motilium for vomiting in a child, for nausea, for diarrhea for children

The American Academy of Environmental Medicine officially confirms that the increase in gastrointestinal diseases is associated with the cumulative effect of unnatural food. But supermarkets leave the buyer no choice. As a result, there is a growing need for drugs that restore the functioning of the gastrointestinal tract. According to public reviews, Motilium is in the top five among drugs for vomiting and nausea prescribed for children.

Composition and release form

The drug Motilium has four formulations, but in all of them the active ingredient is domperidone. The drug does not have any other active ingredients, but there are auxiliary ingredients, the set of which depends on the release form of Motilium:

Tablets to swallow are biconvex, white or beige in color, and the sides of the tablets are engraved with “Janssen” and “M/10.” It also contains lactose, hypromelose, microcrystalline cellulose, magnesium stearate, hydrogenated vegetable oil, sodium lauryl sulfate, polyvidone, corn and potato starch.
Lozenges are white, matte, round in shape. They additionally contain mannitol, aspartame, gelatin, poloxamer 188 and mint essence.
Suspension for children (also called syrup for children) is a liquid in a special bottle. In addition to domperidone, it contains sodium hydroxide and saccharinate, methyl parahydroxybenzoate, carboxymethylcellulose and the drug is based on water.

It is better to select the form of Motilium depending on the reason for prescribing the medicine and the age of the person (in a child, tablets can further cause a gag reflex, and in syrup it is convenient to use the drug at any age).

pharmachologic effect

Manufacturer: Catalent/Janssen-Cilag, UK or Italy
Release form: tablets, dispersible tablets, suspension

Active ingredient: domperidone

Synonyms: Motilak, Motonium, Passazhiks, Motizhekt, Motinorm, Motogastrik, etc.

The drug is a dopamine antagonist with antiemetic properties. Contains domperidone, which accelerates intestinal motility, improves the movement of food and prevents stagnation in the stomach.

At the same time, Motilium does not change gastric secretion and does not affect the production of hydrochloric acid, like proton pump inhibitors (Omez, Nolpaza, etc.).

Activity in the body

The drug Motilium acts as an antiemetic and relieves nausea and heaviness in the stomach due to its component composition, or rather domperidone. It helps cleanse the stomach and close the sphincter valve so that food is not thrown back into the esophagus and does not provoke heartburn and other unpleasant sensations.

The maximum concentration of the drug in the body is reached 1-1.5 hours after administration , and is completely eliminated after 7-9 hours. But such a good concentration will occur in a short period of time if you take the medicine correctly - before meals, otherwise the absorption of the drug will be reduced.

Regarding the withdrawal time of Motilium, everything is very individual, if a person has problems with kidney and liver functions.

Regimen and dosage

Motilium Express is dissolved half an hour before meals, and in no case should the medicine be taken after lunch or dinner. The lower the acidity of the stomach, the worse the drug is absorbed.

The tablets are fragile, so it is not recommended to squeeze them out of the cell. It is better to remove the foil from the cell and take out the drug. Motilium is immediately placed under the tongue, where the medicine dissolves in a few seconds. There is no need to drink water.

Instructions for use of the antiemetic Motilium Express contain all the necessary instructions:

Patients over the age of 12 years when vomiting take 1 tablet 3 times in 24 hours. The appointment lasts 7 days. If Motilium Express does not work, you need to contact a specialist.
Children from 5 to 12 years old are prescribed the same dosage. In this case, the condition is met: the child’s weight must be above 35 kg.

Against the background of kidney dysfunction, the dose is reduced to 1 tablet 1-2 times a day. The dosage is also reduced in case of severe liver damage.

Indications for use

The use of the drug Motilium should be carried out according to the instructions, which spell out what the drug helps with.

Most often, Motilium is prescribed to adults and children for:

Nausea and vomiting.
Motion sickness while traveling.
Reflux esophagitis.
Cholecystitis.
Heartburn and belching.
Baby burping.
Peptic ulcers of the intestines.
Hypotension or atony of the stomach and intestines.
Hiccup.
Cholangitis.
Flatulence and bloating.
Biliary dyskinesia.
Pain in the stomach caused by vomiting or malfunction of the organ itself.

Advertising of the drug:

This is what Motilium cures. But you can also drink it to speed up the digestion process. Motilium is also used in complex treatment to eliminate stomach and duodenal ulcers, but here the prescription must be carried out by a doctor.

