"Octolipen 300 mg": instructions for use, analogues and reviews

A medicine with an antioxidant effect that regulates lipid and carbohydrate metabolism is Octolipen. Instructions for use prescribe taking 300 mg capsules, 600 mg tablets, injections in injection ampoules for liver problems. According to doctors, this drug helps in the treatment of hepatitis, liver cirrhosis and weight loss.

Release forms of this drug

"Octolipen" is available in several dosage forms: capsules, tablets and concentrates for the preparation of infusion solutions.

Capsules: gelatin hard, yellow, no transparency. Their contents are a pale yellow or yellow powdery mass with possible inclusions of white. The capsules are packaged in contour cell packs, 10 pieces each. A cardboard box contains 6 or 3 such packs of Octolipen 300.

The instructions for use for the tablets indicate that they are pale yellow or yellow in color, oval, biconvex, with a line on one side. Packaged in blister packs of 10 pieces. Contents in a cardboard pack – 10, 6 or 3 packs.

You can also find the drug on sale in Octolipen 300 mg ampoules.

Concentrate for the preparation of a solution for infusion: a greenish-yellow transparent liquid, which is bottled in dark glass ampoules in a volume of 10 ml. Packaged in contour cell packs. Packed in a cardboard box of 1 or 2 ampoules.

Detailed information about Octolipen 600 mg and 300 mg will be presented below. First, let's find out what the composition of the drug is.

Price

Release form	Amount in a package	Price in Russia	Price in Ukraine
Capsules	30 pcs.	from 287 to 320 rub.	from 222 to 360 UAH.
Pills	30 pcs.	625 - 653 rub.	690 UAH
Concentrate for infusions	10 ampoules	from 349 to 395 rub.	150-290 UAH.

Composition of the drug

In accordance with the instructions for use for "Octolipen" 300 mg, one capsule contains the active element - α-lipoic (thioctic) acid, in a dosage of 300 mg. The following additional components are presented: pregelatinized starch, magnesium stearate, calcium hydrogen phosphate (disubstituted calcium phosphate), colloidal silicon dioxide (Aerosil). The capsule shell contains sunset yellow dye (E110), quinoline yellow dye (E104), medical gelatin, titanium dioxide (E171).

According to the instructions for use, Octolipen 300 mg tablets do not exist. They have a different dosage.

The film-coated tablets contain the main substance: α-lipoic (thioctic) acid 600 mg and some additional elements: hydroxypropylcellulose (hyprolose), low-substituted hyprolose (low-substituted hydroxypropylcellulose), magnesium stearate, colloidal silicon dioxide, croscarmellose sodium (croscarmellose) . The film shells of the tablets contain: opadry yellow, macrogol 6000, talc, hydroxypropyl methylcellulose (hypromellose), titanium dioxide, yellow iron oxide dye (E172), aluminum varnish based on quinoline yellow (E104).

Is Octolipen available for sale in ampoules at a dosage of 600 mg?

The concentrate for infusion solutions contains the active substance - α-lipoic (thioctic) acid in a volume of 30 mg and auxiliary components: disodium edetate, water for injection, ethylenediamine. Dosage of 1 ampoule – 300 mg.

Compound

Thioctic acid is the active substance in Octolipen. It is better known as α-lipoic acid. The acid reduces blood glucose levels and increases the concentration of glycogen in the liver. Its effect is similar to the effect of B vitamins on the body. It has a beneficial effect on the metabolism of fats and carbohydrates, and helps improve the functioning of the main biochemical laboratory of the body - the liver.

Additionally, capsules and tablets contain:

magnesium stearate;
calcium hydrogen phosphate dihydrate;
medical gelatin;
colloidal silicon dioxide;
food additives: E 104, E 171, E 110.

The powder for preparing the solution does not require such a quantity of auxiliary substances. In addition to the active substance, it contains only sterile water, ethylenediamine and disodium salt of ethylenediaminetetraacetic acid.

Pharmacological characteristics

The active substance "Octolipen" 300 and 600 mg - α-lipoic (thioctic) acid in the body is formed due to the processes of oxidative decarboxylation of α-keto acids and is defined by medical science as an endogenous antioxidant. This substance ensures the binding of free radicals in the blood, promotes the rapid restoration of intracellular glutathione concentration and enhances the activity of superoxide dismutase.

In addition, thioctic acid normalizes axonal conduction and trophism of neurons. Being a coenzyme of multienzyme mitochondrial complexes, this active element is directly involved in the oxidative decarboxylation of α-keto acids and pyruvic acid.

Due to the effect of the medicinal drug "Octolipen" 300 mg and 600 mg on the human body, there is a natural increase in the level of glycogen content in the liver structures and a significant decrease in the concentration of glucose in the blood.

In addition, overcoming insulin resistance is observed. The intensity of the biochemical effect of thioctic acid is similar to that of B vitamins. This biologically active substance normalizes the processes of lipid and carbohydrate metabolism, activates cholesterol metabolism, exhibits a pronounced lipotropic effect, normalizes the functional parameters of the liver, demonstrates a strong detoxification effect in a variety of intoxications, including heavy metal poisoning.

Indications for use

Due to the complex effects of the drug and the mildness of the effect, it is used for a number of pathologies. The scope of application of Octolipen depends on the form of release.

According to the official instructions, the product in tablets and capsules is used for the treatment of the following pathologies:

diabetic polyneuropathy;
polyneuropathy of alcoholic origin.

Indications for the use of the concentrate for the preparation of a solution for infusion are somewhat more extensive. In addition to the above conditions, doctors prescribe the drug as an addition to basic therapy in the treatment of various liver pathologies:

fatty degeneration;
chronic hepatitis of various etiologies;
cirrhosis;
hepatitis A.

In addition, the drug in ampoules is used in the complex treatment of various intoxications. In case of poisoning with heavy metals or toadstool.

Considering the neuroprotective effect of Octolipen, it can be prescribed as an antioxidant for diseases of the nervous system: multiple sclerosis, neuralgia, osteochondrosis. The product is used in cosmetology to increase the elastic properties of the skin. Research is being conducted on its use in the fight against excess weight.

You should not self-medicate. Only a qualified specialist can determine the appropriateness of using the drug in each specific clinical case.

Pharmacokinetic properties of this drug

When taken orally, the drug "Octolipen" 300 and 600 mg is characterized by complete and rapid absorption in the stomach and intestines. Taking it with food slightly reduces its absorption. As a result of the first pass effect through the liver, the bioavailability of the drug is approximately 30–60%. The highest plasma concentration of the active substance is achieved after approximately 25–60 minutes. The half-life for tablets is 25 minutes, for the drug in the form of an injection solution and capsules – 20–50 minutes. The maximum concentration of the substance will be 25–38 mcg/ml with intramuscular and intravenous injections of Octolipen in ampoules. 600 mg tablets are distributed in a volume of 450 ml/kg.

Metabolic transformation of α-lipoic acid occurs in the liver through conjugation and side chain oxidation. The overall plasma clearance is 10–15 ml/min. The active element of the drug, as well as its metabolites, are excreted through the kidneys in a volume of 80–90% of the initial dosage.

Absolute and relative contraindications

Like many pharmaceutical medications, the drug "Octolipen" has a number of restrictions on its use. Of the absolute and relative contraindications, the attached instructions indicate:

individual hyperreaction to active or auxiliary substances of the drug;
moment of intrauterine formation of the fetus;
lactation;
pediatric category of patients

The drug should be used with caution by people with impaired renal function. Dynamic monitoring of creatinine concentrations in blood tests is required.

Instructions for use

"Octolipen" 600 mg tablets should be taken orally, on an empty stomach, about half an hour before breakfast, should not be broken or chewed, washed down with water.

In most cases, the medication is recommended to be taken once a day at a dosage of 600 mg. In some cases, step therapy may be prescribed: during the first 2–4 weeks of the treatment course, α-lipoic acid is administered as an intravenous infusion (using a concentrate to prepare an infusion solution), after which tablets are started in a standard dosage. The duration of treatment is determined by a specialist.

It is not advisable to take tablets of the drug “Octolipen” at a dose of 600 mg for more than 3 months, however, if necessary, as prescribed by a doctor, the use of the medication can be longer. “Octolipen” 300 mg in capsules is taken in the same course.

Concentrates for the preparation of solutions for infusions in a dosage of 300–600 mg (corresponding to 1–2 ampoules) must be diluted in an isotonic solution of sodium chloride 0.9% (50–250 ml). The prepared infusion solution should be administered intravenously by drip once a day at a dose of 300–600 mg for 2–4 weeks. Subsequently, patients are most often transferred to oral administration of the drug.

As the instructions for use indicate, Octolipen 300 mg and 600 mg are sensitive to sunlight, so ampoules with concentrate are removed from the cardboard packaging immediately before use. During injection infusion, it is also advisable to protect the bottle with the prepared solution from light. To do this, you can use aluminum foil or special light-protective bags. The prepared solution is stored in a place protected from sunlight for no longer than 6 hours from the time of preparation.

