Troxerutin: gel and tablets description, how it works

As the manufacturer reports in the instructions for use, the pharmaceutical drug Troxerutin has a wide range of therapeutic effects. What it helps with: its main purpose is to solve problems caused by impaired venous outflow of blood. The vessels most often affected are the vessels of the lower extremities, the veins of the anus and the lower part of the rectum. Based on the results of tests and practical experience, it has been established that when used correctly, Troxerutin reduces pain symptoms and prevents the progression of the pathological process.

Comparative characteristics of drugs

To ensure that there is no doubt that the drugs are analogues, their characteristics can be compared.
How are Troxerutin and Troxevasin similar:

What are the similarities between the drugs Description Active ingredient Troxerutin. Release form: 2% gel and capsules. Duration of treatment Depends on the severity of the process. Usually the capsules are taken for at least 5–7 weeks (the daily dosage is determined by the doctor), the gel is applied up to 2–3 times a day. Properties They have a pronounced anti-inflammatory, angioprotective and capillary protective effect. Relieves itching, swelling, pain. They increase the elasticity of vascular walls, prevent the formation of blood clots, and enhance metabolic processes in the walls of blood vessels. When prescribed: In the initial stages and with severe venous insufficiency, for the treatment of phlebitis, superficial thrombophlebitis, varicose ulcers, varicose dermatitis, hemorrhoids, including in pregnant women. Contraindications The use of medications is not recommended for renal and liver failure, lactose and galactose intolerance

Prescribe with caution to patients with gastrointestinal diseases, under 15 years of age, with sensitivity to components, and pregnant women in the 1st trimester. Side effects It is possible to develop skin allergic reactions - urticaria, dermatitis.

No negative effects of the active substance on the fetus during pregnancy have been identified. But since all information is limited to individual cases of prescription, without clinical trials, the attending physician assumes full responsibility for the consequences.

What is the difference between Troxerutin and Troxevasin:

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Description of the drug

Troxerutin gel is used both for the treatment of venous pathologies and for their prevention. Many patients complain to phlebologists about discomfort in their legs that occurs in the evening. They are worried about nagging pain, swelling in the ankle area, and the appearance of spider veins and spider veins.

These are the first symptoms of diseases of the vascular system, the intensity of which will constantly increase. If you use Troxerutin at the initial stage of the pathology, you can prevent the development of irreversible complications.

A course of use of venotonic helps to avoid serious surgical intervention.

What does Troxerutin gel help with:

• high permeability of capillary walls;
• low tone of the veins of the lower extremities;
• disruption of metabolic processes in the venous walls;
• inflammatory swelling due to excessive secretion of exudate from blood and lymphatic vessels.

The active ingredient of the drug is able to strengthen vascular walls and restore their optimal permeability. It prevents platelet aggregation, blood clot formation, and blockage of blood vessels. The venotonic effect of Troxerutin gel has found application in proctology. It is recommended for patients diagnosed with external hemorrhoids, inflammation of the hemorrhoids.

The drug is often prescribed to people whose work requires constant standing. These are sellers, hairdressers, pharmacists, waiters. They are at risk of developing venous insufficiency and varicose veins. Course use of Troxerutin gel 2-3 times a year helps to avoid the occurrence of dangerous diseases.

Clinical and pharmacological group

Gel (cream, ointment) Troxerutin is included in the group of angioprotectors and microcirculation correctors. Pharmacological properties allow it to be classified as an anti-inflammatory and decongestant drug.

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pharmachologic effect

The gel and capsules (tablets) contain troxerutin, which has phleboprotective activity. The pharmacological effect of the drug is identical to rutin from the vitamin P group. The active ingredient takes part in redox reactions occurring in the human body.

It inhibits the enzyme hyaluronidase, which blocks the biosynthesis of hyaluronic acid. By reducing the fragility and permeability of capillaries, it increases the density of blood vessels.

Troxerutin gel is also characterized by the following therapeutic properties:

• preventing the release of blood cells through the walls of capillaries and small veins;
• reduction of plasma fluid exudation;
• relief of inflammatory processes occurring in the walls of veins;
• limiting the adsorption of platelets to the walls of blood vessels, reducing their lumen.

Troxerutin prevents the formation of free radicals. It is these compounds that are responsible for cell damage and further tissue destruction. At the initial stage of the pathology, doctors prescribe the drug as monotherapy. This helps reduce the pharmacological burden on the human body.

Improving lymphatic drainage function allows the drug to be used at a severe stage of the disease. In this case, it is combined with Troxerutin capsules or medications with diosmin.

Release form and composition

Troxerutin gel is produced by many Russian and foreign pharmaceutical factories. On pharmacy shelves you can find a drug from the Bulgarian manufacturer Vramed and the Russian manufacturer Biokhimik. It is packaged in sealed aluminum tubes of 40.0 g.

Secondary packaging is a cardboard box with instructions for use attached. The gel is a transparent jelly-like substance with a yellowish tint and no odor. According to pharmacological standards, the presence of foreign particles is not allowed.

The composition of Troxerutin gel includes the following ingredients:

• troxerutin;
• methylparaben;
• carbopol;
• triethanolamine;
• trilon B;
• distilled water.

Auxiliary components are used not only to form a gel base.
Some of them have weak antiseptic activity. The absence of substances with a greasy consistency ensures rapid absorption of the ingredients by the skin. Due to accelerated transepidermal absorption, troxerutin is detected in blood vessels within 30 minutes.

Patients often ask doctors what is best to use to treat chronic venous insufficiency. Preparations with diosmin have a better effect than Troxerutin gel (ointment). They stop the inflammatory process in the walls of blood vessels much faster.

Diosmin also does not provoke side effects even with long-term use.

Terms and conditions of storage

The drug must be stored in places protected from direct sunlight. Temperature indicators differ among manufacturers and range from 8-25°C.

Shelf life is 24 months, reduced to 3 weeks after opening the sealed tube. Do not use an external remedy for treatment if a foreign odor appears or the consistency changes.

Pharmacodynamics

The active substance of the drug, having P-vitamin activity, is involved in the redox processes of the body. "Troxerutin" is able to block hyaluronidase, thereby exerting a stabilizing effect on hyaluronic acid in cell membranes. By reducing the level of permeability and fragility of capillaries, it effectively increases their tone. Under the influence of “Troxerutin”, the density of the vascular wall increases. As a result, the exudation of the liquid part of the plasma decreases and the diapedesis of blood cells decreases. By limiting the adhesion of platelets to the surface of the vascular wall, Troxerutin reduces inflammation in it. Having a wide range of therapeutic effects, Troxerutin is recommended as a single drug. Considering that the medicine can effectively stop inflammation, have a positive effect on the tone of veins and improve lymphatic drainage function, as well as microcirculation, Troxerutin, prescribed without additional drugs, can significantly reduce the level of drug load on the patient’s body.

Drug interactions

According to the instructions for use, Troxerutin tablets can be combined with Regulon, but before this you need to consult a specialist. Most often, these drugs do not have any effect on mutual effectiveness, but there are situations when women experience brown discharge that frightens them. That is why, to eliminate possible risks, it is best to consult a doctor.

Due to the composition of the Troxerutin tablet, it is possible, and sometimes even necessary, to be combined with ascorbic acid. A similar combination is presented in a drug called “Ascorutin”, in which ascorbic acid and rutin act as active active elements. Vitamin C, when combined with rutin, has a complex effect on the patient’s body; these substances perfectly complement each other, while restoring defects in the weakened venous wall, the functioning of the valves, blood stagnation in the affected veins, protecting them.

It is best to find out about the combination of “Troxerutin” with “Lucetam” from your doctor, since “Lucetam” is a nootropic drug that contains piracetam as an active substance. This component, in turn, increases the effect of indirect anticoagulants. That is why simultaneous use is possible, however, if the required dosage is violated, negative side effects may develop.

Instructions for use of Troxerutin

Troxerutin capsules: instructions for use

Troxerutin tablets are taken with meals, swallowed whole. In accordance with the standard treatment regimen, 0.9 grams of troxerutin per day is prescribed orally (one tablet three times a day). If the medicine is used as a maintenance agent, it should be taken one capsule twice a day.

