Papaverine injections: instructions for use, indications

Properties of the medicine

Papaverine hydrochloride suppositories, after administration into the rectum, affect the smooth muscles of the bronchi, lungs, large and small intestines, stomach, and uterus.
However, the effect of the drug does not apply to the muscles of the skeleton and heart. After the product enters the body, these muscles work as usual. Properties of the drug:

• elimination of smooth muscle tone in various pathologies;
• lowering blood pressure, dilating blood vessels;
• increased blood flow in all internal organs;
• normalization of heart rate;
• providing a sedative effect.

https://www.youtube.com/watch?v=N-_IYd3OZj4

During childbirth, women are prescribed Papaverine suppositories to relieve cervical hypertonicity. Many people are interested in how to administer the drug vaginally or rectally? Papaverine suppositories are inserted into the patient's anus.

Composition and release form

Papaverine suppositories can be bought in pharmacies without a prescription; it is produced by various pharmaceutical companies. In Russian pharmacies the drug is available from Belarusian and Russian manufacturers.

Three dosage forms can be found on sale, each of which differs in its purpose, namely: tablets, rectal suppositories and injection solution.

Rectal papaverine suppositories are white to yellowish-white or creamy-white, torpedo-shaped.

One suppository contains 20 mg of papaverine hydrochloride.

In addition to the active ingredient, candles contain stearins and solid fats that melt at human body temperature, and emulsifiers.

Papaverine has several forms of release:

• solutions for injections;
• pills;
• suppositories.

Papaverine is sold in ampoules made of glass. They are sealed in blister packs in a cardboard pack of 10 pieces. The volume of one ampoule is 2 ml. This includes the active substance (papaverine hydrochloride) - 0.02 g and auxiliary components. The latter include methionine, disodium salt of ethylenediaminetetraacetic acid (Trilon B), and water for injection.

14Manufacturer

Papaverine is produced by the following pharmaceutical companies:

• "Akrikhin"
• "Asfarma";
• "ICN Tomskhimpharm";
• "ICN October";
• "ICN Polypharm";
• "Wifitech";
• "Organic";
• "Lekform"
• "Bivitekh";
• "Bryntsalov-A";
• Moscow Pharmaceutical Factory;
• Tyumen Chemical and Pharmaceutical Plant.

Structural analogues of the active substance are suppositories with papaverine hydrochloride.

https://youtu.be/swSwvjttxWw

Instructions for using injections

For the most effective effect of the drug, it is necessary to follow the dosages and injection rules specified in the instructions.

Method of administration

The drug can be administered in one of three ways.

1. Intravenously.
2. Intramuscularly (upper outer quadrant of the gluteal muscle).
3. Subcutaneously (outer thigh or shoulder).

For intravenous administration, it is necessary to first dilute the drug with sodium chloride solution (0.9%). For 20 ml of papaverine there should be 10-20 ml of solvent. The finished mixture must be introduced very slowly. Otherwise, the patient will feel severe pain in the injection area. It is recommended that the procedure be performed by a qualified healthcare professional.

When administered intravenously, the following regimen should be followed.

1. Heat the drug by squeezing it in your palms for a few minutes.
2. Disinfect the ampoule by wiping it with a cotton pad soaked in alcohol.
3. Add papaverine and other components of the lytic mixture into the syringe in the required proportions.
4. Disinfect the injection site.
5. Place the syringe perpendicular to the injection site. Insert the needle into the skin 2/3 of the way.
6. Introduce the medicine slowly.
7. When lumps appear, it is necessary to apply an iodine net to them and the surrounding area.

Papaverine is often used as an antipyretic agent as part of a lytic mixture. In addition to it, Analgin and Diphenhydramine are added to the syringe. The mixture can be used by both children and adults.

The effectiveness of the injection composition is significantly higher than that of tablets with a similar effect. This is due to several factors:

• the finished drug is combined, which means that its components affect the body from several sides simultaneously;
• high degree of absorption of Papaverine, due to which rapid spread to the site of inflammation and its elimination are achieved.

Doctors recommend using a complex solution for injection only in cases where the body temperature exceeds 39 degrees. This most often occurs during acute respiratory viral infections and various inflammatory processes. The combination of Diphenhydramine, Papaverine and Analgin is also used by emergency doctors when it is necessary to relieve a patient’s fever as quickly as possible.