Contraindications

Among the indications for use are:

State of pregnancy. Due to the fact that the effect of the active component of the drug on the fetus has not been identified, it is recommended to refrain from taking it for the entire period.
Lactation.
Age limit. Not assigned until adulthood.
The presence of individual intolerance to the components of the product.

Side effects

When treated with Otktolipen 600 mg in tablets and Otktolipen 300 mg in capsules and ampoules, the following undesirable reactions of the body may occur:

From the digestive organs: stool disorders in the form of diarrhea, nausea, vomiting, heartburn, abdominal pain.
On the metabolic side: decreased blood sugar levels, the occurrence of hypoglycemic symptoms (as a result of improved glucose absorption processes) in the form of dizziness, increased sweating, headache, visual impairment.
Blood coagulation system: side effects are observed only with intravenous infusion of the drug. In this case, the following may develop: purpura (hemorrhagic rash), pinpoint hemorrhages in the structures of the mucous membranes and skin, thrombophlebitis, thrombocytopathy.
Allergic reactions: urticaria, itching, skin rash, some systemic reactions (including anaphylactic shock).
CNS: disturbance/change in taste sensations (during oral administration), convulsions (with intravenous administration), diplopia.
Other undesirable effects: with rapid intravenous administration, difficulty breathing, increased intracranial pressure (a feeling of heaviness in the head) may occur.

Side effects

The following side effects are identified when taking the medicine in any form:

allergic reaction;
decreased glucose levels;
disturbances in the digestive tract (feeling of nausea, vomiting);
headache;
if the drug is administered by injection, burning and pain during infusion and thrombophlebitis may occur.

If the patient exceeds the maximum permissible dose of the drug, then nausea, vomiting, and headaches occur. These are symptoms of an overdose.

In addition, loss of consciousness, muscle necrosis, etc. may occur.

To eliminate side effects, you need to perform gastric lavage, give the patient activated charcoal, and induce vomiting.

Overdose symptoms

The most pronounced symptoms of an overdose of α-lipoic acid may be the following pathological conditions: dyspeptic disorders, headache. In severe forms of overdose of this medication (when using more than 6 g in adults and 0.05 g/kg body weight in children), there is a high probability of developing generalized convulsions, clouding of consciousness, psychomotor agitation, hypoglycemia (up to coma), severe acid disorders - alkaline balance with lactic acidosis, hemolysis, acute necrosis of skeletal muscles, suppression of bone marrow activity, intravascular disseminated coagulation syndrome, multiple organ failure.

If there is a suspicion of the development of a severe overdose of the drug "Octolipen", the patient requires immediate hospitalization in a hospital and intensive therapeutic measures that are used in case of accidental poisoning - induction of vomiting, gastric lavage, symptomatic treatment, including the use of enterosorbents.

Filtration techniques involving forced removal of thioctic acid from the body, hemodialysis and hemoperfusion, in case of overdose, as a rule, do not have the necessary effectiveness. A specific antidote is currently unknown to medicine.

Undesirable effects

Unlike other pharmaceutical drugs, the endogenous antioxidant “Octolipen” has a list of undesirable consequences from its use that is practically reduced to a minimum. In rare cases the following were recorded:

allergic reactions - for example, urticaria;
dyspeptic disorders - nausea, vomiting, difficulty in bowel movement;
hypoglycemia – a sharp decrease in the concentration of glucose in the bloodstream;
persistent dizziness, headaches;
increasing feeling of fatigue;
previously uncharacteristic drowsiness.

It is recommended to notify your doctor about the occurrence of the above-mentioned undesirable consequences of therapy with Octolipen. They will undergo a dose adjustment of the mediant, or it will be discontinued.

Special Recommendations

During treatment with Octolipen 300 mg and 600 mg tablets, ampoules and capsules, diabetics need to regularly monitor blood glucose levels, especially at the beginning of therapy. In certain cases, a slight reduction in the dosage of insulin or oral antidiabetic medication is required to prevent the development of hypoglycemia.

During the treatment period, it is also necessary to stop drinking alcohol to prevent the weakening of the therapeutic effect of α-lipoic acid. When using oral forms of the drug "Octolipen", it is recommended to refrain from consuming dairy products due to the calcium content they contain. A time interval of at least 2 hours should be maintained between doses of the medication.

Features of application

There are separate instructions on how to take Octolipen for diabetes. First of all, frequent monitoring of blood glucose is important. When starting a course of therapy, special attention should be paid to this. In case of a sharp decrease in blood sugar concentration, it may be necessary to reduce the dosage of hypoglycemic drugs.

A special feature is the fact that when taking this medicine one should refrain from drinking even a small amount of alcohol. This is due to the fact that when it interacts with the drug, the therapeutic effect of the latter is reduced.

Due to the insufficient number of studies on the effect of Octolipen on the ability to concentrate and react, the drug should be taken with caution. The drug is contraindicated for children under 18 years of age, pregnant women and breastfeeding women for the same reason.

Use during pregnancy and lactation

What does the instructions for the tablets tell us about this issue? "Octolipen" 300 mg and 600 mg is contraindicated, since there is no sufficient clinical data on the use of α-lipoic acid during this period. This also applies to ampoules.

In the process of scientific studies of the reproductive toxicity of the drug, risks to fertility, as well as its teratogenic and embryotoxic effects, were not identified.

During breastfeeding, treatment with this pharmacological product is also contraindicated, since there is no information on its penetration into breast milk.

Composition, storage and sales conditions

Available in one of three possible forms: tablets, capsules, or ampoules with a concentrate necessary for preparing solutions for droppers.

The following are used as auxiliary components: in tablets - calcium hydrogen orthophosphate (white or colorless crystals), magnesium stearate (fine white-gray powder) and titanium oxide - a white dye. The capsules use slightly different substances that provide a partially liquid structure - gelatin, a colloidal suspension of silicon oxide, as well as two yellow dyes: quinoline yellow and “sunset” (E 104 and 110, respectively). Ampoules with concentrate are supplied complete with a solvent made from a mixture of distilled water and soluble EDTA salt.

Drug interactions

When used simultaneously with cisplatin, its effect decreases when combined with α-lipoic acid in the form of an infusion solution.

Oral hypoglycemic agents, insulin: when used in combination, the therapeutic effect of these medications is enhanced.

When used with glucocorticosteroids, their anti-inflammatory properties increase.

With the combined use of ethanol and its metabolites, the therapeutic effectiveness of thioctic acid is weakened.

With calcium, iron and magnesium preparations, when taken in parallel orally, the formation of a complex with metals can be observed (the interval between taking such drugs and the Octolipen drug should be at least 2 hours).

The prepared solution for intravenous infusion is incompatible with solutions of glucose, levulose, Ringer's solution, and with some compounds (including their solutions) that react with SH- and disulfide groups. This is confirmed by the instructions for use for Octolipen 600 and 300 mg.

When α-lipoic acid interacts with sugar molecules, complex, poorly soluble compounds are formed.

Interaction

The drug stimulates the hypoglycemic effect of insulin and antidiabetic drugs taken orally. That is why, when combining these drugs, it is necessary to constantly monitor the level of glucose in the blood plasma and adjust the dosage of antidiabetic drugs if necessary.

In addition, you should observe a half-hour interval between taking Octolipen and dairy products, as well as preparations with iron, calcium and magnesium. In this case, it is advisable to take Octolipen in the morning, and products with iron, magnesium and calcium in the evening. In addition, this medication decreases the effects of cisplatin when taken concomitantly.

The effectiveness of Octolipen itself is reduced by ethyl alcohol. So during the course of this drug it is recommended to refrain from drinking alcohol.

Thioctic acid also activates the anti-inflammatory properties of glucocorticosteroid drugs.

How does thioctic acid affect the body?

According to the latest scientific data, the following functions of α-lipoic acid in the human body can be distinguished:

Reduced activity and increased release of toxins accumulated in tissues, as well as heavy metals and other harmful substances.
Accelerating the processing of sugar molecules.
Activation of metabolism, which occurs through a beneficial effect on mitochondria, the organelles that produce energy. With the help of this function of thioctic acid, energy reserves are more quickly extracted from food.
Improving the processes of restoration of damaged tissues and organs.
Dulling of the feeling of hunger.
Reducing the level of fat deposits in the liver.

In practice, it is noted that overweight people who want to lose weight, as well as athletes, often start taking thioctic acid. For them, this substance is a real salvation, and this is due to the fact that most weight loss medications cause harm to the body, destroy it, disrupt metabolic rhythms and hormonal levels.

Overdose

When taking an overdose of Octolipen 600, standard symptoms are observed: severe headaches, loss of orientation, and increased side effects such as nausea, heartburn and vomiting are also observed. Therapy is prescribed to eliminate the body’s negative reactions. Can be taken: analgin, activated carbon; gastric lavage or taking a magnesium oxide suspension is acceptable.

