Leprosy (leprosy): disease, symptoms, treatment, causes, prognosis

The peak prevalence of leprosy occurred in the Middle Ages (12 - 16), when the majority of the population of European countries was affected by this disease. In those days, leprosy was considered an incurable disease; lepers were expelled from the city and were forced to wear a crow's foot around their necks and ring a bell, warning of their appearance.

Despite the decline in incidence, leprosy still occurs on Earth and doctors of any specialty must be alert to the diagnosis of this disease. The last case of officially registered leprosy in Russia was identified in 2019 in a migrant from Tajikistan working as a construction worker in Moscow.

Case history of leprosy

Leprosy has been known since ancient times. Information about the disease was recorded already in the 15th - 10th centuries BC. Leprosy is mentioned in the Bible and the Ebers papyri. Hippocrates described the disease. In ancient times, leprosy was rampant in the east. The widespread spread of the disease was noted in the Middle Ages. At the beginning of the 13th century, epidemics began in Europe. Presumably the disease was brought to this territory by the Crusaders. The deformation of appearance and deformity of leprosy patients caused disgust and fear. Such patients were called “lepers.” They were turned into real outcasts. In order to prevent the spread of infection, many places of settlement for “lepers” were created - leper colonies, where patients were kept until the end of their lives. The first leprosariums were located within the monasteries and contributed to the non-spread of infection, acting as quarantine institutions. In the middle of the 13th century, there were about 19 thousand leper colonies in Europe. Despite the fact that leprosy has been known since ancient times, the causative agent of the disease was discovered by Gerhard Hansen only in 1873. In 1948, the French journalist Raoul Follero founded the Order of Charity, and in 1966 the Federation of European Antileprozoal Associations. January 30th is Leprosy Rights Day.

Henry XIV, Louis XI, the Byzantine Emperor Constantine, and the impressionist artist Paul Gauguin suffered from leprosy.

Rice. 2. Patients with leprosy (“lepers”) were expelled from settlements in ancient times.

Prevalence of the disease

Leprosy is common mainly in countries with tropical climates. The maximum number of patients is recorded in countries such as Brazil, India, Burma, Indonesia, the Philippines, Nepal, Tanzania and the Republic of Congo.

Leprosy in Russia

In the territory of the former USSR, leprosy was recorded in the Lower Volga region, the Far East, Karakalpakia, the North Caucasus, Kazakhstan and the Baltic states. In modern Russia, the disease is rare - isolated cases every year. In total, there are about 700 patients who live in 4 leper colonies located in Astrakhan, Tver, Moscow region and Krasnodar Territory.

Rice. 3. Consequences of leprosy. Loss of fingers.

Historical facts

• The spread of leprosy is associated with the Crusades, when knights participating in them became infected with leprosy in conquered countries and brought the disease to Europe.
• Leprosy was stopped by the plague. During the epidemic of this disease in Europe, weakened and exhausted people, including those with leprosy, fell ill first.
• In France, the king issued a decree according to which all lepers were subjected to a “religious tribunal”, according to which they were taken to the church, where they were laid in a coffin and had a funeral service, and then taken to the cemetery and lowered into the grave. After the coffin was lowered into the grave, the words were said: “You are dead to us, not alive,” and several shovels of earth were thrown onto the coffin. Then the “dead man” was removed and sent to the leper colony. He had no right to return, and for his family and friends he was considered officially dead.
• Lepers in the Middle Ages were deprived of social rights. They were not supposed to visit churches, taverns, fairs and other public places, as well as wash in open water, drink running water, eat with healthy people, touch their things and talk to them.
• Leprosy in the Catholic Church was a legal ground for divorce, although the Catholic faith prohibits the latter.
• Other names for leprosy in the Middle Ages were: black sickness, Phoenician disease, lazy death, slow death, mournful disease. In Russia, leprosy began to be called leprosy, from the Old Russian word “kazyt”, which means to distort, disfigure.

The causative agent of leprosy. Microbiology

Despite the fact that leprosy has been known since ancient times, the causative agent of the disease was first discovered by the Norwegian scientist Gerhard Hansen only in 1873.

Taxonomy of the pathogen

The cause of leprosy turned out to be a bacterium (bacillus) belonging to the Mycobacteriacea family, called Mycobacterium Leprae hominis (Hansen's bacillus, Hansen's bacillus).