The duration of treatment with Papaverine is not limited by the instructions. The course of treatment is continued either until the symptoms of the disease are eliminated, or until the prescription is canceled by the attending physician.

Intravenous and intramuscular injections must be performed in accordance with the dosages regulated by the instructions.

For children, the following rules apply:

• 6-12 months – 0.005 g of the drug;
• 1-3 years – 0.01 g;
• 3-4 years – 0.015 g;
• 4-6 years – 0.02 g;
• 6-9 years – 0.03 g;
• 9-14 years – 0.06 g.

No more than two injections are allowed per day.

After the patient reaches 14 years of age, the dosage of Papaverine for him is 0.1 g. If necessary, up to 3 injections per day can be given. The interval between two injections should be at least 4 hours.

If the injection is injected under the skin, the contents of 1 full ampoule are drawn into the syringe.

The drug, produced in ampoules, is a sterile solution of papaverine hydrochloride 2%, ready for parenteral administration. Each 2 ml ampoule contains 40 mg of active substance - this amount is equivalent to a single dose for an adult. The same amount of papaverine hydrochloride is contained in the tablet.

When using a whole undiluted solution, the drug can only be administered subcutaneously or intramuscularly. After dilution, it is allowed to give an intravenous injection of Papaverine. The dosage depends on the patient's age:

• adults and adolescent children can be given no more than 2 ml of medication at a time, with the maximum daily dose being 4-8 ml;
• children 7-10 years old are allowed to give 0.5-0.75 ml of the drug no more than twice a day;
• babies from six months to two years – 0.25 solution up to four times a day;
• children 2-4 years old - up to 0.5 ml of medication twice a day;
• children from 4-7 years old - 0.5 ml no more than two times.

In the annotation for this drug, the manufacturer notes that the effect of the drug during pregnancy has not been studied. At the same time, in practice, “Papaverine” has been used for a long time for various health problems in expectant mothers without any consequences.

Obstetricians and gynecologists everywhere prescribe this antispasmodic during pregnancy. In reviews of “Papaverine” injections, women note that experts call gestosis and uterine hypertonicity as indications for its use, which in itself is a threat to miscarriage. When prescribing medicine to expectant mothers at any stage of pregnancy, specialists usually pursue the following goals:

• relax muscles and reduce muscle tone;
• improve blood supply to the fetus and pelvic organs;
• reduce blood pressure levels.

Why are Papaverine injections prescribed? Women carrying a baby can use this drug if they have the same diseases and conditions that are indications for using the drug even in the absence of pregnancy.

The drug in the form of a solution for intramuscular administration helps in a short time to get rid of painful symptoms that arise against the background of spasms of various origins. The maximum number of procedures per day is 4, while the dosage can range from 1 to 2 milliliters.

If it is necessary to administer the drug intravenously, then the process should be carried out as slowly as possible and always by an experienced medical professional. You should first dilute 20 milliliters of the drug with a sodium chlorine solution of 0.9% concentration in a volume of 10-20 milliliters.

The interval between injections should be at least four hours. Before performing the procedure on a patient who is 60 years of age or older, a medical consultation is required. In most cases, the duration of therapy and the required dose are determined by a specialist, based on the patient’s condition and the established diagnosis.

High temperature appears in various diseases and painful conditions. Since not only an adult, but also a child can have a fever, parents need to know how and with what to bring down the temperature.

Popular There will be no pain or arrhythmia after injection with Lidocaine

Doctors advise fighting signs of temperature after 39 degrees. Today there are many pharmaceutical agents that help reduce fever. But the most effective substance for reducing fever is considered to be an injection of three drugs - Analgin Papaverine Diphenhydramine. Since the injection solution contains three drugs, they have different effects and reduce the rising temperature well.

This unique medicine will help with inflammation, and also with the diagnosis of acute respiratory viral infections. The drug is much more effective than different tablets, since its effect is combined compared to other medications. Often used by emergency physicians as the first remedy to relieve a patient's fever. This is one of the most common combinations that everyone should know.

Principles of drug treatment of colitis

The large intestine is the final section of the digestive tract. It forms feces, absorbs water, nutrients and vitamins. Its walls are covered with a mucous membrane, which consists of epithelial cells. When this membrane becomes inflamed, a diagnosis of colitis is made.