Who else can be prescribed the drug?

According to the instructions for use, Octolipen 600 mg and 300 mg are indicated for use in cases of alcoholic and diabetic polyneuropathy, but doctors also prescribe it for the following pathological conditions:

disorders of the peripheral nervous system;
periodic minor paralysis caused by excessive drinking or diabetes;
fatty liver and disruption of its functioning;
chronic hepatitis;
cirrhosis of the liver;
overdose of narcotic substances, antibiotics;
obesity;
poisoning from poor quality food.

Injections, Octolipen tablets: what does the medicine help with?

Experts recommend the endogenous antioxidant “Octolipen” for use in the following pathological disorders:

polyneuropathy of various origins, especially diabetic origin;
nerve fiber damage due to alcohol abuse;
fatty degeneration of hepatocytes;
chronic course of hepatitis;
diagnosed excess of cholesterol parameters in the bloodstream - hypercholesterolemia;
cirrhosis;
toxic liver damage.

Why is Octolipen still prescribed? Only a specialist should determine the need to include a drug in complex pharmacotherapy of a particular disease. Self-medication is unacceptable.

Analogs "Octolipen" 300 and 600 mg

The most popular analogues of the medicine are the following drugs:

"Berlition" is an antioxidant medicine that is produced in Germany. Its main active element is thioctic acid. This drug is available in the form of tablets and infusion solutions, in doses of the main substance of 300 and 600 mg.
"Thioctacid BV" is a medicine based on thioctic acid, manufactured in Germany. This analogue is produced only in tablet form, where the main element is contained in a volume of 600 mg.
"Tiogamma" is another German analogue of the drug "Octolipen", the active element of which is lipoic acid. This medication is available in the form of tablets, ready-made solution for injection and concentrates for the preparation of infusion solutions.
"Tiolepta" is a Russian-made metabolic drug, which is available in three dosage forms: solution for infusion, 300 mg tablets and 600 mg tablets. This is the cheapest analogue of Octolipen 300

According to reviews, analogues of tablets are no less effective than the drug we are describing.

Analogs

The following are distinguished as analogues:

Thiolepta,
Thiogamma,
Neurolipon,
Berlition, etc.

It is worth noting that replacement with similar drugs must be carried out taking into account all the recommendations of a specialist.

Since Octolipen is used by girls to correct their own weight, the doctor must explain the consequences of such use of the medicine.

Reviews

For the most part, there are positive reviews about Octolipen 300 mg tablets. Patients have noted good results from the use of this remedy in the treatment of diabetic polyneuropathy, radiculopathy, and also as a medicine that normalizes liver function and restores its structure. People also like Octolipen 300 mg in capsules and ampoules.

According to information obtained from reviews, this medicine helps reduce blood sugar levels and reduce body weight. In addition, there are quite a lot of reports in which consumers indicate that the effect of the pharmaceutical product is no less effective than that of its well-known analogue “Berlition”, and the price is much lower.

The main disadvantages of this medication (especially in tablet form) include the development of various adverse reactions, mainly from the digestive system. Among these undesirable effects, the most common was severe nausea after taking the pill. In addition, the drug often caused stool disorders, pain in the intestinal area, in the hypochondrium. Some patients noted adverse reactions arising from the nervous system, for example, sudden dizziness, headaches, and mood changes. What other reviews are there about Octolipen 300 mg?

Experts leave positive comments about him. They characterize it as a highly effective medicine that normalizes the body's metabolic processes, restoring the metabolism of carbohydrates and lipids. Despite the relative safety and good quality of this medication, doctors do not recommend taking it on your own, as this can provoke allergic reactions and deterioration of health due to the development of unwanted reactions.

Reviews and impressions

Patients with diabetes note an active effect on blood glucose levels.

While taking Octolipen, the dose of insulin and antidiabetic tablets administered using syringes or a pump was adjusted with the help of a doctor downward, in some cases to the minimum.

Diabetics also indicate an improvement in peripheral sensitivity, a decrease in pain and burning sensations in the extremities, and an increase in walking endurance.

Most patients taking Octolipen indicate positive statistics in cases of treatment of neurotic numbness of the extremities, prostatitis, multiple sclerosis, and metabolic disorders in liver cells.

Some users, based on the instructions for use of the drug, suggest using Octolipen as a means of losing weight.

However, it should be borne in mind that taking lipoic acid in no way affects body weight, despite the fact that while taking it there is a decrease in appetite.

It can only help normalize lipid metabolism and protect the body from toxic breakdown products of fats formed as a result of active physical activity and diet.

One of the advantages of Octolipen is its relative affordability compared to some similar products (for example, Berlition 600).

At the same time, no significant differences were noticed in the action and effectiveness of Octolipen compared to more expensive lipoic acid preparations.

You can read other reviews below.

What to consider

If you want to get not a short-term, but a stable effect, that is, to become slimmer for many years, then we recommend that you seriously think about whether you need to take any medications. They can be expensive or cheap, effective or useless, safe or even harmful to your health, but they have a general principle of action that you definitely need to know about.

If you are overweight, it means that your calorie intake exceeds your calorie expenditure, or you have a metabolic disorder. In the first case, you need to adjust the balance between incoming and expended energy, and in the second, you need to undergo a course of treatment and adjust the distribution of protein, fats and carbohydrates for the benefit of the body. What do weight loss drugs offer us? That's right: continue to eat the same way, lead a sedentary lifestyle, but at the same time swallow miracle remedies. Even if you get a result, it will be short-term and will only lead to an even greater imbalance in the metabolism.

Why did we decide today to figure out whether Octolipen can be used for weight loss? Reviews from doctors say that if there is a need to take drugs for weight correction, then these should be natural compounds that the body itself uses to normalize energy metabolism. Interested in this statement, we decided to find out whether a lipoic acid-based drug could solve such a complex problem as weight loss. Advertising can be very tempting, but is everything really so rosy?

Special patients and instructions

Caution is necessary when prescribing the drug to certain groups of people, since their body may react unpredictably to this medicine.

These include:

Pregnant women. According to research, thioctic acid does not harm the fetus or the expectant mother, but the specifics of its effects have not been studied in detail. Therefore, doctors avoid prescribing Octolipen during this period.
Women who practice natural feeding. There is no information about whether the active substance of the drug passes into breast milk. In this regard, this drug is not used during lactation.
Children and teenagers. It was not possible to establish the effectiveness and safety of thioctic acid for this category of patients, which is why the medicine is considered contraindicated for them.

Other patients can use the drug if they do not have individual intolerance.

When using Octolipen in people with diabetes, you should remember the ability of thioctic acid to reduce glucose concentrations.

This may enhance the effect of other hypoglycemic agents if the patient is taking them. Therefore, you should regularly check your blood sugar levels and adjust the dosage of medications accordingly.

Another important feature of the drug is the distortion of its action under the influence of alcohol. In this regard, specialists prohibit the consumption of alcohol during the course of therapy.

There is also no information about how Octolipen affects reaction speed and concentration. To avoid possible risks, you need to exercise caution when driving and engaging in hazardous activities.

Characteristics of Octolipen

Octolipen is a domestic vitamin-like product that has a powerful antioxidant effect and regulates the metabolism of fats and carbohydrates. The drug is available in three forms:

solution for intravenous administration;
pills;
capsules.

The drug is prescribed for alcoholic and diabetic polyneuropathy.

The drug has the following effects:

activates carbohydrate or fat metabolism;
normalizes the supply of organs and tissues with nerves, thereby ensuring their connection with the central nervous system;
fights seizures, loss of sensation in the limbs, ataxia;
removes salts of heavy metals and some biological poisonous compounds from the body;
improves the absorption of potassium and magnesium preparations;
reduces blood sugar levels and increases glycogen levels in the liver;
improves skin turgor and smoothes wrinkles.

Octolipen activates carbohydrate or fat metabolism in the body.

Tablets and capsules are taken orally on an empty stomach 30 minutes before meals, without chewing and with a sufficient amount of water. The solution is administered intravenously. The dosage and duration of therapy is determined by the doctor (individually for each patient).

According to the instructions, the use of Octolipen is prohibited:

during gestation;
during the lactation period;
minors;
in case of individual intolerance to any components of the product.

This is a medicine of the hepatoprotective and antioxidant group, which has hypolipidemic and hypoglycemic properties. The product is produced in 2 forms:

pills;
infusion solution.

The active component of Berlition is alpha-lipoic acid. Indications for use:

osteochondrosis of any localization;
diabetic polyneuropathy;
hypotension;
anemia;
liver diseases: fatty degeneration, hepatitis, cirrhosis;
atherosclerotic deposits in the coronary arteries;
intoxication with salts of heavy metals and other toxic substances.

