Nitroxoline tablets: indications for use. When suffering from a bladder infection, patients resort to searching for effective medications that can relieve excruciating pain and other unpleasant symptoms in the lower abdomen. Patients who have repeatedly encountered cystitis know for sure what the drug “Nitroxoline” is and what it helps with. The following provides complete information about the drug and how to use it for cystitis.
The drug "Nitroxoline"
pharmachologic effect
Nitroxolin shows activity against gram -positive and gram -negative bacteria (hay wand, enterococci, streptococci, causative agents of gonorrhea and diphtheria, Klebsiella, salmonella, staphylococci, shigella, enterobacter), vaginal trichomonas, mycobacteria of tuberculosis, dermatophytes, and dermatophytes, and mushrooms of the family of candidate and plesy and plesy and plesy and plesy and pleseni Some deep pathogens mycoses.
After oral administration, Nitroxoline is highly absorbed from the gastrointestinal tract. This drug is excreted unchanged by the kidneys. High concentrations of the drug are detected in the urine.
Cross-drug interactions
The use of Nitroxoline simultaneously with tetracycline antibiotics and Nystatin leads to an increase in the therapeutic effect of both drugs. Because of this, it is recommended to reduce the dose of the latter drugs by half.
The use of Nitroxoline simultaneously with tetracycline antibiotics leads to an increase in the therapeutic effect of both drugs.
The simultaneous use of uroantiseptics with nitrofurans is not recommended, as this may lead to increased adverse reactions on the central nervous system.
During treatment with Netroxoline, you should stop taking medications containing magnesium, as they reduce the absorption effect and effectiveness of the former.
The uroantiseptic can reduce the absorption of drugs based on nalidixic acid.
Indications for use
What does Nitroxoline help with? Tablets are prescribed:
- prevention of infectious complications during diagnostic and therapeutic procedures (catheterization, cystoscopy) in the postoperative period during surgical interventions on the kidneys and genitourinary tract;
- infectious and inflammatory diseases mainly of the genitourinary tract (including pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or prostate carcinoma), caused by microorganisms sensitive to nitroxoline.
Purpose
The substance Nitroxoline is part of a drug belonging to the antibacterial group. It is active in the fight against several types of fungus and mycobacteria. The drug has a selective inhibitory effect on bacterial DNA.
Nitroxoline is prescribed for the treatment of acute and chronic inflammatory processes caused by infections of the genitourinary tract and kidneys:
- cystitis;
- pyelonephritis;
- urethritis;
- prostatitis.
It is advisable to use the drug for infections against which the substance is active. In addition, the drug is prescribed for prophylactic purposes after surgical interventions, cytological sampling of material and installation of a catheter for urinary disorders.
Instructions for use
Nitroxoline tablets are taken orally during meals or immediately after meals. Adults are prescribed 100 mg 4 times a day. In severe cases, the single dose is increased to 150-200 mg, the frequency of use is 4 times a day.
The maximum permissible daily dose is 800 mg. The duration of treatment depends on the type and severity of the disease. On average, the course of therapy is 2-3 weeks. If there is a need for repeated courses, 2-week breaks are taken between them.
Children over 5 years old are prescribed 50-100 mg 4 times a day, children under 5 years old - no more than 200 mg per day. Duration of treatment is 2-3 weeks. For chronic urinary tract infections, the drug is prescribed in courses of 2 weeks with a 2-week break.
By
Nitroxoline and pregnancy
Clinical studies have not been conducted on pregnant women, so the effect of the drug on mother and baby has not been studied. The manufacturer is required to provide precautionary measures in the instructions for use.
Nitroxoline has been considered for many years one of the best drugs for the treatment of inflammatory processes of the kidneys and urinary tract; it is also used during pregnancy, when the disease itself poses a threat to the life of the mother and child. The exception is the first trimester and the period before childbirth, when the fetus is especially sensitive to any external influence.
Side effects
When using Nitroxoline tablets, side effects from various organs and systems may develop:
- Allergic reactions - skin rash, itching.
- Nervous system - ataxia (gait disturbance), paresthesia (impaired skin sensitivity), polyneuropathy (metabolic disorders in the nerves), headache, isolated cases of the development of optic neuritis have been described.
- Cardiovascular system – tachycardia (increased heart rate).