How to treat intestinal colitis is determined by the attending physician, since therapeutic tactics depend on the type of disease. Thus, colitis is classified into ulcerative, pseudomembranous, ischemic, chronic, acute, spastic, enterocolitis.

Each patient is given an individual treatment regimen, and what medications will be prescribed depends on the severity of the disease, clinical manifestations, degree of pain intensity and associated complications. Each type of disease has its own therapeutic tactics and set of medications:

• Ischemic colitis: drugs to normalize blood viscosity, vasoconstrictors and hypoglycemic agents, antispasmodics, enzymes and phospholipids.
• Enterocolitis: antispasmodics, antibiotics, detoxification therapy, rehydration agents.
• Spastic colitis: antispasmodics, intestinal motility regulators, antidiarrheal drugs, sedatives, enzymes, probiotics.
• Ulcerative colitis: anti-inflammatory, healing and antidiarrheal drugs, painkillers, immunomodulators, iron preparations.

Treatment of intestinal colitis with medications is aimed at alleviating pain, stopping bleeding from the rectum, eliminating dyspeptic symptoms such as flatulence, stool upset, etc. In chronic colitis, treatment tactics are determined by the phase of the disease and combine drug therapy and diet.

If colitis is of infectious origin, antibacterial drugs are prescribed. If the cause of inflammation is a helminthic infestation, then anthelmintic drugs are prescribed. Since the disease can be accompanied by severe pain, the patient is recommended to take antispasmodics.

Diarrhea is a constant companion of colitis, so the treatment regimen includes means to stop it. In addition, correction of the intestinal microflora is necessary. For all types of colitis, sorbents are prescribed; they remove toxins and harmful substances, as well as bacterial waste products. Smecta, Enterosgel, Filtrum-sti, Neosmectin, Polysorb are used as such.

pharmachologic effect

Papaverine, first of all, helps eliminate spasms. During therapy, blood pressure decreases and spasmodic pain in the smooth muscles of internal organs is relieved. This happens by blocking phosphodiestrase, reducing the concentration of calcium in tissues and accumulating cyclic adenosine monophosphates.

As a result of Papaverine injections, relaxation of the walls of blood vessels and smooth muscles of internal organs is achieved. Increased blood flow helps dilate the arteries.

Large doses of the drug have a sedative effect on the central nervous system. The excitability of cardiac muscle tissue is noticeably reduced. At the same time, intracardiac conduction slows down.

Composition for injection Papaverine has a high degree of absorption. Thanks to this, the active substance is quickly and evenly distributed throughout the tissues, providing a therapeutic effect. At the same time, it even passes histohematic barriers.

The distribution of the drug throughout the body is facilitated by the work of the liver. Thanks to this, the therapeutic effect is achieved 15-20 minutes after administration of the drug. The average duration of exposure to the body is 5 hours. After this, the substance is excreted from the body by the kidneys. If the treatment coincides with hemodialysis, a complete elimination of all components of Papaverine from the blood is observed.

The therapeutic effect of Papaverine suppositories is ensured by suppressing the phosphodiesterase enzyme. Thanks to this, it is possible to relieve muscle spasms and relax muscle fibers. The medicine has an effect on the human genitourinary, digestive, and hepatobiliary systems, and also relieves vasospasm.

The active component papaverine hydrochloride increases the lumen of blood vessels, thereby normalizing systemic blood pressure. After administration of the drug, its active component quickly penetrates the bloodstream. Papaverine hydrochloride is evenly distributed throughout the body, affecting the central nervous system.

Important! During use during pregnancy, the drug can penetrate the placenta to the fetus and enter milk during breastfeeding.

When prescribing a medicine, a doctor evaluates the effect of the drugs the patient is taking on the outcome of treatment. Papaverine also reduces (increases) the therapeutic effect of some drugs.

Important! During treatment you should not drink alcohol or smoke. Ethanol enhances the hypotensive effect of taking Papaverine and increases the risk of loss of consciousness. Nicotine reduces the therapeutic effect of the drug.

The simultaneous use of Alprostadiol and Papaverine increases the likelihood of priapism (painful erection).

Active substance

Papaverine is an alkaloid of the opium poppy. Despite the fact that the medicine is produced from poppy straw, it is not a narcotic drug. Papaverine injections are prescribed to combat muscle hypertonicity in various body systems, including the gastrointestinal tract, respiratory, cardiovascular and genitourinary systems.