In 2008, a second type of bacterium that causes leprosy, Mycobacterium lepromatosis, was discovered. These bacteria have been found to cause diffuse lepromatous leprosy, prevalent mainly in the Caribbean. The disease is characterized by extensive ulcerations on the skin, damage to nerves and internal organs.

The structure of the causative agent of leprosy

Mycobacterium leprosy is similar to tuberculosis bacilli in a number of ways.

• The bacteria are cylindrical in shape. Straight or slightly curved. Their length ranges from 1 to 8 microns, width - from 0.3 to 0.5 microns. The ends are rounded or slightly pointed.
• They are located singly or in clusters, resembling cigarette packs or balls (leptospirosis balls). Motionless.
• The causative agents of leprosy do not form spores.
• Bacteria are obligate intracellular parasites. They are ingested by macrophages, but are not digested (incomplete phagocytosis).
• Pathogens have the property of pleocytosis (diversity of forms). In leprosy you can find granular, club-shaped, budding, branched, filamentous, coccoid and dumbbell-shaped forms of bacteria.
• The cytoplasm of mycobacteria is surrounded by several membranes:

1. the first (innermost) shell is represented by a three-layer cytoplasmic membrane, which includes lipoprotein complexes and enzyme systems;
2. Next is the cell wall, which ensures the stability of the shape and size of the pathogen and provides mechanical, chemical and osmotic protection. The wall contains lipids, mycolic and leprosic acids, and wax (leprosin). Its thickness is 3 - 10 nm;
3. A microcapsule is closely associated with the cell wall - the outermost wall, which is a polysaccharide shell, consists of 3 - 4 layers, its thickness is 5 - 10 nm. The microcapsule protects the cell from the effects of negative environmental factors.

Rice. 4. Mycobacteria leprosy are cylindrical, straight or slightly curved.

Pathogenicity factors

The virulence factor of Mycobacterium Leprae is the phosphatide fraction, which is part of the cell wall lipids.

Antigens of the causative agent of leprosy

The microcapsule of the leprosy bacterium has antigenic properties. Two antigens have been identified: heat-stable and heat-labile. The heat-stable antigen (polysaccharide) is common to all mycobacteria; the heat-labile antigen (protein) is highly specific for leprosy mycobacteria.

Pathogen genome

The genome of the causative agent of leprosy was first deciphered in 2001. It consists of 3,268,203 nucleotide base pairs. Genetics from the University of Tübingen (Germany) have proven that the genome of Mycobacterium leprae has not changed over the past 500 years.

Reproduction

Mycobacterium leprosy reproduces by transverse fission. The process of reproduction occurs only in the cytoplasm of tissue cells.

Sustainability

In the external environment, leprosy pathogens exhibit increased resistance, but at the same time their virulent properties are quickly lost.

Microscopy

According to Ziehl-Neelsen, mycobacteria leprae are stained pink (Gram-positive, acid-fast). In recent years, the technique of staining smears using the Marcinowski method has become widespread.

Cultivation

It is not possible to grow Mycobacterium Leprae on artificial media. For cultivation, special media are used that contain human serum. In vitro, lineages of isolated mycobacteria are maintained in armadillos and on the paws of infected mice.

Rice. 5. The causative agents of leprosy (Mycobacterium Leprae) are located singly or in clusters, reminiscent of cigarette packs or balloons.

Traditional methods

Traditional medicine for the treatment of leprosy, unfortunately, is useless. However, local skin treatments can be combined with the main treatment.

Aloe juice compress

How to use: squeeze aloe juice, apply compresses to the affected areas twice a day for a month, repeat the course of treatment every 2 months.

Result: aloe juice has strong anti-inflammatory properties; with this treatment, skin manifestations of leprosy heal much faster. But this is subject to systemic medical therapy with special drugs.

Epidemiology

Leprosy is a low-contagious disease. When infected, the disease develops in 10 - 20% of cases. There is a high natural resistance to leprosy infection. A strong immune system guarantees that a person will not get leprosy.

Risk group

Those at high risk for leprosy include those living in endemic areas. There is a high risk of getting sick among armadillo hunters, those who make crafts from the animals' shells, and when eating animal meat. Living in unsanitary conditions, malnutrition, alcoholism, hard physical labor, and diseases that weaken the immune system contribute to the disease. Leprosy is common in economically underdeveloped countries among the poorest segments of the population.

Source of infection

The reservoir and source of leprosy pathogens is a sick person and the armadillo animal. A person becomes infected from an animal through scratches received while hunting or by eating meat. Armadillos live in Central and South America and belong to the class of mammals. Every year, up to 150 people become ill with leprosy in the United States. All of them either hunted armadillos, or ate their meat, or made fakes from the armor of the animals.