Analogues of Motilium

The medicine is used to eliminate many dyspeptic symptoms. The cost of 30 tablets is quite high. For an adult they last up to 10 days. Motilium substitutes differ in active substances, pharmacological group, and indications. Depending on the symptoms and cause, the following groups may be prescribed:

enzyme preparations;
synonyms – analogues according to INN;
antidiarrheals;
antacids;
antispasmodics;
sorbents;
agents that regulate intestinal motility.

The choice of a cheap Motilium substitute should be entrusted to a gastroenterologist to determine the cause of dyspepsia and comprehensive treatment.

Motilium and structural analogues can be used on their own for up to 28 days without a doctor’s prescription, provided there are no side effects or worsening of the condition.

List of analogues on the Russian market with approximate prices

Analogue	Price, in rubles	Manufacturer country
Motilium	620-840	UK, Italy
Passazhiks	140-330	Russia
Motilak	290-410	Russia
Domperidone	70-230	Russia, Hungary
Duspatalin	500-760	Russia or Korea
Enterofuril	270-480	Bosnia and Herzegovina
Cerucal	120-310	Germany or Croatia
Ganaton	350-1040	Japan
Trimedat	280-850	Russia
Smecta	130-340	France
Espumisan	290-740	Germany

Synonyms

Motilium is presented in syrup for young patients and tablets for older children and adults. A synonym or analogue for the active substance in the form of a suspension based on domperidone is the Indian drug Motinorm. It is rarely found in pharmacies, it has been allowed since the year.

The drugs differ in technology and manufacturer, frequency of side effects and price. The high cost of Motilium is explained by the high costs of development and clinical research.

How to replace Motilium if treatment with the drug is not affordable:

Passengers;
Domperidone;
Motonium;
Motilak.

The difference between Passazhix and other synonyms is the convenient and fast-acting form of chewable tablets.

Enzyme preparations

If dyspeptic symptoms are associated with insufficient secretion of enzymes, Motilium can be replaced with a drug from this group.

Representatives:

Pancreatin;
Creon;
Mezim;
Enzistal;
Festal;
Hermital;
Panzinorm et al.

Medicines compensate for the lack of enzymes necessary for the digestion and absorption of food and eliminate dyspeptic symptoms. Disadvantage: with constant use and abuse, the synthesis of enzymes in the body is disrupted.

Antacids

Drugs in this group are used for heartburn and stomach pain. They envelop the gastric mucosa, protecting against the negative effects of hydrochloric acid and other irritants.

Representatives:

Maalox;
Rennie;
Phosphalugel;
Gaviscon;
Gastal et al.

Some medications can cause constipation.

Motilium analogues from the antacid group are used for symptomatic relief of heartburn, they do not treat it.

Duspatalin

Manufacturer: Mylan or Veropharm, Russia or Korea
Release form: tablets, capsules

Active ingredient: mebeverine

Synonyms: Niaspam, Sparex, Mebeverine

The medicine in tablets and capsules Duspatalin is used for pain and cramps in the intestines. The main component of the analogue is mebeverine. The product normalizes peristalsis and treats irritable bowel syndrome. This is a condition characterized by pain, stool disturbance, changes in its frequency, and flatulence. Not used in pediatrics.

The drug No-spasm has a similar effect to Duspatalin.

Smecta

Manufacturer: Bofur Ipsen Industry, France
Release form: powder or suspension

Active ingredient: dioctahedral smectite

Synonyms: Diosmectite, Neosmectin, Endosorb

Smecta is an analogue of Motilium in suspension or powder for its preparation, suitable for adults and children. Belongs to the group of antidiarrheal drugs. Acts in the lumen of the small intestine. This analogue of Motilium for children in suspension adsorbs bacteria, viruses, toxins, and allergens that cause diarrhea on the surface.

The advantage of Smecta is its low price, the disadvantage is its unpleasant taste.

Espumisan

Manufacturer: Berlin-Chemie, Germany
Release form: capsules, solution in drops

Active ingredient: simethicone

Synonyms: Bobotik, Sub Simlex, Simethicone with fennel, Espumisan extra

An analogue of Motilium syrup and tablets is the drug Espumisan, which is classified as a carminative. When it enters the gastrointestinal tract, it collapses gas bubbles and is excreted unchanged.

