We provide instructions for using the drug nimesulide

1132
The drug Nimesulide belongs to the group of medications that do not contain steroids and is characterized by pronounced anti-inflammatory, antipyretic and analgesic effects. It has a high degree of safety, and thanks to the variety of release forms, it can be actively used in various situations and for different categories of patients. Despite its widespread use against the symptoms of certain diseases, this drug also has contraindications, so you should consult your doctor before treatment.

How to dilute Nimesil powder

The medicine Nimesil is granules for the preparation of an oral suspension in the form of a light yellow powder with the smell of orange - 2 grams of Nimesil in a paper bag; 9, 30 or 15 sachets in a cardboard box.

How to take medicine to make the disease go away? After administration, it is well absorbed from the intestines, reaching its highest concentration in the blood after 2-3 hours. Reaction with plasma proteins is 97.5%. The half-life is 4-5 hours. Quickly penetrates histohematic barriers.

How to drink Nimesil if the disease takes you by surprise? The drug in powder (granules) is placed in a glass and diluted in approximately 100 ml. water. The prepared solution cannot be stored; it must be taken as soon as possible. There is a common question about what water to dissolve the powder in. The instructions recommend dissolving the medicine in warm, boiled water.

Cost of Nimesil and its analogues

Nimesil is an imported drug; it is produced by several pharmaceutical companies - Laboratorios Menarini (Italy) and Fine Foods & Pharmaceutical (Spain). This is one of the first nimesulide-based drugs registered in Europe. At the moment, a large number of generics have appeared on the market, which have the same clinical effect, but have a lower cost.

Directions for use and doses

Nimesil is taken orally, 1 sachet (100 mg 2 g of nimesulide) twice a day. The anti-inflammatory drug is recommended to be taken after meals. The contents of the sachet are poured into a glass and dissolved in approximately 100 ml. water. The prepared solution cannot be stored.

• Nimesil is used only to treat patients over 12 years of age;
• Adolescents (12 to 18 years): Based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need for dose adjustment in adolescents;
• Patients with impaired renal function: based on pharmacokinetic data, there is no need for dose adjustment in patients with mild to moderate forms of renal failure (creatinine clearance 30-80 ml/min);
• Elderly patients: when treating elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs;
• The maximum duration of treatment with nimesulide is 15 days;
• To reduce the risk of unwanted side effects, the minimum effective dose should be used for the shortest possible course. Now you know how to take Nimesil

Analogues with a minimum of side effects

When choosing an NSAID, you need to take into account a large number of factors - the severity of pathological symptoms, age, the presence of concomitant diseases

There are no medications without side effects, so it is very important to follow the instructions, choose the safest medications and use the minimum effective doses. You can replace Nimesil with over-the-counter analgesics, which have fewer unwanted effects and contraindications

Ibuprofen

The international nonproprietary name is similar to the active ingredient - Ibuprofenum. According to its chemical structure, it is a derivative of propionic acid, which has a blocking effect on the COX enzyme and reduces the production of inflammatory mediators. The drug also helps eliminate fever and chills. Can be used during pregnancy and lactation as prescribed by a doctor. Special forms of ibuprofen have been developed in the form of syrup and suspension, which allows it to be prescribed to children after 3 months.

The most popular tablets from these manufacturers:

• Darnitsa, Ukraine;
• Borisov ZMP, Belarus;
• Borshchagovsky Chemical Plant, Ukraine;
• Akrikhin, Russian Federation;
• Hemofarm, Serbia;
• Tatchimpharmpreparaty, Russia.

Tablets contain 100, 200 or 400 mg of ibuprofen. The drug can be used for 2-3 weeks. Dosage regimen: 1 tablet 2 times a day, depending on the clinical situation.

Nalgesin

A modern analgesic-antipyretic containing 275 mg of naproxen in the form of sodium salt. The mechanism of action is associated with inhibition of the activity of enzymes involved in the synthesis of inflammatory mediators (prostaglandins and leukotrienes). This medicine also has antithrombotic properties. The drug has high bioavailability and is well tolerated by most patients.

According to the instructions, Naproxen is indicated for the treatment of radiculitis, ischalgia, radicular neuralgia, headache, muscle, joint and menstrual pain.

Contraindications:

• pregnancy and lactation;
• acute inflammatory diseases of the gastrointestinal tract (gastritis, duodenitis, peptic ulcer);
• intolerance to one of the components;
• bleeding disorders.

Undesirable effects when taking Nalgesin are associated with the individual characteristics of the body or an incorrectly selected dosage. They may manifest as a feeling of drowsiness and depression, abdominal discomfort, and dizziness.

The drug is produced in Slovenia by the company KRKA. A prescription is not required to purchase Nalgesin tablets.

Ketonal

The main active ingredient is ketoprofen. It is a representative of the latest generation of NSAIDs. In addition to blocking the action of all types of COX, it has the ability to inhibit the enzyme lipoxygenase. As a result, the concentration of bradykinin, prostaglandin and other inflammatory mediators decreases.

Indications for use:

• hyperthermia;
• infectious and inflammatory diseases of various localizations;
• acute and chronic pain.

The drug is contraindicated in cases of aspirin intolerance, bronchial asthma, gastric and duodenal ulcers, and increased bleeding.

Ketonal is available in capsules and tablets of 25, 150 and 200 mg. The presence of an injection form and a variety of dosages allows you to select the minimum effective dose, method and frequency of use of the drug. Ketonal can be used either as symptomatic therapy once or in a course of 2-3 weeks. Manufacturer: Lek DD, Slovenia.

Pharmacological action of the drug

Nimesil belongs to the non-steroidal anti-inflammatory group of drugs. The active substance of the drug, nimesulide, blocks the synthesis of arachidonic acid, thereby reducing the release of prostaglandins. As a result, pain is significantly reduced. The anti-inflammatory effect of this drug cannot be diminished. Therefore, it is quite successfully used to reduce pain during regulation. In addition, Nimesil is recommended:

• as part of therapy after gynecological and surgical operations;
• for osteochondrosis, rheumatism and other diseases of this series;
• if there are dental and otorhinolaryngological problems;
• for urological diseases, etc.

httpv://www.youtube.com/watch?v=embed/oT3y6fpFQNw

Of course, it is impossible to say that Nimesil is a panacea for dysmenorrhea (pain during menstruation) or pain caused by other reasons.

Due to its effect on the walls of the stomach and intestines, the drug should be taken with caution

Smelly period

Any disease, be it gynecological or otherwise, has negative consequences and symptoms. At the same time, our...

More information about the drug Nise

If you are considering cheap drugs that are similar in principle to Nimulid, you can pay attention to the drug Nise. This is a replacement that fits the release form

You can buy tablets, gel or granules for preparing a suspension, marketed under the name Nise. If you need to select analogues, Nimulid will cost more than Nise. Its average cost is 250 rubles (tablets). Nise costs around 200 rubles.

The main substance in the composition is nimesulide. It is contained in an amount of 50 mg per 1 tablet. Nise is another drug that belongs to the group of selective COX-2 inhibitors. Properties of this medicine: eliminates inflammation, reduces temperature, helps reduce pain intensity. The drug is indicated for use in a number of cases:

• arthritis of rheumatoid and psoriatic nature;
• ankylosing spondylitis;
• radiculitis and osteochondrosis;
• lumbago;
• arthralgia and myalgia;
• pain in various conditions of the body;
• injuries of various origins.

Nise is not prescribed in a number of cases:

• exacerbation of erosive processes in the gastrointestinal tract;
• bleeding in the digestive tract;
• liver dysfunction;
• renal failure;
• hypersensitivity to one of the components;
• age up to 2 years.

If you plan to use the gel, it is better to choose a product in a different form, since such medications are not prescribed if there are lesions, rashes or infections on the skin. Nise is not used during pregnancy and lactation due to the risk of negative effects on the child.

Side effects from the digestive and nervous systems are noted, fluid retention often occurs, and allergic reactions develop. In general, Nise has fewer side effects than Nimulid. The use of the gel may cause local reactions in the form of rash and redness.

Special Recommendations

Before you start taking Nimesil, you must carefully study the instructions supplied with the drug. There are a number of recommendations for the correct use of the drug, namely:

The active component of Nimesil is not compatible with all medications, so before you start taking it, you must consult a doctor, making sure to notify the specialist about all the medications you are currently taking. When using the drug in an effective therapeutic dosage and subject to a short course of administration, the risk of side effects is significantly reduced. Moderate renal failure may require a downward adjustment of the drug dosage taken. An additional component of the powder is sucrose, so patients with diabetes should take the drug with extreme caution and regularly monitor their blood sugar levels. Nimesil should not be taken simultaneously with other drugs from the category of non-steroidal anti-inflammatory drugs. The effect of the components of Nimesil on the functioning of the central nervous system has not been fully studied, therefore, during treatment with the drug, you should not perform work that requires increased concentration of attention, or drive a car.

"Nimesil" in sachets should be sold in pharmacies with a doctor's prescription. It should not be taken on its own.