“Papaverine” is both the trade name of the drug and the international name of the active ingredient. Papaverine hydrochloride is an active substance that helps dilate arteries and accelerate blood flow. This drug is often used to lower blood pressure, since the drug has a pronounced hypotensive effect.

The medicine quickly enters the blood: Papaverine reaches the site of its main effect in 20-30 minutes, while its concentration is evenly distributed throughout the body. The active component is broken down in the liver, which eliminates the possibility of accumulation of the substance with repeated use. The antispasmodic leaves the body with urine.

Indications

Papaverine is prescribed for the following diseases and conditions:

• rehabilitation after a hypertensive crisis;
• renal colic;
• angina pectoris;
• bronchospasm;
• spasm of the urinary tract, accompanied by problems with urination;
• prophylaxis before operations on the abdominal organs, in the areas of urology and proctology;
• elevated temperature (as part of a lytic mixture);
• spasms of the peripheral vascular bed and smooth muscles of the abdominal cavity;
• endarteritis;
• reduction of arterial renal inflow of vascular origin;
• reduction of the lumen of cerebral vessels.

Before prescribing the drug, the attending physician must ensure that the patient has no contraindications to it. First of all, an analysis is carried out to identify a tendency to allergies to one or more components of the drug. It must be remembered that the body’s reaction may not appear immediately, but during the course of treatment. In this case, at the first signs of allergy, you must stop taking the drug and consult your doctor.

You should also avoid taking Papaverine in the following cases:

• for children - up to 6 months of age (in some cases, the drug is contraindicated until the baby reaches 1 year);
• for adults, the age limit for taking the drug is 60 years;
• the patient often experiences a decrease in blood pressure (arterial hypotension);
• glaucoma;
• coma;
• taking drugs that inhibit monoamine oxidase;
• renal failure;
• disturbance of atrioventricular conduction.

There are situations when Papaverine is not completely contraindicated, but treatment should be under the constant supervision of the attending physician:

• receiving a traumatic brain injury;
• liver and kidney pathologies;
• dysfunction of the thyroid gland.

What is the medicine used for? Papaverine suppositories are used for many diseases that are accompanied by pain. The drug is widely used in gynecology, urology, and surgery.

Main indications:

• all types and stages of hemorrhoids;
• headaches caused by vasospasm;
• pain syndrome in various diseases of the digestive system;
• renal colic;
• pathologies of the urinary tract – pyelonephritis, cystitis, urolithiasis, urethritis;
• bronchitis, pneumonia;
• pain in women during menstruation.

Papaverine helps relieve spasms in various diseases

Papaverine suppositories have a positive effect on the gastrointestinal tract during constipation and help normalize stool. The drug effectively fights migraines. For bronchitis, the medicine relieves spasm from the bronchi and helps prevent swelling of the mucous membrane.

Read the article: Relief Ultra suppositories for hemorrhoids and their instructions

• presence of allergies to the components of the drug;
• increased intraocular pressure in glaucoma and other diseases;
• liver failure, accompanied by severe course;
• blockade of the heart muscle;
• old age of the patient;
• children's age up to 12 years.

Papaverine is prescribed by a doctor who must study the patient’s medical history and exclude all possible contraindications.

How to give in childhood

“Papaverine” in ampoules, tablets and suppositories can be used to treat infants starting from the age of three months. Despite the fact that the instructions contain a contraindication for the use of this drug for children under six months old, most domestic pediatricians consider taking the drug justified and safe from three months. The doctors' arguments are based on many years of observations of the use of Papaverine. In addition, its active ingredient is included in Omnopon, a medicine intended for women in labor. A drug based on papaverine hydrochloride has an analgesic effect and helps make childbirth easier.

For children in the first year of life, the drug is prescribed mainly for the relief of spastic pain syndrome and intestinal colic. In older age, “Papaverine” in ampoules can be used to relieve bronchospasm and be an element of complex treatment of diseases of the pancreas, liver, and urinary tract.

When planning to give a child an injection, it is advisable to draw the solution from the ampoule with a small-volume syringe, which will allow you to accurately measure the required amount of medicine. The dosage of the drug for small patients is determined by the doctor.