The imported analogue is used to eliminate bloating, flatulence, and colic in newborns. It is actively prescribed before examining the abdominal organs for accurate x-ray diagnostics.

The advantage of Espumisan is safety, possibility of use from the first days of life, small capsule size. The latter form can be swallowed without drinking water.

Enterofuril

Manufacturer: Bosnalek, Bosnia and Herzegovina
Release form: capsules, syrup

Active ingredient: nifuroxazide

Synonyms: Nifuroxazide, Elufor, Mirofuril, Ecofuril, Contrdiar, Nifural, Adisorb, Stopdiar

The drug Enterofuril is used to treat bacterial diarrhea. Belongs to the group of nitrofurans, antimicrobial agents. It can be used in the form of syrup from a month onwards and has a pleasant banana taste. The effect of the medicine occurs on the first day after use.

Other antidiarrheal drugs:

Imodium (Russian analogue – Loperamide);
Enterosgel;
Polysorb;
Furazolidone and others.

Instructions for use

The description of the drug contains instructions on how it is used and all people are strongly advised to use the drug exclusively in accordance with these instructions. But if the doctor prescribes Motilium with a different course or dosage, then you must follow his instructions. Let's look at how to take the drug in general cases, depending on the pathology:

For vomiting and nausea Motilium helps if you take it in 20 ml syrup or 2 tablets. Should I do this before or after meals? - definitely up to, three times a day, and also at night. Children are given a suspension based on their body weight (5 ml of Motilium per 10 kg). The number of applications and time are the same. The daily dosage of the drug should not exceed 80 mg (for tablets and syrup) and 2.4 mg/kg (for suspension).
For heartburn, chronic dyspepsia, bloating Motilium is given in tablets of 10 mg three times a day on an empty stomach. Another tablet can be taken before bedtime as needed. But only adults are given tablets; liquid Motilium is more suitable for children. Its dosage is 2.5 ml per 10 kg of child’s weight, drink three times a day before meals. The daily dosage, as in the first case, should not exceed the indicated units.
Read also: Signs of peritonitis: main symptoms for acute and chronic inflammation

You should always find out more about the drug and its dosage methods in various cases from your doctor, since self-administration of the medication can cause negative side effects.

Motilium or Motilak – which is better?

Manufacturer: Veropharm, Russia
Release form: tablets

Active ingredient: domperidone

Both drugs are used to restore gastrointestinal contractility. Eliminate abdominal pain, heartburn, bloating, heaviness in the abdomen and nausea. There is only one active ingredient – domperidone.

The difference between drugs is in the form of release, manufacturer and pricing policy. Motilium is a regular and orally soluble tablet and suspension. Motilak is available in film-coated tablets. The cost of the second one is lower.

Motilium and Motilak are synonyms. However, for the quality, variety of release forms and the ability to use the express formula in early childhood, many patients and doctors prefer Motilium. The quality and effectiveness have been confirmed by clinical studies, on the basis of which the instructions have been compiled.

Motilium in syrup is better for a child. If the weight is more than 35 kg, you can replace it with an analogue - Motilak.

Contraindications

Drinking Motilium is strictly prohibited for people with:

Bleeding in the gastrointestinal tract.
Prolactinoma.
Mechanical intestinal obstruction.
Perforation of the intestines or stomach.
Liver dysfunction.
An allergic reaction to any of the components of the drug.
Renal dysfunction (with great caution and under the supervision of a doctor, taking the drug is allowed).

Contraindications may vary from person to person, so you should consult your doctor before taking the drug.

Pharmacokinetics

Motilium is quickly absorbed from the gastrointestinal tract. Maximum accumulation in plasma is observed an hour after a meal. The drug is characterized by fairly low bioavailability - about 15%. If the patient has low acidity, the absorption of domperidone is markedly reduced.

The active substance binds to blood plasma proteins within 91–93%. It is quickly distributed in tissues, but at this time it is weakly concentrated in the brain area. Metabolism of the drug components is carried out by the intestines and liver. Motilium is excreted in feces up to 66%, in urine - about 33%, unchanged. The half-life of the drug is 7–9 hours. In patients diagnosed with severe renal failure, this figure increases even more.

