course of use of Nise gel allows you to prevent the development of events in such a negative scenario, reduce the severity of discomfort by stopping the inflammatory process.

What is Clotrimazole

An acute infection or a chronic form of the disease can be quickly treated thanks to a drug from the group of imidazole derivatives. Clotrimazole is a broad-spectrum antifungal agent that is available in the form of vaginal tablets, ointments, suppositories and other dosage forms. The active substance, which has proven effective in the treatment of certain gynecological diseases, disrupts the synthesis of ergosterol, which forms the cell membrane of the fungus, which contributes to its destruction.

A similar effect, when the active component contributes to the deformation of the cell membrane, is demonstrated by Clotrimazole tablets in relation to bacteria. By influencing the production of components that are necessary to strengthen membranes, the drug destroys the vital activity of microorganisms that provoke inflammation of the mucous membranes and skin. The main property of the drug will not manifest itself immediately: the symptoms of the disease of the female reproductive system may continue to bother you for several days after the start of using the medicine until it manifests itself.

Analogues substitutes

The pharmaceutical market offers a fairly wide range of drugs similar to Nise:

Ibuprofen (tablets). The main active ingredient of the drug is ibuprofen. Gives an analgesic, antipyretic, anti-inflammatory effect.

Diclofenac (injection solution, capsules, tablets, gel, rectal suppositories). The main active ingredient of the drug is diclofenac sodium. Gives an analgesic, anti-inflammatory, anti-edematous effect.

Nimesulide (tablets). Drug group: sulfanilides, with the main active ingredient nimesulide. Indicated for acute pain of various etiologies.

Photos of drugs:

Diclofenac

Ibuprofen

Nimesulide

Nimesil (granules). Belongs to the group of non-steroidal anti-inflammatory drugs. Indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis.

Movalis (tablets, rectal suppositories, injection solution, suspension). Ethanolic acid derivative, non-steroidal drug. Has a pronounced anti-inflammatory effect. Analgesic and antipyretic.

Ketorol (tablets, injection solution). A non-steroidal drug with a predominantly analgesic effect.

Photos of analogues:

Ketorol

Movalis

Nimesil

Ketanov (tablets, injection solution). Non-narcotic analgesic. The main active ingredient is ketorolac.

Aertal (tablets). The main active ingredient is aceclofenac. Non-steroidal anti-inflammatory, analgesic drug.

Nurofen (tablets). Belongs to the group of non-steroidal anti-inflammatory substances with the main active ingredient ibuprofen.

Photos on the topic:

Ketanov

Aertal

Nurofen

Meloxicam (injection solution). A drug from the oxicam group, the active ingredient is meloxicam.

Ketonal (tablets, capsules, injection solution, rectal suppositories). Non-steroidal anti-inflammatory drug with the main active ingredient ketoprofen. Analgesic and antiperetic.

Fastum gel (gel-based external agent). The main active ingredient of the drug is ketoprofen. Eliminates the inflammatory process in joints, muscle tissue, tendons.

Xecofam (tablets, injection solution). The main active ingredient is lornoxicam. A drug with a pronounced anti-inflammatory effect, moderate analgesic and decongestant.

Ibuklin (tablets). Combined drug. Active ingredients of the drug: paracetamol, brufen. Analgesic, antipyretic, anti-inflammatory drug.

Photo gallery:

Fastum gel

Ibuklin

Ketonal

Xecofam

Meloxicam

According to the mechanism of action, the gels and ointments Sulaydin, Bioran, Ortoflex, Voltaren are also similar to Nise gel.

Approximate cost of the drug

Clotrimazole is sold in almost every pharmacy, as it is a very popular medicine for the treatment of fungal diseases. It is also allowed to be ordered on the Internet, since if the required temperature is maintained, the medicinal drug can exist for a long time and not lose its qualities. Here is a list of retail outlets and their prices where it is easy to buy Clotrimazole:

Drug, manufacturer	Price, rub	Shop
"Clotrimazole" solution, 100 g	70	eapteka.ru
"Clotrimazole-Acri" D01AC01	68	rlsnet.ru
CREAM "Clotrimazole" 1% 20G	49	webapteka.ru
1% 20.0 OINTMENT “Clotrimazole” Synthesis	47,90	apteka.ru

Price and analogues

In stationary pharmacies and online you can purchase Nise at the following price:

• tablets 100 mg, 20 pcs. – 230 rub., India;
• bags of granules 9 pcs. for preparing a suspension 0.1 – 280 rubles, Russia;
• gel 1%: 20 g – 213 rub., 50 g – 320 rub., India.