The full course of treatment lasts from 3 to 4 weeks. The advisability of longer-term use is determined individually by the attending physician.

Instructions for drugs from different manufacturers may differ slightly.

So, for example, Troxerutin Zentiva capsules are taken according to the scheme described above, and Troxerutin Vramed capsules in the initial stages of treatment are taken one 2 or 3 times a day, after which they switch to maintenance treatment, which involves taking one capsule per day.

Treatment with Troxerutin-MIC begins with intravenous or intramuscular administration of 0.5 grams of troxerutin in the form of an injection solution. The procedures are repeated every other day, and it is recommended to give at least 5 injections of the drug.

After this, they switch to oral dosage forms. The starting dose is 0.6-0.9 grams per day, the maintenance dose is 0.3 grams per day. The course of treatment is from 2 to 4 weeks, unless there are other indications.

Gel Troxerutin: instructions for use

Troxerutin ointment is a product for external use. It should be applied twice a day (in the morning and evening), in a thin layer, evenly distributed on the skin of the painful area from the distal (most distant) to the proximal (closest) part of it and lightly massaging until completely absorbed.

The dose is determined by the area of ​​the damaged surface, but should not exceed 1-2 grams (this corresponds to approximately 3-4 cm of gel). After applying the medication, an occlusive dressing can be applied to the affected area of ​​skin.

Unlike capsules, the treatment regimen using gels from different manufacturers is no different, that is, the instructions for using Troxerutin Vramed ointment are identical to the instructions, for example, Troxerutin Vetprom.

Features of application

Treatment with the drug must be carried out over a long period, since its effectiveness does not appear immediately, but only several weeks after the start of its use.

Troxerutin capsules should be taken with meals, swallowing them whole. It is impossible to violate the integrity of the tablet, since the medicinal substance contained in it, penetrating into the gastrointestinal tract, will be influenced by hydrochloric acid and gastric juice, and its properties will be lost. If the capsule is in a shell, then thanks to it the medicine will not lose its effectiveness, since it acts as a protection for the active substance until it completely dissolves and penetrates the blood. The dosage of "Troxerutin" must be strictly observed.

You need to take one capsule three times a day, that is, the daily dose is nine hundred milligrams. When taking the drug for preventive purposes, you need to take one capsule twice a day. The duration of their use is approximately three to four weeks. If such a need arises, the therapeutic course can be extended, but before doing so, you should consult your doctor.

Contraindications for use

Contraindications in this case are the presence of the following ailments:

• Problems with skin integrity.
• Infected wounds with suppuration.
• The presence of discharge from an open wound.
• Intolerance to the active components of the drug.

The use of this medication in children is not recommended due to the lack of necessary information regarding the safety of using the gel during the treatment of patients of a younger age category. "Troxerutin" is also not recommended for long-term use by persons with a history of liver dysfunction. This drug should also not be used in the treatment of edema caused by impaired functioning of the kidneys and heart. In this case, the remedy will not have the necessary therapeutic effect.

Contraindications

Absolute contraindications to the use of Troxerutin capsules:

• chronic form of gastritis and peptic ulcer of the stomach/duodenum in the acute phase;
• lactase deficiency, lactose intolerance or glucose-galactose malabsorption syndrome;
• first trimester of pregnancy and lactation period;
• age under 18 years;
• individual intolerance to troxerutin or excipients included in the drug.

Troxerutin capsules should be used with caution in patients with chronic renal failure. Contraindications for the use of Troxerutin gel are: children and adolescents under 15 years of age, damage to the integrity of the skin and hypersensitivity to components

When using the gel for a long time, patients with renal failure should be careful.

Contraindications for the use of Troxerutin gel are: children and adolescents under 15 years of age, damage to the integrity of the skin and hypersensitivity to components

When using the gel for a long time, patients with renal failure should be careful.

Specifics of use during pregnancy

The drug in tablet form is not recommended for use in the first trimester of pregnancy. But in the second and third trimesters, it can be prescribed by the attending physician if the benefits expected for the mother are significantly higher than the possible risks for the development of the fetus.

In gel form, the drug can be used during pregnancy after consulting a doctor.

If there is a need to take the drug in capsule form during the lactation period, you should first consult with your doctor and clarify the problem of possible cessation of breastfeeding. But in the form of a gel, the drug can be used without interrupting breastfeeding, since it has low systemic absorption. Here are some recommendations for the use of Troxerutin tablets and ointment.

What is the difference between Troxerutin and Troxevasin?

Patients are often interested in the question of which drug is better to use - Troxevasin or Troxerutin? This question can be answered very simply: the fact is that these funds are completely identical. They differ only in the company that produces them, as well as in price. But in their influence and side effects they are similar. That is why, if it is not possible to purchase the expensive drug “Troxevasin”, you can limit yourself to its cheap analogue – “Troxerutin”.

Troxerutin contraindications for use

The manufacturers of the product noted that it should not be used by people who are allergic to the components present in the drug.

• Troxerutin should not be used by patients who complain of insufficiency of lactase synthesis, galactosemia, or glucose-galactose malabsorption.
• People who have impaired kidney function should not use the product for a long time.
• The doctor must definitely reconsider the course of treatment for patients who develop edema caused by impaired renal or heart function. In such situations, the remedy will not have a positive effect.
• Troxerutin tablets are never prescribed to children under 15 years of age. This requirement is due to the following: an insufficient number of studies have been conducted, the product has been poorly tested for safety and effectiveness.

Prohibited for children under 15

• The drug, available in the form of an ointment (gel), cannot be used by adolescents under 18 years of age.
• The ointment should not be used to treat areas where there is suppuration, infected or open wounds.
• Troxerutin gel has the same pH level as human skin. Therefore, as a rule, it does not increase skin sensitivity, dermatitis or irritation does not occur.
• The use of the drug does not have a negative effect on human concentration. Consequently, a patient using the drug can drive a car, engage in sports or work that requires high attention.

Troxerutin: important recommendations

Before you start using the product, be sure to study the following recommendations:

• Troxerutin gel is applied only to the area that is not damaged.
• If the patient has deep vein blood clots, superficial thrombophlebitis and takes Troxerutin in tablet form , the doctor may prescribe medications that have an antithrombotic or anti-inflammatory effect.
• This drug cannot get rid of edema that occurs due to improper functioning of the kidneys, heart or liver. In such cases, the doctor prescribes other drugs.
• After unintentionally taking the drug, a person may complain of nausea, vomiting, burning in the mouth, and excessive salivation. In such a situation, it is urgent to rinse the stomach and mouth. If necessary, the doctor prescribes symptomatic therapy.
• If the gel gets into the eyes, mucous membranes or an open wound, irritation may occur in the form of burning, tear formation, and pain. In this situation, the eyes and skin should be immediately rinsed using an isotonic sodium chloride solution or distilled water. This must be done until the severity of the reaction decreases or disappears completely.

Avoid contact with eyes

• You cannot increase the dosage and duration of therapy indicated in the instructions if a person is treating himself.
• The gel should be used together with ascorbic acid to enhance the effect during treatment with the drug.
• Pregnant women can use the gel, but before doing so, you should consult a doctor.
• The product is allowed to be used by women who are breastfeeding.
• It is allowed to combine Troxerutin with other types of medications, but only on the recommendation of a doctor.
• After opening the package of gel, it must be used for one month. The drug must be stored in a closed place where sunlight does not penetrate and children cannot reach it. It is also necessary to observe the temperature regime for storing the drug. It is no more than +25°C.

Some tips for using the drug

Experts advise the drug as quite safe and effective. It is prescribed to people who are overweight, as well as women who often wear high heels. A number of doctors recommend using this drug in the first stages of the development of varicose veins for those women who work in professions where they need to be constantly on their feet: salespeople, hairdressers, advertising agents, etc.

Experts give the following advice regarding the use of the drug:

• to achieve the fastest possible effect, you need to combine Troxerutin capsules with the gel of the same name from the same production;
• thrombophlebitis in mild forms can be treated with various herbs, for example, hazel, rowan, licorice root, horse chestnut, sweet clover;
• If there are no contraindications, the drug can be used simultaneously with vitamin C, due to which its effectiveness will significantly increase, and the manifestation of side symptoms will be prevented. What is the price of Troxerutin tablets?

