Nurofen - instructions for use, reviews, analogs and formulations tablets 200 mg, forte, plus, children's syrup or suspension, suppositories 60 mg, gel 5 medications for the treatment of pain and fever in adults, children and pregnancy

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Nurofen is a non-steroidal anti-inflammatory drug that has an analgesic and antiseptic effect. Often used to relieve headaches and migraines. The therapeutic effect lasts for 8 hours. There are several types of Nurofen, so the medicine is universal.

Features of application

If the product gets into the eyes, mucous membranes of the mouth or nose, a burning sensation occurs. To eliminate it, rinse under running clean water. If you accidentally ingest the drug, you should consult a doctor. This is especially true for young children, as the likelihood of overdose and poisoning increases. Their clinical manifestations include the following symptoms:

nausea, vomiting;
weakness, apathy.

To neutralize the ingredients, gastric lavage with detoxification solutions is required.

The external product is combined with bandages and fixing bandages made from natural fabrics. Using the gel with airtight orthoses will cause severe skin irritation. Nurofen is also not used for occlusive sealed dressings.

The drug does not affect the reaction rate. It is used while driving vehicles and performing work that requires concentration and attention.

Structural analogues of Nurofen gel (with identical composition)	Analogues of Nurofen gel from the group of anti-inflammatory non-steroidal drugs
Ibuprofen ointment	Gel Diclofenac
Ibuprofen-Verte ointment	Indomethacin ointment
Cream Dolgit	Fastum-gel
Gel Dolgit	Gel Voltaren
—	Ortofen ointment
—	Gel Ketoprofen
—	Gel Artrosilene
—	Gel Nise
—	Diklak ointment

Nurofen gel is available over-the-counter from pharmacies. Despite this, its use without a doctor’s prescription is inappropriate. The drug is intended to reduce the severity of symptoms, but it cannot eliminate the cause of the disease. Only doctors with a narrow specialization - rheumatologists, vertebrologists, neuropathologists - can correctly treat joint pathology. After conducting a series of diagnostic studies, the doctor will draw up a treatment regimen that will help speed up recovery and avoid irreversible complications.

"Nurofen MultiSymptom"

This is a combined medication containing two active components:

Paracetamol - predominantly in the central nervous system, indiscriminately blocks cyclooxygenase (COX). It has a weak effect on the gastrointestinal mucosa and water-salt metabolism. Has a non-narcotic analgesic effect.
Ibuprofen - NSAIDs reduce the amount of mediators of hyperthermic reaction, inflammation and pain in the area of inflammation, as well as in healthy tissues. Suppresses some phases of inflammation.

The effectiveness of this combination gives a tangible effect:

helps increase range of motion;
reduces swelling of joints;
weakens arthralgia during movement and at rest;
relieves morning stiffness.

"Nurofen MultiSymptom" is indicated for various types of pain:

dental;
muscular;
post-traumatic;
head;
articular;
postoperative;
for dislocations, sprains, bruises or fractures;
with algodismenorrhea;
for degenerative and inflammatory pathologies of the musculoskeletal system;
neuralgia.

Pharmacokinetics

The maximum therapeutic concentration of ibuprofen in all layers of the epidermis is detected after a day. 5% of the active ingredient penetrates into inflammatory foci. It accumulates in the synovial capsule and periarticular soft tissues. Only trace amounts of ibuprofen are found in the systemic circulation.

After the gel is absorbed by the skin, more of the inactive form of the NSAID is transformed into the active form, which exhibits pharmacological effects. 90% of the components of the drug are metabolized in liver cells. Inactive and active metabolites are excreted by the urinary organs. About 20% is evacuated with bile acids during bowel movements.

Side effects

Treatment with Nurofen Plus and Nurofen for children for a short time (up to 4 days) does not lead to adverse reactions. However, in case of long-term use (more than 5 days), it is possible to develop disturbances in the functioning of the digestive, nervous, cardiovascular, urinary and respiratory systems, dermatological problems and visual impairment are also possible. The doctor must prescribe the drug correctly to avoid side effects.

The most common gastrointestinal symptoms include vomiting, nausea, heartburn, diarrhea, bloating, and discomfort. Ulcers, constipation, dry mouth, and stomatitis are less common.

The following abnormalities in the functioning of the central nervous system may be observed: dizziness and pain, sleep disturbance, overexcitation, depression, hallucinations, hearing impairment (decreased quality, noise).

Ophthalmological disorders associated with long-term use of Nurofen include blurred vision, double vision, swelling of the eyelids, dryness, irritation, and increased lacrimation.

From the side of the heart muscle, hypertension, tachycardia and failure are possible. From the circulatory system - a decrease in the quantitative indicator of platelets and the development of bleeding against this background (Werlhof's disease), a decrease in white blood cell counts and anemia.

Since the drug is excreted by the kidneys, it is possible that their functioning may be impaired - the development of insufficiency or nephrotic syndrome, which is characterized by a decrease in albumin in the blood, the appearance of protein in the urine and a decrease in its amount in the heme, as well as increased swelling of the body.

Dermatological problems include rash, itching, urticaria, runny nose, as well as other diseases of an allergic nature that occur in severe form (Quincke's edema and others).

Carefully

If you have the conditions listed in this section, you should consult a doctor before using the drug.

Concomitant use of other NSAIDs, a history of a single episode of gastric and duodenal ulcers or gastrointestinal ulcerative bleeding; gastritis, enteritis, colitis, the presence of Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or in history - bronchospasm may develop; systemic lupus erythematosus or mixed connective tissue disease (Sharpe's syndrome) - increased risk of aseptic meningitis; chicken pox; renal failure, including dehydration (creatinine clearance less than 30-60 ml/min), nephrotic syndrome, liver failure, liver cirrhosis with portal hypertension, hyperbilirubinemia, arterial hypertension and/or heart failure, cerebrovascular diseases, blood diseases of unknown etiology ( leukopenia and anemia), severe somatic diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, concomitant use of medications that may increase the risk of ulcers or bleeding, in particular oral glucocorticosteroids (including prednisone ), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), pregnancy I-II trimester, breastfeeding period, elderly age, age under 12 years.

Interaction with other drugs

The simultaneous use of ibuprofen with the following drugs should be avoided:

Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg per day) prescribed by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent is possible after starting ibuprofen).
Other NSAIDs, in particular selective COX-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.

Use with caution simultaneously with the following medications:

Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs.

Antihypertensives (ACE inhibitors and angiotensin II antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. In some patients with impaired renal function (eg, dehydrated patients or elderly patients with impaired renal function), coadministration of ACE inhibitors or angiotensin II antagonists and cyclooxygenase inhibitors may lead to a deterioration of renal function, including the development of acute renal failure. (usually reversible). These interactions should be considered in patients taking coxibs concomitantly with ACE inhibitors or angiotensin II antagonists.

In this regard, the combined use of the above drugs should be prescribed with caution, especially in the elderly. Patients should be prevented from becoming dehydrated and renal function monitoring should be considered upon initiation of this combination treatment and periodically thereafter.

Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.

Glucocorticosteroids: increased risk of gastrointestinal ulceration and gastrointestinal bleeding.

Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.

Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.

Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs.

Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.

Cyclosporine: increased risk of nephrotoxicity when NSAIDs are administered concomitantly with cyclosporine.

Mifepristone: NSAIDs should be started no earlier than 8 to 12 days after taking mifepristone, as NSAIDs may reduce the effectiveness of mifepristone.

Tacrolimus: When NSAIDs and tacrolimus are coadministered, the risk of nephrotoxicity may increase.

Zidovudine: Concomitant use of NSAIDs and zidovudine may result in increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.