How is leprosy transmitted?

Airborne droplets and contact are the main routes of transmission. The disease is not transmitted in utero.

• A sick person who is not undergoing treatment spreads Mycobacterium leprosy by coughing and sneezing. When talking, bacteria spread within a radius of up to 1.5 meters.
• Somewhat less frequently, pathogens enter the human body by contact through microcracks, scratches, wounds or scratches. The patient's belongings are also a factor in the transmission of infection. Mycobacterium leprosy in patients during periods of exacerbation is found in urine, tears, semen, urethral discharge, blood and breast milk.

Rice. 6. The photo shows an armadillo. The animal has a shell consisting of horny scutes, movably connected to each other.

Reasons for development

The causative agent of leprosy was discovered in 1874 by the Norwegian scientist A. Hansen. Mycobacterium leprae is a gram-positive bacteria that belongs to intracellular parasites, the morphological properties of which are highly similar to Koch's bacillus (causes tuberculosis).

Transmission routes

Contrary to popular belief, leprosy is not very contagious.

The source of infection is sick people. The bacillus is excreted in nasal mucus, feces, urine, and saliva; Leprosy also releases bacilli from the ulcerated surface into the environment. Infection most often occurs through direct skin contact (mycobacteria penetrates through microcracks or wounds). Also, transmission of the disease can occur through kissing, sexual intercourse or bites of blood-sucking insects. It is also believed that the infection can be transmitted through a patient's cough.

People with strong immune systems are resistant to leprosy. The disease in this case is less contagious and infection can occur only through prolonged close contact. The incubation period (the time from infection to the appearance of the first signs) lasts on average from three to seven years.

Pathogenesis

Leprosy pathogens enter the human body through the mucous membrane of the upper respiratory tract and damaged skin. The full picture of the disease develops after an incubation period of years or decades. The penetration of Mycobacterium leprosy into the human body causes disease only in 10 - 20% of cases.

Lepromatous granulomas

Mycobacteria affect the skin, mucous membranes, superficially located peripheral nerves and internal organs, where granulomas form. In the lepromatous type of leprosy, granulomas consist of foamy macrophages stuffed with mycobacteria. Clusters of granulomas form lepromas. In the tuberculoid type of leprosy, granulomas consist of epithelioid cells and contain a small number of pathogens.

Rice. 7. Patients with leprosy. Lepromatous granulomas are visible on the face and neck.

Lepromatous neuritis

Leprosy affects the peripheral nervous system. There is a pronounced tropism of pathogens for lemmocytes - Schwann cells, located along the axons of nerve cells (long process), which perform supporting and trophic functions. Inflammation of peripheral nerves and associated neurological disorders develop more quickly in the tuberculoid type. In lepromatous leprosy, peripheral nerves are affected late. Lepromatous neuritis has an ascending nature. Gradually, the nerve fibers are destroyed and replaced by connective tissue. Damage to peripheral nerves leads to the development of motor and trophic disorders.

Rice. 8. Damage to peripheral nerves. Claw-shaped brush.

Damage to internal organs

More pronounced inflammation of internal organs is observed in the lepromatous type of leprosy. In the mucous membrane of the upper respiratory tract, lymph nodes, liver, spleen, testicles, adrenal glands, kidneys, heart, lungs, granulomas appear, consisting of macrophages filled with a huge number of leprosy pathogens.

Types of leprosy

Depending on the degree of immunological reactivity (cellular immunity), the patient develops one or another type of leprosy.

• The tuberculoid type of leprosy (the most favorable) is formed in individuals with a high degree of immunological reactivity. The disease is less dangerous for others. The course is not severe, with primary damage to the skin and peripheral nerves. The rashes on the skin look like small papules and are accompanied by anesthesia. The infiltrates contain a small number of pathogens.
• The lepromatous type of leprosy occurs in individuals with a low degree of immunological reactivity. Antibodies produced during illness do not protect the body from infection. The disease affects the skin and mucous membranes, nerve trunks, lymph nodes and internal organs. Leproma infiltrates contain a huge number of mycobacteria. Over time, lepromas disintegrate. The resulting ulcers heal slowly. The lepromatous type of leprosy may have blurred and atypical forms.
• The undifferentiated type of leprosy develops when the type of immunological activity has not yet been formed in patients. With a favorable course, the tuberculoid type of leprosy develops in the future; with a low degree of immunological reactivity, the lepromatous type of leprosy develops.