Side effects

Motilium is well tolerated by people, but in some cases it can cause:

Rash in the form of urticaria.
Intestinal spasms.
Amenorrhea.
Gynecomastia.
Hyperprolactinemia.
Extrapyramidal disorders.

Side effects from taking Motilium occur extremely rarely and more often with an overdose of the drug, or if its composition is not suitable for the person or the patient’s body itself suffers from other functional disorders.

Side effects

The medicine "Motilium", instructions and patient reviews indicate this, can cause the following negative effects:

hyperprolactinemia;
intestinal spasms;
allergies;
amenorrhea,
passing extrapyramidal disorders in children;
gynecomastia;
problems in the functioning of the stomach and intestines;
neurological abnormalities in children under one year of age.

If the drug is taken excessively, drowsiness, disorientation, and extrapyramidal abnormalities are observed (usually in children). These symptoms are treated by gastric lavage.

Overdose

In case of an overdose of Motilium, a person may experience disorientation, drowsiness, and extrapyramidal reactions. If the first two symptoms of a drug overdose appear, you must rinse your stomach, drink activated charcoal and stop taking the medicine.

If a person has extrapyramidal reactions, then the help of specialists is needed; only they can prescribe the correct treatment to avoid negative consequences for the human body.

Use in children

Instructions for children regarding the use of Motilium suspension for diarrhea state that the drug can be prescribed to children for various manifestations of hypotension of the gastric walls, which are associated with difficulties in the evacuation of products from the stomach into the duodenum.

As a symptomatic medication, such a drug is prescribed to relieve dyspeptic disorders caused by the following phenomena:

nutritional disorders of nursing mothers;
motion sickness in transport (Motilium quickly helps with vomiting in a child);
improper complementary feeding in the first year of a newborn’s life (the instructions for Motilium regarding the use of a suspension for children with diarrhea directly indicate this);
carrying out medical procedures (endoscopy);
taking certain medications that provoke cyclic vomiting.

The drug can be used during the neonatal period, but strictly as prescribed by the attending physician and under his supervision.

For infants 2–3 months of age, Motilium is recommended for extensive and frequent regurgitation. The medication must be taken before feeding. It cannot be mixed with milk or complementary foods.

Motilium for vomiting in a 3-year-old child is prescribed only in the form of a suspension. Then its dosage is 0.25–0.5 ml per kilogram of the baby’s weight. The amount of suspension is measured using a special dispenser syringe with dosage divisions marked on it, taking into account the child’s body weight (in increments of 1 kg). The medicine is prescribed before meals (15–30 minutes before it) three times a day.

Sometimes it is possible to increase the amount of the drug, but it is necessary that it does not exceed the daily volume (2.4 ml per kilogram of weight). If the child is over 5 years old, but body weight does not exceed 35 kg, then the dosage is set in a similar amount.

For children of the older age group, the drug is prescribed according to the following scheme:

in the period of 5–12 years, you should take a tablet before each meal (4 times);
after the age of twelve, 2 tablets are prescribed, but only three times a day.

The duration of the therapeutic course depends on the severity of the symptoms. The minimum duration of a therapeutic course for children is limited to a term per week.

Motilium is prohibited for use if the child has a pathology associated with dysfunction of prolactin synthesis (hyperprolactinemia). An absolute contraindication is also prolactinoma, a tumor of the anterior pituitary gland, which is often benign in nature.

Parents are obliged to scrupulously monitor compliance with the dosages recommended by the pediatrician, since exceeding them can provoke serious consequences:

speech disorder;
convulsive syndrome;
confusion;
violation of spatial orientation.

If you unintentionally exceed the prescribed dose, you must immediately organize gastric lavage. For the procedure, you need to use a saline solution, and then give the child any sorbent to drink. After providing emergency care, you should definitely consult with a specialist.

Analogs

In some cases, there is a need to replace one medicine with another. , the following analogues are suitable for replacement

Motoricum.
Motilak.
Domidon.
Domperidone-Stoma.
Domperidone Hexal.
Domperidone-Creopharm.
Domperidone Sandoz.
Nausilum.
Perilum.
Motinorm.
Motinol.
Motorix.
Peridonium.
Peridon.

The need for replacement may arise if a person has allergic reactions to the components of Motilium, as well as if the price of the drug does not meet the person’s capabilities.

Also, the drug should always be selected not only according to indications, but also according to the person’s age, since not all drugs have a children’s dosage and are, in principle, allowed for children.