Quinolone antibiotics: In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may be increased.

Myelotoxic drugs: increased hematotoxicity.

Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin: increased incidence of hypoprothrombinemia.

Drugs that block tubular secretion: decreased excretion and increased plasma concentrations of ibuprofen.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increased production of hydroxylated active metabolites, increased risk of developing severe intoxications.

Microsomal oxidation inhibitors: reducing the risk of hepatotoxicity.

Oral hypoglycemic drugs and insulin, sulfonylurea derivatives: increased effect of drugs.

Antacids and cholestyramine: decreased absorption.

Uricosuric drugs: decreased effectiveness of drugs.

Caffeine: increased analgesic effect.

Compound

One film-coated tablet contains the active ingredient - ibuprofen 200 mg;

excipients: croscarmellose sodium 30 mg, sodium lauryl sulfate 0.5 mg, sodium citrate dihydrate 43.5 mg, stearic acid 2 mg, colloidal silicon dioxide 1 mg.

shell composition: carmellose sodium 0.7 mg, talc 33 mg, acacia gum 0.6 mg, sucrose 116.1 mg, titanium dioxide 1.4 mg, macrogol 6000 0.2 mg, black ink (shellac 28.225%, iron dye black oxide (E172) 24.65%, propylene glycol 1.3%, isopropanol* 0.55%, butanol* 9.75%, ethanol* 32.275%, purified water* 3.25%).

*Solvents that have evaporated after the printing process.

Instructions for use

Pills

The tablets are taken orally after eating. Effervescent tablets are first dissolved in 200 ml of warm water, and then the resulting solution is drunk.

For an adult patient, the recommended dose of the drug is 200-400 mg. They should be taken 3 times a day with an interval of 4-6 hours. The highest daily dose is 1200 mg.

Baby syrup

Syrup is the children's form of Nurofen. It can be given to a child from 3 months. When determining the dosage and selecting a treatment regimen, it is necessary to take into account the age of the child.

Age	Single dose, ml	Interval between medication doses, h	Maximum daily dose, ml
3-6 months	2,5	8	7,5
6-12 months	2,5	6	10
1-3 years	5	8	15
3-6 years	7,5	6-8	22,5
6-9 years	10	6-8	30
9-12	15	6-8	45

It is convenient to dosage using the included dosing syringe. Also, a single dose can be calculated based on the child’s body weight: per 1 kg there should be 5-10 mg of active substance (in each milliliter of syrup its content is 20 mg).

Candles

Rectal suppositories are used for children from 3 months to 2 years. They are often used if, for objective reasons, it is impossible to drink the syrup (for example, with incessant vomiting).

For children up to 9 months, suppositories can be placed anally, 1 piece up to 3 times a day, and from 9 months to 2 years, up to 4 suppositories per day are allowed.

If a child under 1 year of age does not tolerate immunization well (this is expressed in the development of a febrile state), 1 suppository can be administered to him when negative symptoms appear, and if the therapeutic effect is insufficient, the procedure can be repeated after 6 hours.

Gel

The gel is used externally for pain in muscles, joints, and back, including due to diseases of the musculoskeletal system, neuralgia, and injuries. Its use is allowed from the age of 12 years.

A strip of gel 4 to 10 cm long should be applied to the area of skin in which pain is felt and rubbed in thoroughly. It should be completely absorbed into the skin. It should be used at intervals of 4 hours maximum 4 times a day.

The maximum period for using Nurofen, regardless of its form, is 2-3 days. If after this period the pain and other unpleasant symptoms have not disappeared, you should definitely visit a doctor.

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Price and analogues of the product

The price of Nurofen gel in the Russian Federation is from 150 rubles. for 50 gr. and from 300 rub. for 100 gr. How much the gel costs depends on the volume of the package. The ointment is available at any pharmacy without a doctor's prescription. If the consumer is not satisfied with the cost of the drug or has an intolerance to its components, a suitable analogue with a similar effect should be selected.

An analogue of Nurofen gel is Ibuprofen in the form of an ointment. This is the cheapest analogue, its price is 50-70 rubles. Allowed for children over 3 years old.

Another analogue is Dolgit. This is a German drug, its price is much higher. The product should not be used for dermatosis.

Diclofenac is an inexpensive pain reliever. The list of indications for use includes a large number of pathologies. Can be used for neuralgia and inflammatory processes. It has been used in medicine for a long time and is sold in any pharmacy, costs about 90 rubles. for 50g.

Fastum gel is an ointment for topical use for pain and inflammation. The composition includes lavender oil, which gives the product a pleasant smell. Allowed for children over 14 years of age. Do not apply to wounds or cuts. The cost of the ointment is 400 rubles. for 50 g.

Interaction with other drugs

The simultaneous use of Nurofen with Acetylsalicylic acid leads to a decrease in the therapeutic effect of the latter;
The simultaneous use of Nurofen with drugs that reduce the ability of blood to clot leads to the risk of bleeding of various locations;
The simultaneous use of Nurofen with Cyclosporine leads to increased toxic effects of the latter and the development of toxic kidney damage;
The simultaneous use of Nurofen with Plicamycin, Cefamandole, Cefotetan, Cefoperazone and Valproic acid leads to a decrease in prothrombin levels in the blood plasma;
The simultaneous use of Nurofen with drugs that block or reduce macrosomal oxidation of substances in the body leads to the development of severe liver poisoning;
The simultaneous use of Nurofen with drugs that reduce renal tubular secretion leads to an increase in the concentration of Nurofen in the blood plasma and the development of corresponding side effects;
The simultaneous use of Nurofen with drugs that reduce the concentration of hydrochloric acid in gastric juice and Kolestyramine leads to a decrease in the absorption of Nurofen;
The simultaneous use of Nurofen with drugs that reduce glucose levels in the form of tablets leads to an increase in the therapeutic effect of the latter;
The simultaneous use of Nurofen with drugs that contain caffeine leads to an increase in the analgesic effect of Nurofen.

Pharmacological properties

Pharmacodynamics

The mechanism of action of ibuprofen, a derivative of propionic acid from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it inhibits the synthesis of prostaglandins. It has a rapid, targeted effect against pain (analgesic), antipyretic and anti-inflammatory effects. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics

Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). After taking the drug on an empty stomach, the maximum concentration (Cmax) of ibuprofen in the blood plasma is reached after 45 minutes. Taking the drug with food may increase the time to reach maximum concentration (TCmax) by up to 1-2 hours. Connection with blood plasma proteins – 90%. Slowly penetrates into the joint cavity, lingers in the synovial fluid, creating higher concentrations in it than in the blood plasma. Lower concentrations of ibuprofen are found in cerebrospinal fluid compared to blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized in the liver. The half-life (T1/2) is 2 hours. It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile.

In limited studies, ibuprofen has been found in breast milk at very low concentrations.

Pharmacological effect

An anti-inflammatory drug of a non-hormonal nature that has anti-inflammatory and antipyretic effects. It also has a mild antipyretic effect. The mechanism for achieving a therapeutic effect is associated with selective blocking of enzymes leading to the formation of biologically active substances that have the opposite effect.

Nurofen is absorbed quite quickly and is distributed throughout all tissues in a short time, retaining mainly in the periarticular fluid, where its maximum concentration is achieved. This property of the drug is due to the high degree of binding to plasma proteins (about 90%). The drug enters the joint cavity to a small extent or does not enter at all.

Neutralization of Nurofen occurs in the liver with the formation of active breakdown products. Its elimination occurs through the kidneys and bile. The time it takes to remove the drug from the body is about 4 hours.

Mode of application

It must be remembered that the drug is prescribed for people over 12 years of age. Nurofen gel is used externally only.