There are no analogues for the ATX code. Synonyms for Nise, drugs also containing Nimesulide, are:

• tablets Aponil, Nimesulide, Flolid, Nimesan, Aulin, Nimulid, Nimesulid-Teva;
• lozenges Nimulid, dispersible Nimika, Prolid;
• gel Nimesulide, Nimulid, Sulaydin;
• granules for semi-suspension Nimesil, Flolid, Nemulex, Nimesulin Canon.

Description

It is a non-steroidal anti-inflammatory drug and is widely used to relieve pain syndromes of various origins, however, there are a number of contraindications, and in case of some diseases, it is necessary to give your child medications for toothache with extreme caution.

The tablets are white or light yellow, odorless. The surface is smooth, biconvex.

Each pack contains blisters of 10 tablets. The package may contain one, two or ten blisters. Cardboard packaging.

Reviews about Nise

Wanting to get rid of pain faster and taking advantage of the lack of need to see a doctor for a prescription, many self-medicate. Patients note that the gel perfectly helps relieve joint pain and swelling - the result is felt within half an hour after application and lasts 4-6 hours. It is economical, does not leave a greasy residue, and is quickly absorbed. If you apply it correctly and follow the instructions, there are no adverse reactions. In addition to the availability of the medicine, patients name its other advantages:

• high efficiency of oral medications - 1 tablet or glass of suspension is enough to work productively and not feel pain for 10-20 hours;
• quickly reduces temperature;
• helps restore motor reflexes;
• improves the condition of the spine;
• can be used in old age;
• by the 10th day of taking the pain disappear.

Disadvantages include prohibition on use by children and the risk of liver dysfunction. Doctors summarize that when used wisely, Nise is an effective, safe drug and does not have a strong toxic effect. Unlike traditional NSAIDs, it also has chondroprotective properties, which increases its value. Doctors do not recommend using Nise as an antipyretic, because cases of a sharp, below normal, decrease in temperature have been recorded.

Analogues of "Nise gel"

If necessary, the medication can be replaced. The most popular analogues of Nise Gel are Dicloran Plus, Movalis, Diclofenac, Nimesulide.

It is important to consider that all of these drugs have their own characteristics - some of them can be used during pregnancy, others cannot. In addition, each of them is contraindicated for certain diseases, and their use can cause the development of negative effects.

How to set up a mining program

To work on the NiceHash cryptomining site, you must go through the registration procedure.

• Enter your e-mail and password, confirm the creation of your account and log into your nude hash pool account;
• It is recommended to immediately enable two-factor authentication to enhance protection against hacking;

• Each registered user receives an internal Bitcoin address for payment of rewards; it can be seen in your personal account or in the “Wallet” section.

How to install nicehash

Go to the NiceHash Miner section to download a nice hash program for mining on AMD or Nvidia video cards.

Important! Never download nicehash miner from unverified sources. Be sure to catch a virus or hidden miner. The application downloaded from the official website must be added to the firewall and antivirus software exclusion lists.

The utility for green cards is a miner with a graphical interface and a minimal set of functions.

I was surprised by the lack of Russian language. Those who want to install a nice hash in Russian need to go to the next section. NiceHashMinerLegacy for red processors has more extensive functionality. This version of nicehash can be downloaded in Russian, the folder contains CudaDeviceDetection, which means it can work with Nvidia. To download, users are redirected to GitHub , a reliable service where almost all cryptocurrency software is located. To install the nice hash, unpack nhm_windows_1.9.0.10.zip and run the program.

We wait until nicehash miner identifies compatible devices and downloads the necessary software, then we perform a benchmark. The term benchmark refers to a benchmark test of the productivity of nicehash mining hardware.

Correction of nicehash miner settings is allowed. The user independently selects the algorithms and speed of benchmark execution. Please note that when choosing the precise (slow) nicehash miner settings for all hash algorithms, the process will last several hours.