- Digestive system - nausea, vomiting, loss of appetite, rarely a functional disorder of the liver may develop.
The need to stop taking Nitroxoline tablets is determined by the doctor, depending on the nature and severity of the side effects.
Contraindications and side effects
In most cases, patients tolerate treatment of infectious diseases of the urinary system using Nitroxoline well.
Undesirable effects from taking these pills are rare.
Among them are:
- disturbances in the gastrointestinal tract (vomiting, nausea, diarrhea, abdominal discomfort);
- allergic reactions in the form of rash, itching, urticaria, angioedema;
- bronchial asthma;
- decrease in the concentration of uric acid and transaminases in the blood serum;
- deterioration or complete loss of appetite;
- allergic thrombocytopenia (decreased platelet concentration in peripheral blood);
- liver dysfunction;
- tachycardia - increased heart rate to 90 beats per minute or more;
- periodic staining of urine in a bright orange color;
- ataxia - inconsistency in the movements of various muscles;
- headache;
- paresthesia - disorders of skin sensitivity, manifested by sudden sensations of tingling, burning and crawling;
- polyneuropathy - damage to the peripheral nervous system;
- inflammation of the optic nerve (develops with prolonged use of the drug).
When taking Nitroxoline, it is very important to take into account the existing contraindications. The drug is not prescribed if the patient has:
- hereditary disorders of carbohydrate metabolism;
- allergies to nitroxoline and other components included in the drug;
- individual intolerance to acetylsalicylic acid and quinoline drugs;
- cataracts - a disease manifested by clouding of the lens of the eye;
- severe renal failure, characterized by a decrease in creatinine clearance to 0.33 ml/min and below;
- lack of glucose-6-phosphate dehydrogenase in the body;
- severe liver diseases;
- oliguria - a pathology characterized by a decrease in the amount of urine excreted by the kidneys;
- inflammatory damage to peripheral nerves;
- anuria - a malfunction of the body, accompanied by a cessation of urine flow into the bladder.
In addition, Nitroxoline is contraindicated for pregnant women, mothers during breastfeeding and children under five years of age.
special instructions
Nitroxoline, as a rule, is well tolerated if you strictly follow the prescribed dosage and do not combine the use of these tablets with other undesirable drugs. As for the reception features, the following points should be taken into account:
- People with renal failure need to use the tablets very carefully to avoid cumulation (accumulation) of the drug.
- During treatment, the color of the urine may become bright yellow.
- It is not recommended to drink alcohol together with Nitroxoline, so as not to burden the liver.
- Long-term use of the drug stimulates the development of optic neuritis, so the course of treatment should be determined strictly by a doctor.
During treatment, urine may turn saffron yellow. When taking Nitroxoline, it is possible to develop side effects from the central nervous system (dizziness, headache), therefore, during the course of treatment, it is recommended to be careful when driving vehicles and performing potentially dangerous work that requires increased concentration and immediate psychomotor reactions.
Reviews about Nitroxoline
As reviews of Nitroxoline show, many patients use this drug for cystitis. It should be noted that this remedy is well known to women. However, some of them are interested in Nitroxoline tablets - what they are for and how to take the medicine correctly.
In most cases, reviews of Nitroxoline for cystitis confirm the fairly high effectiveness of these tablets. But there are also reports when the medicine did not help quickly eliminate the unpleasant symptoms of the disease.
There are especially frequent discussions about how to take Nitroxoline during pregnancy, although its use is contraindicated during this period. However, sometimes women wonder whether these pills can be taken during pregnancy, and what the consequences might be?
Sometimes this medicine is prescribed to children, but most parents, after carefully studying the annotation, doubt whether patients can take the pills at an early age. They also find out whether Nitroxoline is an antibiotic or not, and at what age is it prescribed for cystitis?
Experts recommend that before starting to take these tablets, get tested and find out how sensitive the pathogen microorganisms are to the effects of this antibiotic. Thanks to this, you can understand how effective this treatment will be.
Until patients receive test results, taking antibiotics is not recommended. But you can use local antimicrobial agents, not forgetting to drink plenty of fluids, for example, herbal decoctions.
In addition, you should discuss possible replacement options with your doctor, and if this drug is not suitable for treatment, find out how you can quickly find an effective treatment. Only with this approach can we hope that health will be restored fully and in a short time.