When using the tube for the first time, you should check the integrity of the protective foil. Having unscrewed the lid, use a special device located on the outer surface of the lid to open the protective foil on the neck of the tube, pressing the lid on the foil to do this.

When used, squeeze out 4 to 10 cm of gel onto your hand (which corresponds to doses of 50-125 mg of ibuprofen), then rub into the skin until absorbed. Repeated rubbing is recommended after 4 hours. The drug should not be used more than four times a day. After using Nurofen, you must wash your hands thoroughly.

In a situation where the symptoms do not go away, let alone worsen, or there is no improvement after a 2-week period of use, discontinuation of therapy and seeking advice from a doctor is required.

In the event that the drug is accidentally ingested, it is necessary to rinse your mouth and consult a doctor, because if Nurofen gel is ingested, gastrointestinal upset may occur.

Types and dosage

There are several types of Nurofen. Each of them has its own indications and features of use:

Nurofen 200 mg;
Nurofen Express;
Nurofen Forte;
Nurofen Long.

Nurofen with a dosage of 200 mg is taken 1 tablet with an interval of 4-6 hours. The maximum daily dose is 6 tablets. If 5 days after use no positive changes are observed, then it is necessary to change the medicine. To obtain the fastest possible results, the doctor may increase the dosage to 400 mg. Nurofen can only be prescribed to children whose weight is more than 20 kg.

Nurofen Express should be taken 1 tablet. You can take no more than 4 tablets per day. The therapeutic effect should appear 3 days after the start of treatment. Nurofen Forte has the same dosage as Express. The maximum period for using the medicine is 10 days. According to the instructions for use, Nurofen Long is prescribed 1 tablet 3 times a day, with an interval between doses of about 6 hours.

Nurofen in gel form is for external use only. The optimal single dosage is 4-19 cm of the drug, depending on the extent of the affected area. The gel can be used no more than 4 times a day, with a minimum interval between doses of about 4 hours. The product is rubbed into the skin until completely dry.

When using the drug to treat elderly patients or people with chronic liver pathologies, the doctor must monitor the treatment process. If you miss a dose, it is recommended to take the next tablet as usual, without doubling the dosage.

In the first 12 weeks, a pregnant woman is prohibited from taking any medications, since during this period there is a high risk of developing a “cleft lip” in the unborn child. In the second trimester, the medicine can be used only if the benefits from it exceed all possible risks for the child. Therapy should be carried out only under the supervision of a physician.

In the third trimester, you should not take medications that contain ibuprofen. This is explained by the fact that there is a high risk of developing a pathology of the circulatory system or disruption of the child’s kidneys.

Contraindications and side effects

Nurofen ointment should not be applied to areas of skin damaged due to:

injuries;
scratches;
fungal infection;
dermatitis;
eczema;
rash of any etiology (infectious, allergic).

Hypersensitivity to Ibuprofen, other types of non-steroidal anti-inflammatory drugs, an allergic reaction to components require discontinuation of the drug.

Childhood:

do not use under 6 years of age;
limited use from 6 to 12 years of age;
from 12 years of age - dosing as usual.

During pregnancy, in the 1st and 2nd trimester, the use of the gel is as prescribed by a doctor; in the 3rd trimester, use is prohibited. During lactation, do not apply the gel to skin areas located close to the mammary glands.

Elderly patients need to increase the time interval between applications of Nurofen ointment.

There is a high risk of complications in people suffering from bronchial asthma, allergic rhinitis, and a reaction to acetylsalicylic acid.

Persons with kidney, liver, gastrointestinal dysfunction, anemia, and arterial hypertension should use the gel with caution. Caution should be exercised when taking medications simultaneously:

Caution should be exercised when taking medications simultaneously:

Acetylsalicylic acid. The anti-inflammatory effect is blocked. The development of coronary insufficiency is possible.
NSAIDs. Strengthening or inhibiting the effect of drugs depending on the composition.
Antibiotics based on Cefoperazone. Impaired hematopoietic function (reduced blood clotting).
Antibiotic Cyclosporine. Ibuprofen increases its nephrotoxicity due to its effect on kidney function.
Furosemide, Hydrochlorothiazide. The hypotensive effect of the drugs is blocked.
Oral hypoglycemic agents. Increased effects can lead to coma.
Caffeine. Strengthens the analgesic effect of Ibuprofen.
Steroid hormones. The risk of adverse hormonal effects increases.

The body's reaction to the ointment can be expressed in redness and burning at the site of Nurofen application. With a long course of treatment, allergic reactions may develop in the form of:

swelling;
rash;
ailments;
irritation of mucous membranes;
increased sweating.

The use of the drug with existing contraindications may manifest itself in the form of side effects:

bronchospasm, shortness of breath that appears after applying the ointment;
headache, insomnia, drowsiness, irritability.
increased blood pressure, increased heart rate.
Lyell's syndrome (allergic dermatitis).
feverish condition;
stomach pain, nausea, vomiting.

Severe side effects require discontinuation of treatment with Nurofen ointment.

Interaction with other drugs

Paracetamol

Antiemetics: decreased rate of absorption of paracetamol when used simultaneously with metoclopramide or domperidone.
Anticoagulants: Long-term use of drugs containing paracetamol may enhance the effect of anticoagulants, in particular warfarin, and increase the risk of bleeding.
Cholestyramine: decreased rate of absorption of paracetamol when used simultaneously with cholestyramine.

Ibuprofen

The simultaneous use of ibuprofen with the following drugs should be avoided:

Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg per day) prescribed by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent is possible after starting ibuprofen).
Other NSAIDs, in particular selective COX-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.

Use with caution simultaneously with the following medications:

Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs. Antihypertensives (ACE inhibitors and angiotensin II antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. In some patients with impaired renal function (eg, dehydrated patients or elderly patients with impaired renal function), coadministration of ACE inhibitors or angiotensin II antagonists and cyclooxygenase inhibitors may lead to a deterioration of renal function, including the development of acute renal failure. (usually reversible). These interactions should be considered in patients taking coxibs concomitantly with ACE inhibitors or angiotensin II antagonists.

Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs. Glucocorticosteroids: increased risk of gastrointestinal ulceration and gastrointestinal bleeding. Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding. Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma. Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs. Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs. Cyclosporine: increased risk of nephrotoxicity when NSAIDs are administered concomitantly with cyclosporine. Mifepristone: NSAIDs should be started no earlier than 8 to 12 days after taking mifepristone, as NSAIDs may reduce the effectiveness of mifepristone. Tacrolimus: When NSAIDs and tacrolimus are coadministered, the risk of nephrotoxicity may increase. Zidovudine: Concomitant use of NSAIDs and zidovudine may result in increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen. Quinolone antibiotics: In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may be increased. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Caffeine enhances the analgesic effect.

Release form and composition

Nurofen gel is sold in pharmacies, in aluminum tubes of 30, 50, 100 g.

The basis of the gel is the non-steroidal anti-inflammatory drug Ibuprofen. 1 g of ointment contains 50 mg of NSAIDs. Ibuprofen affects the production of prostaglandins, hormone-like substances synthesized in all tissues of the body. Thanks to prostaglandins, the sensitivity of pain (nociceptive) receptors increases.

Ibuprofen blocks the synthesis of the cycloogenase enzyme (COX-1 and COX-2), which regulates the reproduction of prostaglandins. Thus, it raises the pain threshold, reducing sensitivity to pain, and also prevents the development of the inflammatory process.

The nonsteroidal drug stimulates the formation of organic interferon, a protein that provides antiviral protection to cells.