Special Purpose

Motilium does not allow compatibility with various medications and has a number of restrictions for use. If it is impossible to use the drug, a substitute with a similar effect is prescribed.

Drug interactions and other conditions

Antacids and medications that impair the secretory function of gastric juice reduce the absorption of the drug, and under the influence of anticholinergic medications, the activity of Motilium is neutralized. The drug is incompatible with Erythromycin, antibiotics, Ketoconazole, Amiodarone, Clarithromycin, Fluconazole, Antacids, antisecretory and other drugs.

There is little information about the use of the drug during pregnancy, so it cannot be stated that it is harmless . The doctor determines the risk for the pregnant woman and baby at his own discretion, focusing on test results and the mother’s well-being. The product passes into breast milk, so use is not advisable. The active substance stimulates the effect on the tissues of the esophagus and enhances the penetration of other drug formulations.

The shelf life of lozenges is two years, for sublingual tablets - five years, for suspension - three years. Motilium is stored at temperatures from +15 to +30 degrees; after opening, the bottle should be kept in the refrigerator or at room temperature, stored away from children.

Substitutes and similar drugs

If Motilium is not suitable for stopping an attack of vomiting or disruption of the gastrointestinal tract, the doctor selects effective analogues. Depending on how much the proposed drug costs, recommendations and effectiveness, the optimal treatment option is selected.

The following substitutes exist:

Motilak.
Ganaton.
Trimedat.
Diara.
Omeprazole.
Filtrum.
Domperidone.
Cerucal
Omez.
Domstal.
Motonium.
Metoclopramide.

All medications are available in the form of a suspension or tablets and have the same or similar composition.

Ganaton improves the motility of the stomach and intestines, and accelerates digestion. The active ingredient is itopride, which relieves the unpleasant symptoms of vomiting, flatulence, and intestinal discomfort. The medicine is used in combination with other drugs. The price is 250−300 rubles.

Price

When buying Motilium, people pay attention to its price. This drug is not cheap, but there is never any particular problem with purchasing it due to the fabulous amount. Depending on the number of tablets in the package (or the size of the bottle), the pharmacy chain and the city where the drug was purchased, the cost of Motilium will vary greatly.

City	Price
Moscow	391-585 rub.
Saint Petersburg	411-640 rub.
Permian	426-629 rub.
Kyiv	68-167 UAH.
Kharkiv	69-158 UAH.
Odessa	65-81 UAH.

Motilium tablets are always cheaper than children's syrup or suspension, but the difference in price is not very noticeable (about 20 rubles or 5-10 hryvnia).

Motilium or Domperidone – which is better?

Manufacturer: Alsi Pharma, Ozon, Russia
Release form: tablets

Active ingredient: domperidone

Domperidone and Motilium - drugs with the same composition, are synonymous. They have the same indications, contraindications, and side effects.

A significant disadvantage of the domestic analogue of Domperidone is the low quality of raw materials (from India or China) and the frequent occurrence of side effects. The cost of the substitute is several times lower.

Another difference between Domperidone and Motilium is the release form. Pharmacies stock only regular tablets; the imported analogue is presented in display cases as dispersible tablets and syrup for children.

Analogue Metoclopramide

This drug is also a cheap analogue containing metoclopramide hydrochloride. The indications for use of this substitute are the same as Motilium, but the contraindications are somewhat different. For example, Metoclopramide should not be taken if you have bronchial asthma or during pregnancy.

The number of possible adverse reactions is slightly greater than that of the original. For example, when taking it, people may experience extrapyramidal symptoms and spasms of the facial muscles. The price of the drug is about one hundred and twenty rubles. Thus, the main advantage of this substitute is its price, and the disadvantage is that it has more contraindications than Motilium.

What kind of drug

Motilium is a drug that improves intestinal motor function, has an antiemetic effect, it increases the tone of the sphincter of the lower part of the esophagus. It does not affect the activity of gastric juice and its production.

The active substance of the drug is domperidone (a substance that has antipsychotic properties, but does not have side effects). Taking the drug increases the production of prolactin.

Available in the form of tablets, lozenges and suspension. Each form has different dosages of the active substance and differs in the country of origin.