• It is not recommended to use the computer during the benchmark; this will cause the process to crash and Windows to restart. Those who wish can work nicehash miner with only one algorithm; to do this, you need to tick the selected parameters, for example, Ethash or Cryptonight .

At the second stage, nicehash miner setup requires registering a wallet and computer name.

NiceHash Pool strongly recommends using an internal Bitcoin address.

NiceHashMinerLegacy refuses to start mining on an external wallet. But if you download a nice hash for nvidia, any address is saved there without any problems.

How to add to startup

In the “Settings” tab we set the parameters for launching equipment for nicehash mining. Check the box next to: “ Run with Windows ” and “ Autostart mining ”, save the values ​​and run NiceHashMinerLegacy.

The program automatically selects the mining of the most profitable coin and the miner window appears.

• Information about your work and current balance is displayed in your personal account.

Overdose

With long-term use of tablets in large quantities, a person experiences signs of overdose. They manifest themselves as increased side effects. Symptoms of overdose include the following conditions:

• bleeding in the stomach;
• increased blood pressure;
• inhibition of kidney/liver function;
• breathing problems.

In case of overdose, rinse the stomach, drink activated carbon or Polysorb. If the condition is severe, symptomatic therapy is carried out.

How to take it and in what doses

Nice adults need to take 1 tablet twice a day before meals, that is, the daily dose is 200 mg. If necessary, the doctor may prescribe 2 tablets of the medicine.

Treatment lasts approximately 15 days.

The instructions for use contain important recommendations that you should read.

The drug is prescribed orally, with preference given to taking the medication before meals. But if certain discomfort appears in the stomach area, then the drug should be taken after meals.

Reviews about the effectiveness of the drug

Attention!
The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and give treatment recommendations based on the individual characteristics of a particular patient. The main component of the drug Nise is nimesulide (100 mg).

Also includes:

• microcrystalline cellulose and sodium starch glycolate;
• calcium hydrogen phosphate and corn starch.

In smaller quantities:

• anhydrous colloidal silicon and purified talc;
• Magnesium stearate.

If the patient does not follow the instructions for using the medication Nice, he may experience an overdose. Then adverse reactions are clearly expressed. For example, gastrointestinal irritation, kidney dysfunction or liver failure, seizures or increased blood pressure. A person may suffer from severe headaches for several days.

Dosage form and brief description

Release forms:

• Nise tablets. Contains 100 mg nimesulide. There are 10 pieces in a blister;
• Nise dispersible tablets. Contains 50 mg nimesulide. There are 10 pieces in a blister;
• Nise oral suspension. Contains 50 mg nimesulide per 5 ml. 60 ml bottle, special dosage cap;
• Gel Nise 1% for external use. Contains 10 mg nimesulide per 1 g. Tube 20 g and 50 g.

Nise tablets are recommended for use by adults in case of pain syndromes of various origins. Nise suspension is convenient for relieving pain in children. When topical NSAIDs are needed, Nise gel is an excellent choice. The gel does not contain warming components, so it is recommended for use during exacerbations of osteochondrosis, osteoarthritis, and radiculitis. According to reviews, Nise gel helps well with inflammation of ligaments and tendons, post-traumatic inflammation of soft tissues, bursitis and bruises.

The drug is available in several dosage forms:

• Nise tablets containing 100 mg of the active ingredient nimesulide, 10 pieces in a blister;
• Nise dispersible tablets containing 50 mg of the active ingredient nimesulide, 10 pieces in a blister;
• Suspensions for oral administration, 5 ml - 50 mg of nimesulide, in 60 ml bottles with a dosage cap;
• Gel Nise 1% for external use, 1 g - 10 mg of nimesulide, in aluminum tubes of 20 g.

Nice is an excellent anti-inflammatory, antipyretic, antiplatelet and analgesic agent. Its main actions: suppression of prostaglandin synthesis directly at the site of inflammation, slowing down oxidative processes. If we take the description of the effect on the body, or rather, whether it causes addiction to itself, then we can say that the body does not get used to any of the components that are included in the composition.

The maximum amount of Nise in the blood can be determined 1.5 - 2.5 hours after administration.

The tablets must be stored in a dry place, out of direct sunlight and out of the reach of children. They are stored for a maximum of 3 years at an air temperature of less than 25 degrees.