Excipients:

as solvents for Ibuprofen - benzyl and isopropyl alcohols;
to impart uniform viscosity - hyaetellosis;
caustic soda, component for hyaetellose;
water - to dissolve sodium hydrochloride.

The drug has a transparent, homogeneous consistency with a specific odor of isopropyl alcohol.

Pharmacological effect

Ibuprofen is characterized by pronounced analgesic, anti-inflammatory and antipyretic effects.
It blocks cyclooxygenase (COX-1 and COX-2), due to which the biosynthesis of prostaglandins, which are mediators of inflammation, is sharply reduced. After oral administration, the active component is quickly absorbed in the digestive tract. The highest plasma concentration is normally observed after 1-2 hours. Ibuprofen tends to penetrate to a significant extent into the synovial fluid. Biotransformation of ibuprofen occurs in the liver, and the resulting metabolites are excreted mainly in the urine. The half-life is approximately 2 hours.

note

Concurrent intake of food and antacids somewhat inhibits the absorption of the drug.

The analgesic effect is most pronounced during the inflammatory process. The duration of action of 1 Nurofen tablet is up to 8 hours.

Contraindications

A contraindication to the use of the drug is the appearance of an increased reaction of the body to ibuprofen or to other components of the drug.

It is not used if the patient has bronchial asthma, urticaria or rhinitis caused by the use of acetylsalicylic acid (salicylates), as well as other NSAIDs.

Use in pediatrics in young patients (under 12 years) is not practiced.

Monitoring and caution are required when using Nurofen if the patient has a history of gastrointestinal, liver or kidney diseases, as well as when using the drug in pregnant and breastfeeding women

Nurofen syrup for children

Nurofen for children in suspension (syrup) is dosed using a special syringe, which is in the package with the medicine. Sold in different volumes in bottles of 100, 150 and 200 ml. Depending on the additives, the flavor may be strawberry or orange.

Important! If the medicine has not been opened, it can be stored until the expiration date indicated on the package. After opening the package, the drug can be used for no longer than 6 months.

special instructions

It is recommended to take the drug for the shortest possible course and in the minimum effective dose necessary to eliminate symptoms. If you need to take the drug for more than 10 days, you should consult a doctor.

In patients with bronchial asthma or an allergic disease in the acute stage, as well as in patients with a history of bronchial asthma/allergic disease, the drug may provoke bronchospasm. Use of the drug in patients with systemic lupus erythematosus or mixed connective tissue disease is associated with an increased risk of developing aseptic meningitis.

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (hemoglobin determination), and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. During the treatment period, ethanol intake is not recommended.

Patients with renal failure should consult a doctor before using the drug, as there is a risk of deterioration in the functional state of the kidneys.

Patients with hypertension, including a history of hypertension and/or chronic heart failure, should consult a physician before using the drug, as the drug may cause fluid retention, increased blood pressure, and edema.

In patients with uncontrolled hypertension, NYHA class II-III congestive heart failure, coronary artery disease, peripheral arterial disease and/or cerebrovascular disease, ibuprofen should be prescribed only after a careful benefit-risk assessment, and high doses of ibuprofen should be avoided (≥ 2400 mg/day).

The use of NSAIDs in patients with chickenpox may be associated with an increased risk of developing severe purulent complications of infectious and inflammatory diseases of the skin and subcutaneous fat (for example, necrotizing fasciitis). In this regard, it is recommended to avoid using the drug for chickenpox.

Information for women planning pregnancy: the drug suppresses cyclooxygenase and prostaglandin synthesis, affects ovulation, disrupting female reproductive function (reversible after discontinuation of treatment).

Helpful information

According to reviews from both parents and children's doctors, Nurofen for children is recognized as one of the fastest-acting drugs with anti-inflammatory, analgesic and antipyretic effects.

How quickly does this medicine work? This depends on the form in which the drug was used. On average, the result is noticeable after fifteen minutes and lasts from six to eight hours. A decrease in temperature is observed half an hour to an hour after taking it. Among children's forms, suppositories administered rectally have the fastest effect. The effect is visible in literally five to ten minutes. The intensity of pain, the course of the disease and the individual characteristics of the little patient should not be discounted.

How to give Nurofen to a child? Take it on an empty stomach, during and after meals. In the first case, the effect will occur faster in about forty-five minutes. In other cases, this will take about two hours. It is important to follow the dosage and duration of use recommended by the doctor - no more than three days to relieve fever, no more than five to get rid of pain.

What does Nurofen help with? Doctors often prescribe it to reduce symptoms caused by colds, infections, viral pathologies, as well as post-vaccination adverse events in the child’s body. In addition to the above, it will help:

for injuries;
neuralgia;
sprains;
bruises;
teething;
various pain sensations, including in the ears.

Indications for use

What does Nurofen ointment help with? Nurofen is used for painful conditions:

in the spine;
hip, knee, elbow, shoulder joints;
muscles;
ligaments;
peripheral nerves.

Ointment is prescribed for:

rheumatic attacks;
attacks of gout;
lumbar osteochondrosis;
inflammation of the tendons (tendinitis);
inflammation of the joint capsule (bursitis);
arthritis;
arthrosis;
lumbago (acute lumbar pain);
sciatica (inflammation of the sciatic nerve);
sprained ligaments, tendons;
muscle pain after physical activity.

The drug is effective for pain of mild to moderate severity.

Application of suppository

What do Nurofen suppositories help with? The medicine is indicated for symptomatic therapy (does not affect the progression of the disease) as a means of providing the following effects - antipyretic and analgesic. In the first case it is used:

for childhood infections;
flu;
acute respiratory infections;
reactions to vaccination;
infectious and inflammatory diseases;
other conditions that are accompanied by an increase in temperature.

In the second - for pain:

in the ears;
throat;
joints;
teeth;
head;
ligaments when they are stretched.

And also for rheumatic, muscular, neuralgic and other types of pain.

Analogs

The composition of Nurofen ointment is identical in composition:

gel and cream Dolgit;
Ibuprofen gel 5%;
Brufen gel;
Deep Relief.

Differences in the use of these drugs:

Dolgit is not used for dermatitis;
Ibuprofen gel is allowed for children after one year;
Deep Relief is prohibited for children under 14 years of age, pregnant and lactating women.

According to the mechanism of action, ointment-gels analogues of Nurofen:

Ortofen (active ingredient diclofenac sodium);
Dolobene (active components – dimethyl sulfoxide, sodium heparin, dexapanthenol; additional substances – essential oils of pine, rosemary, citronella);
Voltaren Emulgel (diclofenac sodium);
Finalgel (piroxicam);
Fastum gel (ketoprofen);
Ketonal (ketoprofen);
Diclofenac (diclofenac sodium);
Apizarthron (bee venom, methyl salicylate, allyl isothiocyanate);
Indovazin (troxerutin, indomethacin).

Medicines are used to relieve pain, inflammatory manifestations in joints, soft tissues, ligaments and tendons. Contraindications and side effects are similar to Nurofen ointment.

Cheaper than Nurofen are gels and ointments Ortofen, Ibuprfen, Dolgit, Finalgel, Ketonal, Diclofenac.

Nurofen for children

For children aged 6 to 12 years, the use of Nurofen tablets is allowed. You can repeat the dose no more than 4 times a day, with an interval of 6 hours.

Children from 6 to 9 years old take 1 tablet of ibuprofen, but not more than three times a day.

For use by children aged 3 months to 6 years, a special sweet syrup is indicated. Nurofen liquid instructions, which are attached, must be taken according to the age and weight of the baby, the annotation contains a table describing the correct dosage regimen.

How to take Nurofen before or after meals? There is no big difference, however, taking the drug on an empty stomach, without eating at the same time, allows the active substance to begin its active work faster. Otherwise, the absorption rate of the active components may be delayed.