Berlition helps accelerate metabolic processes and improve the production of enzymes.
The drug promotes:

acceleration of metabolic processes;
improving enzyme production;
regulation of fat and carbohydrate balance;
normalization of nerve bundles;
improving the course of trophic processes;
deactivation and removal of free radicals;
improving the absorption of vitamins and antioxidants.

The medicine is contraindicated for:

pregnancy and breastfeeding;
allergies to the components of the product;
lactose intolerance;
galactosemia.

In addition, the drug is not prescribed to children under 18 years of age.

Dosage and method of administration

Today, not only Octolipen is sold in pharmacies. Analogues are presented in such a variety that it is better to compare reviews before making the final choice. These are Espa-Lipon, Berlition 300 and much more. In addition to these, lipoic acid is sold directly.

To make the final choice, you need to decide on the dosage. Only the attending physician will help with this. The dosage varies greatly: 50-400 mg/day. Sometimes the doctor prescribes up to 1000 mg, but this is rather an exception. The instructions for the drug contain information that it is not recommended to exceed the dose of 600 mg. You need to start taking it with a smaller amount. For example, from half the daily portion. If you feel normal, then you can move on to the general dosage. It should not be exceeded without a doctor’s recommendation, as blood sugar may drop.

Let's dwell a little more on the issue of using the drug "Octolipen" for weight loss. How to take capsules or tablets with minimal health risks? There is not much difference between them, so see what is more convenient for you. Capsules contain 300 mg of active ingredient. Therefore, it is enough to take two per day, without chewing, 30 minutes before the first meal.

Tablets are used in a similar way. Their dosage is higher, 600 mg, so you will need 1 piece per day. Exceeding the prescribed amount can lead to headaches and a sharp drop in sugar, diarrhea and nausea, vomiting and an allergic reaction.

What kind of medicine is Octolipen

Alpha lipoic acid is a substance that is found in every cell of our body. It promotes the conversion of glucose into energy and plays an important role in carbohydrate metabolism. It is also an antioxidant that is more powerful than tocopherol, which was previously considered one of the most effective vitamins in the fight against free radicals. All over the world, doctors began to give preference to drugs with thioctic acid, replacing vitamin E with them in the treatment of cardiovascular diseases, diabetes, hepatitis and other serious diseases.

Octolipen is not only an effective medicine, but also an excellent anti-aging cosmetic product

Octolipen is prescribed for the treatment of diabetic and alcoholic polyneuropathy - a disorder of the conduction of peripheral nerve fibers. It reduces the body's resistance to insulin in diabetes mellitus. But the therapeutic effect of Octolipen is not limited to this. It is used as:

hepatoprotector;
means for regulating fat metabolism;
to relieve intoxication;
hypoglycemic agent (but do not replace hypoglycemic drugs with it);
a drug that regulates cholesterol levels.

The effect of alpha lipoic acid is similar to the effect of taking B vitamins.

Alpha lipoic acid is unique in its nature. Thanks to its ability to dissolve in fats and water, it has a universal protective effect. In particular, alpha lipoic acid is able to restore vitamins E and C and coenzyme Q10 after they have already been used by the body, and also replace other antioxidants when necessary, effectively restoring cell membranes and scavenging free radicals.

How to take the drug

To reduce body weight at home, it is recommended to use oral forms of the drug (tablets and capsules). The use of the drug in liquid form is advisable only for severe obesity. In this case, treatment is carried out in a hospital setting.

Capsules and tablets for weight loss should be taken once a day 30 minutes before breakfast. They should be swallowed whole and washed down with a few sips of water. The daily dose of medication for an adult is 600 mg. The duration of therapy is determined by the doctor individually depending on the patient’s weight.

Instructions for the drug in capsule form.

The concentrate is administered intravenously using droppers at 300-600 mg 1 time per day. Use of this form of the drug should not last more than 4 weeks. After completion of infusion therapy, the patient continues treatment with Octolipen tablets or capsules.

Throughout the entire period of using the medicine, it is necessary to limit the consumption of high-calorie foods and completely abstain from alcohol. The thioctic acid contained in the product is incompatible with calcium, magnesium and iron, so preparations containing them should be taken after lunch. You also need to ensure that the time interval between taking Octolipen and eating foods containing these minerals (cottage cheese, milk, red meat, etc.) is at least 6 hours.

Pharmacology and pharmacokinetics

The active component has a broad effect on the body. When taking it, patients have a decrease in blood sugar concentration, since thioctic acid increases sensitivity to insulin. Accordingly, glucose is actively absorbed by cells and distributed in tissues.

Acid neutralizes the effects of pathogenic substances, cleanses the body of toxic elements and helps strengthen the immune system. Thanks to it, the amount of cholesterol is reduced, which prevents the development of atherosclerosis. In addition, the acid improves liver activity and affects the processes of lipid and carbohydrate metabolism.

When taken orally, the therapeutic component is absorbed and distributed at a rapid pace. Its concentration reaches its maximum after about 40 minutes. Even greater effectiveness can be achieved with injections. The absorption process is affected by the timing of meals - it is advisable to use the drug before meals.

Acid processing is carried out by the liver. Most of this substance is eliminated from the body through the kidneys. Half-life requires about an hour.

Video about the properties of thioctic acid:

Experts' opinions on the drug Octolipen

All of them are of the opinion that Octolipen is a useful drug. Its use gives real results and helps patients regain their health. An additional positive point is the possibility of use by diabetics and people with liver diseases.

The use of the drug is not only in the treatment, but also in the prevention of complex diseases. An important point is compliance with the prescribed dosage. Good results will be noticeable approximately on the 7th day of treatment.

Treatment will be lengthy and should always be under medical supervision. The use of the drug parenterally allows it to be used by many patients suffering from diseases of the digestive system.

The cost of the medicine is not the cheapest, but it cannot be considered expensive either. Ampoules cost from 370 rubles, capsules from 310 rubles, tablets from 620 rubles.

Why is Octolipen prescribed?

If you have a number of diseases associated with damage to nerve fibers and metabolic disorders, experts recommend taking Octolipen. Indications for the use of lipoic acid allow the drug to be used in the treatment of the following pathologies:

polyneuropathy, diabetic or alcoholic origin;
insulin resistance, in type 1 and type 2 diabetes;
fatty fibrosis;
chronic hepatitis;
atherosclerosis;
pancreatitis;
cholecystitis.

Customer Reviews

"Octolipen 600" has many positive reviews; As a rule, many patients highly value this drug - it is much cheaper than Berlition, but more effective than Neurolipon, as a result of which it is the most preferred when purchasing and prescribing.

The ampoule drug is sold at an average price of 380 rubles, and tablets and capsules sold by prescription cost 290-300 rubles.

And remember - take care of your health. Do not self-medicate; Octolipen tablets 600 should be taken only after consulting a doctor. Self-administration of the drug without a doctor's prescription can lead to bad consequences for your health, including death.

Similar to Octolipen

The drug Octolipen is in great demand due to its effects on the body. But there are many similar tools:

Alpha Lipon;
Thioctacid;
Tioktodar;
Berlition 600;
Espa-Lipon;

All these analogues have almost the same effect, but you should not replace the medicine yourself; it is better to consult a specialist. Any drug from this group is dispensed strictly according to a doctor's prescription.

The price of Octolipen tablets in Moscow is approximately 700 rubles. Ampoules are cheaper - about 400 rubles per package. Cost is the main reason why people prefer similar products.

Drug interactions and analogues

For therapy to be productive, the following features of the drug must be taken into account:

Octolipen enhances the effect of oral hypoglycemic agents and insulin;
when taken together, the medicine may reduce the effectiveness of Cisplatin;
preparations containing iron, magnesium or calcium should be taken before or after Octolipen with a gap of several hours;
the medicine enhances the anti-inflammatory properties of glucocorticosteroids;
Under the influence of alcohol, the effectiveness of Octolipen itself decreases.

In this regard, it is necessary to change the dose of the medicine and maintain the prescribed time intervals. Although it is better to avoid combining this drug with inappropriate drugs.

Sometimes patients refuse to take this medicine and ask to find cheaper analogues. In other cases, a replacement is needed due to problems with this particular drug.

Synonymous drugs include:

The choice of Octolipen substitutes should be made by a healthcare professional.

What is octolipene good for weight loss?

Of course, resorting to the help of pharmacists in order to get rid of extra pounds and such hated fat is not the best option, but not the worst either. The process of improving your appearance and well-being with the help of octolipene has many advantages:

this is a natural drug, which means that when taking it you do not need to be afraid of negative effects on your health (of course, if you follow the dosage and take into account the individual characteristics of the body);
it is relatively inexpensive, that is, this method of normalizing metabolic processes will not undermine your financial condition;
accessible because it is produced in Russia;
octolipene, affecting metabolism, will inevitably affect the condition of your skin, and for the better - it will become more elastic, smooth and healthy;
the fight against excess weight with the help of octolipene will not require additional time expenditure and the development of special culinary skills;
The drug is well tolerated by most people; stomach discomfort is observed in rare cases.