The most pronounced therapeutic effect is increased peristalsis, which helps accelerate the removal of food from the stomach and duodenum. With rapid evacuation, food does not rot or ferment in the digestive tract, which helps reduce heartburn, nausea and increased gas formation.

Motilium helps improve motility of the gastrointestinal tract, so that food does not have time to ferment and does not cause heartburn, nausea and flatulence

Use during pregnancy

Motilium is not recommended for diarrhea during pregnancy, because There is insufficient data on its effect on the fetus.

Therefore, along with the fact that the medicine has many indications and helps to cope with various painful conditions, its use during pregnancy is allowed when the expected effect outweighs the possible risks.

To date, there is no confirmed data on the effect of medication on a child during breastfeeding. Therefore, if the drug is used in the treatment of diarrhea, feeding should be stopped at this time.

Purpose of the drug

Take for the following conditions and diseases:

Disorders of the digestive process due to inflammation of the esophagus, movement of stomach contents in the opposite direction or stagnation. Accompanied by bloating and pain.
Feeling nauseous and vomiting due to medications used to treat Parkinson's.
The presence of infectious diseases, food poisoning, intoxication, functional disorders of the digestive system. When side effects occur from taking medications, chemotherapy or radiotherapy, it is accompanied by vomiting.
Problems with the natural movement of food through the gastrointestinal tract, when there is pain in the abdomen with vomiting.

Contraindications and side effects

Motilium has a fairly wide range of contraindications:

a tumor in the pituitary gland that produces prolactin;
simultaneous use with Motilium of tablet forms of fluconazole, ketoconazole, voriconazole, erythromycin, amiodarone, clarithromycin, telithromycin;
suspicion of internal bleeding in the stomach and intestines;
intestinal obstruction;
perforation of an intestinal or stomach ulcer;
serious liver diseases;
special sensitivity to sorbitol (contained in Motilium Suspension);
intolerance to domperidone, another component.

The medicine is contraindicated in any cases where it is prohibited to stimulate intestinal motility. You should also be especially careful when using Motilium if you have kidney problems, problems with heart rhythm, or heart failure.

According to the results of medical studies, very rare negative effects occur when using Motilium - no more often than 1% of small patients . This:

headaches, weakness, tearfulness, anxiety, drowsiness, leg cramps;
conjunctivitis (swelling of the eyelids, pain and itching, redness of the eyelids and mucous membranes);
dry mouth, heartburn, loss of appetite,
diarrhea, severe thirst, symptoms of stomatitis, constipation, urinary retention;
swelling of the mammary glands in girls over 10 years old,
spasms of the stomach and intestines,
allergic reactions (extremely rare): skin rashes, itching, swelling of the face, hands, feet, urticaria.
extremely rarely - anaphylactic shock.

Sometimes Motilium gives unwanted negative manifestations of a neurological nature, most likely in children under 3 years of age. Considering these data, a strict calculation of the dose of Motilium for newborns, infants and children 3–5 years is necessary. .

Mental disorders in children can also be caused by an overdose of the drug, but when contacting a doctor, it is imperative to exclude more serious causes of such neurological symptoms.

They appear extremely rarely (mainly in babies under one year):

strong excitement with whims, crying, fear;
increased nervousness, tic, trembling fingers, erratic movements of arms and legs, convulsions.

List of the cheapest analogues of Motilium with prices in Russia

Prices for medicines play a significant role in choosing the right drug, compliance with the dosage and course. Therefore, pharmacies inform doctors about the availability of drugs and their prices. When offering a drug to a patient, the doctor must control the situation and offer the patient different options for similar medications.

A list of cheap Motilium substitutes is presented in the table.

Trade name of the drug	Packaging price in rubles
Domperidone	100-110
Dimetpramide	140-170
Perinorm	140-190
Cerucal	120-168
Domet	About 100
Passazhiks	90-130
Tseruglan	50
Motilak	80-180
Motonium	100

We are not talking about the patient “dictating” his choice to the doctor, but the pricing policy of the pharmaceutical industry does not yet provide stable information on the cost of drugs. This means that doctors have to adapt and look for cheaper substitutes. Otherwise, people give up treatment due to the inability to purchase an imported drug at a high price.

Compound

The doctor can prescribe to the patient any dosage form of the drug "Motilium", the active substance in the composition predominates one, but in different dosages. The active component of the drug is domperidone.