Contraindications

If the previous use of NSAIDs or aspirin caused rhinitis, bronchospasm, or urticaria, then Nurofen gel is prohibited for use. Contraindications to the drug also include:

age up to 14 years;
3rd trimester of pregnancy;
individual predisposition to developing allergies to ibuprofen or auxiliary ingredients of the gel;
skin injury at the site of application of the external agent, including dry and weeping eczema, trophic ulcers, dermatitis.

Nurofen gel is prescribed to patients in the 1st and 2nd trimesters of pregnancy only if absolutely necessary. When recommending a drug, the doctor evaluates its benefits for the mother’s health and the potential risk for the growth and development of the fetus. Relative contraindications for use are acute and chronic diseases of the liver and kidneys.

The drug should be used with caution if there is a history of gastritis, ulcerative lesions of the gastrointestinal tract, enteritis, colitis, or hemorrhagic diathesis. Rheumatologists recommend temporarily stopping breastfeeding during lactation

Nurofen for peace of mind for mothers

When a baby gets sick, parents look for the best and most effective remedies. But alas, the baby refuses to take them, because they smell bad, taste bitter, etc. In this case, a miracle medicine tested by many mothers in practice will come to the rescue. Its name is Nurofen suspension. It has not only a pleasant taste, but also a triple effect:

pain reliever;
antipyretic;
anti-inflammatory.

It is allowed to be used for children from three months of age to twelve years, which is very important. It does not contain substances harmful to the child’s body, which include dyes, sugar, and alcohol. As a result, the risk of allergic reactions is minimized.

Pharmacological action of the drug

The drug is an ointment for external local use, intended for the treatment of pain of any intensity. The main functions of Nurofen are to eliminate pain and relieve inflammation. The substance is quickly absorbed and has a cooling effect. The maximum effect of the drug after application to the skin is detected after a few hours, after 24 hours it is noticeable in the dermis. The absorption of the active substances included in the drug into the blood is a small percentage.

Composition and release form

The drug contains ibuprofen, which reduces the permeability of vascular walls, improves blood circulation and blocks the spread of inflammatory mediators. In addition, the drug reduces the synthesis of bradykinin, thereby providing an anti-inflammatory effect.

The gel contains the following additional substances:

benzyl alcohol;
sodium hydroxide;
isopropanol;
hyaetellosis.

Indications and contraindications for use

Not all diseases of the musculoskeletal system can be treated with the drug. According to the instructions for use, Nurofen gel is prescribed for the following conditions:

arthritis;
back pain;
sprains;
osteochondrosis;
neuralgia;
osteoarthritis;
inflammation in soft tissues;
joint damage due to gout.

It is recommended to store the drug at room temperature in a dark place inaccessible to children. The shelf life is 3 years.

Like any other medicine, the gel must be taken taking all precautions and following the instructions for use. Nurofen express gel should be used with caution:

people with hypersensitivity to active substances;
in the presence of disturbances in the gastrointestinal tract;
people with urticaria.

Nurofen gel is contraindicated in children under 14 years of age, as well as during pregnancy and breastfeeding.

Nurofen should be taken with caution with Enterosgel, thrombolytic agents and non-steroidal anti-inflammatory drugs (NSAIDs). https://www.youtube.com/embed/rP1ZU0gGtlk

Composition and features of the release

Nurofen belongs to the nonsteroidal anti-inflammatory drugs (NSAIDs), which are based on the compound ibuprofen. The medicine is available in different forms: tablets, suppositories, syrup. Older editions were based on making syrup. Currently, tablets can be used from 6 years of age. The shape of the tablet is in the form of a circle, with a convexity on both sides, covered with a special white coating, with the imprint of Nurofen’s signature. When viewed cross-section, the shade corresponds to the color of the outer contour.

The drug Nurofen is available for children from 6 years of age in tablet form, 200 mg. Blisters of 6, 8, 10, 12 tablets are placed in a cardboard package. The number of blisters per 1 unit is 1, 3, 4 or 8 pieces. Instructions for use are included with each package.

Overdose

In children, overdose symptoms may occur after taking a dose exceeding 400 mg/kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. The half-life of the drug in case of overdose is 1.5-3 hours.

Treatment: symptomatic, with mandatory maintenance of airway patency, monitoring of ECG and vital signs until the patient’s condition is normalized. Oral use of activated charcoal or gastric lavage is recommended within 1 hour after taking a potentially toxic dose of ibuprofen. If ibuprofen has already been absorbed, an alkaline drink may be prescribed in order to eliminate the acidic derivative of ibuprofen by the kidneys, forced diuresis. Frequent or prolonged seizures should be treated with intravenous diazepam or lorazepam. If bronchial asthma worsens, the use of bronchodilators is recommended.

Different forms of Nurofen for adults

The instructions for use contain complete information about this medicine. For adult patients, it is available in the form of regular or effervescent tablets, as well as capsules. All forms have different dosages, and some have a prolonged effect. For example, capsules are produced using modern technology, which allows the active substance to be present in them in liquid form. As a result, ibuprofen penetrates the blood faster.

As a pain reliever, Nurofen is mainly used to relieve pain of various origins. The prolonged form of the drug eliminates muscle pain well. Effervescent tablets, which are dissolved in water before administration, have a faster therapeutic effect at elevated temperatures. In addition, they are endowed with a pleasant taste. Nurofen Plus also contains codeine, which has an antitussive and analgesic effect. It has proven itself well for muscle and rheumatic pain syndromes.

Overdose is manifested by the following symptoms:

drowsy state;
bradycardia;
nausea;
decreased blood pressure;
constriction of the pupils;
coma;
respiratory arrest;
tachycardia;
atrial fibrillation.

Therefore, it is undesirable to exceed the permitted doses. The doctor can select the dosage individually or prescribe it in accordance with the one specified in the instructions. We must remember that taking the medicine on an empty stomach can injure the gastric mucosa. Before taking it, be sure to carefully read the contraindications, side effects, and interactions with other medications.

Pharmacological properties

The drug Nurofen Express in gel dosage form for external use is easily applied and quickly absorbed into the skin.

Pharmacodynamics

The drug belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs).

Has a double effect: analgesic and anti-inflammatory. Ibuprofen, being a derivative of propionic acid, indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it inhibits the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.

When applied to the skin, the gel has an additional cooling effect due to the rapid evaporation of benzyl alcohol contained in the composition.

Pharmacokinetics

After application to the skin, ibuprofen is detected in the epidermis and dermis after 24 hours. The maximum plasma concentration of ibuprofen when applied topically is 5% of the maximum concentration level when using oral forms of ibuprofen. Clinically significant systemic absorption practically does not occur.

Metabolized in the liver. It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile.

Interaction with other drugs

Nurofen for adults cannot be used with all medications. Some drugs, when used together, change their effect on the body, not always for the better.

Especially the simultaneous use of Nurofen and other drugs:

This medication should not be taken together with anticoagulants, aspirin, or other non-steroidal anti-inflammatory drugs (this situation increases the risk of bleeding);
taken together with cyclosporine increases its amount in the blood, increasing the toxic effect on the liver;
you cannot drink Nurofen and Rifampicin, drugs from the group of barbiturates, tricyclic antidepressants at the same time;
ibuprofen reduces the contraceptive effect of oral contraceptives;
joint use of Nurofen and glucocorticosteroids, as well as products containing estrogen, increases the risk of adverse reactions;
ibuprofen has the ability to increase the effectiveness of hypoglycemic agents, so patients with diabetes require constant monitoring of blood sugar.