Nitroxoline tablets for cystitis
Nitroxoline is a modern drug from the group of oxyquinolines, which has a powerful antimicrobial effect. Unlike other popular medications of similar action, Nitroxoline tablets for cystitis are not an antibiotic, but are destructive against many microorganisms:
- staphylococcus;
- streptococcus;
- gonococcus;
- enterobacteriaceae and bacteria that cause tuberculosis;
- various fungi and E. coli;
- salmonella, trichomonas and many others.
Taking into account the huge list of possibilities and reviews of Nitroxoline for cystitis , the drug is also prescribed for pyelonephritis and urethritis. It has been proven to treat inflammation of the prostate gland. The effectiveness of treating diseases has been proven by many doctors and patients.
Among other things, therapists prescribe Nitroxoline not only for cystitis in women, but also in men. With caution and a small dosage, treatment of cystitis with Nitroxoline is allowed for minor children and positive reviews from doctors about Nitroxoline are proof of this.
Antibiotic or not?
You can often come across the opinion that Nitroxoline belongs to the group of antibiotics, but this is not so. This is a misconception; the main active ingredient has an antimicrobial effect, but the product is not an antibiotic. Although it is used for a fairly wide range of pathologies.
Important! "Nitroxoline" refers to quinol derivatives, which have a strong antimicrobial effect.
The drug, like other antibiotics, is characterized by rapid absorption into the blood, which means it treats well and quickly gives a positive result. After exposure to the source, the disease is excreted in the urine through the kidneys. The accumulation and highest concentration is achieved in the urine, which is why it is often used to treat infections in this system. Among them: cystitis, prostatitis, pyelonephritis and many others.
Characteristics of the drug
Nitroxoline is a yellow, odorless tablet with a bitter taste. By selectively inhibiting the DNA connection, it blocks the affected cell and causes a bacteriostatic effect. Actively acts against many microorganisms. When prescribing Nitroxoline, an annotation is included in the package. It indicates whether the product can be used while breastfeeding.
- Nitroxoline contains active substances that stop the proliferation of bacteria, suppressing them at the molecular level.
- Quickly and easily absorbed from the gastrointestinal tract.
- Does not provoke addiction. Excreted by the kidneys.
Action and forms of the drug
First of all, you need to understand the question: Is Nitroxoline an antibiotic or not? Since it is used to treat diseases of the genitourinary system, the development of which was caused by pathogenic bacteria, the answer is obvious: this drug is an antibiotic. Moreover, this is a very strong broad-spectrum agent belonging to the group of hydroxyquinolines. It must be used with extreme caution, and only after prior consultation with a urologist.
Nitroxoline is dispensed in the form of film-coated tablets intended for oral administration. The medicine contains the active substance nitroxoline, as well as a number of auxiliary components. Additionally, this drug contains:
starch;
- sugar;
- talc;
- calcium;
- lactose;
- beeswax;
- Vaseline oil;
- titanium;
- povidone, etc.
After the patient has taken the dose of the drug prescribed by the doctor, it is rapidly absorbed in the stomach. The kidneys are not able to process nitroxoline, as a result of which the substance is fully excreted in the urine. That is why, if a large amount of this substance is found in urine, you should not be afraid: as soon as the course of therapy is over, not a trace will remain of it.
Nitroxoline tablets have a detrimental effect on such types of pathogenic bacteria as:
- staphylococci;
- streptococci;
- fecal enterococcus;
- e if;
- Proteus;
- Klebsiella;
- salmonella;
- shigella;
- Enterobacter pylori;
- Trichomonas vaginalis, etc.
In addition to the pathogenic microorganisms described above, under the influence of the active components of the drug, the vital activity of candida fungi, dermatophytes, molds, etc. is stopped.
It is important to know! The drug Nitroxoline cannot be used at the request of the patient to prevent or prevent pathologies of the genitourinary system. This is a very dangerous medicine that should only be used as prescribed by a urologist!
Self-medication can greatly harm the patient’s health, since this tablet drug has many side effects.
How to remove a stone from the ureter?
A stone in the ureter is a fairly common occurrence in urolithiasis, and the choice of method for removing stones from the urinary tract depends on their size and location.