All this makes octolipene such a popular drug in the fight for a beautiful figure.

Reviews about octolipene

Most people taking Octolipene as a weight loss aid share positive reviews. Many note that this drug gives a more pronounced effect than regular lipoic acid, although it is more expensive. Also, the advantages of octolipene include its effect on appetite - it decreases, so that weight loss is achieved due to a general decrease in daily caloric intake. Another interesting feature noted by those losing weight is that when losing weight, not everyone experienced changes in volume. That is, the kilograms went away, but the centimeters remained.

Overall, the overall effect of taking octopylene is not considered outstanding, but with gradual weight loss it becomes more long-term. The main thing is not to overdo it with the dosage and not to ignore contraindications.

Octolipene as a remedy for wrinkles

The fact that the medicine began to be used as a remedy for wrinkles is due to the antioxidant properties of alpha-lipoic acid.

The cosmetic effect of Octolipen is manifested in the following:

removes excess moisture, relieving swelling;
prevents collagen fibers from sticking together;
has an anti-inflammatory effect;
evens out skin tone, eliminating age-related pigmentation;
eliminates dark circles and puffiness under the eyes;
accelerates metabolic processes in the skin;
improves its turgor, creating a lifting effect;
slows down the aging process of the skin.

In what form is it used?

Octolipen is available in capsules, tablets and ampoules. As a cosmetic product, it is better to use it in liquid form or in capsules; there are fewer ballast substances than in tablets, and it is also simply more convenient. The contents of the capsule or ampoule are dissolved in water, added to masks and to the usual day cream.

Ampoule Octolipen cannot be used in its pure form; it is a concentrated drug that is diluted with saline solution for drip intravenous infusion. For the face, Octolipen is used only when dissolved in other liquids.

Octolipen prices in online pharmacies

OCTOLIPEN 30mg/ml 10ml 10 pcs. concentrate for the preparation of solution for infusion

OCTOLIPEN 300 mg 30 pcs. capsules

Octolipen 30 mg/ml concentrate for the preparation of solution for infusion 10 ml 10 pcs.

Octolipen capsules 300 mg 30 pcs.

Octolipen 300 mg capsules 30 pcs.

Octolipene conc. for prig solution for inf. 30mg/ml 10ml 10 pcs.

OCTOLIPEN 600 mg 30 pcs. film-coated tablets

Octolipen 600 mg film-coated tablets 30 pcs.

Octolipen tablets p.p.o. 600 mg 30 pcs.

Education: First Moscow State Medical University named after I.M. Sechenov, specialty “General Medicine”.

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Indications

Based on the instructions. The number of contraindications for Octolipen is quite similar to Berlition 600 and is small. This is a list of symptoms with syndromes, diseases, various external and internal conditions under which the use of Octolipen and Berlition 600 may be undesirable or unacceptable.

The drug Berlition thioctic acid is prescribed:

For osteochondrosis of any localization.
For diabetic polyneuropathy.
For all kinds of liver pathologies (fatty liver degeneration, all hepatitis, cirrhosis).
Atherosclerotic deposits in the coronary arteries.
Chronic poisoning with salts of heavy metals and other toxins.

Based on the instructions. The number of contraindications for Octolipen is quite similar to Berlition and is small. This is a list of symptoms with syndromes, diseases, various external and internal conditions under which the use of Octolipen and Berlition may be undesirable or unacceptable.

Nutritionist's comments

Despite the fact that this drug is indeed used by women for weight loss, an experienced doctor should warn you against such experiments, unless we are talking about impaired carbohydrate and protein metabolism, as well as weight correction in diabetics.

In all other cases, there is no evidence that the drug actually breaks down fats. We have not found a single confirmed experiment, so the effectiveness of the drug can be considered unproven. Lipoic acid is not foreign to your body, but it cannot burn fat and significantly improve metabolism. That is, a number of nutritionists attribute the entire effect to self-hypnosis, active training and dietary restrictions. All these measures can be taken without additional expenses in the form of purchasing medications. Therefore, sign up for a gym, remove mayonnaise and ketchup from the refrigerator, and lose weight gradually, but without harm to your body. In this case, the lost kilograms will definitely not return, as they are supported by rational, proper nutrition.

What is better Berlition or Octolipen?

Anna, 35 years old, Moscow

Because Because of diabetes, I constantly have a feeling of unpleasant numbness in my limbs, the doctor prescribed Octolipen, but it caused me side effects - nausea, dizziness. Therefore, he was replaced by Berlition. This medicine is better tolerated, it begins to act faster, improves blood circulation, which is why the feet stop freezing. The frequent feeling of goosebumps crawling on the skin also disappeared.

Ekaterina, 55 years old, St. Petersburg

My husband has been suffering from alcohol addiction for a long time. As a result, neuropathy developed. Treatment started a few months ago. The doctor prescribed Berlition. He helped a lot, but... The treatment is long and the drug is expensive, so we asked the doctor to replace it. Octolipen was prescribed. It's cheaper, but it helps just as much.

Irina, 40 years old, Rostov-on-Don

I have been suffering from diabetes for 5 years. I began to feel numbness in my lower extremities, coldness, and cramps. The doctor explained that this happens due to high blood sugar and advised the use of lipoic acid preparations - Berlition and Octolipen. At first, I recommended taking a course of treatment with Berlition, and then, to avoid addiction, start taking its domestic equivalent.

Alena, 26 years old, Samara: “I decided to buy the drug Octolipen for weight loss, because I found out that it normalizes fat metabolism and controls appetite. I took it according to the instructions. After a while I noticed a significant result.”

Oksana, 44 years old, Omsk: “I suffer from diabetic encephalopathy. The doctor prescribed the drug Octolipen to relieve the symptoms of the disease and stop further changes in the nerve fibers. I took the product for 2 weeks. During this period I felt an improvement.”

Dmitry, 56 years old, Dimitrovgrad: “The doctor prescribed Berlition in the form of droppers to treat complications caused by diabetes. At the very beginning of treatment, a headache occurred and a burning sensation was felt in the legs. After a short break, the doctor prescribed this drug in tablet form. No such side effects were observed after their use.”

Marina, 45 years old, Tver

She took Berlition to eliminate numbness and coldness of the extremities caused by diabetes mellitus. After completing the course of therapy, all unpleasant symptoms disappeared. The drug acts quickly, improves blood circulation, without causing negative reactions.

Dmitry, 50 years old, Murmansk

I took Octolipen for the treatment of alcoholic polyneuropathy. After completing the course of treatment, I began to feel much better. The drug helped normalize liver function and accelerated the excretion of bile. I recommend this inexpensive and effective medication to people who have overcome alcohol addiction in order to improve the health of the body.

Vitaly Alexandrovich, 43 years old, neurologist, Moscow

I prescribe Octolipen to my patients for the treatment of polyneuropathy. After completing the course of treatment, patients’ nerve fibers regain their functionality, and innervation is normalized.

Lyudmila Vasilievna, 52 years old, endocrinologist, Samara

Berlition is an effective foreign medicine based on alpha-lipoic acid, which I prescribe to people suffering from diabetic polyneuropathy. The drug helps improve the process of innervation of the limbs, stimulates lipid and carbohydrate metabolism, and also stops the progression of severe complications of diabetes.

My husband has been suffering from alcohol addiction for a long time. As a result, neuropathy developed. Treatment started a few months ago. The doctor prescribed Berlition. He helped a lot, but... The treatment is long and the drug is expensive, so we asked the doctor to replace it. Octolipen was prescribed. It's cheaper, but it helps just as much.

Which is better – Berlition or Octolipen?

Both drugs are used in two cases: alcoholic or diabetic polyneuropathy and liver damage of various types. It is not possible to reliably compare the effectiveness of these drugs, since they are always part of complex therapy. In general, both Berlition and Octolipen have approximately the same effect.

If financial resources do not allow you to purchase a foreign medicine, then Octolipen will be an excellent replacement. In other cases, however, preference should be given to Berlition.

Berlition is a drug of the hepatoprotective and antioxidant group, which also has hypolipidemic and hypoglycemic properties, which consist in reducing the concentration of glucose and excessive lipids in the blood.

The active ingredient of the drug is thioctic (α-lipoic) acid. This substance is found in almost all human organs, but its dominant amount is found in the kidneys, liver, and heart.

Thioctic acid is a powerful antioxidant that helps reduce the pathogenic effects of heavy metals, toxins and other toxic compounds. In addition, the substance protects the liver from external negative factors and improves its activity.

Thioctic acid normalizes carbohydrate and lipid metabolic processes, promotes weight and sugar reduction. In terms of biochemical action, thioctic acid is almost identical to B vitamins; it stimulates the metabolic processes of cholesterol, prevents the development of atherosclerotic plaques, promotes their resorption and removal from the body.

The action of the active components of Berlition reduces the production of by-products of the glycosylation mechanism. Thanks to this, neuro-peripheral function is improved, the level of glutathione increases (a powerful antioxidant produced naturally in the body, protects against toxins, viruses and all kinds of diseases).