Rice. 9. Tuberculoid (photo on the left) and lepromatous (photo on the right) type of leprosy.

Prevention

• If there are cases of leprosy in the family, everyone needs to undergo medical examination every year.
• Newborn babies must be isolated from their mother and transferred to artificial feeding.
• School-age children can attend regular schools, but screening for infection is carried out twice a year.
• Anyone who has had close contact with the patient is given a lepromin test or Mitsuda test. Suspensions of mycobacteria are injected into the skin and the body's reaction is monitored. If the immune response is strong, then the risk of infection is minimal. In the absence of an immune response, the person is subject to more detailed examination.

Lepromatous type. Signs and symptoms

The lepromatous type of leprosy is characterized by the development of various elements of skin lesions - fuzzy spots, plaques, infiltrates and nodes. When the disease occurs, the mucous membranes and internal organs are involved in the pathological process quite early, and the nervous system quite late. This type of leprosy is difficult to treat. A huge number of pathogens are localized in the elements of skin lesions. The lepromine reaction is negative due to the developed anergy.

Leprosy skin lesions

The disease most often affects the skin of the face, ears, wrists, elbows, knees and buttocks. Lepromas appear extremely rarely on the scalp, inner parts of the eyelids, armpits, elbows and popliteal fossae.

Spots and plaques

At the beginning of the disease, barely noticeable, blurred, reddish spots appear on the skin, transforming into plaques. Plaques do not have clear boundaries. Over time, as a result of the development of vascular paresis and hemosiderosis, spots and plaques acquire a brown or copper (rusty) tint. Due to increased sebum secretion, their surface becomes smooth, shiny, glossy (greasy). Enlarged excretory ducts of sweat glands and vellus hair follicles in the area of ​​infiltrates give the skin an “orange peel” appearance. Over time, sweating decreases and stops altogether. Sensitivity in the affected areas is not impaired. After 3 - 5 years, spots and plaques transform into lepromas.

Lepromas

Initially, lepromas resemble small single or multiple dense nodules ranging in size from 1 - 2 mm to 2 - 3 cm, painless, with a greasy surface, sharply demarcated from the surrounding tissues, and contain many leprosy pathogens. Over time, the tubercles transform into powerful infiltrates - nodes. Lepromas are dermal and hypodermal.

Hypodermal lepromas are located under the dermis (the skin itself) and at first the diseases are detected only by palpation. When they reach the dermis they become visible to the eye.

Dermal lepromas initially look like oval-shaped papules, gradually turning into bumps that have a reddish-rusty color, with a shiny surface, and rise above the surface of the skin.

Sometimes lepromas resolve. A pigmented spot remains in their place. Sometimes lepromas ulcerate. The formation of ulcers occurs from the center. They have steep, steep, raised edges. The bottom of the ulcers is covered with a yellowish-gray coating. Ulcers can merge to form extensive ulcerative surfaces. The bloody discharge contains a huge number of mycobacteria (up to 1 billion per 1 cm3). Gradually the ulcers scar. In their place, a sunken (sometimes keloid) scar remains. When ulceration of deep-lying lepromas occurs, joints and small bones are involved in the pathological process, which are destroyed and fall off (mutilatio), leading to deformities and disfigurement.

Signs and symptoms of leprosy affecting the face

Diffuse infiltration of facial skin leads to deepening of natural wrinkles and folds. The brow ridges begin to protrude sharply forward. The earlobes are growing. The nose, lips, cheeks and chin thicken. They take on a lobed appearance and a fierce expression, reminiscent of a “lion's face” (fades leonina).

Rice. 10. Photos of people suffering from leprosy. Multiple lepromas are visible on the skin of the face.

Signs and symptoms of leprosy with nasal lesions

The nasal mucosa is always affected in leprosy and long before the skin is affected. Rhinitis and nosebleeds are the first signs of leprosy. The nasal mucosa turns red and swells, then small erosions appear and massive crusts form, which leads to difficulty breathing. A picture of leprosy rhinitis develops.

Leprosy ulceration leads to destruction of the nasal septum. First, the tip of the nose rises upward, then the nose sinks (“saddle nose”).

Mycobacterium leprosy is detected in mucosal staples. Especially many pathogens are localized in the mucous membrane of the cartilaginous part of the septum.

Rice. 11. People suffering from lepromatous leprosy were called lepers. The photo shows patients whose faces are disfigured by leprosy.