Nurofen should be taken for the shortest possible time; if this period exceeds five days, you need to consult a doctor, adjust the dosage or select another, more effective therapy. Long-term use of the drug requires constant monitoring of blood functions by taking appropriate tests (liver and kidney).

People suffering from dizziness and changes in visual acuity while taking Nurofen should refrain from driving vehicles or working on complex mechanisms or machines for the entire period of therapy.

The principle of action of the medication

The question of whether Nurofen helps with colds can be answered positively. This medicine is available in the form of tablets for adults and a suspension for children. The medication is a symptomatic remedy, that is, it makes you feel better, but does not in any way affect the cause of the illness.

By taking Nurofen for colds and flu, you can achieve the following results:

reduce elevated body temperature;
eliminate headache and muscle pain;
increase performance by eliminating disturbing symptoms;
get anti-inflammatory effect.

Once in the body of a sick person, Nurofen inhibits the synthesis of mediators of pain and inflammation, and also blocks the production of substances that increase body temperature. An important point in the work of the drug is that during colds it prevents platelets from sticking together, which often becomes a catastrophic problem due to elevated body temperature and dehydration.

You can purchase the medicine Nurofen Plus at a pharmacy if prescribed by a doctor. In addition to the above advantages, it also has an antitussive effect. When using this drug to treat colds and flu, you must be especially careful, as it has a lot of side effects, and with prolonged use, the tablets become addictive.

Nuances when reducing fever in children

The use of suppositories or syrup for elevated body temperature in children should be strictly according to the instructions. Otherwise, the risks of overdose or taking an insufficient dose increase.

Important details:

prohibition of taking the drug on an empty stomach;
take the next drug when Nurofen has not worked within half an hour - an hour, preferably after 1-2 hours;
when the fever remains, call an ambulance;
give the baby rectal suppositories at night, keep body temperature under control, without interfering with the child’s rest;
when a baby has a fever and cold hands, feet, or has vascular spasm, before using antipyretic medications, he is given No-shpa in an age-appropriate dose.

In addition to medications, maintaining cool, humid air in the apartment will help lower your baby’s temperature. It is allowed to wipe the child with a damp cloth and give him enough to drink. With viral infections, the temperature goes away on its own after 5-7 days. When this does not happen, you should seek medical advice.

"Nurofen" (tablets): reviews of parents about the medicine

Parents of children say that the drug described in the article is one of the most popular. The drug has long been used in pediatrics to treat bacterial and viral diseases accompanied by fever and pain. It is very convenient for children to use the medicine "Nurofen". After all, it acts for 6-8 hours. You can give the medicine to your child before bedtime and get proper rest. After all, you won’t have to worry about the temperature rising until the morning.

Many mothers and fathers use the drug "Nurofen" for children (4 years old). The medication is not prescribed for this age in tablet form. But if a child weighs more than 20 kilograms and is able to swallow the medicine without first crushing it, then it is quite acceptable to use this form. This information is indirectly communicated to the consumer by the instructions for use.

What are the analogues of the product?

Today there are several analogues of this drug. Among them:

Nimesil - it is available in powder form to create a suspension;
Ibufen;
Ibuprofen in the form of tablets and suspensions, including for children;
Diclofenac - solution for injections and many others.

Nimesil

Ibufen

Ibuprofen

Diclofenac

Despite the fact that there are a lot of replacement options, you should not abuse them. After all, the prescribed drug is calculated by the doctor based on observations of the patient and his condition. And the replacement may not always be adequate to the proposed treatment.

You should not select a replacement on your own, as the dosage may be inadequate. And then no quality treatment will be possible.

Therefore, it is worth consulting with your doctor in advance about what kind of replacement you can use. Then there will be a chance that everything will be selected properly.

What are the indications for use?

Nurofen, whose instructions are simple, should be taken strictly according to indications. For the adult version, the same indications for use apply, regardless of the release form. The only exceptions are local remedies. It is proposed to use tablet forms of the drug for:

Pain;
Heat;
Inflammation;
Arthritis of various types, which can be accompanied by pain and inflammatory processes in the joints (including rheumatoid arthritis, osteochondrosis, arthritis due to autoimmune conditions, such as lupus);
Neuralgic pathologies of various types;
Gout;
Ankylosing spondylitis;
Pain of any nature and location;
Pain after surgery or due to injury;
Pain that occurs during the progression of oncology;
Pain due to inflammation in the pelvic area - adnexitis, endometritis, etc.;
Pain during childbirth;
Temperature during various viral diseases.

Nurofen is used in complex therapy - it will not work as an independent remedy.
It has no effect on the course of the pathology. Nurofen gel is used topically. There are also clear indications for it:

Muscle pain;
Painful sensations in the back;
Arthritis;
Injuries and other damage to ligaments;
Sports injuries;
Attacks of neuralgia.

The gel should be applied topically and pointwise - it allows for a quick effect. This drug relieves inflammatory manifestations and leads to a decrease in pain.

However, it should not be used on wider areas of the body. It is also considered a purely symptomatic remedy.

Nurofen for children, the instructions for use of which are simple and understandable to every parent, also has its own specific indications for use. Moreover, they are the same for different forms of release - syrup, tablets and suppositories. Such indications include:

Increased temperature in various pathologies, where there is an increase in temperature and pain - it is often recommended to use it for various acute respiratory viral infections, influenza, childhood infections and the development of reactions to vaccinations;
Pain – this refers to various painful manifestations: headaches, toothaches, neuralgia, earaches (for example, with otitis media), sore throat, etc.

The product should be used only according to strict indications. It is advisable to consult with a doctor in advance about the advisability of such a remedy - both in adults and in children.

At the same time, the drug is freely available, sold without a prescription, and many people purchase it at the pharmacy on their own. In this case, it is necessary to strictly follow the instructions so as not to achieve the opposite effect and not aggravate the situation.

How the product works

Nurofen works quite simply in the human body. When it enters the bloodstream, it is able to block an enzyme such as cyclooxygenase-2, which causes the active production of prostaglandins. It is these substances that cause pain, develop inflammation in various tissues and systems and lead to an increase in body temperature. They also cause a local feeling of heat in the affected area, for example, in case of injury. If a knee injury occurs, a feeling of increased temperature may manifest itself in it.

To put it as simply as possible, Nurofen simply blocks the production of biologically active substances that cause pain, fever and various inflammations.

Ibuprofen, when entering the body, helps thin the blood, and it is also able to protect the blood from platelet aggregation. When the tablet enters the digestive system, ibuprofen begins to be released almost instantly.

In the body, the active substance begins to act quite selectively directly at the sites of damage and inflammation.

Medicines to lower fever in children

Nurofen does not reduce the temperature, what should I do? There are many medications that can bring the temperature back to normal. It is better to seek help from a doctor and consult with him which substance is best for a particular person.

For children, the use of paracetamol is recommended. They have different shapes and trade names:

rectal suppositories Tsefekon;
Paracetamol syrup, Panadol;
Paracetamol tablets.

Medicines act at the same speed as Nurofen. It takes 40 minutes to an hour to reduce the heat. You can try Viburkol, Calpol, Analidim. A specialist will tell you what to do if Nurofen does not help, so in especially difficult cases, you need to seek medical help.

Adult patients can use Paracetamol, Aspirin, Analgin, Nurofen, Theraflu.

Is it possible to give Nurofen without fever? Some experts recommend using this composition in infants from three to five months, when the teething process has begun.

The product should not be used for more than three to five days in a row. If unpleasant symptoms remain, you should definitely consult a doctor for advice.

For children, taking medications containing aspirin or analgin is strictly prohibited. These drugs are not always allowed for adults, and for children under 15 years of age they are prohibited in principle. They have an extremely negative effect on the organs of the gastrointestinal tract, as well as the hematopoietic system.