Sources

• https://TvoiMesyachnye.ru/boli/nimesil-pri-mesyachnyh
• https://cikl.online/aptechka/nimesil-pri-mesyachnyh
• https://healthy-teeth.su/kak-pit-nimesil.html
• https://pocki.top/tsistit/nimesulid-pri-tsistite/
• https://dentoland.com/preparat/nimesil-poroshok-instrukciya.html
• https://vse-o-spine.com/lechenie/medicamenty/nimesil.html
• https://dieta-dlja-pohudenija.ru/kak-prinimat-nimesil-instrykciia-po-primeneniu-sostav-poroshka-analogi/
• https://stopzaraza.com/lechenie/nimesil.html
• https://1labhealth.ru/tsistit/lekarstva/nimesil-pri-tsistite-u-zhenshhin-instruktsiya.html
• https://www.syl.ru/article/347881/kak-pit-nimesil-pokazaniya-k-primeneniyu-instruktsiya
• https://tmbgift.ru/skolko-po-vremeni-dejstvuet-nimesil/
• https://pillsman.org/25400-nimesil-ot-temperatury.html
• https://temperatura03.ru/lechenie/nimesil-detyam-pri-temperature.html
• https://pillsman.org/25417-nimesil-pri-mesyachnyh.html
• https://pivunet.com/sovmestimost-s-alkogolem/nimesil
• https://systavi.com/preparaty/nimesil.html
• https://lcistit.ru/nimesil-pri-tsistite/
• https://stomatronix.ru/poleznoe-o-zubah/skolko-dejstvuet-nimesil-pri-zubnoj-boli.html
• https://fb.ru/article/383006/nimesil-cherez-skolko-nachinaet-deystvovat-pokazaniya-k-primeneniyu-forma-vyipuska-pobochnyie-effektyi-i-protivopokazaniya

Inexpensive substitutes for Nimesil powder

If you need to quickly eliminate pain or fever, it is rational to use the drug in powder. This ensures high bioavailability of the drug and the fastest possible clinical effect. Sachets containing a single dose can be purchased individually at pharmacies.

Nise

Belongs to the group of non-steroidal anti-inflammatory drugs. The active ingredient is nimesulide. The chemical properties are sulfonanilide, and the mechanism is associated with blocking type 2 cyclooxygenase receptors. Indicated for the treatment of lumbago, gout attacks, arthritis of various etiologies. The drug has a fairly large number of side effects, which is associated with high hepatotoxicity, therefore it is not recommended in routine practice and is a second-line therapy.

Produced by the pharmaceutical company Dr. Reddis, India. A special feature is the presence of several forms of release:

• Sachets of granulated powder for preparing a solution, 2g;
• Enteric tablets;
• Oral suspension.

The drug can be used by children over 7 years of age with strict adherence to the instructions and constant medical supervision.

Nemulex

The drug is packaged in the Russian Federation by Sotex PharmFirma, which carries out control before sale. Raw materials based on nimesulide are produced in Romania at the Rompharm Company plant.

Release form: dry powder in the form of granules. After dissolution in water, a homogeneous suspension with a pleasant orange taste and smell is formed. The drug is used as symptomatic treatment of diseases that are accompanied by severe pain - osteochondrosis, arthrosis and arthritis, bursitis, myalgia, toothache and headache, radicular syndrome. It is prohibited to use the drug during pregnancy and breastfeeding.

Possible adverse reactions include allergies, urticaria, dizziness, drowsiness, depressed emotional state, nausea, abdominal pain.

Nimid

An anesthetic drug based on nimesulide, which is available in sachets containing 2 g of instant powder. It belongs to non-narcotic analgesics of category B, sold by prescription.

Recommended as a second-line anti-inflammatory and analgesic agent. Effectively eliminates pain of any etiology, helps reduce signs of inflammation during infection or injury.

Produced in India by the pharmaceutical company Kusum in several dosage forms that can be combined to achieve maximum effect:

• powder for suspension;
• pills;
• gel for external use.

Compatibility and side effects

From the hematopoietic system: rarely - anemia, eosinophilia, hemorrhagic syndrome; very rarely - thrombocytopenia, pacytopenia, thrombocytopenic purpura.

Allergic reactions: uncommon - itching, rash, increased sweating; rarely - hypersensitivity reactions, erythema, dermatitis; very rarely - anaphylactoid reactions, urticaria, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the side of the central nervous system: infrequently - dizziness; rarely - a feeling of fear, nervousness, nightmares; very rarely - headache, drowsiness, encephalopathy (Reye's syndrome).

From the side of the organ of vision: rarely - blurred vision.

General disorders: rarely - malaise, asthenia; very rarely - hypothermia.

Other: rarely - hyperkalemia.

The abstract for Nimesil recommends using the drug with caution if severe forms of type 2 diabetes mellitus or arterial hypertension are present; ischemic disease, heart failure, dyslipidemia, cerebrovascular diseases, peripheral arterial diseases, old age;

peptic ulcer in the past, infections associated with Helicobacter pylori; long-term previous use of non-steroidal anti-inflammatory drugs; decompensated somatic diseases; with smoking and concomitant treatment with anticoagulants, oral glucocorticosteroids, antiplatelet agents, selective serotonin reuptake blockers.

How much does Nimulid and analogues cost?

Nimulid is an effective remedy for fever for children, so many parents, without even thinking about its danger, begin to “treat” the child. Gone are the days when self-medication gave positive results. Now the number of different diseases is so large that an incorrect diagnosis can lead to a number of complications. Sometimes even experienced doctors find it difficult to make an accurate diagnosis, prescribing additional tests and examinations.

Although the drug Nimulid cannot be called too expensive, it really is an effective medicine, as confirmed by reviews. The cost of Nimulid in the form of a suspension in a 60 ml bottle is about 700 rubles. But the final cost depends not only on the region, but also on the manufacturer. The cost of analogues is as follows:

• Prolide in tablet form – 50 rubles;
• Aponil in tablet form – 100 rubles;
• Nimika – 120 rubles;
• Nise - 100 rubles.

In conclusion, it should be noted that Nimulid should be used in exceptional cases when there is a need. If a child has a very difficult time with teething, then this drug is recommended to be used first. In all other cases, for children under 12 years of age, this remedy should be in the background.

special instructions

To reduce the risk of side effects, it is necessary to use the drug in the minimum effective dose for the shortest duration. If the patient's condition does not improve, treatment should be stopped.

It is necessary to stop taking the drug if the temperature rises or flu-like symptoms develop while taking it.

If patients taking Nimesulide develop symptoms indicating liver damage (for example, anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine), or increased levels of liver transaminases, the drug should be discontinued. It is not recommended to prescribe Nimesulide to such patients in the future.

Gastrointestinal bleeding or ulcer/perforation of the stomach or duodenum may develop at any time while using the drug, which may not be accompanied by clinically significant symptoms (including pain). If gastrointestinal bleeding or ulcers occur, the drug should be discontinued.

If renal function deteriorates, the drug should be discontinued.

If the drug is used for more than 2 weeks, monitoring of liver function indicators is necessary.

In patients with liver cirrhosis or renal failure with hypoalbuminemia or hyperbilirubinemia, nimesulide binding is reduced.

Elderly patients most often develop side effects when taking the drug, including gastrointestinal bleeding, perforation, dysfunction of the heart, kidneys and liver. Therefore, regular clinical monitoring of the patient’s condition is recommended.

The use of nimesulide may adversely affect female fertility and is not recommended for women planning pregnancy.

Impact on the ability to drive vehicles and operate machinery

If, when using the drug, undesirable effects from the central nervous system and sensory organs occur, it is necessary to refrain from driving vehicles and engaging in activities that require increased concentration and speed of psychomotor reactions.

Special instructions

Nimesulide, which does not require a prescription to purchase from pharmacies, must nevertheless be taken with caution.
The parallel use of the drug and any other non-steroidal anti-inflammatory drugs, concomitant analgesics should be avoided. If patients develop symptoms characteristic of liver damage (nausea, vomiting, anorexia, darkening of urine) or an increase in the level of liver transaminases, the use of Nimesulide should be discontinued. If fever or flu-like symptoms occur, therapy should be discontinued immediately.

Patients who, in parallel with Nimesulide, are taking medications that increase the risk of developing gastrointestinal ulcerations and bleeding should be attentive to themselves.

The drug is prescribed with caution to people who suffer from ulcerative colitis or Crohn's disease, with a history of ulcers, and to elderly patients

Persons who need to take Nimesulide in parallel with aspirin in cardiac doses should be prescribed combination therapy with gastroprotectors.

The use of Nimesulide (or any other NSAIDs) in large volumes and over a long period of time leads to a slight increase in the risk of thromboembolic events (stroke, myocardial infarction, etc.).

For patients with various problems of the cardiovascular system, Nimesulide can be prescribed only if the expected benefit exceeds the risk of side effects.

The medication affects the degree of platelet activity. This information is important for patients suffering from bleeding diathesis. Severe skin lesions most often develop with long-term use of Nimesulide. As soon as skin rashes appear, damage to the mucous membranes becomes noticeable, or any other manifestations of intolerance are recorded, drug therapy should be discontinued.

The use of Nimesulide by pregnant women can cause closure of the ductus botanus before it is necessary, reducing the volume of amniotic fluid. There may be an increased risk of intrauterine bleeding, weakening of labor, and the appearance of edema. For these reasons, expectant mothers are not recommended to take Nimesulide during the first and second trimesters of pregnancy.

The answer to the question of whether it is possible to take Nimesulide and alcohol at the same time must be obvious: such a combination is unacceptable!

Adverse reactions

When using the drug to relieve pain during menstruation, some adverse reactions are possible:

• Dyspeptic reactions from the gastrointestinal tract, such as nausea, vomiting, pain, and possible bleeding;
• On the part of the heart, changes such as increased heart rate, decreased blood pressure are possible;
• The central nervous system also undergoes some changes. Headache, dizziness and asthenic syndrome are characteristic when taking the above drug;
• If you conduct blood tests, you can notice a decrease in the level of hemoglobin, red blood cells, an increase in eosinophils and changes in liver tests.