Signs and symptoms of leprosy in the mouth

In severe leprosy, damage to the mucous membrane of the oral cavity and larynx is noted. The soft and hard palate, the back of the tongue and the red border of the lips are affected.

Damage to the vocal cords and epiglottis leads to a narrowing of the glottis and aphonia (loss of sonority of the voice).

Rice. 12. With leprosy, the earlobes grow.

Signs and symptoms of leprosy in the eyes

With lepromatous leprosy, the organs of vision are often affected: the episclera becomes inflamed (episcleritis), the cornea of ​​the eye (focal keratitis), the iris (iridocyclitis), the outer layer of the eye (conjunctivitis), clouding of the lens is noted, and the edges of the eyelids become inflamed.

The appearance of lepromas on the surface of the iris leads to disruption of accommodation and deformation of the pupil. Lepronose keratitis and iridocyclitis without treatment lead to complete loss of vision. When the edges of the eyelids become inflamed, eyelashes fall out. Leprosy keratitis is characterized by the absence of discharge and mild symptoms of inflammation.

Rice. 13. Damage to the organs of vision due to leprosy.

Damage to hair and nails due to leprosy

After 3 - 5 years from the onset of the disease, hair loss is observed in areas of infiltration. Hair falls out from the eyebrows, eyelashes, beard and mustache areas. On the eyebrows, hair begins to fall out from the outer edge. In areas of infiltration, vellus hair loss is noted.

Nails with leprosy lose their shine, become dull, thickened, brittle, and acquire a grayish tint.

Rice. 14. As a result of trophic disorders in leprosy, mutilation (rejection) of the hands and feet develops.

Signs and symptoms of leprosy affecting internal organs

In lepromatous leprosy, damage to internal organs is noted.

• The liver and spleen increase in size and become denser. Many millet-like lepromas appear in the tissues of these organs. Chronic hepatitis develops.
• All groups of lymph nodes (except for the thoracic and mesenteric ones) are enlarged. They acquire a dense consistency, are mobile and painless.
• Leprosy affects the endocrine glands. A person ages quickly. Women experience menstrual irregularities and early menopause. In men, the testicles (orchitis) and appendages (epididymitis) are affected. Testicular function decreases. The sclerotic process leads to azospermia. Gynecomastia and infantilism develop. Potency decreases to the point of impotence.

Rice. 15. With atrophy of the circular muscles, the eyes do not close completely.

Signs and symptoms of leprosy affecting the nervous system

In leprosy, the peripheral nervous system is affected late. This is due to the high resistance of the axial cylinders to lepromatous infection. Basically, patients develop symmetrical polyneuritis. Nerve trunks affected by infection thicken, become dense and smooth, and are easily palpated.

In areas where leprosy infiltrates develop, sensitivity persists for a long time, but is lost over time until complete anesthesia is achieved, which leads to frequent burns and injuries that patients do not notice. Its causes are compression of the nerves by cellular infiltrates.

Deep sensitivity, periosteal and tendon reflexes are preserved.

When the central nervous system is damaged, neuroses and psychoses develop.

When the peripheral nervous system is damaged, patients with leprosy develop motor and trophic disorders, and sensitivity is impaired.

Trophic disorders:

• Skin pigmentation is disrupted.
• Trophic ulcers appear on the feet.
• Mutilation (rejection) of the hands and feet is noted. At first, the hands and feet become soft, like the legs of frogs or seals, and then spontaneously tear off. The hands and feet are shortened.
• The function of the sweat and sebaceous glands is impaired. Over time, hypofunction is replaced by a complete absence of sweating and sebum secretion. The skin becomes rough and further cracks.

Movement disorders:

• As a result of the predominance of flexor tone, contractures develop. The fingers and toes bend (claw-shaped hand, cauda equina).
• As a result of muscle atrophy, the interosseous spaces collapse. The hand becomes flattened and resembles a monkey's paw.
• With atrophy of the orbicularis muscles, the eyes cannot close completely (lagophthalmos).
• Damage to the facial nerve leads to atrophy of the facial muscles. The face becomes mask-like and takes on a sad expression.
• With the disease, paresis of the masticatory muscles develops.

Rice. 16. Consequences of leprosy. When the nervous system is damaged, contractures, muscle atrophy and trophic disorders develop.

Diagnostics – testing doctors’ knowledge

Even today, leprosy is not a forgotten disease and is encountered from time to time in modern medical practice. Its definition can cause particular difficulties in countries where this disease is very common, despite developed medicine (for example, in the USA).