Manufacturer

The capsules are produced by the pharmaceutical company Sopharma. Its production facilities and office are located in Sofia, Bulgaria.

Analogs

The most popular analogue of Troxerutin is Troxevasin. Many people are interested in Troxevasin or Troxerutin, which is better? Most phlebologists agree that the drugs are equally effective: they are available in similar dosage forms, have the same active ingredient and list of contraindications and side effects. You can see reviews online about the higher effectiveness of Troxevasin, but doctors believe that the effectiveness of therapy and the bioavailability of the components are the same for both drugs.

• Other analogues of the drug according to the active substance and mechanism of action:
• Venoruton (370-660 rubles). A highly effective drug from the group of microcirculation correctors and angioprotectors. It has a high cost and is available in the form of gel and tablets. The active ingredient is rutoside (300 mg in 1 tablet). The course of treatment is no more than 4 weeks.
• Phlebodia 600 (510-1790 rubles). The drug is in the form of tablets based on diosmin, which has pronounced angioprotective properties. Used to treat chronic venous insufficiency of the peripheral blood system, hemorrhoids, and varicose veins. Cannot be used in the 1st trimester of pregnancy and childhood.
• Venarus (460-940 rubles). Venotonic and venoprotective medicine. Copes well with trophic ulcers on the lower extremities, spasms, convulsive syndrome and swelling.

Replacement of the prescribed drug is allowed only after agreement with the attending physician.

Troxerutin composition

The active ingredient of the drug, troxerutin, is a flavonoid, a derivative of rutin of semi-synthetic origin. Rutin is a substance with P-vitamin properties, first obtained from an extract of fragrant rue (a wild plant widespread in Southern Europe and on the coasts of Crimea). According to its pharmacological properties, troxerutin is classified as a corrector of the movement of blood and lymph in the microvasculature and an angioprotector. The drug is used primarily to increase the tone of the venous walls, to prevent platelet fusion in patients at risk for the development of thrombosis and thromboembolism (patients over 50 years of age, people with chronic heart disease, patients after surgical treatment).

• Therapeutic effect of Troxerutin:
• increases the elasticity of venous walls;
• reduces platelet aggregation;
• removes excess fluid, relieving edema syndrome (often found in chronic venous insufficiency);
• exhibits antioxidant properties (removes toxins, waste, cleanses blood vessels).

The use of Troxerutin for hemorrhoids is widespread, since the drug has a pronounced anti-inflammatory effect and reduces the degree of inflammation in the vessels and veins of the hemorrhoidal plexus. The drug is indicated for use in elderly and senile people, adolescents, and pregnant women to restore vascular tone in case of hematomas, contusions and bruises.

Release form

The medicine is available in two dosage forms. Troxerutin gel is used for topical use.

Despite the minimal list of side effects, it cannot be used without a doctor’s prescription: first you need to get a consultation and find out what Troxerutin ointment helps with (by ointment we mean a drug in the form of a gel). The gel may be indicated for pain and swelling of the lower extremities associated with varicose veins or other pathologies of the veins (including deep veins). The remedy helps well with tired legs in people whose work involves prolonged standing or who are professionally involved in sports.

Troxerutin tablets are used in cases where systemic correction of microcirculation in blood vessels is required.

• The concentration of the active substance is:
• in 1 tablet – 300 mg;
• in 1 g of gel – 20 mg.

The shelf life of the tablets is 5 years from the date indicated on the packaging. The gel can be stored at room temperature for 2 years.

How does Troxerutin work?

The therapeutic effect of the drug is largely due to its ability to block the action of hyaluronidase. The main function of this enzyme is to break down acidic mucopolysaccharides that make up tissues. As a result of suppression of hyaluronidase, the concentration of hyaluronic acid increases, which is an indispensable participant in many physiological processes, incl. it has a beneficial effect on the elasticity and degree of permeability of capillary membranes.

As the instructions for use dictate, the drug Troxerutin can have both a local effect (in the form of an ointment) and a systemic effect (capsule form of Troxerutin).

What does Troxerutin ointment help with and what are the capsules used for:

• normalizes the filling of veins with blood, prevents stagnation of venous blood and the leakage of fluid from blood vessels into the surrounding tissues, which would lead to the formation of edema;
• eliminates the symptoms of diseases characterized by obstructed venous outflow - relieves spastic pain, heaviness in the legs, pain from hemorrhoids, relieves cramps of the calf muscles at night, stops anal bleeding;
• increases the elasticity of red blood cells, making it easier for them to pass through narrow capillaries, ultimately reducing blood viscosity and the risk of developing serious consequences for the body;
• relieves the symptom complex that manifests itself during inflammation of the vascular walls - pain in the affected area, redness of the skin, fever, chills, painful compaction, swelling of the limb;
• reduces platelet adhesion, their reaction to violation of the integrity of the vascular wall (formation of a blood clot, hematoma);
• has a vasodilating effect, inhibiting blood clotting;
• ensures sufficient oxygen supply to cells;
• reduces the load on blood vessels, prevents the destruction of the internal walls (by trapping free radicals), promotes their restoration, and prevents the destruction of the vein frame.

The medicine can be taken at the initial stage of the disease, at the height of the disease and in the later stages. Analyzing the effectiveness of Troxerutin - the benefits and harms of its use, it is necessary to note the breadth of its therapeutic action, which allows it to be used as a single drug in the treatment of vascular pathology (CVI), thereby reducing the drug burden on the patient. This explains the great popularity of the drug.

Practice shows that Troxerutin is the most commonly prescribed ointment for veins. Another significant advantage of Troxerutin is its low price (the instructions for use recommend taking ascorbic acid tablets at the same time - thereby increasing the effectiveness of treating capillary lesions).

The drug is not toxic, but with repeated use it can cause allergic reactions and provoke gastrointestinal symptoms. This is a disadvantage of this drug.

For proper use and prevention of adverse events, it is important to know the mechanisms of action and pharmacokinetics of the drug. The instructions indicate that troxerutin ointment is well absorbed by the surface layer, but taking capsules (after absorption from the gastrointestinal tract and passing physiological barriers) provides an order of magnitude higher concentration of the active element in the blood.

Troxerutin ointment slowly overcomes the skin barrier, accumulating in the tissues. In the middle layer of the skin, located under the epidermis, the active substance appears after 30 minutes, in the subcutaneous fat - after 2-5 hours. After taking the capsule, the peak concentration in the blood is recorded after 2 hours.

The level of Troxerutin sufficient to produce a therapeutic effect is maintained for another 8 hours. The drug undergoes enterohepatic recirculation, which prolongs the pharmacological effect (the second peak is after 30 hours). The end products of metabolism (11% in their original form) are excreted within a day.

Pharmacological properties

Troxerutin Vramed has an effective therapeutic effect. It provides medicinal properties:

• anti-inflammatory;
• decongestants;
• venotonic;
• antioxidant;
• angioprotective.

Pharmacodynamics and pharmacokinetics

The gel is quickly absorbed from the surface of the skin, penetrates into the deep layers of the dermis and selectively accumulates in the endothelium of the veins.
It also penetrates deeply into the subendothelial layers of the venous walls. Troxerutin ointment has an antioxidant effect, preventing damage to cell membranes.

The antioxidant effect is the ability to eliminate or reduce the oxidative properties of oxygen, blocking lipid peroxidation, protecting the endothelium from oxidative reactions produced by hydroxyl free agents.

It has a cytoprotective effect, which manifests itself in reducing the tendency of red blood cells to stick together, increasing their resistance to deformation and limiting the release of inflammatory mediators.

The substance prolongs the time of venous filling, normalizes the functioning of venous and arterial valves. Reduces blood flow to the skin in a lying position, normalizes microcirculation and capillary refill.

The drug improves tissue trophism, eliminates and prevents pathological changes in vascular tissues and restores blood circulation.

Troxerutin penetrates into the vessels of the subcutaneous tissue; with prolonged use of the ointment, systemic effects are possible.