It should be noted that women, in order to enhance the pharmacological effect, resort to taking a dose of the drug that exceeds the norm. This leads to an overdose of the body, in response it responds with changes in the gastrointestinal tract and heart. To prevent the development of complications, it is necessary to rinse the stomach, take activated charcoal and consult a specialist.

Before taking any drug, you should consult your doctor. It is he who will give recommendations, tell you about the rules of administration and side effects.

• In case of gastritis, ulcers or other gastrointestinal diseases, the drug is contraindicated, since taking it will only aggravate the situation;
• If you have kidney or liver diseases, taking Nimesil is also contraindicated;
• If there are disorders of the blood coagulation system. Among the properties of Nimesil is the provocation of bleeding;
• Females with heart problems are also not eligible to take the proposed drug.

Also, no one has canceled the development of allergies, so if you have such a reaction to non-steroidal anti-inflammatory drugs, you should stop taking them. Pregnant and lactating women should also forget about taking this remedy.

The presented drug is a fairly strong analgesic, so among many women the choice falls on it. For menstrual pain, if you take this medicine, you can get rid of it in 15 minutes. The duration of action of the medicine is 5-8 hours. It is this property that attracts women and makes them buy this drug, because not every analgesic can quickly and permanently get rid of pain.

It should be noted that the medicine can be taken 2 days before the start of menstruation. In this situation, the woman will endure the expected period much easier.

Despite the many positive qualities and reviews about this drug, doctors recommend using it in combination with other drugs. They may be no-shpa and baralgin. This combination will give a quick, reliable effect and eliminate many adverse reactions and complications.

Nimesil is a powder. The quantity of this drug is 30 sachets in one package. The cost of this medicine is 220-250 hryvnia, in Russia its price is 500-800 rubles. The difference depends on the region in which it is sold. Nimesil is produced by Spanish and German pharmaceutical companies.

Nimesil is a fairly strong and high-quality drug. However, before using it, you should consult a doctor, as its effect may be negative.

How to use this drug correctly

The instructions for Nimesulide describe the immediate precautions for this substance.

It is worth noting that people who have stomach disease should use this drug with great caution, since its active ingredient can cause an exacerbation of existing diseases

If you use the drug for more than two weeks, you should undergo a kidney examination, as it may affect the activity of liver transaminases. If the patient's kidney function is impaired, he may experience nausea, vomiting, abdominal pain, and dark urine. In such cases, you should immediately consult a doctor and stop taking the drug (we are talking about tablets, granules). It is also worth understanding that the drug is excreted by the kidneys, and if you have impaired renal function, the dose of the drug should be reduced. Be sure to tell your doctor about your ailments, as the drug is considered quite strong.

Those who have disorders of the cardiovascular system should carefully consider the use of such a drug. The condition may worsen. This means you should stop taking the pills and consult a doctor.

When the patient uses this drug, it is worth stopping taking drugs from the following groups:

• Painkillers (analgesics);
• Other drugs from the NSAID group.

Many patients are concerned that the drug has negative side effects in the gastrointestinal tract. But problems with the stomach and intestines can occur in two cases:

1. If the patient has problems with these body systems;
2. Large dose of drug use.

If you have diabetes, also pay attention to the use of the drug, since the drug contains substances that are dangerous for diabetics.

There are clear rules on how to properly use the drug Nimesulide, and what you should pay attention to during its use. If you are a taxi driver, or often sit behind the wheel, then you will be interested in the question of how the drug affects driving.

In fact, scientists have not studied this issue. Therefore, drive carefully throughout the course of treatment.

If you use a gel during treatment, then you should understand that you should never apply it to your eyes or wounds! After applying the drug, a burning sensation may occur in the affected areas, but it disappears after a couple of days. After you have applied the gel, do not touch sensitive areas of your skin with your hands, and do not touch your eyes. If the gel gets into your eye, rinse it with plenty of water.

Pharmacokinetics

Absorption when taken orally is high (food intake reduces the rate of absorption without affecting its degree). Time to reach Cmax - 1.5-2.5 hours. Binding to plasma proteins - 95%, to erythrocytes - 2%, to lipoproteins - 1%, to acidic alpha1-glycoprotein - 1%. Changing the dose does not affect the degree of binding. Cmax - 3.5-6.5 mg/l. Vd - 0.19-0.35 l/kg. Penetrates well into the acidic environment of the inflammation site (40%) and synovial fluid (43%). Easily penetrates histohematic barriers. Metabolized in the liver by tissue monooxygenases. The main metabolite, 4-hydroxynimesulide (25%), has similar pharmacological activity, but due to a decrease in molecular size, it is able to quickly diffuse through the hydrophobic COX-2 channel to the active binding site of the methyl group. 4-hydroxynimesulide is a water-soluble compound, the elimination of which does not require glutathione and conjugation reactions of phase II metabolism (sulfation, glucuronidation, etc.). T1/2 of nimesulide - 1.56-4.95 hours, 4-hydroxynimesulide - 2.89-4.78 hours. 4 - Hydroxynimesulide is excreted by the kidneys (65%) and bile (35%), and undergoes enterohepatic recirculation.

Release form and composition

Nimesulide is available in the following forms:

• Tablets (10 pieces in a blister; 1,2 or 3 blisters per package);
• Suspension for oral administration (60 ml in a bottle);
• Gel 0.1%: homogeneous, transparent or almost transparent, yellow (30 g per tube, 1 tube in a cardboard box);
• Powder for preparing a suspension: white to white with a yellowish tint; when dissolved, it forms a white or light yellow suspension with a characteristic lemon odor (2 g per bag; 9 or 30 bags per pack).

Active ingredient: nimesulide (100 mg in 1 tablet; 50 mg in 1 g of powder; 10 mg in 1 ml of suspension; 10 mg in 1 g of gel).

Auxiliary components:

• Tablets: lactose monohydrate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, calcium hydrogen phosphate dihydrate, sodium lauryl sulfate, talc, hydroxypropylcellulose, aerosil;
• Gel: macrogol 400, carbomer, dimexide, propylene glycol, ethyl alcohol.

Pharmacological effect for colds

As already mentioned, the basis of Nimesil is nimesulide. This means that we will now talk about him. This substance is, as mentioned earlier, anti-inflammatory and belongs to the group of sulfonamides.

Nimesulide is an excellent remedy for reducing fever and relieving inflammatory processes. In addition, this drug has proven itself as a remedy that can relieve severe pain.

This helps with colds, relieves headaches, muscle pain, and can also serve as a strong pain reliever when other pain occurs.

Let's look at how this medicine works from a medical point of view and try to describe it in more understandable words:

After consumption, it is quickly absorbed (absorbed) into the gastrointestinal tract, and also quickly enters the blood. This means that this medicine very quickly has the desired effect and reaches all organs. That is why serious improvements are noticeable within 20-30 minutes after taking it.

Interaction with plasma proteins is more than 95%. This means that the medicine interacts very well with proteins, which means it is quickly accepted by the body and does not cause rejection.

The half-life of the drug from the body takes about three hours. Complete elimination of the drug from the human body occurs in about a day. This is an excellent indicator, because the concentration of a large amount of such substances in the human body can cause bad consequences

This is especially important when treatment takes a long time.

It is also important to note that the pharmacokinetic effect does not change in any way depending on age. This means that this medicine will work equally well in both teenagers and non-elderly people.

Side effects from the pills

When using the drug, you should understand that it has its own side effects that you should be aware of:

• Possible development of anemia, thrombocytopenia (rarely) - from the blood;
• A person becomes sensitive – from the immune system;
• Possible development of hyperkalemia - from the metabolic side;
• With severe pain, sleep disturbances and anxiety may manifest in the psyche;
• Dizziness – from the vestibular apparatus;
• Frequent urination, possible swelling - from the genitourinary system;
• Breathing becomes difficult - from the respiratory system.

The instructions for nimesulide also describe precautions that should be taken before you begin the course of treatment.

It is important to monitor the functioning of the kidneys and gastrointestinal tract. Use carefully in elderly people and children

You should definitely consult a doctor to avoid an overdose or problems with internal organs.

You should take the pills only after a doctor’s prescription, as you need to choose the right course of treatment, dosage and duration of use. If you take more tablets than you need, thereby causing an overdose, you should immediately induce vomiting and then take charcoal.

The use of nimesulide tablets should be carried out competently. And you need to know how the drug interacts with other tablets and suspensions. If the patient takes additional medications, such as those containing digoxin, phenytoin, as well as other drugs from the NSAID group, then the body competes in the area of ​​protein binding.

The drug nimesulide can cause a decrease in blood clotting, which means that they should not be used with acetylsalicylic acid, as there is a possible risk of bleeding. Conclusion - this combination is not desirable.

Also, tablets can cause sodium and potassium leaching. When the patient has taken the drug, the onset of side effects may appear within 24 hours. Therefore, if the use of the drug was prescribed by a doctor, it is worth finding out whether it can be taken with the medications that the patient is already taking. Since incompatibility of drugs can lead to dire consequences.

Contraindications for use

Whether it is possible to drink Nise during menstruation in a particular case is determined by other health problems. You should not take the drug if the following are diagnosed:

• intolerance to the components of the drug (in addition to nimesulide, it contains several other substances);
• exacerbation of bronchial asthma;
• allergy to acetylsalicylic acid;
• gastritis in the acute stage, stomach ulcer;
• enterocolitis, intestinal infection;
• problems with blood clotting;
• serious liver pathologies;
• severe renal failure;
• heart problems, as well as the recovery period after heart surgery.