Tablets can sometimes cause drowsiness, and therefore their use by drivers while driving as a drug for headaches or any other pain is unacceptable. Even if Nice was prescribed by a doctor.

Also, Nise is not the best way to get rid of pain for people who need good reaction and speed of movement at work.

People who have fully followed the instructions for using the drug are satisfied with the results of the treatment and leave positive reviews.

Main characteristics of Nise ointment

Nise ointment is an anti-inflammatory medicine that is available in the form of a cream for external use. The drug is a highly selective Cox-2 inhibitor and affects the site of inflammation. Nise is the main medicine for inflammatory lesions of muscles and joints for external use.

Pharmacokinetics

Pharmacodynamics

The main component of the gel quickly penetrates the muscles and joints, the drug is practically not absorbed systemically and does not enter the bloodstream, the clinical effect of external use develops within a month from the start of use. Within 15 minutes of application, the drug reaches its maximum concentration in the inflamed tissue.

The active ingredient of the drug belongs to the class of sulfonamides and selectively inhibits the activity of a special enzyme - cyclooxygenase 2, which is responsible for the formation of biologically active prostaglandin compounds that enhance the inflammatory response, attract immune system cells responsible for inflammation to the site of the lesion, increase vascular permeability and increase pain. Suppression of this enzyme is achieved through the following effects: anti-inflammatory; antipyretic; analgesic; reduction of swelling; decrease in vascular permeability.

The ointment is available in the form of a gel of 20 and 50 grams, available without a prescription. The production of the drug belongs to the Indian pharmaceutical company Dr. Reddy's Lab. Ltd. The manufacturer produces the medicine in convenient tubes, which should be stored at room temperature no higher than 24 degrees, out of reach of sunlight and children. The shelf life from the date of production is 2 years.

We recommend reading the article on how to choose an ointment for joints. From the article you will learn about the best ointments for joints with anti-inflammatory, warming and analgesic effects, and the benefits of using chondroprotectors. And here is more information about why to use ointment for a bruise.

Composition of the drug

The drug contains the active substance Nimesulide, which determines all the main effects of the ointment . It also includes additional components:

• menthol;
• thimerosal;
• water;
• potassium phosphate;
• flavoring;
• propylene glycol;
• isopropanol;
• trometamol;
• capsaicin;
• diethyl phthalate;
• diethylene glycol monoethyl ether;
• hydrogenated polyoxyl castor oil.

Mechanisms of action of Nimesulide
Menthol, thimerosal and capsaicin are the main components that determine the properties of the drug, the rest are auxiliary: they help create the smell, consistency and delivery of the drug inside.

Properties

The active substance exhibits the main property of reducing inflammation. Nimesulide also inhibits peroxidation at the site of injury, having an antioxidant effect. The affected joint or muscle under the influence of the drug decreases in volume, the temperature of the skin decreases under the influence of the substance, and normal metabolism is restored in the tissues of the joint due to the pharmacodynamic properties of nimesulide.

Other active components also participate in the action of the gel:

• thimerosal has antiseptic properties;
• menthol and capsaicin irritate the nerve endings in the affected area, which causes a decrease in pain and discomfort: the nervous system “switches” to another source of excitation.

Watch this video about the mechanism of action of the drug Nise, indications and contraindications for its use:

Reviews

• Veronica, 27 years old. While playing sports, I injured my knee joint. At first I didn’t see a doctor, but after a week of suffering I went to a traumatologist. He prescribed Nise in tablets for 10 days. After only 4 days of taking it, all the symptoms began to disappear, but I finished the course to the end in order to be sure to overcome the inflammation.
• Igor, 56 years old. After forty years, my joints began to constantly bother me. From time to time, all large joints begin to ache, swell, and sometimes the aggravation is so severe that redness of the skin above the joint appears. I save myself only with Nise-gel, which quickly relieves inflammation.
• Vasilisa, 45 years old. Pain in the knee joint has accompanied me for the past 5 years. There was a minor injury, but even after a course of treatment, severe discomfort periodically occurs. I tried many medications, but settled on Nise in the form of a gel, because it begins to act the fastest, and this is very important when you cannot step on your foot due to pain.

Reception by pregnant women

Side effects from taking the pills are not very serious and are rare.