To diagnose pathology caused by Mycobacterium leprae, highly specialized doctors are involved: infectious disease specialists, dermatologists, neurologists. In addition to the patient’s complaints and external signs of pathology, laboratory tests are taken into account, the most accurate being the bacterioscopic detection of the Mycobacterium leprae bacillus or by detecting DNA using polymerase chain reaction. A scraping is taken from the nasal mucosa and affected areas of the skin; material isolated from the tubercles and lymph nodes is also studied.

It is important for the doctor to be attentive, since at first leprosy can be confused with another pathological process. In this case, a series of laboratory tests should be performed to clarify the diagnosis.

Diseases whose dermatological manifestations are highly similar to leprosy (taking into account the nature of the rash and spots):

• tertiary syphilis;
• erythema multiforme;
• toxicoderma;
• neurofibromatosis;
• lichen planus;
• tuberculosis and sarcoidosis of the skin;
• leishmaniasis;
• Erythema nodosum.

There is another way (not always effective, but simple and harmless) for differential diagnosis of leprosy - a test with nicotinic acid (injected 1 ml, 1% solution). 1-3 minutes after the procedure, the spotted leprosy rash turns red and swells.

Signs and symptoms of leprosy. Tuberculoid type

Tuberculoid leprosy is relatively benign and slow. The disease affects the skin and peripheral nerves. Internal organs are slightly affected. Cases of spontaneous regression are often observed. In most cases, the prognosis of the disease is favorable. Tuberculoid leprosy has a low degree of contagiousness.

Skin lesions

In the tuberculoid form of the disease, depigmented or reddish spots with central blanching and sharply defined boundaries appear on the skin. The spots increase in size over time, and their edges rise. Along the edges of the spots there are dense and flat papules, delimiting the damaged area from healthy skin. When spots merge on the skin, patterns of a bizarre ring-shaped configuration are formed. The central part of the spots undergoes depigmentation and atrophy, and fades over time. Within the affected area, there is no skin sensitivity, sweating and sebum secretion stops. The resulting injuries, damage and burns lead to the development of secondary flora.

Rice. 17. Tuberculoid leprosy.

Damage to the peripheral nerves develops in the same way as in the lepromatous form of the disease, but already in the first stages of the disease and more easily. The affected nerve trunks (usually the radial, ulnar, facial and parotid nerves) become painful over time, thicken and begin to be palpated. Contractures and muscle atrophy develop, causing the limbs and face to take on a characteristic appearance (mask-like face, claw-shaped hand, horse foot). The skin appendages are affected - the work of the sebaceous and sweat glands is disrupted, hair and eyelashes fall out, nails thicken and crumble. The lepromine reaction is sharply positive.

Rice. 18. Tuberculoid type of leprosy.

Complications

The consequences depend on the type of leprosy, its location and the timeliness of treatment. A person may experience the following complications:

• plantar ulcers;
• keratitis, laryngitis;
• chronic nosebleeds due to nasal deformity;
• corneal ulcer, lagophthalmos, glaucoma, blindness;
• distortion of appearance, facial deformation, mutation of phalanges, twisting of limbs;
• renal failure;
• erectile dysfunction and infertility in men.

A person with leprosy loses sensitivity and is often injured, which makes his appearance even more unattractive.

If the patient does not seek medical help, necrotizing vasculitis develops, so death is inevitable.

Undifferentiated type of leprosy

The undifferentiated (borderline) type of leprosy develops when the patient has not yet developed a type of immunological activity. With a favorable course, the tuberculoid type of leprosy subsequently develops; with a low degree of immunological reactivity, the lepromatous type of leprosy develops. The lepromine reaction, depending on the direction of the pathological process, can be negative or positive. The undifferentiated (borderline) type of leprosy combines the clinical manifestations of 2 main types of the disease, but with a milder course.

Rice. 19. The undifferentiated (borderline) type of leprosy develops in cases where the type of immunological activity has not yet formed.

Treatment

Medicine has made great strides forward and therefore leprosy today is curable, especially if the disease is “captured” at an early stage, when the person has not yet become disabled. Treatment of such patients is carried out in leper colonies - special anti-leprosy institutions or on an outpatient basis. Leper colonies have been known since the Middle Ages, when society tried to limit the contact of lepers with healthy people.