Nise is contraindicated during pregnancy and lactation, as it can negatively affect the fetus and is deposited in breast milk.

With caution, using the minimum dosage, and after consulting a specialist, you can drink it for the following health problems:

• coronary heart disease;
• diabetes mellitus;
• pathologies of peripheral arteries.

If your health sharply worsens after taking the drug, urgent medical attention is needed. But this happens extremely rarely.

Dosage

The required dose should be calculated by the therapist depending on the age and weight of the patient, the diagnosis, and also taking into account individual factors, if any.

The general regimen for taking tablets is as follows:

• Adults and children over 12 years of age , in the absence of kidney pathologies, can take 50–100 mg of nimesulide twice a day. The classic course of treatment is five days.
• If there are problems with kidney function , then the dose should be reduced to a maximum of 100 mg per day.

Soluble nimesulide is taken in a dosage of no more than 4 tablets per day, dissolving each in a glass of warm water. Suspension and soluble tablets are most often used for children from 3 to 12 years old. The instructions for using Nimesulide powder recommend taking a diluted suspension of 1 sachet per day, as needed, and when using factory-prepared liquid, no more than 2 measuring spoons of 5 ml per day.

In some countries, drugs with nimesulide are prohibited by the Ministry of Health for children's treatment, but in Russia there is no such ban. Although doctors still recommend using safer Paracetamol and Ibuprofen to reduce a child’s body temperature with acute respiratory viral infections and acute respiratory infections, and only if these medications do not have the desired effect, use Nimesulide.

Use the ointment no more than 4 times a day, applying it in a thin layer to the affected area, trying not to rub it into the skin. In addition, applying the gel to mucous membranes, open wounds and damaged skin is prohibited.

Negative consequences

In terms of safety, Nimesil powder usually surpasses many similar products from the NSAID group. Due to the suspension form, the product is well accepted by the body. Nimesil is usually well tolerated by patients, but side effects occur:

• stool instability;
• pain in the umbilical region;
• persistent dyspepsia;
• nausea (rarely vomiting);
• flatulence.

According to the test results, there is a temporary increase in AST or ALT of the liver, a decrease in hemoglobin, and an increase in eosinophils. Allergic reactions often occur: rashes, itching, hyperemia or swelling. If the patient has a complicated allergy history, there is a risk of developing shock reactions.

Pharmacodynamics

Nimesulide selectively inhibits cyclooxygenase-2; in relation to cyclooxygenase-1, its effect is manifested to a much lesser extent. In this regard, inhibition of prostaglandin synthesis, provoked by an inflammatory reaction, is observed. However, nimesulide has a barely noticeable effect on the formation of regulatory type prostaglandins, which leads to minimal side effects from the digestive system.

In addition, the effective action of nimesulide is manifested in the inhibition of the formation of free radicals. However, the processes of hemostasis and phagocytosis are not affected by this substance. In the mechanism of the anti-inflammatory effect of the drug, a significant place is occupied by its ability to suppress the release of myeloperoxidase (in many inflammatory diseases it can provoke tissue damage and is one of the most accurate diagnostic characteristics indicating a possible risk of developing a heart attack or stroke).

Etiology of menstrual pain

Menstruation is a monthly process of cleansing the female body, during which girls experience bleeding from the vagina. The first day of menstruation (regulus) is considered the beginning of the menstrual cycle. During menstruation, the myocytes of the uterus begin to contract chaotically, the vessels spasm, as a result of which normal tissue trophism is disrupted. All these factors provoke the development of pain syndrome.

Within a month, the reproductive organ prepares for fertilization of the egg; the endometrium is covered with capillaries, which, during conception, should provide trophism to the embryo.

Intense pain during menstruation often occurs against the background of the following pathologies:

• ectopic pregnancy;
• hormonal imbalance;
• impaired progesterone synthesis;
• myoma;
• endometritis;
• oophoritis;
• endometrial polyps;
• adenomyosis;
• ovarian cyst.

Thoughts of ordinary people

The other day, my son and I fell ill with a viral cold. My son was the first to become infected; he is a child, after all, and his immunity is weaker. On the very first day, his temperature began to rise strongly, when it reached 38.7 and no means helped reduce it, I immediately called a doctor. When the doctor arrived, he examined him, brought down his temperature and recommended buying Nimulid in the form of a suspension. As soon as we gave this medicine, the temperature crept down and stopped at 36.9. Now this is the only way I can save myself!

Oksana, 32 years old

My daughter is 5 years old, the other day her knee became very sick and inflamed. Of course, you can’t give your child strong drugs, but since it was the weekend, it was urgent to reduce the pain.

After various children's pain relief products, I saw Nimulid syrup and was attracted by its characteristics. After I gave the suspension to my daughter, the pain decreased within an hour. And even at temperatures this product works well!

Elena, 28 years old

Read further:

Diflucan suspension for children - instructions for use of fluconazole syrup

Ibufen syrup - instructions for use for children from 3 months, suspension analogues

Amoxiclav suspension 250 and 125 mg - instructions for use for children, syrup dosage

Amoxicillin for children - instructions for use of suspension (125 and 250 mg), syrup and tablets

Ibuprofen suspension: instructions for use for children, dosage of syrup and tablets

Paracetamol for children - instructions for use of syrup, dosage of suspension

Effect of the drug

"Nise" is known as an antirheumatic, antipyretic and analgesic. Its main component is nimesulide. It is this that gives an analgesic effect, relieves inflammation, and returns general well-being to normal. This makes it one of the mandatory treatment options for diseases characterized by severe pain. The action of Nise extends to different parts of the body. The transmission of pain impulses to the brain from its areas is disrupted while the drug is working. This happens due to:

• counteracting inflammatory processes;
• reducing the activity of pain receptors in different parts of the body;
• ability to prevent the destruction of certain tissues.

Composition and mechanism of action

Nimesulide is selective, that is, a selective blocker of cyclooxygenase-2, or COX-2. This enzyme is involved in the development of the inflammatory response, swelling, and pain. This effect on COX-2 provides:

• anti-inflammatory;
• analgesic;
• antipyretic effects.

It slightly blocks COX-1, but does not prevent the formation of prostaglandin E2. Thus, the physiological role of this enzyme is not impaired and the number of side effects is reduced.

The mechanism of action of nimesulide includes suppression of the formation of oxygen radicals, which also affects the condition of the body. Such radicals are formed during phagocytosis - the capture of foreign units by immune cells.

What patients say about Nimesil

1. Irina.
   The only painkiller I have in my home medicine cabinet is Nimesil. It is really better than all other analgesics. More effective, helps very quickly. Previously, I bought analgin tablets, citramon and similar drugs. But the most they can help with is a mild headache. If we compare Nimesil with other painkillers, then it is a doubly winner. Firstly, Nimesil is a strong pain reliever, and secondly, Nimesil is a safe medicine. For example, if you take Ketanov, then this drug is quite harmful. For me Nimesil is No. 1;
2. Ivan.
   After my wisdom tooth was removed, I just live on Nimesil, we tried Nurofen, but it doesn’t help at all. And the next day they also cut out the papilloma, and the dentist and surgeon, both doctors, recommended taking Nimesil and indeed, after 20-40 minutes. the pain goes away, lasts for 5-6 hours. Before this, I saved myself with ketanov, but the doctor categorically forbade it, since this drug is a very strong painkiller and has too many side effects, but in fact I don’t see the point in it, since Nimesil, in comparison with Ketanov, works no worse, and maybe even and it’s better, personally it lasts longer for me and I haven’t observed any side effects;
3. Anastatsia.
   I have been familiar with Nimesil powder for a long time. At the first symptoms of a cold, for example, poor general condition, low temperature, he always came to the rescue, and even with a high temperature and the disease had already begun, Nimesil quickly relieved the symptoms - using the drug put him back on his feet in a few days. Once, my gums were inflamed, with swelling of my cheek and pain in the throat and ear, near the wisdom tooth, I had an operation to cut the hood, but recovery was accompanied by a high fever, and here Nimesil also helped me. It comes in the form of a packet of powder and is easy to prepare – just add hot water, stir and drink. It has a slightly sweet and sour, not cloying taste. The drug has helped me more than once, and I noticed that it is much more effective than other powders for colds;
4. Diana. I use it in high temperatures. Powder in bags. Twice a day. Dilute in hot water and drink. It will relieve the fever and aches in the joints too. Not very good for liver function, but no worse than other drugs). After taking the solution, you feel slightly sleepy. Both for viruses and colds - it will ease the symptoms, and maybe put you back on your feet;
5. Julia. For toothache, when I read several interesting publications of Nimesil, Nimid turned out to be the best analgesic and anti-inflammatory drug. Do not rinse a teaspoon of salt into a glass of warm water, but put it in your mouth and hold it until it cools down. Dentists do not allow rinsing; the inflammatory process can go inside;
6. Dmitriy.
   One evening after dinner my tooth began to ache. Out of habit, I tried to pick at my tooth with a toothpick. But somehow I was getting worse and worse, but not to such an extent that I needed to go to the hospital at night. I asked my wife to look for something for the pain. But as always, there was nothing in the first aid kit. A 24-hour pharmacy is located on the other side of the city. But my wife says that when she has women’s days, she takes Nimesil and an online pharmacy helped her with this; she once bought the medicine there. She brought me instructions and said that it is also taken for toothache. Indeed, after 10 minutes the pain subsided. A good remedy helps instantly;
7. Ksenia. I first discovered Nimesil powder when I had a toothache. After visiting the dentist, my tooth started to hurt. I came to him again, he said that this could happen within three days and prescribed the use of Nimesil powder. I bought 6 sachets because I didn’t need more, and a whole package is expensive because there are 30 sachets.
   I drank Nimesil after meals, diluting it in half a glass of water twice a day. The pain subsided within 15 minutes. It turns out that Nimesil can be taken not only for pain, but also as an antipyretic and anti-inflammatory. When I was sick with ARVI, I just bought this powder for myself to relieve my body temperature. Also, the action begins after 15 minutes.