Side effects of Troxerutin capsules

Most often, patients tolerate Troxerutin therapy well. The instructions for use contain a list of side effects that may occur when taken orally.

Gastrointestinal tract

In the digestive system, side effects such as thirst, frequent attacks of nausea and vomiting, lack of appetite, and bowel disorders (constipation or diarrhea) are possible.

Blood-forming organs

The hematopoietic system often responds to treatment with Troxerutin with side effects. With a decrease in red blood cell adhesion, oxygen filling of tissues is reduced. As a result, more ozone compounds are produced and the veins protrude closer to the surface of the skin.

central nervous system

From the nervous system, headaches, dizziness, and psychomotor overexcitement are possible.

Allergies

If patients are intolerant to the components of the drug, they may experience a skin rash, a feeling of heat on the face, hives, itching, and redness.

Impact on the ability to operate machinery

The medicine has no effect on the speed of psychomotor reactions, so during the treatment period you can drive a car and complex machinery.

Indications for use

The above pharmacological effects of the drug make it possible to use the drug as part of the treatment of venous insufficiency. In addition, indications for its use include ailments such as trophic ulcers, along with complex treatment of diseases that provoke an increase in vascular permeability. "Troxerutin" allows you to effectively and quickly cope with bruises, contusions, hematomas and sprains.

It should also be used for the following purposes:

• Elimination of manifestations of chronic forms of venous insufficiency in the form of edema, pain, feelings of fatigue and heaviness, the development of seizures, and the formation of vascular patterns.
• Complex therapy of varicose veins with superficial thrombophlebitis, phlebothrombosis and postphlebilitic syndrome.
• For capillary toxicosis, which develops against the background of influenza, scarlet fever and measles. The indications of "Troxerutin" can be clarified in the annotation.
• Against the background of hemorrhagic diathesis, accompanied by a violation of normal capillary permeability, and with diabetic retinopathy.
• The drug is also used in the treatment of trophic ulcers with dermatitis, which is provoked by varicose veins.

• Treatment of soft tissue bruises, which are accompanied by the formation of edema and hematomas.
• The medicine is used during the recovery period after surgery as an auxiliary element of treatment in order to provide a preventive effect.

The Troxerutin instructions confirm all this.

When is Troxerutin used?

This medicine is used in the following cases:

• with rosacea;
• with varicose veins, including its presence in pregnant women;
• with venous insufficiency;
• with thrombophlebitis;
• with ulcers of a trophic nature;
• for post-traumatic hematomas and edema;
• for hemorrhoidal cones;

• for bruises, abrasions and bruises;
• with capillary toxicosis of a hemorrhagic nature;
• with spider veins;
• as a prophylactic against varicose veins and after vein surgery;
• for diabetic micro- and retinoangiopathy.

Clinical trials of the drug

According to the results of clinical studies conducted at the 1st City Clinical Hospital named after. N.I. Pirogov Moscow, the optimal duration of treatment with Troxerutin for patients with chronic venous insufficiency, as well as in order to eliminate the symptoms of venous stagnation, is a month. In this case, it is recommended to accompany the effectiveness of the drug with the use of compression products (specially created medical knitwear or elastic bandages). The effectiveness of the drug has also been confirmed by clinical studies at the Russian Federal State Institution State Research Center for Coloproctology. As experts have established, Troxerutin has the most pronounced therapeutic effect in patients with thrombosis of external hemorrhoids. After a ten-day course of treatment with the drug, patients noted a complete disappearance or a significant decrease in the intensity of pain. In addition, the medicine helped stop anal bleeding and reduce the size of thrombosed hemorrhoids. At the same time, it turned out that Troxerutin does not have a significant therapeutic effect on symptoms such as itching and burning in the anus in patients with acute hemorrhoids.

Side effects

The manufacturer, in the instructions for Troxerutin, reports that the drug is well tolerated, warning that in some cases (extremely rarely) patients experienced:

• local immune (allergic) reactions;
• headaches, sleep problems;
• vomiting, gastralgia, increased gas formation, diarrhea, burning in the epigastric region, defects of the gastrointestinal mucosa;
• sudden rush of blood to the face;
• the appearance of spots on the body (erythema, other skin rashes), abnormal redness, itching of the skin.

pharmachologic effect

The drug has a venotonic, anti-inflammatory effect. The characteristics of the drug include anti-edematous and antioxidant effects. It has been proven to have an angioprotective effect.

The activity of the drug is based on the properties of the rutin derivative it contains - the substance troxerutin. This bioflavonoid has a positive effect through P-vitamin-activating activity. Due to these properties, the substance actively takes part in redox processes and stabilization of hyaluronic acid located in cell membranes.

The end result is a significant reduction in their permeability and an improvement in overall tone. The product also has a pronounced anti-inflammatory effect. Due to the action of the active substance, it reduces the inflammation occurring in the vascular wall.

The active substance has a pronounced antioxidant effect, preventing the oxidation of important substances, including ascorbic acid.

It is recommended to use Troxerutin together with ascorbic acid in cases of diseases accompanied by increased permeability of capillaries and blood vessels. This recommendation is based on the fact that when used together, the effect of the active ingredients of the drug is enhanced.

The drug in gel form is characterized by good absorption from the skin. If the patient uses the drug in capsule form (orally), then good absorption from the human digestive system has been noted. It is excreted by the body through the kidneys and bile. Withdrawal from the body occurs within twenty-four hours after use.

After entering the digestive tract, the metabolites of the substance enter the liver. As a result of decomposition, two substances are formed. The required concentration of the active substance in the blood plasma is maintained for at least two hours.

Troxerutin reviews

Anna, Biysk:

“Troxerutin is a cheap substitute for the popular Troxevasin. It was prescribed to me after surgery to remove a fibrous tumor of the breast to reduce swelling at the site of the sutures. I smeared the skin around the seam 2 times a day for 10 days. I don’t know if this drug is to blame, but the stitches healed very well and quickly, and all the bruises at the incision site disappeared within 3-4 days after the operation. I didn’t like the aluminum tube, which cracked over time and all the gel began to come out. Otherwise, there are no complaints."

Margarita, Rostov-on-Don:

“I needed Troxerutin gel after an unsuccessful injection, when a very painful and dense lump formed at the injection site. The doctor said to apply the gel 2-3 times a day. In the first days I didn’t see any results, but after a week the lump became very small, after which it completely resolved.”

Karina, Pskov:

“I regularly buy medications for veins for my mother, since she has chronic varicose veins in her legs. Troxerutin is one of the most favorite medicines in our medicine cabinet: it helps quickly, is inexpensive, and does not cause side effects. I recommend it to anyone who suffers from heaviness in the legs associated with venous diseases.”

Instructions for use

For systemic pathologies of the hematopoietic system, treatment should begin with the injection of Troxerutin-MIC solution. The daily dosage of the drug is 0.5 g. The drug must be injected into a vein or muscle, slowly, over 10 days with an interval of 48 hours. From the tenth day of therapy, the patient is transferred to oral dosage forms, if necessary.

Troxerutin tablets (capsules)

The tablets must be taken with meals 3 times a day for 2-4 weeks. The daily dosage of the drug indicated in the instructions is 0.9 g, but in practice, most vascular surgeons and phlebologists increase this figure to 1.5 g (5 tablets). This is due to the rather low bioavailability of synthetic rutin derivatives, but you cannot increase the dosage on your own due to the high risk of developing systemic side effects: allergic reactions, abdominal pain, exacerbation of chronic pathologies of the digestive tract.

Ointment (gel)

The gel should be applied to painful areas 2 times a day. A single dosage of the drug should not exceed 2 g - this is about 3.5 cm of gel. It is necessary to use the product until the symptoms disappear completely, but no more than 7-10 days in a row.

What is Troxerutin gel used for? To eliminate fatigue in the legs or combat edema syndrome, the product is applied once a day after a cool foot bath (in the evening).

What kind of gel

Troxerutin gel is an effective over-the-counter drug. It has anti-edematous, analgesic, anti-inflammatory and venotonic effects. It is used for trophic lesions of the lower leg and heaviness of the legs. The drug belongs to the group of angioprotectors and phlebotonics.