If we talk about Papaverine tablets, they should be given to children in a special dose. They produce the so-called children's "Papaverine", one pill of which contains 10 mg of the active ingredient. If there are no tablets in children's dosage, you can find another way out: calculate the dosage and divide the adult pill into small parts. If the child has been prescribed rectal suppositories, they can also be divided into two or four parts, but they should be cut along the suppository rather than across it.

“No-Shpa” and “Papaverine” are a dangerous combination

This medicinal complex is often used to prepare the cervix for the upcoming birth. “No-Shpu” and “Papaverine” are administered twice a day for two weeks before the expected date of birth of the baby. You can use not only injections, but also tablets and suppositories.

Many pregnant women are prescribed these drugs in combination with each other. This is a very common practice, but in fact, these cervical preparation products do more harm to a woman than good. Before labor, the uterus must actively contract and prepare for childbirth, and instead of stimulating its contractions, the process is artificially stopped with antispasmodics, which relax the muscles and reduce tone.

In fact, “Papaverine” together with “No-Shpa” inhibits labor. The opinion that these drugs supposedly help prevent tissue ruptures in women is erroneous. This point depends solely on the experience and qualifications of the obstetrician-gynecologist. In modern clinics, this combination of drugs has not been used for a long time.

If it is necessary to prepare the cervix for childbirth, the woman is prescribed other drugs and methods (for example, Prostin, kelp sticks, Foley catheter). The doctor can decide to intervene after the fortieth week of pregnancy or if an urgent delivery is necessary due to a threat to the woman’s life.

Possible side effects

Negative phenomena associated with the use of suppositories are extremely rare. This is evidenced by numerous positive reviews from patients and doctors who have tested the drug in practice. Sometimes during treatment with the product, minor itching and irritation occurs in the anal area. If the dose is greatly exceeded, the patient may experience the following complications:

• heart rhythm disturbance;
• dizziness;
• apathy and drowsiness;
• difficulty urinating and defecating;
• nausea, less often vomiting.

Treatment of the complications described above consists of blood purification and symptomatic treatment of the patient.

Important! If alarming signs develop during therapy with Papaverine, you should stop taking the drug and immediately visit a doctor.

While taking Papaverine, the body may develop adverse reactions to the action of the active substance. They appear as follows:

• allergy;
• decreased blood pressure;
• acceleration of heart rate or its failure;
• headache;
• dizziness;
• problems with the gastrointestinal tract (diarrhea, constipation, nausea and others);
• increased sweating;
• increase in the amount of transaminases in the liver;
• increase in the number of eosinophils in the blood.

Drinking alcohol during treatment may increase the risk of adverse reactions to taking Papaverine. The duration of the therapeutic course is not limited, however, a high concentration of the active substance in the body can cause the following reactions:

• rash and itching;
• formation of a hematoma or bruise at the injection site;
• skin redness;
• disorders of the kidneys and liver.

If these symptoms appear, you should consult your doctor to reduce the dosage of the drug or discontinue it and then replace it with another drug.

Other medicines

Drug treatment of colitis includes the mandatory use of drugs that help repopulate normal microflora and restore intestinal functions. Such a correction is carried out after the main course of treatment. Such drugs include:

• Eubiotics (Intestopan, Mexaza);
• Probiotics (Bifidumbacterin, Acipol, Atsilact, Bifiform, Bioflor);
• Prebiotics (Lactofiltrum, Maxilak).

Due to the fact that patients with colitis often experience pain, antispasmodics are prescribed to reduce it. For these purposes, No-shpa, Drotaverine Platiphylline, Papaverine are used. They also normalize intestinal motility. If pain does not go away while taking them, then after consultation with a proctologist, antispasmodics are replaced with anticholinergics (Atrovent, Vesicare, Atropine, Gastrozem).

If colitis is accompanied by damage to the sigmoid and rectum, drugs for local treatment are prescribed in the form of rectal suppositories (Natalsid, Ultraproct, Salofalk, suppositories with sea buckthorn, methyluracil, propolis).

These suppositories have a powerful anti-inflammatory effect. They promote the regeneration of damaged colon mucosa and accelerate healing processes.

Inflammatory disease of the large intestine negatively affects not only the functioning of the gastrointestinal tract, but also the general well-being of the patient. Therefore, it is recommended to include in the treatment regimen the use of sedatives and sedatives, for example, Glycine or Persen. They will help get rid of internal discomfort, insomnia, irritability and fatigue.