   The powder tastes pleasant, with a lemony taste. There were no side effects when taking the drug. But it should not be taken frequently as it may cause stomach irritation. Therefore, it is important to drink it after meals. The cost of Nimesil powder for 6 sachets is 120 rubles, that is, the whole pack costs 600 rubles.

The drug Nimesulide instructions for use

According to the observations of doctors, the substance, like its analogues, always gives a noticeable effect, but it is better to keep it as a last resort. A large number of contraindications suggests that the instructions for nimesulide are very important to read. There are certain rules of application that should not be forgotten:

• Pills. Take 1 piece orally 2 times a day. Dragees should be washed down with plenty of clean water. The maximum daily dose should not exceed 400 mg.
• Powder. It is accepted in the same way as pills, but its price is a little more expensive. The daily dose should not exceed 400 mg.
• Creams and gels. Apply a small amount of ointment to the affected area 3-4 times. Using an overlay overlay is not recommended.

Nimesulide tablets

The most widely used form of release. Nimesulide tablets can be found in pharmacies under different names. Depending on the country of origin, the price may vary significantly. The most popular commercial names are Nimesulide, Flolid, Ameolin. Dragees can dissolve with water. You are allowed to take 2 or a maximum of 4 tablets per day. The total amount of the drug per day should not exceed 400 mg. Take tablets 2 times a day after meals.

Nimesulide powder - instructions for use

This form of drug release, such as powder, is an excellent replacement for dragees. Helps dull toothache, aching sensations in the lower abdomen during menstruation, fever during a cold. An adult patient needs to consume 100 mg of powder 2 times a day after meals. The granules need to be diluted in warm water. If this dose does not produce results, it can be doubled. The course of treatment lasts no more than 15 days.

The most famous powders in this category are Nimesil and Nemulex. They can be prescribed for gynecological diseases, dental pain, headaches and other ailments that require immediate elimination of discomfort and inflammation. For long-term use, it is better to act according to the doctor's prescription. If the patient has liver failure, then Nimesulide powder is allowed only in an amount of 100 mg.

Nimesulide gel - instructions

The gel is prescribed for problems with the musculoskeletal system. If the patient feels pain in the joints, then squeeze out a small amount of a creamy substance and apply it to the affected area with massage movements. It takes several minutes to rub in Nimesulide gel. To get quick results, the procedure should be repeated 3-4 times a day.

Please note that the gel should not be applied to open wounds or skin affected by various dermatological problems.

Nimesulide ointment - instructions for use

Here the situation is almost the same as with gels. It is necessary to use Nimesulide ointment for pain in the joints according to the instructions. Regular rubbing of the creamy substance will help you get rid of the unpleasant feeling in just a few days. The procedure needs to be carried out 3-4 times a day. The price of ointments is slightly lower than the cost of gels, especially if we are talking about a domestic manufacturer.

Nimesulide suspension for children

The use of the substance by children under 12 years of age is prohibited, but in practice there is not a single case where the medicine has had negative consequences. The child should be given a suspension or syrup. This pharmacological form of release is considered safe for children's health. The main indication for use in young patients is high fever during ARVI. It must be remembered that such a suspension for children is given in cases where simple paracetamol does not give the desired effect.

The dose calculation for a child must be done very carefully, because the medicine is strong. The standard formula for determining the amount of the drug looks like this: 1.5-3 mg per 1 kg of baby’s weight. Taking into account the activity of the substance, the dose received must be divided by 2. The found volume is the daily amount of medication, which is taken in 2-3 approaches. If this dose of suspension or syrup per day does not provide an effect for the child, it can be increased by 1/3.

Contraindications

• complete or incomplete combination of bronchial asthma,
• recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid (ASA) and other NSAIDs (incl.
• in the anamnesis);
• erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum;
• active gastrointestinal bleeding;
• cerebrovascular or other bleeding;
• inflammatory bowel diseases (Crohn's disease,
• ulcerative colitis) in the acute phase;
• hemophilia and other bleeding disorders;
• decompensated chronic heart failure (CHF);
• liver failure or any active liver disease;
• history of hepatotoxic reactions when using nimesulide;
• alcoholism;
• addiction;
• severe chronic renal failure (CRF) (creatinine clearance less than 30 ml/min);
• progressive kidney disease;
• confirmed hyperkalemia;
• period after coronary artery bypass surgery;
• simultaneous use of other hepatotoxic drugs;
• children under 12 years of age;
• pregnancy;
• lactation period;
• increased sensitivity.

With caution: IHD, cerebrovascular diseases, CHF, dyslipidemia/hyperlylidemia, diabetes mellitus, peripheral arterial disease, smoking, renal failure (creatinine clearance less than 30-60 ml/min), anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, the presence of Helicobacter pylori infection, elderly age, long-term use of NSAIDs, severe somatic diseases, simultaneous use of anticoagulants (including warfarin), antiplatelet agents (including

ASA, clopidogrel), oral corticosteroids, selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline).

Nimesulide instructions for use

Pills

The medicine is taken orally on a full stomach. Take the tablet with water. Dosage:

1. adults 100 mg (one tablet) twice a day;
2. children over 12 years old, one tablet twice a day (body weight above 40 kg);
3. for children over 12 years of age weighing up to 40 kg, take according to the formula: 1.5 mg per 1 kg of body weight twice a day.

The duration of treatment with tablets is no more than 15 days.

Powder

The drug in the form of granular powder (1 sachet with 100 mg of nimesulide) is dissolved in ½ glass of clean water. When the granules are completely dissolved, the medicine is ready for use.

The dosage of granular powder is identical to the tablet form.

The maximum permissible daily dose of oral medications with nimesulide is 200 mg. For special medical indications, a maximum daily dose of 400 mg is allowed.

Gel

Gels and ointments with nimesulide are applied topically to the affected areas. For a therapeutic effect, a 3-5 cm column of the drug is sufficient. The daily amount should not exceed 4 procedures. The course of treatment is 10 days.

Therefore, remember the following points

• The patient should not take the drug if he is a child under 12 years of age;
• Elderly people should use Nimesil only under the supervision of a doctor with regular blood tests;
• It is forbidden to take Nimesil at a temperature if the patient has an intolerance to its components, as well as an allergic reaction to them and acetylsalicylic acid;
• Another contraindication is renal failure and toxic damage to the excretory system;
• The drug is incompatible with alcohol and drugs;
• People who smoke should take it only under the supervision of a doctor;
• It is also not recommended to use this medicine for people who have gastrointestinal diseases.

A packet of Nimesil against fever is a good way out of the situation. But if there are contraindications, you need to be extremely careful. Doctors do not recommend taking it in parallel with other potent medications, as well as analogues. If you are being treated for a cold with Nimesil, do not use Aspirin, Analgin or paracetamol-containing products.

Pharmacological properties

The active substance included in all dosage forms of this drug is nimesulide, the chemical name of which is N-(4-Nitro-2-phenoxyphenyl) methanesulfonamide.

The main property of this type of substance is the ability to influence the production of prostaglandins, which trigger all the visible symptoms of a typical inflammatory process - pain, swelling and redness of the inflammation, local or general increase in body temperature, as well as disruption of the normal functioning of the inflamed part of the body.

Nimesulide acts by blocking the enzyme cyclooxygenase, which provokes the synthesis of prostaglandins themselves, thereby stopping the process and completely relieving inflammation and its obvious signs.

Due to the fact that Nimesulide affects COX-2 and does not affect COX-1, which is responsible for protecting the mucous membranes of the gastrointestinal tract, it does not harm the gastrointestinal tract. This compares favorably with the drug, which is similar in action to aspirin, which can ulcerate and perforate the mucous membranes of the mouth, stomach and intestines. Although in case of an overdose, nimesulide is still harmful to the gastrointestinal tract and kidneys.

Another positive quality of the drug is its low allergenicity, which allows it to be prescribed to people suffering from hypersensitivity to other non-steroidal anti-inflammatory drugs.

What does Nimesil consist of and how does it work in the body?

The drug belongs to non-steroidal anti-inflammatory drugs from the sulfonamide class; It is a white or yellowish granular powder with an orange aroma that dissolves quickly in water.

Nimesil is a powder that is easily soluble in water.

Once in the body, Nimesil is capable of:

• reduce high temperature;
• fight inflammation - for example, reduce tissue swelling;
• reduce pain.

The main component of the drug is nimesulide; it inhibits the production of prostaglandins, which stimulate pain receptors. The medicine seems to disorient the body, but it relieves the person of unpleasant sensations, which are often difficult to bear.

However, while relieving the patient from pain, Nimesil does not treat diseases as such.

Doctors do not recommend reducing fever with the help of the drug; During acute respiratory viral infections and influenza, the heart already works under overload, and Nimesil further complicates cardiac activity.