• Currently, patients with multiple skin rashes and positive results of bacterioscopic examination are admitted to anti-leprosy medical institutions for the purpose of conducting the primary stage of treatment.
• Also, patients who are under dispensary registration are sent to the leper colony if they develop a relapse of the disease.
• Patients with a small number of rashes and negative results of bacterioscopic examination are treated on an outpatient basis.

Treatment of leprosy should be carried out comprehensively and include the simultaneous administration of two to three anti-leprosy drugs with the parallel administration of stimulants and restoratives (methyluracil, vitamins, autohemotransfusion, pyrogenal, gamma globulin and other drugs).

• The main anti-leprosy drugs include sulfone drugs (diaphenylsulfone, solusolphone and diucifone).
• Antibiotics are used together with them: rifampicin, lampren, ofloxacin, ethionamide, clofazimine.
• The duration of one course of treatment with anti-leprosy drugs is 6 months. If the patient tolerates the therapy well, there are no breaks between courses. Complex treatment in one course includes the prescription of one sulfone drug and 1 - 2 antibiotics. To prevent the development of drug resistance, drugs are alternated every 2 courses of therapy.

Treatment of patients with leprosy is long-term and lasts from 12 months to 2 – 3 years.

Notes

1. Han, XY, Seo, YH, Sizer, KC, Schoberle, T., May, GS, Spencer, JS, Li, W., Nair, RG “A new Mycobacterium species causing diffuse lepromatous leprosy.” Am.
   J. Clin. Pathol. 2008 Dec;130(6):856-64.
2. RMZh, Vol. 9 No. 23, 2001 candidate. honey. Sciences L.E. Gorelova. "Leprosy was treated with death."
3. ↑ 123
   Leprosy. WHO Fact Sheet No. 101. February 2010.
4. Some issues of epidemiology and organization of the fight against leprosy at the present stage. Duyko V.V. Federal State Institution Research Institute for the Study of Leprosy of the Russian Health Service, Astrakhan, 2007.
5. Leprosy - Infectious diseases and their treatment - Modern medical encyclopedia

What it is?

At the very beginning, you need to understand what leprosy is. The disease is infectious and chronic in nature. The causative agent is the microorganism Mycobacterium leprae. The problem mainly affects human skin, as well as mucous membranes and the nervous system. It is also worth mentioning that the incubation period of the disease is very long. So, you can become infected with a virus, and external manifestations will begin only after 5-20 years. Important: this disease is incurable. However, if therapy is started in time, disability can be avoided.

Diagnostics

An important stage in making a diagnosis is a medical examination.
To diagnose leprosy, your doctor may use several techniques. In this case, an obligatory part of the patient’s interview is to establish places of stay and contacts over the past few years.

The examination plan for a patient with suspected leprosy includes:

• inspection and survey;
• scraping of the oral or nasal mucosa;
• Minor's test to detect decreased sweating in lesions;
• determination of skin sensitivity;
• nicotine test to detect skin reaction to nicotine;
• lepromin test (injection of a special drug into the skin of the forearm to identify the form of leprosy).

The most accessible and fastest specific method for diagnosing leprosy is the lepromin test. To perform it, the patient is injected intradermally in the forearm with Lepromin, a drug based on an autoclaved homogenate of skin lesions of patients with lepromatous leprosy. After 48 hours, a papule or spot appears on the skin, and after 14-28 days a tubercle (sometimes with an area of ​​necrosis) appears. The appearance of these signs is a positive result and indicates the tuberculoid form of leprosy, and if the result is negative, it indicates the lepromatous form or the absence of the disease.

What are the risk factors for leprosy?

People at greatest risk are those who live in areas where leprosy is endemic (parts of India, China, Japan, Nepal, Egypt and other areas), and especially those people who are constantly in contact with infected people. Additionally, there is some evidence that genetic defects in the immune system (region q25 on chromosome 6) may make some people more susceptible to infection. Additionally, people who interact with certain animals known to carry the bacteria (such as armadillos, African chimpanzees, sooty mangabeys, and cynomolgus macaques) are at risk of contracting leprosy from animals, especially if they do not wear gloves when handling animals.

Question answer

I was diagnosed with leprosy and sent to a leper colony for treatment. Am I going to die there now?

Leprosy is no longer a fatal disease. This disease, especially if detected at an early stage, is highly treatable. The course of therapy lasts 2 years, after which the person is not contagious and can lead a normal life. However, those infected with leprosy are prohibited from working in the food industry and in child care institutions. You will be registered and undergo regular examinations.