Experts talk about the desirability of combining these drugs with taking B vitamins, namely B6 and B12. One of the main tasks of treating any colitis is normalizing stool. If the disease is accompanied by constipation, then magnesium sulfate or lactulose-based drugs are prescribed, for example, Duphalac and Portalac.

If the patient has loose stools, then antidiarrheal drugs cannot be avoided. The most commonly prescribed drugs are loperamide. These are drugs such as:

Solution, suppositories, tablets "Papaverine": what they help with

The medicine is indicated for use in:

• spasms of the muscles of the abdominal organs;
• renal colic;
• in the treatment of hypertensive crisis, the drug “Papaverine” is also prescribed, for which it helps as part of a complex treatment;
• cholecystitis;
• spastic colitis;
• endarteritis;
• pylorospasm;
• angina pectoris;
• spasms of the peripheral vascular bed;
• urinary retention of spastic etiology;
• bronchospasm;
• reduction of the lumen of blood vessels in the brain;
• decreased arterial renal inflow.

Where to insert Papaverine and how often can it be done? Suppositories should be used only as prescribed by a doctor. Typically, adults are administered 20-40 mg of the drug 2-3 times throughout the day. Sometimes a specialist may adjust the dosage depending on the diagnosis. Considering the question of how long the drug takes to act, it should be noted that on average the effect occurs after 30 – 40 minutes. Sometimes you have to wait longer for results. This depends on the characteristics of the disease and the individual qualities of the body.

The suppository should be administered according to the instructions.

Drugs to eliminate the inflammatory process

Antibacterial drugs for the treatment of intestinal colitis are prescribed when the disease is of an infectious nature. Abuse of antibiotics can aggravate the course of the disease, since drugs in this group negatively affect the intestinal microflora. For example, for spastic colitis, antibacterial drugs are not prescribed.

Antibacterial therapy is advisable when pathogenic microflora are activated. The tablets are used strictly according to the scheme, which is selected individually depending on the stage of the disease and the patient’s condition. Most often they resort to sulfonamides (Sulgin, Mesacol, Sulfalazin, Fthalazol). In addition, Enterol, Enterofuril, De-nol, Metronidazole are used in treatment.

They are used in several stages, from intensive treatment to consolidation of the effect. After examining the patient’s microflora, the doctor, if necessary, can prescribe an additional antibacterial drug with a narrow spectrum of action. Its use is aimed at destroying the identified pathogen.

The above antibacterial drugs have a powerful anti-inflammatory effect, due to which the source of bacterial spread is quickly eliminated and their metabolism is suppressed. Antimicrobial drugs are also used to treat the chronic form of the disease.

Almost always, when treating colitis, Enterofuril or Enterol is prescribed. If the first drug is exclusively antimicrobial, Enterol is also effective against helminthic infestations. These medications are available in capsules and suspensions.

If the cause of inflammation of the intestinal mucosa is worms, then the patient will need to take antiparasitic drugs. The most effective of them are Levamisole, Vermox, Decaris. Such medications are prescribed with caution, as they are highly toxic and can impair the functioning of the liver and heart. In this regard, medications are prescribed to minimize such disorders.

special instructions

When starting treatment with the drug, you should carefully study the instructions for use. It includes several special instructions that must be followed. These include:

• the medicine should be used with extreme caution in cases of severe renal failure;
• During treatment with suppositories, it is important to stop drinking alcohol;
• During pregnancy and lactation, suppositories are used under the strict supervision of a doctor. To date, there is not enough information about the safety of using the drug during this period;
• the active component of the drug can have a relaxing effect on the central nervous system, therefore, among people whose work activity requires increased concentration, the drug is used carefully.

In addition, if the patient is taking any other medications, be sure to inform the doctor.

Before starting treatment, it is important to read the instructions for the drug

In addition to drug therapy, Papaverine can be used for other purposes.

1. Sport. Papaverine hydrochloride in the form of an injection solution is injected into the shoulder muscles to increase their size. Injections are given 1-2 times into each muscle at weekly intervals. After the manipulation, physical activity is performed on the muscle group being increased. Thanks to this, as well as increased blood circulation (under the influence of Papaverine), muscle mass growth accelerates.
2. Cosmetology. The drug’s ability to increase blood circulation is also used in the beauty industry. In particular, it is used to combat excess weight and cellulite on the back of the thighs and buttocks. To do this, the contents of the ampoule are mixed with coffee and the finished composition is wrapped. To enhance the effect, it is recommended to lightly massage the muscles before starting the procedure.
3. Veterinary medicine. Papaverine injections eliminate intestinal spasms in cats caused by hair getting into the stomach. Under the influence of the drug, the passage of intestinal contents improves.