Nimesil helps get rid of fever, but in order not to harm the heart, it is better to treat colds with other means

Forms of release of the drug

More often in pharmacies you will find Nimesil packaged in sachets with granules for preparing a suspension. Effervescent tablets are also available; These have two advantages over regular ones:

• are absorbed faster and therefore act in the body;
• less harmful to the gastric mucosa.

Nimesil is sold in the form of effervescent tablets, from which a solution for drinking is prepared.

The sachet and tablet contain the same amount of nimesulide - 100 milligrams; The dosage forms differ in the composition of auxiliary components. So, the granules contain:

• ketomacrogol;
• sucrose;
• maltodextrin;
• lemon acid;
• flavoring

And in effervescent tablets:

• lemon acid;
• sodium bicarbonate;
• sorbitol;
• potassium carbonate;
• sodium saccharinate;
• sodium lauryl sulfate;
• simethicone emulsion;
• macrogol;
• flavoring

Due to the fact that the tablets contain more components, the likelihood of adverse reactions is higher.

Side effects

Nimesulide is in most cases well tolerated by patients. Side effects usually occur when taking large doses of the drug and a long course of therapy.

1. Nausea, vomiting.
2. Pain in the epigastric region.
3. Heartburn.
4. The appearance of blood in vomit and stool.
5. Headache.
6. Sleep disturbance.
7. Hives.
8. When applied topically – itching and flaking of the skin, allergic rash

If side effects occur, the drug should be discontinued and consult a doctor.

How does Nimulid work?

In addition to the strong analgesic and anti-inflammatory, moderate antipyretic effects indicated in the instructions as the main properties of the drug, Nimulid has several secondary effects:

• prevents the destruction of the main components of connective tissue, prevents the thinning and degradation of cartilage, stopping the further progression of osteoarthritis;
• inhibits the aggregation (sticking together) of platelets, preventing the formation of blood clots;
• reduces the severity of bronchospasm;
• blocks the formation of toxic oxygen-containing radicals;
• slows down the growth rate of malignant liver and prostate tumor cells.

The instructions indicate the main clinically significant pharmacokinetic parameters of Nimulid, used by doctors to calculate the prescribed dose:

• Absorption, entry into the systemic circulation - quickly released from the dosage form and absorbed from the gastrointestinal tract (food slightly reduces the rate of absorption), is in the blood in a bound form. When using the gel, Nimulid practically does not penetrate into the blood.
• Distribution - easily overcomes internal physiological barriers, is distributed into all biological tissues, and is found in significant quantities in synovium, pathological lesions, and tissues of the female genital organs.
• The time for maximum concentration to occur is 1.5-3 hours (oral administration), 20-24 hours (first use of an external agent), the effect of the medicine lasts for 24 hours.
• Metabolism is hepatic, with the formation of an active metabolite.
• Excretion - by the kidneys and with bile acids, undergoes reabsorption and enterohepatic circulation. Half-life is 1.6-5 hours.

In elderly, pediatric patients or with renal dysfunction, pharmacokinetic processes change slightly.

How can the drug be dangerous for children?

Medical researchers have not yet reached a consensus on how safe Nimulid suspension is for children. Some experts express their opinion that the drug is not recommended for their young patients under 12 years of age. This is due to the fact that the medicine has a number of side effects. There are no confirming factors that Nimulid suspension will provoke the development of adverse symptoms in a particular child, but parents should still be aware of these signs:

• development of stomach pain in the form of colic;
• nausea, vomiting and heartburn symptoms;
• Gastrointestinal disorders: constipation, bloating, diarrhea, diarrhea;
• headache and dizziness;
• ulcerative lesions of the stomach;
• decreased visual acuity;
• hemorrhage;
• decrease in hemoglobin level in the blood;
• renal and liver failure;
• thrombocytopenia;
• anemia;
• Quincke's edema;
• drop in body temperature below 36 degrees;
• stagnation of bile.

This is only the main list of contraindications that may occur in children after taking Nimulid. The above side symptoms can manifest themselves either individually or in a complex form.

If a child has a tendency to bleeding, convulsions and renal failure, then giving him Nimulid suspension is not recommended. Hypersensitivity of the body to one of the components of the drug can lead to allergic reactions. If allergy symptoms only intensify, the child should be immediately taken to the hospital.

Application and recommended dosage

The suspension is taken three times a day. Before each dose, Nimulid should be shaken so that the components of the medicine are evenly distributed in the water. In addition, it is advisable to give the medication to the child after meals so that the suspension is less irritating to the digestive system. Children usually take this sweet medicine with plain water.

To calculate a single dosage of the suspension, you need to know the weight of a small patient. For every kilogram of body weight, 1.5 mg of the active ingredient is required. In addition, you don’t have to multiply, but use the table of single doses, which is in the annotation for the drug and on its box. In such a table, the weight of the child is indicated in one column, and the single dosage of the suspension and the frequency of its administration are indicated in the second. For example, if a child weighs 11.5 kg, then in the table they look at the dose of the medicine opposite the weight “10-12 kg”, which corresponds to 1.5 ml of suspension per dose.

For example, a patient who weighs 16 kg can take up to 80 mg of the active component Nimulid, which corresponds to 8 ml of suspension. If the child’s weight exceeds 40 kilograms, then the dosage of liquid Nimulid is no longer calculated by weight, but the medicine is given in a dose that is also prescribed for adults - 100 mg (10 ml of suspension) twice a day.

Indications for use

Nimesulide powder is aimed at relieving acute pain (post-traumatic pain, bursitis, toothache, radiculitis, back pain), osteochondrosis.

The tablets treat arthritis, relieve exacerbations in the joints due to gout, arthritis, spondylitis, and myalgia. They perfectly eliminate pain from osteochondrosis, sprains, and inflammation in tissues. They eliminate pain of various origins.

The gel is used to relieve inflammation in diseases of the musculoskeletal system, muscle pain, ligament rupture, etc.

The suspension is used for joint diseases, fevers with high temperatures . The syrup is prescribed as a remedy to relieve pain symptoms after operations, to eliminate pain of various origins.

When and how to take Nimesil for an expectant mother

The increased load on muscles and joints during pregnancy and partial loosening of cartilage under the influence of the hormone relaxin lead to pathological changes in the musculoskeletal system and provoke severe pain.

It is rare that any expectant mother does not “get acquainted” with nagging pain in the lumbar region

Unable to move with the same grace and dexterity, a pregnant woman may accidentally twist her leg, fall, or hurt herself. The torment is unbearable.

Nimesil will help when a woman has:

• sharp “shooting” pain in the back or lower back;
• myalgia - sharp or dull muscle pain;
• neuralgia - pain accompanying damage to the peripheral nerve;
• tendonitis - inflammation of the tendons;
• bursitis - inflammation in the mucous membranes of the joints;
• osteoarthritis - dystrophic changes in the joints, due to which cartilage tissue becomes thinner and destroyed;
• radiculitis - pathology of nerve endings in the spinal cord;
• injuries, severe bruises, sprains.

The medicine begins to act in the body half an hour after administration; relieves pain attacks for six hours.

Nimesil effectively relieves both headaches and toothaches - only in such situations it is not difficult to choose safer medications for expectant mothers. As in the case of high temperature.

Even with severe pain, it is not recommended to drink Nimesil on your own; only a doctor can prescribe such a controversial treatment - at his own responsibility.

Dosage, rules of administration

The standard adult “portion” of Nimesil is 200 milligrams of nimesulide daily: one sachet or tablet twice a day. The maximum course of therapy is two weeks. However, the instructions emphasize that, if possible, use the minimum dosage and limit yourself to a short course.

But during pregnancy, even short-term treatment with the drug can harm the fetus. The risk of negative consequences can be avoided only with a single use of Nimesil, which the responsible doctor will warn the patient about.

Recent Entries

Is it possible to give a mirror: how to protect yourself from bad omens It became known about the influence of cell phone towers on human health Is it possible to eat bananas bought in Russia?

Take the medicine after meals to reduce the irritating effect on the walls of the stomach. It is easy to prepare the solution:

1. After opening the bag of powder, pour the contents into a glass half filled with water at room temperature; stir the granules.
2. After 2-3 minutes, drink the medicine; The granules may not dissolve completely - no problem.
3. The solution cannot be stored - it is used immediately after preparation.

Effervescent tablets are used similarly.

For whom Nimesil is absolutely contraindicated

Even a single dose of the drug should be avoided by those who cannot tolerate nimesulide or any of the auxiliary components, as well as by women who:

• allergies caused by taking products with acetylsalicylic acid (for example, Aspirin) - such a negative reaction is accompanied by bronchospasm, skin rashes, allergic rhinitis;
• acute intestinal inflammation - including ulcerative colitis, Crohn's disease (damage to parts of the digestive tract);
• constantly high body temperature (above 38 ° C) with minor fluctuations, caused by a cold;
• bronchial asthma, polyps in the nasal cavity due to intolerance to non-steroidal anti-inflammatory drugs;
• stomach or duodenal ulcer;
• bleeding in the gastrointestinal tract;
• diseases that increase the risk of bleeding - both external and internal;
• pathologies in which blood clotting is impaired (for example, hemophilia);
• cerebral circulatory disorders, hemorrhages;
• heart failure;
• cardiac ischemia;
• severe disorders of the kidneys and liver;
• persistently high blood pressure.

If a pregnant woman is already taking analgesics - even as weak as Paracetamol - supplementing therapy with Nimesil is contraindicated, otherwise the liver will suffer.

For peripheral vascular diseases, diabetes mellitus, and also when the bacteria Helicobacter pylori is detected in the body, the drug is used carefully; Pregnant women with such pathologies are better off without Nimesil.