What is urolithiasis
In most cases, the site of stone formation is the kidneys.
The reasons for the onset of this process are metabolic disorders, various diseases, taking certain groups of medications, a sedentary lifestyle, excess weight, and pregnancy in women.
Most often, in women and men, stone formation processes occur in the renal collecting system. A stone can enter the urinary tract only after it has exited the renal pelvis through the orifice of the ureter.
Much less often, ureteral stones form directly in its lumen.
Symptoms
Symptoms of urolithiasis in women and men are directly dependent on the size and location of the stone.
The asymptomatic course can last a very long time. It is typical if the edges of the stone do not injure the inner lining of the kidney and it does not interfere with the outflow of urine.
However, the diameter of the ureteral lumen is only 4 mm, in addition, it narrows in several places. Therefore, very often the passage of a kidney stone is accompanied by obstruction of the urinary tract.
Renal colic develops. It is characterized by the following symptoms:
- very strong sharp pain in the lower back, which radiates down the ureter into the perineum;
- urination disturbance occurs only if stones pass simultaneously from both ureters, which is extremely rare;
- the appearance of blood in the urine is caused by damage to the internal epithelium of the kidney and ureter by the sharp edges of the stone. These symptoms are absent if, during the removal of the stone, the lumen of the ureter is completely blocked, and urine enters the bladder only through the unaffected ureter;
- increase in temperature, usually up to 37 - 37.5º;
- nausea, sometimes vomiting;
- chills;
- increased sweating.
The listed symptoms in men and women disappear when the stone leaves the ureter and normal urine flow is restored.
If sand or small crystals come out through the ureter, the symptoms may not be as intense. Removal of a small stone from the ureter is accompanied by sharp, cramping pain, but it quickly disappears.
In addition, the urge to urinate becomes more frequent, and streaks of blood and sediment visible to the naked eye may also appear in the urine.
The process of urination itself may be accompanied by itching and burning. Usually, removal of stones through the urethra is more painless in women due to the peculiarities of the anatomical structure.
Diagnostics
Methods for diagnosing urolithiasis are similar for men and women. An ultrasound is performed for initial diagnosis.
X-ray studies with the introduction of contrast are considered more informative. The movement of the radiopaque contrast agent in the urine is monitored in a series of photographs.
Based on the results of such an examination, it is possible to determine the size of the stones, their location and the degree of disturbance in the passage of urine and possible methods of their removal.
The most informative method of diagnosis is computed tomography. As a result, the doctor receives a three-dimensional image of the ureter and images of a section of the stone, which makes it possible to determine its structure and select the appropriate treatment.
Treatment
Treatment and method of removing stones depends on how severe the symptoms are, as well as the size and location of the stone itself.
If symptoms of renal colic are present, the patient must be quickly taken to the hospital. In the case where the stone is firmly stuck in the ureter, there is a risk of developing severe complications.
Therefore, the obstruction must be eliminated as soon as possible.
Removing a stone from the ureter in men and women in a hospital setting can be done in several ways. If the stone can pass through the urinary tract, its removal is facilitated with medications.
Typically, treatment is carried out with antispasmodics, which selectively act on the muscles of the ureters, and anti-inflammatory drugs.
You can help eliminate the symptoms of pain with potent painkillers.
If independent passage of a stone from the ureter is difficult, it can be removed using instrumental methods. To do this, it is necessary to catheterize the ureter through the bladder and then remove the stone with a special device.
Such treatment is possible only if the stone has left the mouth of the ureter and entered its lumen. In addition, the size of the stone should not exceed 0.5 cm.
If the stone is larger, it is first crushed using ultrasonic waves. To do this, a small operation is performed.
The surgeon needs to make a small incision and insert a catheter. After this, the fragments are removed independently and painlessly.
When a stone in the ureter does not create significant obstacles to the normal outflow of urine, treatment with external lithotripsy is possible.
With this procedure, the stone is crushed using a special apparatus. Ultrasound waves pass through the organs and tissues of the body and act directly on the calculus.
If after this procedure the stone does not come out on its own, then its removal is continued with medication.
In severe cases, surgery is necessary. Usually it is proposed to do it using a minimally invasive laparoscopic method. In this case, the ureter is cut and the stone is evacuated.