Self-medication, ignoring the instructions for use, allergies to the components that make up Nise (including nimesulide) - all this has consequences such as:

• severe sensitivity to the drug, anaphylactoid reaction;
• fear, headaches and dizziness, nervousness, drowsiness, Reye's syndrome;
• increased sweating, rash and itching. Erythema and dermatitis, urticaria and angioedema, Stevens-Johnson syndrome and other exudative erythema, Lyell's syndrome are rare;
• edema, dysuria and hematuria, hyperkalemia and urinary retention. Sometimes tablets can cause deficiency, oliguria, interstitial nephritis;
• nausea and vomiting, diarrhea. Constipation, flatulence, gastritis, tarry stools and stomatitis, stomach ulcers, gastrointestinal bleeding are also possible;
• the level of liver transaminases increases, as well as hepatitis, jaundice and cholestasis;
• anemia and eosinophilia, thrombocytopenia and pancytopenia, purpura;
• shortness of breath, exacerbation of bronchial asthma and bronchospasm;
• blurred vision.

Taking nimesulide is contraindicated for pregnant women. It can seriously harm the health of both mother and child.

In what cases is it not prescribed?

Like many medications, Nise also has contraindications for use. So, tablets should not be taken in the following cases:

• if hypersensitivity to any component, including nimesulide, has been detected;
• a patient with bronchial asthma currently has a relapse of polyposis, an allergy to acetylsalicylic acid;
• if there is erosion or ulcer of the gastrointestinal tract, cerebrovascular or other gastrointestinal bleeding;
• any inflammatory diseases have worsened in the intestines;
• blood clotting is impaired;
• liver diseases;
• heart or liver failure;
• alcoholism, drug addiction;
• hepatotoxic reactions to nimesulide;
• hyperkalemia;
• renal failure and other serious kidney diseases;
• if coronary artery bypass surgery has recently been performed, that is, heart surgery;
• there are contraindications for pregnant women, since the medication causes serious side effects, which can lead to miscarriage or fetal death;
• if the child is under 12 years old.

Considering the listed contraindications for use, the doctor, however, can make an exception and prescribe Nice if there is:

1. coronary heart disease and congestive heart failure;
2. dyslipidemia/hyperlydemia; diabetes; peripheral arterial disease; suspicion of a gastrointestinal ulcer;
3. somatic diseases;
4. elderly age;
5. long-term use of NSAIDs;
6. taking antiplatelet agents, anticoagulants, oral corticosteroids, SSRIs.

The number of cigarettes smoked and alcohol intake are also taken into account.

Composition of the drug

Nise tablets contain the main component nimesulide in an amount of 100 mg. In soluble tablets, the active substance content is half as much - 50 mg. It is nimesulide that fights pain, swelling, and fever.

In addition, the tool has several additional components:

• calcium;
• starch;
• cellulose;
• sodium;
• magnesium;
• silicon;
• talc.

The dispersible form of the drug additionally contains:

• aspartame;
• pineapple flavoring.

What does Nise ointment help with?

The anti-inflammatory effect and analgesic effect of the drug Nise ointment determines its use for:

• rheumatoid arthritis;
• psoriatic joint damage;
• Ankylosing spondylitis (ankylosing spondylitis);
• osteoarthritis;
• infectious arthritis;
• articular syndrome due to gout;
• rheumatic joint pain;
• traumatic effects on the joint;
• radiculopathies, plexopathies;
• tunnel syndromes;
• professional lesions of the musculoskeletal system (tennis elbow, etc.);
• tendonitis, bursitis, tenosynovitis and other inflammatory lesions of soft tissues;
• inflammatory muscle pain;
• pain in soft tissues after operations, during the rehabilitation period;
• arthralgia, lumbar ischialgia:
• pain when sprains and inflammation of ligaments;
• osteochondrosis.

Indications for the drug include almost all lesions of muscles and joints, since inflammation almost always develops. But it should be remembered that the medicine only removes the symptom; Nise does not treat the true cause of the pathological process.

Instructions for bruises

Instructions for use for bruises differ little from use for non-traumatic lesions: the gel should be rubbed into the skin several times a day for two to three weeks.

But it should be remembered that it is undesirable to apply it to an open wound surface, especially if there is discharge from the wound. In this case, the skin around it should be treated, and the wound itself can be smeared after the first signs of healing (soft scar or crust).