It relieves pain, eliminates disorders caused by venous insufficiency, and improves blood circulation in the epidermis. Increases the elasticity of blood vessels.

The drug is available at 20 mg/g, 35 g in tubes.

Which drug to choose

To summarize, we can say: in terms of the mechanism of action and properties, Troxerutin and Troxevasin are identical. The basis of the medicine is troxerutin; slight differences in the composition of additional components are possible, this depends on the formula registered by the pharmaceutical company. But usually they are very minor and do not affect the effectiveness and medicinal properties.

In different forms (gel or capsules), Troxevasin and Troxerutin can equally improve the condition of varicose vessels, especially in combination with other drugs. To choose the form and duration of use, consultation with a phlebologist is required, because it is quite difficult to independently assess the severity of varicose veins. In addition, all medications, even for external use, have side effects.

When choosing one of the two drugs, you can be guided by the price - domestic analogues of Troxerutin are much cheaper than imported Troxevasin. During the course (and it is quite long when treating varicose veins), this will save money.

Dosage form. Manufacturers. Compound

Three Bulgarian pharmaceutical companies produce the drug Troxerutin: Vetprom, Vramed and Sopharma; two Czech ones - “Lechiva” and “Zentiva”; two Russian ones – “Ozon” and “Biokhimik”. The drug is available in the form of a gel for topical use (Sopharma, Vramed, Biokhimik, Ozon) and capsules for oral administration (Sopharma, Zentiva, Lechiva). One gram of gel contains twenty milligrams of troxerutin, the drug is sold in tubes of 25 grams (Biokhimik) and 40 grams (Ozon, Vramed, Vetprom, Sopharma). Capsules are available in packs of thirty pieces (Lechiva, Zentiva) and fifty pieces (Vramed, Sopharma), each unit contains three hundred milligrams of troxerutin.

Pharmacological properties

Gel and Troxerutin capsules belong to the pharmacological group of medications that have an antispasmodic effect. They relax the smooth muscles of blood vessels and internal organs.

The active component of the drug takes an active part in oxidative and reduction processes, blocking the processes of peroxidation of fats, adrenaline and ascorbic acid.

The medicine is accompanied by P-vitamin activity and helps stimulate elimination processes. Can be used during pregnancy (only as prescribed by a medical specialist). Tablets/gel do not have a teratogenic effect and, accordingly, do not have a negative effect on the intrauterine development of the fetus.

When taken orally, the capsules are well absorbed from the digestive tract. The maximum content of the active component is observed 2-8 hours after administration. This time period is determined by the patient’s condition and physiological characteristics. The second peak is detected after 30 hours. During the day, the active component leaves the body. Approximately 80% is eliminated through the liver, the rest leaves the body through the kidneys.

Troxerutin: analogues

The modern pharmacological market offers the buyer a large number of drugs that are analogues in the pharmacological group.
These are products based on such active ingredients as: pentoxifylline, heparin, rutin, diosmin, etc. Sources:

1. https://www.sciencedirect.com/
2. https://www.semanticscholar.org/topic/troxerutin/430824
3. https://www.drugs.com/international/troxerutin.html
4. https://cyberleninka.ru/article/n/primenenie-trokserutina-pri-hronicheskoy-venoznoy-nedostatochnosti
5. https://www.thegoodscentscompany.com/data/rw1804511.html
6. https://cyberleninka.ru/article/n/primenenie-topicheskih-sredstv-v-lechenii-simptomov-hronicheskoy-venoznoy-nedostatochnosti

For an accurate diagnosis, contact a specialist.

Troxerutin, instructions for use

Let's start with the fact that the drug Troxerutin is available in various forms. For example, in the form of a gel or in tablet form. Here is a brief description and instructions for both.

Troxerutin-gel (ointment), instructions for use

Troxerutin in gel form is intended exclusively for application to the skin.
It is applied to problem areas of the skin in a fairly thin layer. Then rub the gel with light massaging movements until completely absorbed. This usually takes a few minutes. However, it is not recommended to apply the gel to damaged skin areas, as well as mucous membranes. You should carefully monitor the correct use of the drug. The manufacturer strongly recommends washing your hands with soap after rubbing in the gel. At the same time, getting it into the eyes and mucous membranes is not allowed.

Typically, the gel is prescribed to be rubbed into the skin with painful areas two to three times a day.

The gel can be used in conjunction with Troxerutin in capsule form.

The duration of treatment depends on the severity of the condition and disease and should be determined by the attending physician. The average treatment period is about three weeks.

Troxerutin, capsules (tablets), instructions for use

Troxerutin in capsule form is produced for internal use. It should be used orally. The medicine is swallowed whole; it should not be opened or chewed. Each capsule is washed down with water or other liquid in sufficient quantity. There are recommendations to take the product after meals.

It is recommended to use the drug in accordance with the doctor's prescription. The timing of the appointment is also determined by the attending physician. Usually the drug is used until the symptoms of the disease cease. Severe symptoms usually disappear 2-3 weeks after the start of treatment.

Reviews

Galina, Kislovodsk

The doctor recommended that I use Troxerutin gel during the postoperative period. A large and painful hematoma formed at the site of the scar. The drug eliminated it within 3 days of use.

Tatiana, Saratov

I work as a cook, so by the evening my legs are swollen and very painful. The phlebologist prescribed Troxerutin capsules and gel. After a month of treatment, the bulging veins and night cramps disappeared. Now I use medications to prevent varicose veins.

Troxerutin gel (review) from 50 rub.

Overall

4.6

• Efficiency
• Price
• Safety
• Availability

Pros

• Efficiency
• Price
• Safety
• Does not leave marks on clothes or skin
• No odor or stickiness

Cons

• Uncomfortable tube

Advantages of the medication

The undeniable advantage of the drug is that it has a wide range of effects.

The drug is characterized by the presence of effects such as:

• antioxidant;
• angioprotective;
• venotonic;
• decongestant;

With the help of the medication, the inflammatory process is eliminated as quickly as possible. Troxerutin is an active participant in oxidative and reduction processes. With the help of the medicine, vascular walls are strengthened, blood microcirculation is improved, and capillary fragility and permeability are reduced.

Thanks to the universal effect of Troxerutin, the tone of venous vessels is improved and the intensity of inflammatory processes is reduced. The drug is characterized by the absence of toxic effects, which makes it possible for its use by a wide range of patients.

Contraindications of the drug

Manufacturers of the drug note that it is prohibited to use Troxerutin in all forms if an individual intolerance (allergy) to any of the components of the drug occurs.

Troxerutin should not be prescribed orally if there is insufficiency of lactase synthesis, galactosemia, or glucose-galactose malabsorption.

Long-term use of the drug is not recommended for patients with impaired renal function.

It is worth reviewing the treatment plan in patients with edema caused by improper functioning of the liver, kidneys and heart. In such cases, the drug will not be effective.

Troxerutin capsules are not allowed to be prescribed for the treatment of children under 15 years of age. This requirement is due to the lack of research into the safety and effectiveness of the drug for this group of consumers.

Troxevasin for hemorrhoids during pregnancy

Hemorrhoids are an extremely unpleasant disease of the venous vessels of the anus. This may be due to congenital and acquired weakness of the vascular wall, as well as frequent constipation caused by poor diet or a sedentary lifestyle.

The active substance of the drug - troxerutin - penetrates the choroid of hemorrhoidal veins, improves tissue nutrition, prevents the formation of blood clots, strengthens the valve system and vascular tone. As a result of the therapeutic effect, hemorrhoids become smaller, venous blood flow improves, and congestion in the vessels disappears. Signs and symptoms of the inflammatory process gradually stop, swelling decreases significantly.

To consolidate the effect of troxevasin in hemorrhoids, it is recommended to carry out preventive measures for dilation of hemorrhoidal veins: treatment of constipation, eating foods rich in fiber, vegetables, fruits; if you have a sedentary lifestyle, periodic gymnastic exercises should be included in your daily routine, massage is indicated, walking in the fresh air air.

Possible overdose

There is no evidence that there was an overdose when using the gel externally. If a burning sensation or severe itching is felt after application, the medicine should be washed off immediately with warm water and soap.