"Motilium" suspension contains 1 mg of active substance per 1 ml of solution. Each swallowable pill contains a dosage of domperidone equal to 10 mg. Motilium lozenges contain the same portion of the active ingredient.

In addition to the specified substance, Motilium contains other substances in one tablet or serving of suspension: asparkam, sorbitol, polyvidone, magnesium stearate, lactose, etc.

How does domperidone work?

Domperidone blocks dopamine receptors in the upper digestive tract. This causes contraction of the muscles at the entrance to the stomach and relaxation of the muscles at the exit from it, and also enhances the peristalsis of the stomach itself. Therefore, the use of Motilium for diarrhea is inappropriate. These actions speed up the passage of food through the stomach into the intestines, which helps prevent vomiting and reduce nausea, bloating and fullness. Domperidone also prevents the backflow of food from the stomach into the esophagus.

Motilium also blocks dopamine receptors in the area of the brain that are activated by nerve signals from the stomach. Once activated, it sends signals to the vomiting center. Blocking dopamine receptors prevents nausea and vomiting.

How to take it correctly

Tablets and suspension should be taken 15–20 minutes before meals. Food may interfere with the absorption of the active substance, so the drug should not be taken during meals. The suspension must be taken by first measuring the required amount using a measuring syringe. Tablets for oral administration should be taken with clean water at room temperature. It is not recommended to drink juices or milk. Lozenges should be held on the tongue until completely dissolved. They are not recommended to be chewed or swallowed whole.

The author of these lines takes Motilium in tablet form, intended for resorption. This method is the most convenient in practice. The tablet dissolves quickly on the tongue and has a pleasant minty taste. I take Motilium for nausea caused by exacerbation of gastritis. I always take the drug on the road.

Composition and description of the medication

The positive properties of the drug are achieved due to the “rich” composition:

starch;
vegetable oil;
magnesium stearate;
sodium lauryl sulfate;
polyvidone;
hypromelose.

Motilium is available in several forms:

suspension;
tablets for oral administration;
lozenges.

Below in the table we list the components included in other forms of the medication:

Suspension	Lozenges	Tablets for oral administration
sodium saccharin	mint essence	lactose
sodium hydroxide	mannitol	cellulose
sorbidol	gelatin
sodium carboxymethylcellulose	aspartame
propyl parahydroxybenzoate	polaxamer

Many people call the suspension syrup or children's Motilium, as it is prescribed by pediatricians for the treatment of children. Lozenges are brown in color and round in shape, with an inscription on the sides.

The coated pills are also round in shape and painted white. On the break there is a tablet of a uniform shade without inclusions.

The light-colored suspension has a consistency similar to jelly. The product is available in a 100 ml volume in a dark glass jar. If the pills are allowed to be taken by children over 12 years of age, then the suspension is also acceptable for babies up to one year old to prevent colic, since it contains less of the active drug.

Motilium suspension

Motilium lozenges

Indications

Experts recommend using the drug for the following symptoms:

frequent regurgitation in infants and small children;
heartburn;
nausea and vomiting caused by infectious agents, pathologies of internal organs or other disorders;
motion sickness on long trips;
violation of gastrointestinal motility in a child;
bloating;

systematic vomiting in children;
belching with a sour aftertaste;
feeling of fullness in the stomach;
pain after eating;
pediatric gastroesophageal reflux;
gastroesophageal reflux disease;
extinguishing the urge to vomit during medical examinations (probing, endoscopy);
Regurgitation is regular;
vomit;
esophagitis;
flatulence;
gastric hypotension;
gastritis;
reflux of the stomach and esophagus;
nausea with bouts of vomiting caused by taking medications;
malaise after treatment of malignant tumors with chemotherapy, radiotherapy (the urge to vomit).

Russian doctors often recommend Motilium; it has proven its effectiveness, and its indications for use cover a wide range of symptoms. This allowed the drug to become one of the most popular.

List of analogues of this drug

The drug has analogues of foreign and domestic production. Motilium analogues (for example, Motilak, Cerucal, Domperidone, Metoclopramide or Ganaton) are very often prescribed as a replacement for this medicine. In our country, Motilak and Domperidone are produced - these analogues are not only domestic, but also cheap compared to the original Motilium. Drugs in the form of “Ganaton” and “Cerucal” are foreign-made drugs. As for Metoclopramide, it is produced both in Russia and abroad. Russian analogues of Motilium are no less effective.