How does an overdose manifest itself?

At the first signs of an overdose of Nurofen, emergency measures must be taken. To provide first aid, gastric lavage is performed using a large amount of activated carbon (up to 10 tablets per dose) orally. Subsequent treatment is carried out in a toxicology hospital by forced diuresis and infusion of large amounts of fluid using intravenous drip injections.

The first signs of an overdose include:

discomfort in the abdomen, even sharp pain;
nausea followed by vomiting;
headaches accompanied by tinnitus;
slow heart rate;
lethargy, which turns into drowsiness and confusion.

In the absence of emergency assistance, myocardial ventricular fibrillation and cardiac arrest may occur, which may result in the death of the sick person.

When to use antipyretics

To answer the question at what temperature to give Nurofen to a child, you need to understand what effect the medicine has on the human body. The main component is ibuprofen, which is a non-steroidal anti-inflammatory substance. It affects cyclooxygenase, preventing the formation of prostaglandin, those enzymes that provoke a rise in body temperature and the appearance of pain.

This medication has different release forms:

syrups, candles for babies;
tablets for children over 6 years old;
capsules and tablets for children over 12 years of age and adult patients.

Experts recommend giving medicine to children when the thermometer readings exceed or reach 38.5 degrees. It should not be earlier; an increase in temperature indicates the beginning of the body’s fight against a viral infection. Now the active production of interferons, special proteins that the body needs to destroy viruses, begins.

While the body temperature is low, the body copes with it on its own. It is enough to provide the sick person with rest, bed rest, humidified cool air, and plenty of fluids. Syrup should be given at a temperature of 39 or when the thermometer approaches these numbers.

Sometimes, if you are prone to seizures, medications should be given without waiting for a strong rise in body temperature. The same rule applies to premature babies, babies with birth injuries, and other cases when there is such a doctor’s recommendation.

Use during pregnancy, lactation

The medication is especially dangerous for women in the 3rd trimester, but it is also undesirable to take it in the first two. In case of severe pain or fever, it is better to take another medication. Women planning a pregnancy should know that the drug can negatively affect ovulation.

Many doctors insist that a small amount of ibuprofen that passes into breast milk is completely safe for the baby, since the drug penetrates into the joints slowly, remaining in the synovial fluid for a long time. Therefore, many doctors recommend taking it during lactation, but only in short courses. Do not express milk or skip feedings. To understand how quickly the drug is eliminated, you need to find out how long Nurofen lasts and after what time the pain stops.

How Nurofen works with other drugs

Doctors have identified a number of drugs with which Nurofen should not be combined. For example, it is advised to exclude the simultaneous use of ibuprofen with anticoagulants, aspirin and other options from the non-steroidal group. Indeed, against the background of an overabundance of painkillers, there is a risk of getting an overdose, which will lead to the development of bleeding.

If Cyclosparin is taken together with Nurofen, then the liver has an extremely detrimental effect. After all, the latter actively accumulates in the plasma and increases in its concentration.

You should not combine Nurofen with antidepressants, which will again negatively affect the condition of the liver.

You should be especially careful with Nurofen when taking oral contraceptives - it may reduce the effect. Therefore, it is recommended that women who use both use an additional protective method during therapy.

How long does it take for Nurofen to work?

Antipyretic suppositories Nurofen, according to research, begin to work 30-40 minutes after oral administration. When rectal suppositories are used, the effect can be seen later, after an hour. These indicators are averaged; each person reacts to medications in a special way. Sometimes the rate at which the fever decreases and the body’s reaction to the composition will depend on the strain of the virus that caused the disease.

The rate at which the numbers on the thermometer decrease depends on how accurately the dosage of the product was selected. For each age, weight category of children, adults, there are clearly measured doses that should be followed. If you refuse to follow the recommendations, there is a high risk of not getting the desired effect. Symptoms of drug overdose may occur.

The effect of the drug lasts about 8 hours, but may end earlier. Take the next dose early, you should wait 6-8 hours before taking the medicine again.

There are cases when Nurofen is given without delay to prevent a person’s condition from worsening:

elevated body temperature is accompanied by dehydration;
chills appear;
the skin turns pale;
headache, dizziness appears;
signs of confusion may be seen;
the temperature rises.

After a person takes capsules, suspension, rectal suppositories, Nurofen solutions, the fever will disappear. When unpleasant symptoms are associated with a reaction from a vaccine or the eruption of baby teeth, there is no cause for concern. When the cause is unclear, you should consult a doctor to find the reasons for the worsening condition.

The use of Nurofen gives the following effect:

decrease in fever;
reduction of pain, relief from joint and muscle pain;
slight anti-inflammatory effect.

Indications for use of the drug are:

flu;
ARVI;
intestinal pathologies;
inflammatory processes affecting organs and tissues;
joint inflammation;
infections that occur in childhood;
diseases of ENT organs;
tonsillitis;
tracheitis;
pneumonia;
bronchitis;
post-vaccination reactions;
eruption of baby teeth.

Contraindications for use:

insufficiency of kidney and liver function;
bleeding of the gastrointestinal tract;
intolerance or previous negative reaction to taking drugs from the NSAID group;
heart failure;
exacerbation of chronic diseases of the gastrointestinal tract (ulcers, gastritis, ulcerative colitis);
the first and third trimesters of pregnancy and breastfeeding (there may be exceptions; for a nursing mother, the drug is prescribed by the attending physician);
hypertension in severe stages;
ac type;
urticaria or rhinitis caused by taking acetylsalicylic acid;
diseases of the optic nerve;
disturbances of “color” vision;
diathesis of hemorrhagic type;
hearing impairment;
recent aortic bypass surgery;
child's age up to six years (tablet form), up to twelve years (capsules), up to three months (any form of the drug);
hyperkalemia;
pathologies of the vestibular apparatus;
childhood bronchial asthma.

The medicine can be taken with caution when:

children under three years of age;
second trimester of pregnancy;
hypertension;
GW period;
liver cirrhosis;
hyperbilirubinemia;
ulcerative pathologies of the gastrointestinal tract in the past;
diabetes mellitus;
ischemic disease;
smoking;
alcoholism;
anemia, leukopenia;
systemic lupus erythematosus;
presence of Helicobacter pylori;
with moderate renal failure;
old age.

How much can you give a child Nurofen with a fever? For each age group there is a dosage regimen.

Dosing Features:

For fever, adults are given Nurofen 200 mg of the drug at six-hour intervals;
long-acting tablets for adults, with a dosage of ibuprofen 400 mg, are taken up to two times a day. The same dosage rules for Nurofen are for children over 12 years of age;
syrup for children has its own dosing rules; it is given after the child is three months old. For each group of babies of a certain weight, there is its own dose size;
rectal suppository contains 60 mg of ibuprofen: children are prescribed suppositories from 3 months to two years. The drug should not be used in children weighing less than 6 kg. The permissible daily dosage for babies over 9 months is 240 mg;
coated tablets are taken by children from six years of age at six-hour intervals.

The effect of the medication lasts from 6 to 8 hours. If a repeated rise in body temperature occurs, use a drug with a different active ingredient (paracetamol).

Rules for using the medication in pregnant women:

Before the twelfth week, medications are prohibited. According to research, the use of medications causes the formation of fetal malformations;
after the onset of the second trimester, Nurofen is prescribed by a doctor who decides on such therapy after weighing the likely benefit for the mother and the potential risk for the baby;
In the last weeks of pregnancy, the drug is completely consumed: it can cause abnormalities in the circulatory system, disruption of the functioning of the liver, kidneys of the mother and baby. The composition increases the risk of postpartum hemorrhage in women.