If a large amount of medication is accidentally ingested, an overdose may occur. In this case, you need to focus your efforts on removing the drug from the body as quickly as possible. To do this, you need to drink a large amount of water to provoke the mechanical removal of stomach contents (vomiting). After this, you need to take the sorbents according to the instructions for them.

If a child accidentally takes a large amount of medicine, you should definitely call an ambulance. When indicated, doctors prescribe peritoneal dialysis.

The medicine can be stored for two years after manufacture. This information is indicated on the packaging. After the expiration date, the medicine must be disposed of. Recommended storage temperature is no more than 25 degrees. Should be stored in a place inaccessible to children.

List of analogs of Troxerutin gel

The drug has a combined composition - 1 gram contains 20 mg of troxerutin and 30 mg of indomethacin.

The gel has an analgesic effect, reduces swelling, protects capillaries, tones veins and blood vessels, and reduces temperature in inflamed areas.

Sold in 45 g tubes, prices start from 40 - 270 rubles. (depending on the manufacturer).

Troxevasin NEO

A three-component drug and a frequently used analogue of Troxerutin gel.

A well-known drug on the pharmaceutical market, it helps reduce blood clots (in complex therapy), has a venotonic effect, improves the regeneration of affected vessels, and also acts as an angioprotector.

Presented in a 40 gram package, the price starts from 200 rubles.

Venolife

A product with a three-component composition, 1 gram contains: 20 mg of troxerutin, 50 mg of dexpanthenol and 2.5 mg of sodium heparin.

When applied, the gel has an anti-inflammatory effect, reduces capillary fragility, reduces congestion in the veins and the formation of blood clots, eliminates swelling by increasing microcirculation in tissues.

The analogue is presented in tubes of 40 and 100 g, the price starts from 365 and 794 rubles (according to weight).

Heparin ointment

The product is not an analogue of the main active ingredient; it contains three active ingredients per 1 gram - 100 IU of heparin, 40 mg of benzocaine, 0.8 mg of benzyl nicotinate.

The product reduces pain, fights blood clots, and has an anti-inflammatory effect.

25 gram tubes are available for sale and cost from 40 rubles.

How to take Troxerutin gel

The gel is applied twice a day to clean skin. A small amount of the medicine should be applied in a thin layer to the damaged areas. You cannot massage, rub or apply compresses and warming bandages. After application, you should wash your hands with soap. The treatment time is determined by the doctor depending on the dynamics of changes.

The structure of the gel is light, so it is quickly absorbed and does not leave greasy marks on the body and clothes, unlike similar fatty ointments.

Taking the drug for diabetes mellitus

During diabetes, the risk of developing cardiovascular pathologies increases, so it is recommended to use drugs to thin the blood and strengthen blood vessels.

Mechanism of action of the drug

Troxerutin gel is prescribed for inflammatory processes, swelling and pain in the lower extremities with varicose veins. In addition, the gel has a pronounced therapeutic effect, toning venous vessels, coping with trophic-type ulcers and heaviness in the legs due to varicose veins. This medication is an angioprotector, having similar effectiveness to vitamin P.

Troxerutin gel helps relieve spasms in venous vessels, relaxing their smooth muscles. It also helps to increase the overall tone in the veins, reducing their distensibility. This allows you to remove congestion in the blood vessels, eliminate swelling and get rid of inflammation.

When penetrated internally, the drug stimulates metabolic processes in tissue structures without causing mutations or disturbances in the development of the fetus. This is an important aspect during pregnancy and lactation.

Note!

When applied to the affected areas, the active substances are not able to pass into the systemic bloodstream, but Troxerutin penetrates well into the adjacent tissue structures.

Circulatory disorders

Circulatory disorders due to vascular damage, blood clots in the veins or mechanical injuries are often accompanied by swelling, inflammation and the formation of hematomas. Troxerutin gel, which is available in a convenient form, does not cause side effects and quickly penetrates the skin, helps to cope with these symptoms.

Composition of the gel Troxerutin 2%

The active ingredient is a rutin derivative (flavonoid) troxerutin. Excipients are:

• sodium hydroxide solution with a concentration of 30%;
• carbomer 940;
• benzalkonium chloride;
• purified water;
• edetate disodium.

The gel has a uniform structure, is transparent, and can acquire a yellowish and greenish-yellow tint.

Troxerutin produces the following effects:

• angioprotective;
• decongestant;
• venotonic;
• anti-inflammatory.

This ingredient also has a P-vitamin effect, stabilizes cell membranes, reduces fragility and permeability of capillaries, relieves the feeling of heaviness in the legs, and improves trophism in tissues.

Indications for use of Troxerutin gel, contraindications and side effects

The drug in question is prescribed for the treatment of the following pathologies:

• venous insufficiency;
• superficial thrombophlebitis;
• varicose and pre-varicose syndrome;
• phlebitis;
• pain of traumatic origin, for example, after a sprain, dislocation, contusion;
• tonic muscle cramps;
• periphlebitis;
• hematoma;
• leg ulcers;
• diabetic microangiopathy;
• post-traumatic swelling of soft tissues;
• phlebothrombosis;
• postthrombotic syndrome;
• complex treatment of inflammation of hemorrhoids when they fall out;
• static heaviness in the legs;
• trophic skin lesions;
• dermatitis;
• hemorrhagic diathesis, accompanied by increased permeability of capillary walls;
• retinopathy;
• complications and their prevention after surgical operations on veins;
• negative concomitant vascular events after radiation therapy.

The only contraindication to the use of Troxerutin gel is considered to be increased sensitivity and the likelihood of developing allergic reactions to one of the components of the product. Caution should also be exercised if long-term use of the drug is necessary in patients with impaired renal function.

It is worth noting that the local medication is ineffective against swelling caused by deterioration of the cardiovascular system, liver and kidneys.

The medicine is well tolerated, usually without side effects. Negative symptoms may appear in case of overdose in the form of local allergic reactions - urticaria, hyperemia, itching, rash, dermatitis.

Application of Troxerutin gel

• The drug should be gently rubbed into the affected areas 2 times a day. In rare cases, its use in the form of occlusive dressings and compresses is allowed.
• The duration of treatment depends on the disease requiring therapy and its stage.
• For hematomas and bruises, Troxerutin gel is recommended to be applied for no longer than 14 days, until the damaged vessels are completely restored and external manifestations on the skin disappear.

Gel Troxerutin for face

An interesting feature of the drug under consideration is its ability to block the action of hyaluronidase, a substance that destroys hyaluronic acid and reduces skin elasticity. Therefore, many women use Troxerutin as an anti-aging, moisturizing and decongestant for the face.

The easiest way to use is to rub a small amount of gel into the skin, including under the eyes, after washing your face in the evening. According to reviews, visible results will be noticeable within 3 days.

Source: https://WomanAdvice.ru/gel-trokserutin

Use of the drug for pregnant and lactating women

Troxevasin tablets are strictly contraindicated in the first 13 weeks of pregnancy.
In the second and third cases, Troxevasin is allowed, but not exceeding the average dosage.

In the first trimester, taking Troxevasin tablets is allowed, only the risk of drug failure outweighs the side effects.

It crosses the placenta, but the effect on the fetus has not yet been proven. This is especially important in the first trimester, since the formation of all vital organs and systems occurs.

It is able to pass through breast milk to the baby. Breastfeeding is not a contraindication to the use of Troxevasin tablets.

In severe cases, it is better to use Troxevasin externally , because it does not have such a systemic effect on the body.

Action of the medicine

Troxerutin is a venotonic and also an angioprotector. Thanks to these properties of the medicine, the fastest possible fight against hemorrhoids is ensured. The drug is characterized by the presence of anti-inflammatory and antioxidant properties.

The action of the drug is aimed at reducing capillary permeability. With regular use of the medication, an increase in the tone of the venous walls is observed.

Troxerutin has a positive effect on metabolic processes in vascular walls. The drug strengthens blood vessels, which promotes rapid healing of hemorrhoids. By reducing the exudation of blood cells and plasma, the active substance significantly reduces swelling in the area of ​​the inflammatory process.