The domestic drug Octolipen, which also contains thioctic acid as an active ingredient, is a vitamin-like drug that has an antioxidant effect and regulates the metabolism of fats and carbohydrates.

Octolipen occupies a very narrow pharmacological “niche”, since it has only two indications for use – diabetic and alcoholic polyneuropathy. In other words, it is damage to the peripheral nerves due to the presence of a history of diabetes mellitus or alcoholism.

Today the word “antioxidant” is very common, but not everyone has the correct understanding of it. In order to eliminate the information vacuum, it makes sense to briefly explain this term. Antioxidants are called oxidation inhibitors that prevent the effects of free radicals on the body, thereby slowing down the process of cellular aging.

Octolipene is an endogenous (naturally formed in the body) antioxidant, the precursor of which is the mechanism of oxidative decarboxylation of alpha-keto acids.

As a coenzyme of the multienzyme systems of mitochondria (cellular “energy stations”), Octolipene is involved in the oxidative decarboxylation of pyruvic (a-ketopropionic) acid and alpha-keto acids.

Octolipene reduces the concentration of glucose in the bloodstream and increases the level of glycogen in the liver. The drug creates conditions to prevent insulin resistance. Octolipene is close in its biochemical properties to B vitamins.

Octolipen is a regulator of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves the functional qualities of the liver. In addition, the drug has hypoglycemic, hypolipidemic, hypocholesterolemic and hepatoprotective effects.

Manufacturers produce Octolipen in three dosage forms:

Pills.
Capsules.
Concentrate for the preparation of infusion solution.

The solution for infusion is used mainly in hospital settings, and tablets and capsules can easily take root in a home medicine cabinet.

Capsules and tablets should be taken on an empty stomach, half an hour before meals and washed down with plenty of liquid. You cannot chew the tablets (we are not talking about capsules in this regard; it is clear that they are swallowed whole).

The recommended dose of Octolipen is 600 mg, which is equal to two capsules or one tablet. The drug is taken once a day. The duration of the therapeutic course is determined by the doctor, taking into account certain factors.

Combining different forms of the drug is allowed: at the first stage, the drug is administered parenterally (2-4 weeks), then switched to any oral form.

Doctors today are arguing about: which is better - Berlition or Octolipen? There is no answer yet, since both of these drugs have identical active ingredients. But if you trust the reviews, the domestic Octolipen is better than the German Berlition both in terms of effectiveness and price.

Berlition or Octolipen are used to treat patients with liver pathologies, polyneuropathies of alcoholic or diabetic origin, as well as to prevent complications of type 1 diabetes. They are effective medications for diabetes.

Berlition and Octolipen are used to treat patients with liver pathologies, polyneuropathies of alcoholic or diabetic origin.

The active substance of the drugs is the same and their effect is the same. Oral forms of drugs have lower bioavailability because some of the active components are metabolized in the digestive tract. Therefore, it is better to start the course of treatment with Berlition in the form of injections. When a therapeutic effect is achieved, treatment is continued with Octolipen.

Berlition is more often used to treat diabetic or alcoholic type lesions. Injections help get rid of severe intoxication if the patient, due to a serious condition, cannot take tablets or capsules on his own. Berlition is also better suited for setting up droppers: the concentrate dissolves well and begins to act quickly.

Ekaterina, vascular surgeon, 50 years old, Moscow

In cases of sensory disturbances in the limbs and the appearance of seizures due to diabetes or alcoholism, I recommend that patients take Berlition and Octolipen. These drugs cope well with vascular disorders and prevent the appearance of atherosclerotic plaques inside large vessels. I often prescribe Octolipen for diabetic vascular damage, and Berlition for acute intoxication with toxins and severe damage to blood vessels and nerves due to alcohol poisoning of the body.

Ivan, therapist, 55 years old, St. Petersburg

Octolipen and Berlition are effective drugs for normalizing the functioning of the cardiovascular and nervous systems. Berlition improves the process of innervation of the lower extremities, stimulates fat and carbohydrate metabolism, and stops the progression of severe complications of diabetic pathology. I recommend Octolipen for patients suffering from alcohol dependence to improve results after the main treatment of the disease. There are practically no side effects from medications, patients tolerate them well.

Octolipen is a cheap analogue of Berlition, but its side effects occur more often. Which drug is better can only be determined after practical use.

The doctor, when deciding which drug is better - Berlition or Octolipen, focuses on the disease itself and the existing contraindications. Octolipen is a cheap analogue of Berlition, so it is prescribed more often.

Irina, neurologist: “I often prescribe Octolipen to my patients for the treatment of polyneuropathy. This disease causes severe discomfort to patients. After the course of treatment, the nerve fibers restore their functionality and innervation is established.”

Tamara, therapist: “I prescribe Berlition for damage to the peripheral nervous system, because it is effective in this regard. But I always warn patients that they should not drink alcohol, as severe poisoning may develop.”

Methods of application

There are several ways to use Octolipen. But they all require course application. This means that a break is necessary, and then, as necessary, a repeat course of skin treatment.

Anti-inflammatory and skin restoration

Dilute one ampoule of Octolipen in two tablespoons of boiled water.
Apply the solution to your face and leave for 30 minutes.
Then apply another layer on top and leave again for half an hour.
After this time, wash and lubricate your face with cosmetic milk.

Treatment is carried out once a day for 14 days, then a break is taken for 4 months.

Using Octolipen will help get rid of facial wrinkles

For wrinkles

Anti-aging cream can be enriched with octolipene. Two tablespoons of cream are mixed with an ampoule of the drug and applied to the face, covering the area around the eyes. In this case, the duration of the course corresponds to the recommendations for the use of the cream.

For aging skin

Octolipen works well in combination with vitamin C.

Mix the contents of one ampoule of the medicine with two tablespoons of water and five drops of lemon juice.
Rub the mixture onto cleansed facial skin and leave until completely dry.
Wash with water and apply nourishing cream to the skin.

After 7 days of use, take a break for 2 months.

Oil mask for rejuvenation

This mask is suitable for achieving instant results before a social reception or other important event, when you urgently need to refresh your face and get rid of signs of fatigue.

For the mask you will need an Octolipen solution, vegetable oil (any) and vitamin E. All components must be in equal proportions. The mask is left for 15 minutes, washed off, and a moisturizer is applied to the face. Alpha lipoic acid will quickly smooth out fine wrinkles and visually reduce deep skin creases.

Registration numbers

caps. 300 mg: 30 pcs. LSR-002211/07 (2015-08-07 – 0000-00-00)

Experimental determination of suitable drugs:

TIOLEPTA
BERLITION 300
OCTOLIPEN
BERLITION 300
THIOGAMMA
ESPA-LIPON
THIOCTACID BV
THIOCTIC ACID
THIOCTACID 600 T
TAMIFLU
KUDEVITA
FORKAN

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ATX code for OCTOLIPEN

A16AX01 (Tioctic acid)

Experimental determination of suitable drugs:

TIOLEPTA 15.013 (A drug that regulates lipid and carbohydrate metabolism), composition and…
BERLITION 300 16.047 (A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism) Form…
OCTOLIPEN 11.090 (A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism. Hepatoprotector)…
BERLITION 300 16.047 (A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism) Form…
THIOGAMMA 15.013 (A drug that regulates lipid and carbohydrate metabolism), composition and…
ESPA-LIPON 11.090 (A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism. Hepatoprotector)…
TIOCTACID BV 16.047 (A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism) Form…
THIOCTIC ACID Clinical and pharmacological groups 17.024 (Multivitamins with macro- and microelements and amino acids) 16.047 (Drug with antioxidant…
TIOCTACID 600 T 16.047 (A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism) Form…
TAMIFLU 10.001 (Antiviral drug), Hard gelatin capsules, size…
KUDEVITA 01.036 (Drug that improves myocardial metabolism), Hard capsules…
FORKAN 09.001 (Antifungal drug), Hard gelatin capsules,…

general information

Octolipene is based on thioctic acid. Sometimes this drug may be called lipoic acid, since it contains the same component. This medicine is aimed at eliminating many diseases.

It has several useful properties:

hepatoprotective;
hypoglycemic;
neuroprotective;
hypocholesterolemic.

You can find out why Octolipen is prescribed from the instructions. It is suitable for the treatment of diabetes, but there are other pathologies for which it is needed.

A doctor must prescribe the medicine. He can assess how appropriate it is to use it in a given situation, select the correct dosage and monitor the progress of treatment.

Octolipen is produced in Russia. To purchase this product at a pharmacy, you must present a prescription.

Opinion of specialists and patients

From the reviews of doctors about the drug Octolipen, we can conclude that it is more readily prescribed in complex therapy for weight loss. In the case of diabetes, there is a high probability of complications in the form of hypoglycemia.