How the drug came about

The history of the development of Nurofen began with the discovery of ibuprofen, the main active ingredient of this product. In the 60s of the 20th century, three scientists in London began developing a product that would be similar to aspirin, which was popular at that time, but at the same time it would be a milder remedy. And they succeeded - they came up with and brought to life ibuprofen, which became a real breakthrough. With its help, it was possible to easily relieve various types of pain and inflammation.

In 1969, ibuprofen went on the public market and was available only by prescription. And this state of affairs continued until 1983, when it finally became over-the-counter and available to everyone. It was then that the drug Nurofen was created, which today is known to the vast majority of people and occupies the top lines of the TOP sales leaders. It is used as an analgesic for various types of pain.

In 1998, another breakthrough - they began producing a special children's product under the trade name Nurofen. This drug was intended to relieve symptoms of pain and fever in babies. Moreover, its undoubted advantage was the fact that it could be used in babies aged 3 months. And today it remains one of the few most frequently chosen remedies by young mothers.

But the developers of the drug did not stop there - today Nurofen continues to improve. In search of even more effective options for its operation and reducing the period of onset of its action, fundamentally new solutions were identified. This is how Nurofen Express and other types of the drug appeared.

How to use

The difference in methods of application depends directly on the form of release. So, if we are talking about Nurofen tablets, then the instructions will be as follows. Tablet versions and the drug in capsules should be used orally after meals. Using it before meals is not recommended, because... may lead to disorders in the digestive tract.

Capsules and tablets must be swallowed whole - they should not be chewed, stirred or crushed in any other way. The drug should be taken with a small amount of liquid.

Effervescent options should first be dissolved in ½ glass of water - it should be clean and still water. You need to drink this solution within 10-15 minutes.

Tablets that are coated with a sweet coating, i.e. Nurofen Express, Nurofen Plus, contain 40 mg of saccharin. This means that people suffering from diabetes should be careful with them.

To get rid of pain of all kinds, adults and children should use 1 tablet of 200 mg 3-4 times a day. If you need a faster effect, it is recommended to use 400 mg 3 times a day. Tablets with a longer action should be used 2 times a day, 300 mg.

For children 6-12 years old, a dosage of 200 mg is prescribed no more than 4 times a day. Adult Nurofen is allowed to be given to children who weigh at least 20 kg. For all other children, only children's options should be used. The interval between uses is allowed at least 6 hours between doses. Long-acting tablets should be taken no more than once every 12 hours.

The following recommendations should be followed when taking Nurofen for children. The suspension must be poured into a special measuring spoon or syringe included with the product packaging. The bottle must be shaken before use. Children who are already 12 years old should use 1.5-15 ml of the product 3 times a day to reduce their temperature, with 8 hours between doses.

You can use the following scheme for using the suspension in children:

Babies aged 3-6 months should be given 50 mg, i.e. 2.5 ml of syrup three times a day;
It is recommended to give children 6-12 months of age 50 mg (2.5 ml) 3-4 times a day;
Children 1-3 years old are given 100 mg, i.e. 5 ml of the product three times a day;
Children 4-6 years old are given 150 mg (7.5 ml) three times a day;
Children 7-9 years old are given 200 mg (10 ml) three times a day;
Children 10-12 years old are prescribed 300 mg (15 ml) three times a day.

These are the maximum permissible options for children, which should not be exceeded. You can reduce it, but you shouldn’t work to increase it. After vaccinations, you can give the product to your baby once. If the need continues, you can repeat again after 6 hours. But you should not give more than 5 ml of the product after vaccination.

You can replace the syrup with suppositories. They will be especially good if the child does not want to drink the syrup or is vomiting. In addition, candles provide a faster effect, because... enter directly into the intestines, where they are immediately resorbed and absorbed into the blood.

For children 3-9 months old, put 1 candle three times a day. For older children - from 9 months to 2 years, 1 suppository is administered 4 times, maintaining a 6-hour interval between doses. If necessary, children over 1 year old can be given another additional suppository, but not earlier than 6 hours after the first. Candles can be used for no longer than 3 days.

Children's Nurofen can be used in children with diabetes, because they have no sugar.

Nurofen gel can only be used in adults and children over 12 years of age. It should be applied topically, only to the site of inflammation, for example, to the joints. For one application, you need to squeeze out a 4-10 cm strip from the tube and, using gentle movements, lightly massaging, rub the gel into the skin until it is completely absorbed.

It is allowed to use the gel 4 times a day. Breaks between procedures must be at least 4 hours. The gel can be used for 2 weeks; if the condition does not improve, you should definitely consult a doctor.

After applying the gel, you must rinse your hands well and wipe dry. If the gel gets on your eyes or mouth, rinse them thoroughly with running water. Nurofen in gel form should not be used on skin areas with wounds or deep cuts.

Drug substitutes: structural analogues and other drugs with the same effect

There are many substitutes for Nurofen (tablets). Analogs have identical active ingredients. Pay attention to the ibuprofen content. After all, it may differ. Therefore, the method of application and dosage will be different. The most popular analogues include Advil, Ibuprofen, Brufen, Burana, Mig, Dolgit and others.

You can also replace the medicine with many other analgesics with an antipyretic effect: Aspirin, Citramon, Paracetamol, Panadol, Analgin and so on. All analogues of the drug must be selected by a doctor after taking into account all individual characteristics. Please note that medications based on acetylsalicylic acid can only be given to children over 16 years of age. They are in no way suitable for treating younger patients.

Description of the drug

Nurofen, the instructions for use of which are as simple and clear as possible, is a drug from a popular group of non-steroidal drugs that are anti-inflammatory in nature. It has several actions at once:

Pain reliever;
Relieving inflammation;
Relieves fever in various diseases.

It is worth understanding that Nurofen is a drug that fights symptoms. It has no effect on the underlying disease. It is used to combat pain, inflammatory processes in tissues and manifestations of fever.

It is often prescribed for:

ARVI and influenza;
Pain in the head and teeth;
Painful manifestations in muscles and joints.

It is also often recommended to be used for menstrual pain, attacks of neuralgia and myalgia, and also for problems with ligaments during injury.

Today there are many drugs that are produced under this name. Among them:

Nurofen Active;
Nurofen Ultracap;
Nurofen Forte;
Nurofen Plus and others.

All of them are essentially just different commercial versions of the same drug. They have similar indications for use, instructions for use, etc. Only they can be in different release forms, which leads to different dosage selections.

To get rid of pain in teeth and menstrual problems, you can use various options for the remedy. If the pain is severe, you should choose a drug where the concentration of ibuprofen will be maximum, etc.

Doctors' recommendations

Doctors give only positive reviews about the drug Nurofen. Pediatricians say that this drug has long been one of the most popular, accessible and effective. The medicine almost never has a negative effect. The most common side effect from it is allergies.

Doctors also report that the drug is often taken independently. If a child suddenly has a fever or a headache, then this is quite justified. But if the symptom reappears, you should consult a doctor. After all, the drug is essentially symptomatic. It relieves the symptoms of the disease, but does not eliminate its cause. Only an experienced doctor can determine what exactly is happening to the child. After the examination, the doctor will prescribe medications that can be combined with Nurofen.

The instructions indicate that the tablets are not recommended for use simultaneously with aspirin or other non-steroidal anti-inflammatory drugs. The medication is not compatible with some antibiotics. Diuretic compounds and sorbents reduce the effectiveness of antipyretic and analgesic agents. Pediatricians do not recommend increasing the dose of the drug on their own or giving children the drug in tablets. This type of medication involves taking it whole (without preliminary crushing). Young children are not always able to swallow a pill.