Among other things, if necessary, the medication can be replaced with generics, which also contain domperidone. We are talking about such drugs as Gastropom, Domidon, Domrid and Brullium. In addition, analogues of Motilium are Intanorm, Motizhekt, Perilium, Nausilium, Passazhiks and others.

The drug "Motilium" differs from the above products from the list mainly only in price and manufacturer. The effectiveness of all these drugs has been proven by scientific research. Next, let's look at Motilium analogues in more detail.

Use of Motilium for newborns

For babies, the need for Motilium occurs with increased regurgitation, insufficient weight gain, diarrhea with the threat of dehydration, and intestinal colic.

Pediatricians prescribe a suspension at the rate of 0.25-0.5 ml/kg. It is given before feeding 3-4 times a day. The child is weighed before the appointment.

The syrup packaging contains a measuring syringe, on which divisions are applied: on the one hand, by weight, on the other, by dose. The bottle should be shaken well before putting into the syringe. The drawn-in amount is poured into a spoon or drops directly into the baby’s mouth. No drinking required. The syringe should always be washed with warm water without detergents.

For regurgitation and colic

The dosage is determined by the weight of the baby according to the method described above. Three applications per day are usually sufficient. If the baby is excited and screams at night, it is allowed to give the dose a fourth time. You can try to get by with drops of Espumisan Baby. The drugs are compatible and do not cause additional negative reactions.

To normalize intestinal motility, you may need to take small doses of Motilium for three months.

For heartburn

The feeling of burning behind the sternum is familiar to almost every person. For some people, it occurs constantly after eating. Unpleasant sensations are a consequence of the reflux of (involuntary) stomach contents into the esophagus. The cause of this condition can be obesity, stress, alcohol abuse, and poor nutrition. Regardless of why the burning sensation occurs, Motilium will help with heartburn. To completely get rid of it, taking medication is not enough. You need to normalize your diet and give up bad habits.

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special instructions

It is not advisable to combine the drugs with the following medications:

broad spectrum antibiotics,
antiarrhythmic,
antidepressants,
antifungal,
antimalarial,
antiallergic,
antitumor.

Motilium should not be taken to prevent nausea after anesthesia. The active substance can provoke the appearance of tachycardia with long-term use; this should be taken into account by persons with a predisposition to heart disease. If arrhythmia occurs, treatment with the drug must be stopped.

It is not recommended to exceed the minimum dose of the medication to avoid side effects.

The main component affects the speed of reactions and concentration, so during treatment you should refrain from driving a car or hazardous activities.

Taking antibiotics simultaneously with Motilium is not recommended

Interaction with other drugs

Some antitussives may significantly reduce the effectiveness of Motilium. Azole antifungals (fluconazole, ketoconazole, etc.), macrolide antibiotics (erythromycin, etc.), HIV protease inhibitors, calcium antagonists, as well as amiodarone, aprepitant, nefazodone, telithromycin can excessively increase the amount of domperidone in the plasma. In addition, some of the medications listed can disrupt the heart rhythm.

Motilium can be combined without fear with antipsychotics, bromocriptine and levodopa.

Prices for the drug and its main analogues, average in Russia

One of the reasons for replacing the drug is its high price. Information on prices for Motilium and its analogues is given in Table 1.

Table 1 - Average prices for Motilium and its analogues

Drug name	Active ingredient	Pharmacological form	Quantity, pieces/ml	Average price, rub.
Motilium	Domperidone	Pills	10	384-637
Suspension	100 ml	552-615
Motilak	Pills	30	223-312
Domperidone	30	58-201
Domidon	30	110-184
Motinorm	30	200-232
Motorix	10	79-117
Perinorm	100	215-254
Riabal	Priphinia bromide	30	700-750
Riabal	Priphinia bromide	Syrup	60 ml	950-1000

As can be seen from the table, Motilium is the most expensive drug compared to its analogues. There are cheaper antiemetics. Some of them contain the same active ingredient – domperidone. There are also drugs that contain other active ingredients (prinfia bromide, bromopride), but their effect is similar to that of Motilium.

There are also analogues that are not sold in the Russian Federation (Domrid, Nausilium, Bromoprid, Brulium lingvatabs and others). If necessary, such a drug can be ordered online or purchased in another country.