How to use Nise gel for sprains

For sprained ligaments, Nise gel should be applied externally along the affected formation 2-3 times a day for 14-20 days. One dose of the drug is a column of 3 centimeters. Ligaments play a connecting role between muscles and bones, so the gel should be applied along their entire length, capturing the attachment points. The gel is applied in a thin layer to a clean, dry surface. You need to let it absorb for a few minutes.

There is no need to rub the gel over the surface; Nimesulide does not enhance its effect, but such application impairs its absorption. Also, do not wash the application area for several hours. The gel has a viscous consistency and can leave marks on your hands.

Contraindications

Nise gel is safe to use and is almost not absorbed orally, however, like any medicine, it has contraindications:

• hypersensitivity to the main components and excipients;
• bronchial asthma or nasal polyps with hypersensitivity to salicylates;
• erosive or ulcerative lesions of the gastrointestinal tract;
• bleeding in the esophagus, stomach or intestines;
• decompensated liver damage;
• renal failure above stage 3;
• bleeding disorders;
• decompensation of cardiovascular failure;
• hyperkalemia;
• alcoholism;
• addiction;
• taking hepatotoxic drugs as indicated in people with liver damage together with the gel;
• age up to 12 years;
• pregnancy and lactation;
• rehabilitation period after coronary artery bypass surgery.

It is not advisable to apply or use with great caution the gel in the following situations:

• cardiac ischemia;
• damage to cerebral vessels;
• condition after a stroke or heart attack;
• diabetes;
• congestive cardiac intoxication;
• alcohol intoxication;
• inflammatory lesions of the gastrointestinal tract;
• active hepatitis of any etiology;
• elderly age;
• isolation of Helicobacter pylori from the body;
• peripheral vascular pathologies;
• blood diseases;
• long-term use of non-steroidal anti-inflammatory drugs.

Prescribe the drug with caution when used together with:

• anticoagulants;
• antiplatelet agents;
• glucocorticosteroids;
• antidepressants from the selective serotonin reuptake group.

Drug price

Gel in a 20 gram tube costs from 100 to 300 rubles. 50 grams of the drug will cost 200-400 rubles. The drug has different prices depending on the volume and pharmacy network.

We recommend reading about what Akriderm ointment is used for. From the article you will learn about the composition of the ointment, indications and contraindications for application, and how to use it. And here is more information about what ointment will help heal the wound.

Nise gel is an effective anti-inflammatory drug for external use and is used for various pathologies of the musculoskeletal system. The gel is applied to the affected surface, the course of treatment is on average 3-4 weeks. Nise successfully combats pain, swelling and other symptoms of inflammation, but does not treat its actual cause.

The gel has contraindications and restrictions for use despite external use and minimal oral absorption. Not recommended for pregnant women and children.

Clotrimazole ointment contraindications

To prevent negative reactions early in pregnancy, avoid the drug in any form. Start therapy no earlier than the 12th week of pregnancy. During lactation, use the ointment carefully. The most favorable form of remedy during the treatment of thrush is considered to be a cream or ointment.

We note that it is strictly forbidden to use the ointment while breastfeeding if a woman is treating the mammary glands with the drug. The components of the ointment enter the child’s body, causing poisoning in the baby and intoxication.

There are also contraindications

Also, doctors do not allow the use of ointment in the following cases:

• If a woman has kidney or liver disease.
• During the menstrual cycle. This is because the ointment can enter the body with the blood, thereby causing side effects.
• For candidiasis of the eye mucosa. Irreversible changes may develop, even causing vision loss.

Interaction with other drugs

An antifungal drug with the same active substance can inhibit the action of other drugs. In the vast majority of cases, this refers to medications for external use, while Clotrimazole in tablets belongs to a different category of drugs. If a doctor has prescribed this broad-spectrum antifungal agent to fight an infection, then, as a specialist, he knows that vaginal tablets with this active ingredient cannot be combined with Nystatin, Natamycin or other polyene antibiotics.

There is also the opposite phenomenon, when taking certain medications can greatly affect the effectiveness of Clotrimazole. Interaction with other drugs in such cases is undesirable, since the recovery process will take time; among such drugs is Dexamethasone. If there is a need to enhance the antimycotic properties of clotrimazole, then adding p-hydroxybenzoic acid propyl ester to the treatment regimen will help achieve the desired result, and the latter must be taken in high concentration.