Adverse reactions to the drug

The medicine has a negative effect on the main systems of the body; Some reactions appear occasionally, others quite often. So, among the common side effects in the instructions are listed:

• nausea;
• vomit;
• diarrhea.

The following violations are less commonly observed:

• itching and rashes on the skin, sweating;
• dizziness;
• increased blood pressure;
• tachycardia;
• dyspnea;
• bloating, constipation;
• gastritis.

Rare and very rare reactions include:

• anemia;
• thrombocytopenia (decreased platelet levels in the blood);
• dermatitis;
• Quincke's edema;
• headache;
• drowsiness;
• nervousness, unreasonable fear;
• nightmares;
• degeneration of brain tissue;
• blurred vision;
• stomatitis;
• bleeding in the stomach and intestines;
• stomach ulcer;
• jaundice, hepatitis;
• urinary retention;
• renal dysfunction;
• hyperkalemia (abnormally high levels of potassium in the blood.

Of course, not every patient will face severe negative consequences, and yet choosing Nimesil during pregnancy seems like a risky step. It is possible that you will pay with your health for getting rid of pain.

How Nimesil is combined with other medications

It is important to know which drugs Nimesil, to put it mildly, does not work well with - otherwise, even with a single dose you will provoke complications. Here are examples of negative interactions:

• with the simultaneous use of Nimesil and glucocorticoids (synthetic adrenal hormones - Prednisolone, Metipred), the risk of ulcerative lesions of the stomach or intestines increases;
• nimesulide enhances the effect of antiplatelet agents and anticoagulants (Curantyl, Warfarin), which increases the risk of bleeding;
• the drug weakens the effect of diuretic medications;
• if you take the medicine simultaneously with immunosuppressants (cyclosporine is sometimes prescribed to pregnant women), the risks of toxic effects on the kidneys increase;
• Nimesil can reduce the therapeutic effect of drugs to lower blood pressure.

Do not use Nimesil together with other non-steroidal anti-inflammatory drugs, otherwise you will get liver problems and provoke adverse reactions.

Features of application

The medication is available in the form of granules, which must be diluted with water.

Use of Nimesil for headaches: the drug is taken after meals, washing down the suspension with water. The maximum daily dose is 200 mg or 2 sachets. For intense syndromes, two doses may be taken at a time. For elderly patients, the dose of the drug can be adjusted depending on individual characteristics.

Drug analogues

The following names of drugs are similar in composition and principle of action:

• Aponil;
• Nise;
• Nimesil;
• Nimesulide;
• Nemulex;
• Nimesan.

If the doctor has prescribed the use of Nimulid strictly, then replacing it with analogues is not recommended. If a child experiences signs of illness after taking Nimulide, it is necessary to inform the doctor who prescribed the medicine.

Most experts claim that the anti-inflammatory property of Nimulid is an order of magnitude higher than that of drugs such as Paracetamol, Ibuprofen and others. But before you rush to use the drug, you should weigh all the possible risks of taking it.

Other analogues

You can replace the drug "Nimesulide-Teva" with other medications. But they have a completely different composition. These could be medications “Nurofen”, “Ibuprofen”, “Panadol”, “Paracetamol”, “Citramon”, “Ketorol”, “Aspirin”, “Analgin” and so on.

The active ingredient of these drugs differs not only in dosage, but also in name. But the principle of operation of medications is the same. All of them are analgesics with anti-inflammatory and antipyretic effects.

Using the drug: basic recommendations

Each package of the drug must include instructions for use, as well as a measuring spoon. Even if your doctor has prescribed the medicine to you, be sure to read the instructions before using it. Instructions for use allow parents to become familiar with possible side effects and contraindications. The medicine is used immediately before meals, which speeds up the process of distribution of the active substance nimesulide throughout the body. In exceptional cases, when the components of Nimulid have an irritating effect on the gastric mucosa, the suspension may be taken with food or after a meal.

The dosage for children is calculated based on the following proportion: 5 mg of the product per 1 kg of the child’s weight per day. In order to measure 5 ml of medicine, you should take a full spoon, which is supplied with the medicine. One such spoon contains 50 mg of the active ingredient nimesulide. Nimesulide in excess amounts in the body can lead to the development of side symptoms. To prevent this from happening, you should divide the daily dose of the drug into 2-3 times. It is not recommended to use the product yourself without a doctor's prescription.

The duration of treatment with Nimulid should not exceed 10 days. The need for further use is decided by the attending physician. If the medicine does not have the desired therapeutic effect, which happens extremely rarely, then it should be replaced with analogues with another active substance.

Nimulid gel for back and joint pain: instructions for use, reviews

Have you been trying to heal your JOINTS for many years?

Head of the Institute for Joint Treatment: “You will be amazed at how easy it is to heal your joints by taking every day...

Read more "

Nimulid gel is an anti-inflammatory drug that does not contain steroid hormones. It reduces inflammation and reduces pain in the spine and joints.

The drug has anti-inflammatory and analgesic effects. Used for topical application only. Stored at a temperature not exceeding 25 degrees Celsius. The shelf life of the gel is no more than 2 years from the date of production.

Composition and release form

The drug contains the following components:

• ethanol;
• hydroxypropylcellulose;
• carbomer;
• purified water;
• triacetin;
• dimethylacetamide N;
• phosphoric acid;
• aromatic components.

The active substance is nimesulide. It reduces the content of short-lived prostaglandin and is the main element of kinin-stimulating prostaglandin synthesis at the site of inflammation. Reduces the activity of prostanoid receptors belonging to the EP type and this manifests itself in an analgesic and anti-inflammatory effect.

Nimulid ointment is sold in 30 gram tubes, of which 10% is the active substance. The ointment has a superficial effect and does not penetrate deep into the tissue.

Nimulids have a translucent structure and a uniform yellow consistency.

The drug is produced in India.

Pharmacology and pharmacokinetics

The pharmacological action of the drug is as follows:

1. Anti-inflammatory effect. The drug fights inflammation due to its effect on the reproduction of prostaglandins. The gel has no effect on healthy tissue.
2. Analgesic and antipyretic effect. The drug inhibits and inhibits the production of histamines and affects glucocorticosteroid neuroreceptors.

Nimulid gel prevents the destruction of cartilage by reducing the content of the enzyme urokinase in the body. It is a selective inhibitor of COX-2 and belongs to the sulfonanilide class of NSAIDs (non-steroidal anti-inflammatory drug).

The ointment has a low concentration of the active substance, so after a single use, cmax is observed only after 20-24 hours. There are no traces of the presence of the main metabolite (4-hydroxynimesulide) in the blood.

Nimulid gel does not affect food absorption, unlike tablets and suspensions. The drug binds well to proteins upon penetration into the body and the proportion of the substance is approximately 96%.

The breakdown of the drug occurs in the liver, resulting in the formation of metabolites that are excreted from the body in the urine.

In people over 55 years of age, in adolescents and in people suffering from renal failure, the pharmacokinetic profile changes slightly.

Indications for use

Nimulid gel is prescribed for the following diseases:

The same banned issue for which Ernst fired Malakhov!

Joints and cartilage will be cured in 14 days with the help of ordinary...

• joint and bone injuries;
• back pain;
• fracture;
• cracks;
• diseases of joints, muscles, bones and ligaments;
• arthrosis, arthritis, arthrosis;
• bursitis;
• psoriatic and rheumatoid arthritis;
• osteoporosis;
• myalgia;
• urethritis;
• cystitis;
• inflammatory processes in the ears.

The ointment is also used for skin infections and viral lesions.

Contraindications for prescribing the drug

The drug should not be used in the following cases:

• in case of hypersensitivity to the components of the product;
• with renal or liver failure;
• in case of allergic reactions to medications;
• children under 8 years of age;
• for alcoholism and drug addiction.

Instructions for use

Nimulid gel can be used externally no more than 4 times in 24 hours. A small amount of medication is applied to the affected area and distributed over the skin with a light massaging movement. The drug should not be rubbed in.

After application, wash your hands with soap to completely remove the ointment or gel. The number of applications can be increased by your doctor.

Overdose and side effects

Currently, there are no reported cases of overdose with Nimulid.

Doctors do not exclude the possibility of an overdose with a one-time application of more than 55 grams of the product to a large area of ​​skin.

If you suspect an overdose, you should immediately consult a doctor.

When using Nimulid ointment, side effects may occur, which include:

• hives;
• skin rash;
• itching;
• peeling and dry skin;
• transient change in skin color.

If the listed negative reactions occur during use of the drug, you should immediately stop using the drug and consult a doctor.

Sometimes, when treating large areas of skin, the following adverse reactions may occur:

• heartburn;
• nausea;
• vomiting and urge;
• bowel dysfunction (constipation, diarrhea);
• headache;
• dizziness;
• swelling;
• anemia;
• agranulocytosis;
• increased renal transaminase activity.

In rare cases, the use of ointment can provoke anaphylactic shock, the development of ulcers in the gastrointestinal tract and gastralgia.

special instructions

The drug Nimulid should not be applied to mucous membranes and parts of the skin affected by dermatosis. Avoid contact of the product with the eyes. Do not apply to open wounds and cuts.

It is not recommended to rub the ointment into the skin. Do not cover the treated area with occlusive dressings.

Interaction with other drugs

Along with the gel, diuretic, antihypertensive and hypoglycemic drugs should be taken with extreme caution.

It is necessary to avoid simultaneous use of Nimulide and drugs that contain lithium, Cyclosporine and Methotrexate.