Reviews from patients are quite contradictory - the drug effectively helps in weight loss, but is characterized by frequent side effects.

I rarely prescribe Octolipen to my patients. Suitable for some, not for others. The drug helps with poisoning, reduces sugar levels, women often ask to prescribe it for weight loss. But, as with any medicine, you need to be careful with it due to contraindications and side effects.

Ekaterina Igorevna, doctor

I recommend Octolipen and its analogues to overweight patients - it really helps with this. I do not recommend using it for diabetics. If they use hypoglycemic drugs, then Octolipen can cause complications.

Irina Sergeevna, doctor

I didn't like this drug. Because of it, my sugar dropped significantly - the doctor did not pay attention to the fact that I was diabetic. I was hospitalized due to hypoglycemia. Some friends praise this product, but I don't want to risk it.

I used Octolipen for weight loss. The first week I felt unwell and was constantly nauseated. Then I got used to it. I liked the results - in 2 months I got rid of 7 kg.

To purchase this drug in capsules you will need from 300 to 400 rubles. Tablets (600 mg) cost 620-750 rubles. The price for a package of Octolipen with ten ampoules is 400-500 rubles.

In this article you can read the instructions for use of the drug Octolipen . Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Octolipen in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Octolipene in the presence of existing structural analogues. Use for the treatment of hepatitis, liver cirrhosis and weight loss in adults, children, as well as during pregnancy and lactation. Composition of the drug.

How to replace Octolipen analogues of the drug

The pharmacological industry produces many variants of drug analogues that replace B vitamins. Let's consider some of the Octolipen substitutes:

Thioctacid. The drug is used for intravenous administration (stream or drip), orally (tablets). Concentration – 600 mg alpha lipoic acid. Indications for use: diabetic polyneuropathy, high cholesterol, hepatitis. Take orally in the morning on an empty stomach.
Thiolipon (complete analogue of Octolipen). Pharmacological group – metabolic medicine. Available in the form of a solution for injection. Administered intravenously (stream or drip), intramuscularly. Injections: 600 mg 1 time per day. In case of diabetes mellitus and drug therapy, sugar levels are adjusted more often. Control: 4 times a day;
Espa lipon. Base: thioctonic acid. The drug corrects liver cirrhosis and restores the conductivity of nerve fibers. Lipolic acid accelerates fat metabolism and causes a decrease in sugar. Diabetic patients require constant monitoring of glucose levels in the body. Take acid: 1 dropper per day. The amount of substance in the drug is 600 mg.

Characteristics of Berlition

The drug is manufactured in the form of a concentrate to obtain a solution for infusion, soft capsules, film-coated tablets.
The concentrate ampoule contains 300 or 600 mg of the active component - thioctic acid. This solution is administered intravenously. 1 soft capsule contains 300 or 600 mg of acid, tablet contains 300 mg of active ingredient. The excipient of the soft capsule is sorbitol, the tablets are lactose monohydrate.

Thioctic acid, or alpha lipoic acid, acts as a coenzyme in the metabolic process of pyruvic acid. The product prevents the deposition of glucose on the matrix proteins of blood vessels and inhibits the synthesis of end products of glycation. Improves blood circulation, stimulates the synthesis of the antioxidant substance glutathione. Berlition improves endoneurial circulation in patients suffering from alcoholic or diabetic polyneuropathy.

Alpha lipoic acid improves liver function and prevents the disease from reaching the terminal stage. It is a strong antioxidant and has a positive effect on the processes of lipid and carbohydrate metabolism. Promotes weight loss. Activates cholesterol metabolism and is effective in resolving cholesterol plaques.

When administered orally (internally), the active substance Berlition is well absorbed. The biological availability of the drug is about 20%. Peak plasma concentrations are observed 30 minutes after oral administration. The time after which half of the drug is eliminated from the body is approximately 25 minutes. It is evacuated from the body mainly in the form of breakdown products, a small amount is released unchanged.

Indications for use:

diabetic, alcoholic polyneuropathy;
paresthesia;
diabetic encephalopathy;
low brain activity;
osteochondrosis of any localization;
deposits of cholesterol plaques in the coronary vessels;
poisoning with salts of heavy metals;
liver pathologies.

Side effects often include digestive disorders - nausea, vomiting, dyspepsia, dysgeusia (changes in the sense of taste). After rapid injection into a vein, an increase in heart rate, redness of the face, pain and tightness in the chest occurs. Some patients experience headaches and cramps.

Other side effects:

allergic reactions in the form of urticaria, eczema, skin rash;
development of hypoglycemia attacks;
increased sweating;
visual impairment;
dizziness;
breathing problems;
thrombocytopenia;
purpura;
increased paresthesia with a sensation of crawling on the skin.

Side effects from taking Berlition are: allergic reactions in the form of urticaria, eczema, skin rash.

Extremely rare adverse reactions of Berlition:

thrombophlebitis;
skin rashes similar to subcutaneous hemorrhages;
increased salivation;
tendency to develop bleeding;
increased intracranial pressure.

The tablets are not prescribed to persons suffering from impaired absorption of glucose or galactose, galactosemia, or lactase deficiency. The combined use of Berlition with alcoholic beverages is prohibited.

Octolipene is produced in the form of capsules and tablets. The active substance is alpha lipoic acid. The tablets are coated with a thin film coating.

Octolipen is used for alcoholic polyneuropathy and diabetic damage to blood vessels. It is often prescribed as a dietary supplement to improve the health of patients with disorders of the nervous or circulatory system, insulin-resistant diabetes and disability.

Octolipen is used for:

activation of carbohydrate or fat metabolism with an integrated approach to weight loss;
normalization of innervation;
combating convulsions, numbness of limbs, impaired coordination of movements;
removal of salts of heavy metals and some toxic compounds of biological origin;
increasing the absorption of potassium or magnesium preparations;
improving skin elasticity and eliminating wrinkles.

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Octolipen is not used during pregnancy and lactation, because There is no information on the safe effects of alpha lipoic acid in pregnant women. There have been cases of negative effects of the drug on the fetus in the form of mental and physical development disorders.

The drug is contraindicated in children under 18 years of age. Do not use if you are intolerant to thioctic acid or prone to allergic reactions to medicinal starch and gelatin.

Octolipen is not used during pregnancy and lactation, because There is no information on the safe effects of alpha lipoic acid in pregnant women.

Octolipen can cause:

skin reaction in the form of hives, rash, redness of the skin;
swelling and redness of the mucous membranes;
vomiting;
intensive formation of intestinal gases;
temporary blurred vision;
heartburn;
pinpoint effusions on the skin.

Octolipene is not used together with alcoholic beverages.

The concentrate ampoule contains 300 or 600 mg of the active component - thioctic acid. This solution is administered intravenously. 1 soft capsule contains 300 or 600 mg of acid, tablet contains 300 mg of active ingredient. The excipient of the soft capsule is sorbitol, the tablets are lactose monohydrate.

When administered orally (internally), the active substance Berlition is well absorbed. The biological availability of the drug is about 20%. Peak plasma concentrations are observed 30 minutes after oral administration. The time after which half of the drug is eliminated from the body is approximately 25 minutes. It is evacuated from the body mainly in the form of breakdown products, a small amount is released unchanged.

Octolipene is produced in the form of capsules and tablets. The active substance is alpha lipoic acid. The tablets are coated with a thin film coating.

Berlition is a drug based on thioctic acid, which belongs to the group of vitamins and is highly soluble in water. Its main action is as follows:

accelerates metabolic processes;
helps the production of enzymes;
regulates fat and carbohydrate balance;
normalizes the functioning of nerve bundles;
has a beneficial effect on the course of trophic processes;
deactivates and removes free radicals;
Helps absorb vitamins and antioxidants.

Berlition helps with such a terrible disease as diabetic polyneuropathy in diabetes mellitus. This disease often leads to disability. But at the same time, the patient must regularly take blood tests to monitor blood sugar levels.

Berlition is used in the following cases:

liver diseases;
glaucoma;
angiopathy;
damage to nerve endings.

The drug helps eliminate the effects of chemical poisoning.

Berlition has the following indications for use:

hypotension;
anemia;
osteochondrosis of any localization;
atherosclerotic changes in the coronary vessels;
endocrine diseases caused by metabolic disorders;
polyneuropathy of the lower and upper extremities;
organic disorder in the cells of the spinal cord and brain;
acute and chronic intoxication of various origins;
diseases of the liver and biliary tract.

A drug based on alpha-lipoic acid is used in endocrinology and cosmetology to normalize metabolic processes, improve skin condition, and lose weight.

Berlition has contraindications:

pregnancy and lactation;
age under 18 years;
fructose intolerance;
galactosemia;
lactose deficiency.

Side effects rarely occur after taking Berlition. It can be:

changed taste sensations;
tremor of limbs, convulsions;
a feeling of heaviness and pain in the head, dizziness, visual impairment, manifested by doubling of objects and flickering of spots;
abdominal pain, constipation, diarrhea, nausea, vomiting;
tachycardia, feeling of suffocation, skin hyperemia;
urticaria, skin itching, rashes.