Which is better Troxevasin or Troxerutin

The active substance of Troxerutin and Troxevasin is troxerutin. Therefore, the mechanism of action, effectiveness, indications, contraindications and side effects of the drugs are almost identical.

The drugs differ slightly in auxiliary components, as well as in price and manufacturer. Troxevasin, depending on the pharmaceutical company, can be produced in Iceland or Bulgaria. Troxerutin is produced in Belarus, the Czech Republic, Russia, and Bulgaria. The price will depend on the manufacturer. So, for example, Troxerutin released in Russia will cost less than Troxevasin.

It is practically impossible to choose the best remedy, because the therapeutic effect of both occurs due to the same substance. At the same time, it is worth taking into account individual characteristics, so Troxevasin may be more suitable for some, and Troxerutin for others. Your doctor will help you choose the most suitable option.

When not to use the medicine

According to the manufacturers of this drug, it cannot be used, regardless of the release form, in the following cases:

• any form of individual intolerance, allergic reaction to one of the constituent substances of the drug;
• the oral form is contraindicated in cases of lactase synthesis disorders, galactosemia and other disorders of glucose and lactase absorption;
• Long-term use of the drug is contraindicated if the patient suffers from any impairment of the kidneys. If swelling occurs after taking the medicine, you need to consult a doctor to adjust the treatment regimen;
• troxerutin is not prescribed orally until the age of 15, since there are no studies regarding the safety of the drug;
• the drug in gel form is not used in the treatment of patients under adult age.

In most situations, the product does not provoke any irritation and does not cause dermatitis. Oral use does not cause impairment of attention. Therefore, the medication can be used by those patients who drive vehicles.

Is it possible to have troxevasin during pregnancy?

In the early stages of pregnancy, you should avoid taking any medications. Starting from the twelfth week of gestation, that is, from the second to third trimester inclusive, the use of troxevasin is possible.

During the first weeks of pregnancy, while taking medications is not recommended, you can use standard preventive measures aimed at reducing the load on the venous system and improving venotonus.

• Try to stand in one place less: if possible, sit down or walk around, do not let the blood stagnate in the veins.
• When lying down, it will be useful to place a pillow or cushion under your legs to facilitate the outflow of venous blood from the lower extremities.
• If long walking or standing is unavoidable, use compression hosiery, which can be purchased at pharmacies: special tights for varicose veins will evenly distribute the load throughout the venous system of the lower extremities and will not allow individual venous areas to bulge outward.
• Try to prevent swelling of the feet: eliminate the consumption of salt and chemical preservatives.
• Eat more vegetables and fruits - a nutritious diet rich in vitamins and valuable microelements will strengthen the vascular walls and maintain venous tone.

Cost of medicine. Analogues

The price of Troxerutin gel depends on the manufacturer. Thus, the average cost of a tube of medicine produced by Russian pharmaceutical companies and Biokhimik is 25-26 rubles (while Ozon produces the gel in tubes of forty grams, and Biokhimik - twenty-five grams each). The drug from Bulgarian, Vramed and Sopharma will cost an average of 31-33 rubles per forty-gram tube. Medicine in capsules is much more expensive. Bulgarian and Sopharma sell it at an average price of 194-197 rubles per fifty capsules, while Czech and Zentiva set an average price of 258-261 rubles per thirty capsules.

The drug "Troxerutin" has structural analogues (drugs with the same active ingredient). These are the drugs “Troxevasin” and “Troxevenol”. The effect of their use will be the same as when using Troxerutin, but they cost several times more.

Prices for drug analogues

The main analogue is Troxevasin. Troxevasin gel will cost you on average from 2017 to 276 rubles. The price for Troxevasin in capsules will be about 350 rubles for 50 capsules in a package and about 650 rubles for a pack of 100 capsules.

The second, also popular analogue, is the drug “Lioton 1000”. It is administered in the form of a gel. The price for a 30 g tube will be 340 rubles, for a larger package - 100 g - you will have to pay about 800 rubles.

Troxerutin, manufacturing companies

The drug Troxerutin is produced by various manufacturers. The most well-known names of this drug are as follows:

1. Troxerutin Vetprom;
2. Troxerutin Vramed;
3. Troxerutin Biokhimik, Saransk;
4. Troxerutin-MIC;
5. Troxerutin, Ozone.

You can find a lot of information on the Internet that the effect of the drug Troxerutin from different manufacturers may differ. But no reliable information on this issue was found.

It should be noted that the dose of the active substance in all of the above drugs is practically the same (the differences concern only the drug Troxerutin-MIC in capsules), so one should not expect large differences in effectiveness from different manufacturers.

Analogues and compatibility with other drugs

The drug Troxerutin is the most inexpensive drug in its group: the difference in cost with Troxevasin is 3–4 times. Other well-known angioprotectors: Ascorutin, Actovegin, Detralex, Phlebodia, Venarus, Thromboless. The cost of purchasing Troxerutin gel will be 40-60 rubles, capsules - 250-270 rubles.

The instructions do not contain data on the nuances of interaction with other medications, but it is known that the drug enhances the effect of ascorbic acid. For this reason, the attending physician may prescribe ascorbic acid as an excipient to enhance the beneficial effects of Troxerutin.

There are known cases of combining the use of Troxerutin and horse chestnut, which together have a powerful preventive effect. The rationality of taking several drugs with similar effects together with Troxerutin is determined by the treating phlebologist.

Doctors' opinion

Reviews from doctors about Troxerutin gel are positive. During the entire period of use of the drug, no side effects were observed.

Patients during the treatment of chronic venous insufficiency speak very positively about the medication. Positive dynamics are noted several days after the start of therapy. The drug has excellent tolerability, since the gel is water-based, which does not interfere with the natural physiological properties of the skin. The gel has a similar pH to the skin, which prevents allergic reactions and various irritations. A pronounced therapeutic effect can be expected in the treatment of the first stages of varicose veins, but in advanced cases radical treatment methods cannot be avoided.

Nikolay Evgenievich, phlebologist

Indications

Reducing capillary fragility, membrane-stimulating effects, anti-inflammatory effects, and antioxidant effects are the main positive results of using Troxerutin. After long-term use, a decrease in exudative inflammation localized in the tissues of the vascular walls is also observed.

Reasons for prescribing Troxerutin:

• chronic venous insufficiency;
• post-thrombic conditions;
• postphlebitic syndrome;
• angiopathy of diabetic nature.

Capsules are prescribed for the rapid rehabilitation of patients after operations involving the removal of dilated veins, as well as after undergoing sclerotherapy. Troxerutin is able to relieve pain caused by toxic muscle cramps and as a result of dislocations.

The gel can also be used as an emergency aid when hematomas appear, which, after applying the product, cover smaller volumes of the skin (usually used as a compress from a gauze bandage with the applied gel).

Additional therapeutic effect: ointment and capsules can alleviate the clinical course of hemorrhoids. The active substance eliminates rectal inflammation and further reduces the risk of bleeding.

Similar drugs

There are a large number of drugs in pharmacy chains that have a similar effect. The following drugs have similar substances:

• Troxevenol;
• Troxevasin.

A popular analogue of Troxerutin is Troxevasin gel. The active substance in the drug is troxerutin. The concentration of the active element is similar - 2 grams. It is difficult to say which drug will be more effective, since they have a similar effect.

Pharmaceutical companies also offer drugs that have a similar effect, but differ in active substances:

• Lyoton 1000;
• Agapurin;
• Vasocket.

Among the listed drugs, Lyoton can be distinguished. It is most often prescribed by doctors for various diseases of the venous or vascular system. The medicine contains heparin, which is an anticoagulant. It has antithrombotic and anti-inflammatory effects. Used to treat the same diseases as Troxerutin.

The drug is produced by various manufacturing companies. This should be taken into account, since, according to patient reviews, the effect of drugs from different companies may differ. Although, according to the companies that produce the products, the effect of taking them is similar, since the composition contains an identical amount of the active substance.

How the drug “works”

After starting to use capsules and gel, swelling and inflammation quickly decrease, permeability and fragility of capillaries are significantly reduced. The drug exhibits a pronounced angioprotective effect - normalizes the condition of vascular walls, improves microcirculation processes, normalizes capillary tone, and restores blood flow.