The attending physician should be notified of all such cases.

Pregnancy and lactation

Nimulid is prohibited for use during pregnancy and lactation. The drug may accumulate in the body and pass into breast milk or through the placenta. This in turn can harm the baby.

From application practice

Reviews, comments and advice on taking Nimulid in the form of an ointment from ordinary people and doctors.

Practical advice

It is not recommended to rub the drug. It should also not be applied to mucous membranes and contact with the eyes should be avoided. If this happens, it is necessary to rinse the contact area with clean, running water.

The gel can only be used on skin without allergic reactions. If side effects occur, you must stop using the gel and immediately consult a doctor.

The drug is not recommended to be applied to the skin more than 4 times in 24 hours and used for more than 10 days.

Purchasing the drug and its analogues

The price of Nimulid gel varies from 197 to 240 rubles. The drug is stored at an air temperature of no more than 25 degrees Celsius for 2 years from the date of manufacture.

The gel is available without a prescription.

The drug Nimulid has analogs that are similar in composition and effects on the body. These include:

• Artrosilene;
• Artrum;
• Bioran;
• Valusal;
• Diclogen;
• Indomethacin;
• Naklofen;
• Ortofen;
• Fastum gel.

How to replace Nimesil

The drug is produced in Italy and is not one of the cheap ones: a package of Nimesil will cost more than 200 rubles. But the medicine has a lot of structural analogues, most of which have affordable prices.

In pharmacies you can find Aponil, Nemulex, Nimulid. Perhaps the most famous analogue of Nimesil is Nise (made in India). But the problem is that none of these nimesulide-based medications are approved for pregnant women. Even the Nise gel, popular thanks to advertising, which is used to treat children from the age of seven (and two-year-old children with the Nise suspension), the list of contraindications includes pregnancy.

Functional analogues of Nimesil - drugs with a different composition, but with a similar effect in the body - have a much greater chance of getting into the home medicine cabinet of an expectant mother.

Table: Nimesil analogues for pregnant women

Photo gallery: Nimesil substitutes

Nurofen acts like Nimesil, but is prohibited only in the 3rd trimester

Paracetamol is the safest analogue, but even it cannot be used in the 1st trimester

No-spa is an antispasmodic with a strong reputation; pregnant women are allowed tablets, not injections

The safety of Papaverine has not been clinically proven, but there is no prohibition for pregnant women in the instructions

Homeopathic ointment Traumeel will relieve pain caused by inflammation

Pay attention to the existing contraindications

For Nimesulide-Teva tablets, instructions for use inform that the drug has contraindications. Even if the medication is prescribed by a doctor, you need to familiarize yourself with them. If you find one of the described points in yourself, then you should stop using this product in favor of its analogues.

• It is forbidden to take the medication if you are hypersensitive to nimesulide, as well as possible allergic to aspirin or other non-steroidal drugs with an anti-inflammatory effect.
• If there are lesions of the gastrointestinal tract of an ulcerative nature or intestinal bleeding.
• Existing liver or kidney failure.
• Heart failure or blood diseases. If these circumstances exist in the anamnesis, consultation with a specialist is necessary.
• The use of the drug in childhood, for expectant mothers and during lactation is unacceptable.

It is necessary to consult a doctor even before a single use for: nicotine addiction, diabetes, use of other medications.

Side effects: negative reviews

Before using Nimesulide-Teva, you need to read the available reviews about the drug. The medicine, like many of its analogues, has side effects. These include allergies in the form of rash, hives or swelling. There is a possibility of developing digestive problems: diarrhea, constipation, abdominal pain, intestinal bleeding. Tablets can cause increased blood pressure and tachycardia. There is a possibility of bronchospasm. In this case, patients prone to such effects should have appropriate medications with them.

Some consumers say that the medication has lowered their body temperature too much. The result of this action was hypothermia. In a group of people, the drug causes dizziness, headaches and even panic attacks. There are negative reviews about the tablets, but they are quite few. For the most part, the product is well tolerated by consumers and has a positive effect.

Overdose

An overdose of the drug causes nausea, vomiting, gastric and intestinal bleeding, confusion, anaphylaxis, and shock. To eliminate intoxication, the stomach is washed, activated carbon and symptomatic medications are prescribed to maintain the vital functions of the body. Nimesulide is 95% bound to plasma transport proteins, so hemodialysis is not effective. There is no special antidote.

Opinions of doctors and patients about the medicine

There are many opinions expressed about Nimulid. The reviews are mostly positive. The drug is characterized by speed and effectiveness. The pills cause the most criticism; patients and doctors fear negative symptoms from the digestive system. Therefore, medical professionals do not recommend using the drug for a long time. Nimulid gel has earned good reviews; it is the most popular form.

Doctors readily prescribe it to retired patients with rheumatic diseases or as an addition to the main methods of therapy. The suspension is also effective, but is gentler than tablets. Dr. Komarovsky advises to first study the child’s reaction to the suspension by giving a minimum dose of the medicine.

The antipyretic effect of Nimulid is quite strong and can lead to a sharp and significant decrease in temperature. To relieve fever, Nimulid suspension is recommended to be used if paracetamol does not cope with this.

Side effects

When taking more than the normal amount of the drug and if you are individually intolerant to the constituent elements of the syrup, side effects may appear, and there are quite a lot of them:

• the appearance of heartburn;
• the occurrence of pain in the abdominal area;
• the appearance of nausea and vomiting;
• the occurrence of dizziness;
• the appearance of headaches, up to the onset of a migraine;
• state of drowsiness;
• the appearance of urticaria, erythema;
• in rare cases, fluid accumulation in the body may occur.

Side effects during treatment of children with syrup occur very rarely

It is important to follow all rules of administration and dosage, then the risk of side effects will be minimal

Incorrect dosage, excessive use of the drug, allergic reactions to components in the drug can cause a number of serious side effects:

• heartburn;
• abdominal pain, nausea, vomiting;
• diarrhea or constipation;
• dizziness, headaches, even migraines;
• drowsiness;
• urticaria, erythema;
• edema.

When the drug is used correctly, side effects are extremely rare. In severe heat, when other drugs do not cope, Nimulid suspension is one of the most effective medicines.

Reviews of some parents left on medical forums indicate an allergic reaction in the child after taking the medicine. To this, the doctors replied that the active substance itself causes allergies only in cases of individual intolerance; in this case, allergic manifestations are caused by dyes and flavors, which are used as additional elements.

https://www.youtube.com/watch{q}v=dQxFIRMjTUk

Hives, rashes and irritations in most cases indicate an overdose of the drug. Children very often drink Nimulid without the knowledge of their parents because of its taste. Therefore, it is extremely necessary to store the medicine in a place that is difficult for children to reach.

Nimesil and pregnancy

The instructions for the drug inform: Nimesil is contraindicated for expectant mothers, and at all stages. No clinical trials were carried out on pregnant women - this is inhumane - but experiments on animals revealed disturbances in the development of the fetus.

The longer you take the drug, the higher the risk. But when a pregnant woman suffers from unbearable pain, and there are no relatively safe medications at hand, the doctor, as a last resort, can “authorize” taking Nimesil - most importantly, not as a course.

The drug for different periods

If you are being treated with drugs that are recognized as dangerous for expectant mothers, you should not take them in the 1st and 3rd trimesters.

1st trimester

Pain is difficult to endure, but Nimesil is not a help for a woman in the early stages. In the womb of a tiny person, the main organs and systems are formed; the invasion of aggressive drugs can disrupt the correct development and lead to the development of congenital defects in the baby. And Nimesil penetrates well into the blood from the digestive tract, which means it reaches the fetus.

Nimesulide is concentrated in the tissues of the woman’s genital organs - and after a single dose.

Threats to the unborn child:

• disruption of the formation of the cardiovascular system;
• the appearance of heart disease;
• the development of gastroschisis - a severe pathology in which internal organs come out through a cleft formed in the anterior abdominal wall; the child's survival is in question;
• miscarriage.

It happens that a woman takes Nimesil without yet knowing about conception; it is possible that the drug will provoke a so-called biochemical pregnancy - a miscarriage will occur in the first weeks, which may go unnoticed (like the conception itself). If pregnancy is detected after treatment with Nimesil, most likely it is absolutely normal, but still requires additional medical monitoring.

2nd and 3rd trimesters

In the 2nd trimester, a placenta is formed to nourish and protect the fetus, which partially blocks access to the baby to toxic substances. The organs and tissues of the unborn child are mostly formed. If you take Nimesil, then only in the 2nd trimester.

But in the later stages, the use of Nimesil provokes:

• malfunction of the heart, blood vessels and lungs of the fetus;
• premature closure of the ductus arteriosus in the baby, which leads to heart failure; Normally, the duct closes in the first hours after birth;
• dysfunction of the stomach and intestines in a pregnant woman;
• kidney problems both in the woman and in the unborn child; renal failure is not excluded;
• swelling of the extremities in a woman;
• risks of internal bleeding in the mother;
• weak uterine contractions, difficult, prolonged labor.

By the 3rd trimester, for physiological reasons, women experience heartburn; aggressive medications can make it worse.

Taking Nimesil in later stages increases heartburn and leads to damage to the gastrointestinal mucosa

Nimesulide reduces the ability of platelets to adhere to blood cells and thins the blood. This threatens heavy bleeding during childbirth.

In the 3rd trimester, taking Nimesil can reduce uterine contractility, weaken contractions and delay delivery; Sometimes drug stimulation of the process is required.