Analogs

How to replace Papaverine suppositories? Among the analogues of the drug, the following drugs can be distinguished:

• No-Shpa is a medicine that is used for diseases associated with spasm of the smooth muscles of internal organs and blood vessels, as well as for the treatment of periodic pain;
• Spazmolysin suppositories - inserted into the anus for pain syndrome arising from diseases of the gastrointestinal tract and other organs, cholecystitis, pancreatitis, cystitis and other pathologies;
• Spascuprel - used to relax the smooth muscles of internal organs in diseases of the stomach, intestines, pancreas, kidneys and other organs;
• Theophedrine ІС – used for bronchial asthma, obstructive bronchitis to eliminate bronchospasm and ease the patient’s breathing;
• GastroComfort is an antispasmodic and carminative drug that is prescribed to patients with diseases of the digestive system;
• Niaspam - used for irritable bowel syndrome, renal and hepatic colic, and other pathologies of the digestive system.

You should take any of the analogues only after examination by a doctor.

Self-medication often causes serious negative consequences.

Papaverine does not have generics. All existing analogs differ in the nature of the active substance.

The most well-known drugs that can replace Papaverine include:

• No-shpa (can be used simultaneously with Papaverine to enhance the effect);
• Drotaverine Hydrochloride (no restrictions for pregnant women);
• Drotaverine and Mebeverine (the antispasmodic effect is higher than that of Papaverine, but the list of adverse reactions is longer).

Bencyclane, Dibazol, Hyoscine butyl bromide, Theophylline can also replace Papaverine in treatment.

To replace the drug with an analogue, you must consult your doctor.

Who is prescribed

This medicine is available not only in injections. "Papaverine" is sold in tablets and in the form of rectal suppositories. Indications for use of the drug, regardless of the release form, do not change. The active substance is absorbed into the patient’s blood in exactly the same way and has a systemic therapeutic effect.

In the majority of cases, “Papaverine” is prescribed for the complex treatment of diseases and conditions such as endarteritis, bronchospasm, pylorospasm, cholecystitis, angina pectoris and spastic colitis. It is recommended to use this medication:

• in order to prevent spasms of muscle tissue of the smooth structure of internal organs - we are talking about inflammation of the gallbladder, irritable bowel syndrome, spasms of the stomach, respiratory organs;
• for relief of acute pain syndrome in renal and hepatic colic;
• for systemic therapy of impotence, erectile dysfunction against the background of diseases of the small organs, disorders of vascular etiology;
• to eliminate spasms in vascular pathologies accompanied by involuntary contraction of the arteries of the brain, upper and lower extremities.

Sometimes Papaverine injections are given to patients before surgery. The drug is used as an additive that helps prepare the patient for the introduction of anesthesia - to reduce the degree of anxiety and enhance the effect of anesthesia.

Overdose

If you constantly increase the recommended therapeutic doses when using papaverine, then signs of overdose may appear:

• drowsiness;
• excessive fatigue;
• double vision;
• weakness;
• decreased blood pressure;
• intoxication of the body;
• disturbance of the rhythm of heart contractions;
• attacks of arrhythmia;
• nausea, vomiting.

Rinse the stomach immediately, drink a glass of milk, take activated charcoal if side effects are observed 1-2 hours after taking papaverine hydrochloride. It is also important to measure your blood pressure.

In case of excessive drop in indicators, vomiting and dizziness, it is better to call an ambulance without waiting for your health to worsen.

11Overdose

Symptoms of overdosage:

• drop in blood pressure;
• blurred vision, double vision;
• fatigue, loss of strength;
• drowsiness.

There is no antidote. Symptomatic treatment is carried out: gastric lavage using Polysorb or Activated Carbon and milk.

A symptom of exceeding the dosage is deterioration of vision, double vision in the eyes.

Patient reviews

Stanislav, Cheboksary “I was prescribed suppositories for exacerbation of hemorrhoids. The drug works quite quickly, relief occurs within 15 to 20 minutes. Papaverine is easy to find in any pharmacy, its cost is affordable. Over the course of several courses of therapy, I did not notice any side effects.”