The manufacturer of Berlition is the pharmaceutical concern Hemi (Germany). In terms of release form, the drug is presented in tablets and solution for injection in ampoules for intravenous administration. Analogs of this drug include: Neurolipon, Thiolipon, Lipothioxone, Thiogamma, Octolipen.

Octolipen is a drug based on thioctic acid. When ingested, it has the following effects:

activates fat and carbohydrate metabolism, reducing blood sugar;
carries out decarboxylation;
removes toxic compounds from the body;
normalizes innervation;
promotes brain activity;
restores the structure of the liver during fatty degeneration and hepatitis;
eliminates wrinkles, increases the elasticity of the skin;
allows medications to be absorbed faster.

For diseases that develop due to metabolic disorders and damage to nerve fibers, doctors prescribe Octolipen. Indications for its use are as follows:

cholecystitis;
pancreatitis;
atherosclerosis;
chronic hepatitis;
fatty fibrosis;
insulin resistance in type 1 diabetes;
polyneuropathy of alcoholic and diabetic origin.

Contraindications include:

pregnancy and lactation;
children under 18 years of age;
intolerance to the components of the drug;
galactosemia;
lactose deficiency.

If you do not follow the dosage and take the medicine incorrectly, negative consequences may develop. A skin reaction may develop - hyperemia of the mucous membranes, urticaria, allergic dermatitis.

Analogues and prices

Among foreign and Russian analogues of Octolipen there are:

Thioctacid 600 t. Manufacturer: Meda Pharma GmbH and Co.KG (Germany). Price in pharmacies from 1510 rubles. Thioctacid bv. Manufacturer: Meda Pharma GmbH and Co.KG (Germany). Price in pharmacies from 3058 rub. Thiolepta. Manufacturer: Kanonpharma (Russia). Price in pharmacies from 578 rubles. Lipoic acid. Manufacturer: Marbiopharm (Russia). Price in pharmacies from 51 rub. Espa lipon. Manufacturer: Esparma (Germany). Price in pharmacies from 824 rubles.

Infusions or tablets?

Due to the peculiarities of metabolism, oral forms have lower bioavailability, which is also highly dependent on food intake.
Therefore, it is better to start the course of Octolipen or Berlition with infusions (2-4 weeks), and then switch to traditional forms. The contents of ampoules (1-2 of both competitors) are diluted in saline and administered through a dropper intravenously, about half an hour once a day. comparison table

Octolipen	Berlition
Main active substance
thioctic acid
Forms and quantity per package
table — 600 mg (30 pcs)	table — 300 mg
solution - 300 mg/amp.
10 pieces	5 pieces
caps. — 600 mg (30 pcs)	—
The presence of lactose in the tablet.
No	Yes
Manufacturer country
Russia	Germany
Price
below	1.5-2 times higher

As a hypotensive. Administration of 300 mg/day for 4 weeks to patients with metabolic syndrome had no significant effect on blood pressure compared with the placebo group. The use of LA thioctic acid with L-carnitine showed little effectiveness in reducing systolic pressure in patients with high blood pressure.
For diabetes. Proven to enhance the hypoglycemic effect of insulin. For diabetic peripheral neuropathy (DPN), an analysis of 15 clinical studies of the effect of 300-600 mg TC per day for a month confirmed the safety and improvement of nerve conduction velocity compared to a pacifier.
Brain activity. According to Cochrane Evidence Based Medicine, alpha lipoic acid is often suggested as an adjunctive treatment for dementia and Alzheimer's disease. However, to date there are no studies that would confirm its effectiveness. The Cochrane Organization does not recommend TC for use in the treatment of any subtype of dementia.
For weight loss. Yale University in the USA analyzed 10 studies on the use of strong antioxidants, including thioctic acid, to correct body mass index (BMI). TC produced little difference in weight loss compared with placebo in the short term. There is no long-term data on maintaining a healthier weight.

Thioctacid

Thioctic acid is present in Thioctacid solution, and trometamol thioctate is used in the tablet version of tablets.

Thioctacid is a metabolic drug that helps reduce the manifestations of diabetic and alcoholic nephropathy.

antioxidant,
hypoglycemic,
hepatoprotective effect.

Thioctacid normalizes metabolic processes in the body, which is important for type 2 diabetes. There are dosage forms:

There are dosage forms:

The main component of the drug is an endogenous antioxidant. The presence of the substance in the body ensures:

active sugar removal,
normalization of neuronal trophism,
protecting cells from toxins,
reduced manifestation of the disease.

This antioxidant is normally present in the body in the required amount and supports its normal functioning.

The active substance contained in the drug Thioctacid is quickly and completely absorbed and partially eliminated from the body in about half an hour. But taking the drug with food impairs the absorption of the main substance. Bioavailability is 20%.

Metabolism is mainly carried out by oxidation and conjugation. A large amount of the drug is excreted by the kidneys. Thioctacid is usually prescribed for diabetic neuropathies.

This drug is also prescribed for liver pathologies. For example, the remedy is prescribed for:

cirrhosis,
chronic hepatitis,
fatty degeneration,
fibrosis.

Thioctacid makes it possible to eliminate the toxic effect of metals.

The price of the product in the form of ampoules is about 1,500 rubles, tablets cost from 1,700 to 3,200 rubles.

Your doctor will help you determine which is better: Thioctacid or Octolipen. The video in this article will tell you about the benefits of lipoic acid for diabetics.

What is the difference?

30 caps.
Oral forms take 600 mg per day: Berlition or Octolipen capsules, one twice a day, Octolipen tablets once. For maximum absorption of thioctic acid, it is advisable to take these medications half an hour before meals, without combining them with other medications.

If you are simultaneously receiving calcium, magnesium, and iron supplements (including as part of vitamin complexes), do an interval of at least 3-4 hours, or better yet, reschedule their intake to the other half of the day.

capsules 300 mg TC
tablets 600 mg TC (maximum dosage)
ampoules 30 mg/ml (one ampoule contains 300 mg TC)

30 caps.

300 mg tablets
ampoules are 25 mg/ml, but since their volume is 12 ml, each contains the same 300 mg as the domestic opponent.

Indications and contraindications

Abusing the drug or using it for no reason can harm the patient.

Indications for use of the product:

polyneuropathy resulting from diabetes or alcoholism (treated with tablets);
poisoning with food or toxic substances;
cirrhosis of the liver;
hyperlipidemia;
hepatitis type A (in these cases, the use of an injection solution is provided).

The product may also be recommended for diseases that are not included in the list of indications. This is allowed in complex treatment.

Having an appropriate diagnosis is a very important factor, but the absence of contraindications is considered much more important. If they are detected, the use of Octolipen is prohibited.

Contraindications include:

intolerance to components;
bearing a child;
natural feeding;
childhood.

In such situations, a replacement for the drug Octolipen is sought from among analogues.

Effect of the drug

It has a whole list of positive effects on the body. Among them:

Neuroprotective – protection of nerve cells, including brain cells, from the negative consequences of certain diseases and poisonings. Allows you to slightly reduce the negative effects of neurotoxin poisoning. Axonal conductivity and trophism of neurons increases. Hypoglycemic – reduction in overall blood sugar levels. Can help diabetic patients with complex therapy in case of polyneuropathy

Should be taken with caution by people immediately after taking insulin or by people with increased pancreatic activity. Hypocholesterolemic - causes a decrease in cholesterol levels in the blood, so this drug is taken for liver failure, fatty degeneration and other cirrhosis of the liver. Hepatoprotective - the medicine weakens or neutralizes pathogenic effects on the liver, aimed at changing and killing cells. It is taken as part of complex therapy for hepatitis, slowing the course of the disease and weakening attacks. Lipid-lowering – measures aimed at reducing the overall level of lipids in the blood; reduces the risk of atherosclerotic plaques on the walls of the vessel.

It is believed that thioctic acid is a powerful internal antioxidant that is activated only after passing through the digestive tract.

Alpha lipoic acid further lowers blood sugar levels and helps partially overcome the effect of insulin resistance. By increasing the degree of glucose absorption by the body, it helps to increase the deposition of glycogen in the liver tissue. In its properties, thioctic acid is similar to B vitamins; it takes part in sugar and fat metabolism in the body, and due to the conversion of cholesterol into a biologically harmless form (cholesterol metabolism), it improves the functioning of the liver glands.

The active substance from tablets and capsules is very quickly absorbed into the blood, but it should be remembered that simultaneous use of the medicine and food slows down the absorption of the drug components. The highest concentration in the body is observed thirty to thirty-five minutes after consumption.

Regardless of the type of administration (oral or infusion), Octolipen 600 is processed in the liver and excreted by the kidneys almost completely - no more than ten percent remains in the body after two half-lives - seventy minutes.