Self-treatment
How to get rid of a stone in the ureter at home? Sand can be expelled only when there is no risk of obstructing the flow of urine.
For treatment, you can try this method. You need to take warming baths regularly. The water temperature should fluctuate around 37.5 - 38º, its level should be above the waist.
At the same time, you need to take a diuretic or eat watermelon. In this way, sand and small crystals can be expelled from the kidneys and ureters.
Decoctions of lingonberry, bearberry, birch leaves, juniper fruits, kidney tea herbs, horsetail, and knotweed also help remove stones.
Any treatment must be accompanied by a diet. It is necessary to drink at least one and a half to two liters of fluid per day, limit the consumption of salt, sweet, fatty and smoked foods, strong broths, coffee, and chocolate.
Otherwise, the diet to facilitate the removal of stones depends on the composition of the stone and the pH value of the urine.
You can live with urolithiasis for a long time without even knowing about your illness.
But this condition is dangerous due to the development of complications, such as hydronephrosis, chronic pyelonephritis, and the proliferation of stones throughout the entire cavity of the renal pelvis.
And to treat such diseases, only surgery is needed. Therefore, when the first symptoms appear, you must consult a doctor.
Nitroxoline price, where to buy
Nitroxoline kidney tablets, following the instructions, should be taken orally after meals, swallowed whole and washed down with a small amount of water. They can be treated continuously for a month, if complete recovery according to laboratory tests does not occur earlier. Dosage:
- The usual daily dose of the drug for adults is 400 mg, divided equally into 4 doses, that is, 2 tablets 4 times a day.
- For severe infections, the doctor may increase the daily dose to a maximum of 800 mg or 4 doses of 4 tablets.
- In the case of chronic cystitis or pyelonephritis, the usual dosage of the medicine is prescribed, but it is not used constantly, but in courses - 2-3 weeks of administration alternated with two-week breaks for several months, but not more than six months.
- For preventive purposes during surgical manipulations of the genitourinary system, the drug is taken from 14 to 21 days, 2 tablets 4 times a day.
The price of Nitroxoline in tablets is approximately 60 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Nitroxoline tablets p.o 50 mg No. 50 Anzhero-Sudzhensky HFZOOO Anzhero-Sudzhensky HFZ
- Nitroxoline tablets p.o 50 mg No. 50 IrbitskyOJSC Irbitsky Chemical Plant
Pharmacy Dialogue
- Nitroxoline (50 mg tablet No. 50)
- Nitroxoline (50 mg tablet No. 50)
- Nitroxoline (50 mg tablet No. 50)
- Nitroxoline (50 mg tablet No. 50)
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- Nitroxoline 50 mg n50 tabletTathimpharmaceuticals OJSC
- Nitroxoline avexima 50 mg No. 50 tabLLC "Avexima Siberia"
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Pharmacy24
- Nitroxoline 0.05g N50 tablets PAT “Vitamin” Ukraine
- Nitroxoline 0.05g No. 50 tablets PAT NVC “Borshchagivsky chemical-pharmaceutical plant”, Kiev, Ukraine
PaniPharmacy
- Nitroxoline coated tablets 0.05g No. 50 Ukraine , Vitamins
- NITROXOLINE tablets Nitroxoline tablets. 0.05g No. 50 Ukraine, Tekhnolog ChAO
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BIOSPHERE
- Nitroxoline 50 mg No. 50 tablet p.o. Tekhnolog ChAO (Ukraine)
- Nitroxoline 50 mg No. 50 tablet p.o. Irbit chemical plant (Russia)
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Nitroxoline price, where to buy
| Number of tablets per package | Manufacturer | Price in rubles |
| 50 | Irbit chemical plant | 88 |
| 50 | Anzhero-Sudzhensky Chemical Plant | 112 |
| 50 | Tatkhimpharmaceuticals | 99 |
| 50 | Uralbiopharm | 104 |
| 50 | Irbitsky HFZ | 67 |
| 50 | Uralbiopharm | 61 |
| 50 | Biosynthesis | 72 |
| 50 | Technologist | 62,13 |
| 50 | Borshchagovsky Chemical Plant | 63,31 |
How to treat?