Anastasia, Prokopyevsk “I was prescribed suppositories during pregnancy, when there was a threat of miscarriage. I lit one candle at night. In the ward where I was lying, this drug was prescribed to many girls. Papaverine does not cause side effects and relaxes the uterus well. The main advantage of candles is their low cost and availability.”

Marina, Cherkessk “At the age of 13, I started menstruating. This period is always very painful. She underwent many medical examinations, but doctors did not find any abnormalities. Papaverine suppositories save me. In the first days of menstruation, I put one candle in the morning and in the evening. Thanks to the drug, critical days pass easily. I haven't noticed any consequences yet. I recommend to everyone".

Natalya, Minsk “For many years I have been suffering from chronic cholecystitis, the disease is often accompanied by pain and other unpleasant sensations. One of the components of complex therapy prescribed by the attending physician is Papaverine suppositories. Despite its inexpensive cost, the medicine works great.

With uterine hypertonicity

Increased uterine tone threatens premature birth. Papaverine suppositories help relieve spasms and relax smooth muscles. According to the doctor’s recommendation, a woman is given 2–3 suppositories throughout the day to tone the uterus. It is advisable for every pregnant woman to have this medicine in her home medicine cabinet, since when a spasm occurs, this drug will become an ambulance. The drug should be used carefully during treatment with other vaginal and rectal suppositories.

Sometimes the medicine is used among women in labor for false contractions. During this period, the woman experiences pain in the uterus and lower back, but this condition is only a harbinger of an imminent birth. To make a woman feel better, suppositories can be prescribed.

Injection technique

When administering subcutaneously or intramuscularly, you first need to decide on the injection site. How to give Papaverine injections? In this case, the technique is practically no different from the parenteral administration of other drugs. The best place for intramuscular injection is considered to be the superolateral outer surface of the thigh or the upper outer part of the shoulder, and for the subcutaneous injection - the periumbilical area.

Before entering the tissue with a needle, the skin around the injection site must be treated with an antiseptic. Then the required amount of “Papaverine” is drawn into the syringe and injected intramuscularly into the prepared area. It is important that the needle goes deep into the tissue, forming a right angle with the surface of the skin.

If there is a need to perform a subcutaneous injection of Papaverine, then the injection should be done differently. First, you need to grab approximately 1 cm of the skin fold with two fingers, then place the syringe at an angle of 45 degrees to the surface of the epidermis and inject the solution into the fold. As soon as all the medicine has been administered, the needle is carefully removed and a cotton pad with an antiseptic is tightly applied to the injection site. If multiple injections of the solution are necessary, with each subsequent injection you should deviate from the previous injection marks by 1-2 cm.

For intravenous infusion, the drug is diluted in the required amount with sodium chloride solution, then the resulting mixture is slowly injected into a vein in the arm. It is advisable to carry out such injections within the walls of a hospital hospital. At the same time, the patient is allowed to administer subcutaneous and intramuscular injections of “Papaverine” independently at home if he knows the described technique.

Injections with Diphenhydramine

A classic lytic mixture with powerful antipyretic properties is an injection of Analgin with Papaverine and Diphenhydramine. What does this medicinal “cocktail” help with? The mixture is designed to quickly reduce high temperatures. The use of drugs is especially effective for so-called cold hyperthermia - a condition in which a person experiences a strong fever, but at the same time the limbs remain cold and pale. Against the background of cold hyperthermia in children, the risk of febrile seizures increases.

"Analgin" in combination with "Diphenhydramine" brings down the temperature, and "Papaverine" is usually given to dilate blood vessels. The antispasmodic is administered 15-20 minutes before the antipyretic. If the patient has icy extremities with a high temperature throughout the body, Analgin with Diphenhydramine alone may not be effective enough. Without first taking an antispasmodic, the narrowed blood vessels are unable to release excess heat and cool the body.

"Analgin" with "Diphenhydramine" and "Papaverine" is often used in inpatient surgery departments. This medicinal mixture helps relieve postoperative pain, relieve inflammation and reduce body temperature. In addition, other drug combinations can be used. For example, “Papaverine” together with “Diphenhydramine” is an effective analgesic combination for people with postoperative spastic pain, and with “Analgin” it is a simplified variation of the above-described lytic mixture.