What to do in case of overdose

An overdose occurs when taking the drug in excess of the maximum permissible daily dose.

Symptoms:

• apathy, drowsiness;
• dyspeptic symptoms;
• pain in the epigastrium, right hypochondrium;
• high blood pressure;
• acute kidney damage;
• respiratory dysfunction;
• bleeding.

Algorithm of actions:

1. Call an ambulance immediately.
2. Induce gastric emptying, rinse it - take a large amount of water and induce a gag reflex. Repeat until clear water comes out of the stomach.
3. After this, take adsorbents: activated carbon, enterosgel, filtrum, smecta, etc.
4. Then you can drink sweet warm tea.

In severe cases, the patient is hospitalized and undergoes detoxification therapy - the administration of intravenous solutions.

There are no specific antidotes.

Patient reviews of Nise tablets

On the Internet you can find both positive reviews about Nise tablets and a sufficient number of negative ones.

Why do people write negative reviews about this drug? And the whole point is in its incorrect use: non-compliance with the dosage. And as a result: a lot of side effects, overdose, ineffective indicator. Some patients self-medicate and prescribe Nice for themselves. But in fact, they need a completely different drug, so they don’t see any results.

Another part of patients respond very positively to this remedy. Some claim that the pill helped them relieve pain for a long time, others claim that they take a course of Nise at the first attack of rheumatoid arthritis, they forget about the pain for a long time.

In any case, if your doctor prescribed this drug, then you should undergo a course of treatment and write your own review about it.

Some more additional information

• In situations where taking pills is long-term, it is worth constantly monitoring the condition of the kidneys.
• Older people with problems of the cardiovascular system should use them while carefully monitoring their condition.
• This medication may cause dizziness and drowsiness, so use it with caution. Especially where quick reaction and attentiveness are required, for example, drivers, machinists.

The price of the drug Nise is quite affordable and varies from 185 rubles to 250 per package of 20 tablets.

Contraindications for use of the product

People with heart pathologies, stage 2 diabetes mellitus and high blood pressure should immediately stop taking Nise tablets if they have not been prescribed by a doctor. There are also contraindications in case of hypersensitivity to the components that are part of Nise tablets.

We have already found out the use of tablets.

But, like other medications, Nice has a number of contraindications:

• Nice tablets are contraindicated for children under 12 years of age; in other forms of release, children under 2 years of age;
• Pregnant women;
• Contraindicated for women while breastfeeding. In cases where the doctor insists on using tablets, you should not feed the baby until you stop taking this medication.
• Do not take during periods of exacerbation of erosions or gastrointestinal ulcers.
• The composition of the medication is contraindicated during bleeding of the digestive system.
• Should not be taken by persons with severe renal failure;
• With aspirin triad syndrome, this is aspirin intolerance with polyps and bronchial asthma;
• Allergy to any component of the product.

Also, this method of treatment with nimesulide should not be abused by people who have the following problems:

• Heart failure;
• Use with caution in patients with stage 2 diabetes mellitus (insulin dependent);
• Persistent high blood pressure;
• For vision problems;
• And kidney dysfunction.

Dosage and features of administration

Adults and children over 12 years of age are allowed to take one 100 mg tablet and two 50 mg tablets twice a day at the end or after meals. Taking the medication before meals is not recommended due to the possibility of damage to the tissues of the gastrointestinal tract.

There is no need to chew the drug; you need to drink it with a sufficient amount of water. It is necessary to maintain a gap of at least 6 hours between taking tablets. Adult patients are allowed to take no more than 400 mg per day. Children over 12 years of age should be limited to the minimum dose. The duration of treatment is prescribed individually and depends on the disease.

For children from 3 to 12 years old, the dose of the medicine is calculated based on body weight. For every kilogram of weight you need to give 3-5 mg of soluble tablets 2-3 times a day.

Dispersible tablets are pre-dissolved in water in the amount of 1 teaspoon. When using two tablets at a time, it is recommended to dissolve them in one tablespoon of water.

If the child weighs more than 40 kg, we can take 200 mg per day.

For kidney disease, it is permissible to use no more than 100 mg of the product per day.