The dosage of the medication is determined by the doctor, as well as the scheme of its use. How many tablets you need to take and how exactly to do it depends on many factors, among which the most important are:
- person's age;
- form and type of disease;
- general health;
- local pathogenesis and complications accompanying cystitis.
The order and quantity in which to take the medicine is also influenced by such factors as the presence of other medications in the course of therapy.
In the event that it is not possible to consult a doctor, but you need treatment, you should focus on the average dosages recommended by pharmacists and the medication dosage regimen described in the annotation.
| Form and type of disease | Daily amount of medication | Admission procedure | Duration of treatment |
| Acute non-infectious | 600 mg | 2 times a day with a constant, identical time interval | 6-8 days |
| Acute infectious | 600-800 mg | 3-4 times a day with a constant, identical time interval | 8-10 days |
| Chronic | 800-1000 mg | 4-5 times a day with a constant, identical time interval | 10-15 days |
| Intercurrent | 800-1000 mg | 4-5 times a day with a constant, identical time interval | From 15 days or more, the treatment period can reach several months, depending on the severity of the pathogenesis and general health |
In case of acute cystitis, it is important to maintain bed rest and eat properly. In the event that a sick person does not adhere to a gentle diet in his daily diet, eats without clear time intervals, in large portions and generously seasons the food with spices, and also drinks carbonated or alcoholic drinks, reconstituted juices with preservatives and dyes, then the treatment will be delayed or it will turn out to be ineffective at all.
Bed rest or gentle rest during treatment of an acute type of disease is no less important than dietary restrictions. Its observance is of particular importance when treating the disease in women. Of course, bed rest does not mean that a person cannot get out of bed.
However, it is necessary to limit all types of physical activity, including housework and shopping. It is strictly forbidden to lift heavy objects during an exacerbation of cystitis, and this prohibition applies not only to exercise in gyms, but also to lifting bags and packages with goods from supermarkets.
Chronic cystitis is not so demanding for the sick person to comply with gentle or bed rest. However, this type of disease requires strict adherence to a dietary diet and eating small portions several times a day. It is also important to drink diuretic teas with antiseptic properties, for example, chamomile drinks, throughout the course of treatment.
As for the intercurrent form of inflammation, this type of cystitis is a complication of any disease, and not a self-occurring illness. For this reason, you should find out what causes the inflammation and get rid of the pathology. It is impossible to replace the treatment of the underlying disease with the treatment of its complications.
Whatever medicine a person uses, it will only relieve the severity of sensations and temporarily alleviate the patient’s condition by relieving symptoms. After completing the use of the medicine, all the uncomfortable signs of cystitis experienced by the patient will inevitably return. Often this is the reason for the patient’s opinion that no medicine helps him. In fact, as a rule, a person simply suffers from an intercurrent form of bladder inflammation.
Of course, during the treatment of cystitis, regardless of its form and type, you should not drink alcohol, energy cocktails and other drinks that irritate the walls of the bladder and urine ducts. Such drinks worsen a person’s condition, contribute to the progress of inflammation and, accordingly, increase the symptoms of cystitis.
Pharmacodynamics and pharmacokinetics
This drug is an antibacterial agent, a derivative of 8-hydroxyquinoline. Its action is due to the selective inhibition of bacterial DNA production. The activity of Nitroxoline is manifested against known gram-positive bacteria and gram-negative bacteria, and some types of fungi.
As a result of oral administration, Nitroxoline-UBF is absorbed from the gastrointestinal tract to a fairly high degree. Excretion occurs through the kidneys, almost unchanged. In this case, high concentrations of the main substance are predominantly determined in the urine.
Terms of sale and storage
The average price of Nitroxoline (50 mg tablets No. 50) in Moscow is 89 rubles. Sold according to prescription.
The shelf life of Nitroxoline tablets is 4 years from the date of manufacture. The drug should be stored in a dark, dry place, out of reach of children, at an air temperature not exceeding 25 C.
Nitroxoline tablets are sold at any pharmacy. The law requires sales only with a prescription, but they can often be bought without it. In the original packaging, the tablets can be stored for 4 years from the date of manufacture. The drug should be stored in a dry, dark place, maintaining a temperature range of 15 to 25 degrees. Be sure to hide the medicine package away from children.
On prescription.
Tablets are stored in a dry, dark place protected from children.