Troxerutin actively reduces exudative inflammation on the walls of blood vessels, while platelets do not adhere to their surface - which reduces the formation of blood clots. After starting therapy, the feeling of heaviness in the legs quickly disappears, trophism improves, and swelling goes away.

Pharmacological effects

According to the instructions for “Troxerutin”, the therapeutic effect of the drug is determined by the active components included in its composition, which contribute to the following series of positive effects:

• Thanks to the anti-inflammatory effect, the development of inflammation in the veins and soft tissues is prevented and eliminated.
• Tissue swelling is prevented. The release form of "Troxerutin" does not affect the effectiveness.

• The tonic effect causes an increase in the tone of the veins, increasing their elasticity and normalizing permeability. As a result, blood flow to the heart area improves, which eliminates the occurrence of congestion in the lower extremities.
• The angioprotective nature of the effect leads to strengthening of the vascular walls, preventing the influence of negative factors. As a result, the vessels can withstand intense stress while continuing to function normally.
• The antioxidant effect eliminates free radicals that can damage the walls of blood vessels, which significantly increases their permeability.

The use of the product leads to a positive therapeutic effect on the capillaries, reducing their permeability, as well as fragility and strengthening the walls. In addition, inflammatory reactions are eliminated, platelet adhesion is prevented and microcirculation is normalized

It is important to know for sure what the ointment helps with before starting treatment. It is recommended to consult your doctor first

There are a lot of reviews about “Troxerutin”.

Reviews of Troxerutin in gel form

For the treatment of varicose veins

Larisa, 40 years old, Nizhny Novgorod “I started using Troxerutin after another exacerbation of varicose veins. The fact is that at work you have to spend a lot of time on your feet. Troxerutin gel helped me very quickly. Before that, I used a more expensive product, but I didn’t notice any difference in the effect.”

For bruises

Anna, 22 years old, St. Petersburg “It just so happens that I am a person who is not known for good coordination. As a result, I often get bruises on my body. It all doesn't look very aesthetically pleasing. But I found a product that helps me - this is Troxerutin gel. Thanks to it, bruises go away much faster.”

For hemorrhoids

Lyubov, 32 years old, Kazan “During pregnancy, I faced a delicate problem - hemorrhoids. I tried everything: from suppositories to ointments. But nothing brought the desired effect. On the recommendation of a proctologist, I began using Troxerutin in gel form to treat my illness. As they explained to me, hemorrhoids are caused by dilated veins due to constipation. Therefore, Troxerutin is an effective remedy for hemorrhoids.

It is not recommended to use this drug in tablets for pregnant women. But even in gel form, it turned out to be an effective remedy for alleviating my condition.”

Troxerutin in capsule form

Maria, 45 years old, Moscow “I have been suffering from vein disease in my legs for a long time. Doctors diagnosed her with varicose veins. From time to time I experience exacerbations of my condition. They prescribed me troxerutin tablets. I used it for about three weeks until the pain went away. I am very pleased with the effect of the drug.”

Ivan, 54 years old, Omsk “Recently I have been suffering from pain in my veins. I went to the doctor, who prescribed me Troxerutin tablets along with the gel. I took the pills until the pain stopped. Now from time to time I use Troxerutin gel. In principle, I’m pleased with the effect.”

Negative reactions

Typically, in most situations the drug is well tolerated by patients. But sometimes, in rare cases, certain negative reactions may still appear; you should familiarize yourself with them in more detail. When using Troxerutin in the form of drops, the following reactions may occur:

• intestinal disorders of various types;
• attacks of migraines and headaches;
• hyperemia of the epidermis.

Such manifestations are very rare.

The use of Troxerutin in gel form may cause the following complications:

• the appearance of irritation on the skin;
• skin rash;
• itching;
• dermatitis in the places where the gel is applied.

Typically, such side effects are rare and are caused by improper use of the drug or individual intolerance to the active components.

Interaction of Troxevasin with alcohol

This medicine should not be taken simultaneously with alcohol:

• But men can use it 18 hours before use, and women can use it 24 hours before use. After drinking alcoholic beverages, it is recommended to take tablets no earlier than 10 hours later. This is due to the process of metabolism of Troxevasin in the liver. After all, the metabolism of alcohol passes through the hepatobiliary system. If you layer two products at the same time, there will be an increased load on the liver.
• When taken simultaneously, it may increase the risk of developing ulcers , and in case of existing liver diseases, liver failure may occur. Some people experience tinnitus and headaches, as well as dizziness.
• If you do take it, you should give up Troxevasin and alcohol in the next 8 hours. You also need to drink a large amount of clean, boiled water.
• , alcoholic beverages should be avoided during administration

Analogues of Troxevasin

Consider the list of known substitutes for Troxevasin:

• Detralex is a drug that has not only a venotonic effect, but also angioprotective. The active ingredients of this product are Diosmin in the amount of 450 mg, as well as Hesperidin 50 mg. There are also excipients, the main ones being gelatin and starch. The tablets are packaged in cardboard packaging and blisters. One of them contains only 15 pieces. Packs may contain 30 or 60 capsules. Detralex tablets are pink, under the shell you can see the main drug, which is white-yellow. Can be used at any stage of the process. As a preoperative preparation on vessels, most often the venous system of the lower extremities. Symptomatic treatment of hemorrhoids. The main route of elimination of tablets is the intestines. Half the concentration of the product is eliminated from the body after about 10 hours. The average duration of treatment is about 3 months. Detralex has many advantages. First of all, it has a rapid venotonic effect; treatment can also be started during pregnancy. This is a big plus, since at this time the body experiences the greatest difficulty and stress. One of the disadvantages of the drug is the fairly high cost, provided that the course is quite long. The cost of the tablets is about 900 rubles.
• Troxerutin is a cheaper analogue of Troxevasin tablets. It contains the original Troxerutin, as well as a small amount of excipients. It is completely analogous in composition. The drug is available in the form of gel and capsules. The packaging is made of cardboard and contains 50 capsules. Troxerutin can have a more effective effect in improving the trophism of surrounding tissues. In addition, it removes harmful metabolic products from cells. This drug is quickly eliminated from the body; within a day it is completely eliminated. Also, its price is much higher than its well-known analogues. Usually it does not exceed 300 rubles per pack of capsules. One of the effective specific actions is the restoration of trophism and tissue microcirculation, the cause of which is diabetic retinopathy. But it needs to be taken comprehensively; it cannot get rid of the pathology on its own.
• Venarus is another well-known analogue of Troxevasin. The drug is not only a venotonic agent, but also one that improves microcirculation. One of its most important effects is angioprotective. It contains 450 mg. Diosmin and 50 mg. Hesperidina. The tablets are orange-pink in color. Their structure is two-layer, which can be seen if you break the tablet. But they need to be consumed entirely, because... the shell has protective properties against the contents of the stomach and is less irritating to it. One lozenge contains 10 or 15 tablets. The amount of lozenge may vary. Liver transformation occurs in the liver, and after 10 hours it is excreted in feces or urine. Tablets are taken on average 1-2 times a day. The regime between doses must be strictly maintained to ensure a constant concentration of the drug in the body. It can also be used for medicinal purposes by pregnant women. There is no evidence of an effect on the fetus. Venarus is an analogue of the French drug Detralex. Produced in Russia. The cost of the Russian analogue is several times less. On average, a package of 30 tablets costs 300 rubles.
• Another popular analogue of Troxevasin is Phlebodia 600 . The tablet contains the active ingredient Diosmin in an amount of 600 mg. Their shell is film, contains auxiliary substances, does not affect the condition of the body. Pink round tablets in a blister of 15 pieces. The advantage of taking it is the frequency of use; the dosage regimen is 1 tablet per day. Use it before meals, preferably on an empty stomach. This is necessary so that the maximum dose of the drug occurs during a period of high physical activity, and therefore, load on the veins. The course of treatment prescribed by a doctor is usually up to 2 months. During pregnancy, or more precisely, the first trimester, use is prohibited, and also not for children under 18 years of age. The cost of the tablets is about 500 rubles.

Detralex

Phlebodia 600

Troxerutin

Venarus