My sister was diagnosed with leprosy, and the whole family is undergoing examination. But my sister is pregnant! The doctor says there is no threat to the child, is that true? My sister is in a leper colony, they say that after the birth the child will be transferred to a family, and the sister will remain for further treatment.

The doctors are absolutely right. Leprosy is not transmitted in utero. The child must be born healthy. However, immediately after birth, it must be isolated from the mother and transferred to artificial feeding, since it can easily become infected through breast milk.

A distant relative of ours was diagnosed with leprosy. We don’t communicate very often, but now we are required to undergo examination. I have two schoolchildren, they are now not allowed to go to school without a certificate, do they have the right to do this?

All relatives and people in close contact must undergo a medical examination. In order for children to attend school, they will now have to undergo a medical examination twice a year. For adults, a diagnostic test once a year is sufficient.

Causes of leprosy disease

Leprosy (also called Hansen's disease, lazy or mournful disease) is a mildly contagious disease. Less than thirty percent of people are susceptible to leprosy.

The disease often occurs in relatives (familial cases), which suggests a hereditary predisposition to the disease.

The famous physician Danielsen, in the mid-nineteenth century, studied the mechanism of transmission of leprosy and the pattern, as well as the stages of its development. For this purpose, he injected himself with the blood of patients infected with leprosy, but he never managed to get sick himself.

Famous patients

• Damian de Veuster, a Catholic missionary who spent the rest of his life in a leper colony on Molokai, Hawaii, has been canonized.
• Baldwin IV, King of Jerusalem.
• Walter of Chatillon, poet-vagant.
• Perhaps Plotinus, the ancient philosopher.
• Possibly Robert I the Bruce, King of the Scots.
• Han Mak Tu ( English
  ), Vietnamese poet.
• Otani Yoshitsugu, Japanese daimyo.
• Artist Paul Gauguin
• Henry XIV, Duke of Bavaria
• Louis XI, King of France
• Uzziah, King of Judah

.

Memo for the patient

Patients, especially those with skin sensitivity disorders, should inspect their extremities daily to ensure that injuries and burns are detected promptly and treated appropriately. They must regularly take the anti-relapse chemotherapy courses prescribed to them, despite subjectively good health and no signs of disease activation.

Gudiya from Nepal, he is only 7, has leprosy, has skin lesions covering the whole body... Leprosy is still not eradicated...

How do medical professionals diagnose leprosy?

Most cases of leprosy are diagnosed clinically, especially since most current cases are diagnosed in areas that have limited or no laboratory facilities.

Hypopigmented patches of skin or reddish areas of skin with loss of sensation, thickened peripheral nerves, or both are clues to the diagnosis of leprosy. Skin smears or biopsy (biopsy) materials that show acid-fast bacilli with Ziel-Neelsen stain or beauty spot can diagnose multibacillary leprosy, or if bacteria are absent, diagnose paucibacillary leprosy. Other tests may also be performed, but most are performed by specialized laboratories and can help the physician diagnose a patient's disease in the more detailed Ridley-Jopling classification, but are not routinely performed (lepromin test, phenolic glycolipid-1 test, PCR, degree of inhibition studies migration of leukocytes). Other tests such as a complete blood count, liver function tests, creatinine test, or nerve biopsy may be done to help determine whether other organ systems have been affected.

First aid for suspected leprosy

If there is any suspicion of leprosy in a patient, you should contact a medical professional. At home, it is recommended that the patient be isolated in a separate room and provided with a set of individual cutlery, clothing, and bed linen. It is better to care for a person with leprosy wearing gloves and disposable masks (change every 2 - 3 hours), clothes with sleeves, or a robe.

In the room where the patient is located, daily wet cleaning with disinfectants and ventilation are recommended. A special diet for leprosy has not been developed, but it must be remembered that a long-term inflammatory process takes a lot of energy from the human body, so it is better to stick to light but nutritious meals.

How is the disease treated?

Contrary to all prejudices, leprosy is curable

, and with the right approach, disability can be avoided. Due to the very long incubation period of the infection and the possibility of a long asymptomatic course of the disease, it is important to start treatment on time.

Leprosy is curable, but treatment takes many years: on average, treatment can last about 3 years, and in some cases it can reach 8 years. Since 1981, complex drug therapy (DMT) has been used in the treatment of leprosy, which makes it possible to get rid of the disease relatively quickly and effectively. This therapy includes drugs such as Dapsone-Fatol, Risima and Clophasam. Since 1995, WHO has provided free CRT to leprosy patients around the world.